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公开(公告)号：US20200325506A1
公开(公告)日：2020-10-15
申请号：US16673326
申请日：2019-11-04
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Julie J. Pruyne , Angelica B. Kielbus , John E. Lallaman , Rajarathnam E. Reddy , Sanjay R. Chemburkar
IPC: C12P13/04
Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
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公开(公告)号：US10113152B1
公开(公告)日：2018-10-30
申请号：US14873706
申请日：2015-10-02
Applicant: AbbVie Inc.
Abstract: Disclosed are, among other things, variant polypeptides, nucleