公开(公告)号：US20200095230A1

公开(公告)日：2020-03-26

申请号：US16586401

申请日：2019-09-27

Applicant: AbbVie Inc.

Inventor： Russell D. Cink ,  Kirill A. Lukin ,  Marvin R. Leanna ,  Matthew J. Pelc ,  Timothy B. Towne ,  Dennie S. Welch ,  Kenneth M. Engstrom ,  Matthew M. Ravn ,  Richard D. Bishop ,  Gang Zhao ,  Jianzhang Mei ,  Jeff M. Kallemeyn ,  David R. Hill ,  Michael J. Abrahamson ,  Westin H. Morrill

IPC: C07D403/12 ,  C07D405/14 ,  C07D241/44 ,  C07D405/06 ,  C07C271/34 ,  C07C69/74 ,  C07C43/196 ,  C07D487/04 ,  C07C269/06 ,  C07C269/04 ,  C07C41/26 ,  C07C67/08 ,  C07C68/02 ,  C07C211/35 ,  C12P1/00 ,  C12P41/00

Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.

公开(公告)号：US10077256B2

公开(公告)日：2018-09-18

申请号：US15804485

申请日：2017-11-06

Applicant: AbbVie Inc.

Inventor： Russell D. Cink ,  Kirill A. Lukin ,  Marvin R. Leanna ,  Matthew J. Pelc ,  Timothy B. Towne ,  Dennie S. Welch ,  Kenneth M. Engstrom ,  Matthew M. Ravn ,  Richard D. Bishop ,  Gang Zhao ,  Jianzhang Mei ,  Jeff M. Kallemeyn ,  David R. Hill ,  Michael J. Abrahamson ,  Westin H. Morrill

IPC: C07D403/12 ,  C07C67/08 ,  C07C41/26 ,  C07C269/04 ,  C07C269/06 ,  C07D487/04 ,  C07C43/196 ,  C07C69/74 ,  C07C271/34 ,  C07D405/06 ,  C07D241/44 ,  C07D405/14

CPC classification number: C07D403/12 ,  C07C41/26 ,  C07C43/196 ,  C07C67/08 ,  C07C68/02 ,  C07C69/74 ,  C07C211/35 ,  C07C269/04 ,  C07C269/06 ,  C07C271/34 ,  C07C2601/08 ,  C07D241/44 ,  C07D405/06 ,  C07D405/14 ,  C07D487/04 ,  C12P1/00 ,  C12P41/005 ,  C07C69/96 ,  C07C69/14

Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.

公开(公告)号：US20200024621A1

公开(公告)日：2020-01-23

申请号：US16435000

申请日：2019-06-07

Applicant: AbbVie Inc.

Inventor： Michael J. Abrahamson ,  Angelica B. Kielbus ,  William T. Riordan ,  David R. Hill ,  Sanjay R. Chemburkar ,  Rajarathnam E. Reddy ,  Timothy B. Towne ,  Jianzhang Mei ,  Stefan Mix ,  Gareth J. Brown

IPC: C12P7/62 ,  C12P41/00

Abstract: Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.

公开(公告)号：US20190084966A1

公开(公告)日：2019-03-21

申请号：US16132997

申请日：2018-09-17

Applicant: AbbVie Inc.

Inventor： Russell D. Cink ,  Kirill A. Lukin ,  Marvin R. Leanna ,  Matthew J. Pelc ,  Timothy B. Towne ,  Dennie S. Welch ,  Kenneth M. Engstrom ,  Matthew M. Ravn ,  Richard D. Bishop ,  Gang Zhao ,  Jianzhang Mei ,  Jeff M. Kallemeyn ,  David R. Hill ,  Michael J. Abrahamson ,  Westin H. Morrill

IPC: C07D403/12 ,  C07C269/06 ,  C07C68/02 ,  C07C67/08 ,  C07C211/35 ,  C07C271/34 ,  C12P1/00 ,  C07C69/74 ,  C07C43/196 ,  C07C41/26 ,  C07D405/14 ,  C07D241/44 ,  C07D405/06 ,  C07D487/04 ,  C07C269/04

CPC classification number: C07D403/12 ,  C07C41/26 ,  C07C43/196 ,  C07C67/08 ,  C07C68/02 ,  C07C69/74 ,  C07C211/35 ,  C07C269/04 ,  C07C269/06 ,  C07C271/34 ,  C07C2601/08 ,  C07D241/44 ,  C07D405/06 ,  C07D405/14 ,  C07D487/04 ,  C12P1/00 ,  C12P41/005 ,  C07C69/96 ,  C07C69/14

Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.

公开(公告)号：US20180194721A1

公开(公告)日：2018-07-12

申请号：US15789133

申请日：2017-10-20

Applicant: AbbVie Inc.

Inventor： Kirill A. Lukin ,  Jianzhang Mei ,  David R. Hill ,  Michael J. Abrahamson

IPC: C07C271/24 ,  C12P7/62 ,  C07C269/06 ,  C07C67/333 ,  C07C67/347 ,  C07C69/74

Abstract: The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.

公开(公告)号：US09809534B1

公开(公告)日：2017-11-07

申请号：US14802392

申请日：2015-07-17

Applicant: AbbVie Inc.

Inventor： Kirill A. Lukin ,  Jianzhang Mei ,  David R. Hill ,  Michael J. Abrahamson

IPC: C07C271/24 ,  C07C269/06 ,  C07C69/74 ,  C07C67/333 ,  C07C67/347 ,  C12P7/62

CPC classification number: C07C271/24 ,  C07B2200/07 ,  C07C67/333 ,  C07C67/347 ,  C07C69/65 ,  C07C69/74 ,  C07C211/27 ,  C07C211/35 ,  C07C269/00 ,  C07C269/06 ,  C07C269/08 ,  C07C2601/02 ,  C07C2601/14 ,  C12P7/62

Abstract: The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.

公开(公告)号：US09809576B1

公开(公告)日：2017-11-07

申请号：US14802372

申请日：2015-07-17

Applicant: AbbVie Inc.

Inventor： Russell D. Cink ,  Kirill A. Lukin ,  Marvin R. Leanna ,  Matthew J. Pelc ,  Timothy B. Towne ,  Dennie S. Welch ,  Kenneth M. Engstrom ,  Matthew M. Ravn ,  Richard D. Bishop ,  Gang Zhao ,  Jianzhang Mei ,  Jeff M. Kallemeyn ,  David R. Hill ,  Michael J. Abrahamson ,  Westin H. Morrill

IPC: C07D403/12 ,  C07C69/74 ,  C07D241/44 ,  C07D405/06 ,  C07C271/34 ,  C07C67/08 ,  C07D405/14 ,  C07D487/04 ,  C07C269/06 ,  C07C269/04 ,  C07C41/26 ,  C07C43/196

CPC classification number: C07D403/12 ,  C07C41/26 ,  C07C43/196 ,  C07C67/08 ,  C07C68/02 ,  C07C69/74 ,  C07C211/35 ,  C07C269/04 ,  C07C269/06 ,  C07C271/34 ,  C07C2601/08 ,  C07D241/44 ,  C07D405/06 ,  C07D405/14 ,  C07D487/04 ,  C12P1/00 ,  C07C69/96 ,  C07C69/14

Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.

公开(公告)号：US10442792B2

公开(公告)日：2019-10-15

申请号：US16132997

申请日：2018-09-17

Applicant: AbbVie Inc.

Inventor： Russell D. Cink ,  Kirill A. Lukin ,  Marvin R. Leanna ,  Matthew J. Pelc ,  Timothy B. Towne ,  Dennie S. Welch ,  Kenneth M. Engstrom ,  Matthew M. Ravn ,  Richard D. Bishop ,  Gang Zhao ,  Jianzhang Mei ,  Jeff M. Kallemeyn ,  David R. Hill ,  Michael J. Abrahamson ,  Westin H. Morrill

IPC: C07D403/12 ,  C07D405/14 ,  C07D241/44 ,  C07D405/06 ,  C07C271/34 ,  C07C43/196 ,  C07D487/04 ,  C07C269/06 ,  C07C41/26 ,  C07C67/08 ,  C07C68/02 ,  C12P1/00 ,  C07C211/35 ,  C12P41/00 ,  C07C69/74 ,  C07C269/04

Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.

公开(公告)号：US10421712B2

公开(公告)日：2019-09-24

申请号：US15789133

申请日：2017-10-20

Applicant: AbbVie Inc.

Inventor： Kirill A. Lukin ,  Jianzhang Mei ,  David R. Hill ,  Michael J. Abrahamson

IPC: C12P7/62 ,  C07C69/65 ,  C07C69/74 ,  C07C211/27 ,  C07C211/35 ,  C07C269/00 ,  C07C269/06 ,  C07C269/08 ,  C07C271/24 ,  C07C67/333 ,  C07C67/347

Abstract: The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.

公开(公告)号：US10316338B1

公开(公告)日：2019-06-11

申请号：US15010557

申请日：2016-01-29

Applicant: AbbVie Inc.

Inventor： Michael J. Abrahamson ,  Angelica B. Kielbus ,  William T. Riordan ,  David R. Hill ,  Sanjay R. Chemburkar ,  Rajarathnam E. Reddy ,  Timothy B. Towne ,  Jianzhang Mei ,  Gareth J. Brown ,  Stefan Mix

IPC: C12P7/62

Abstract: Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.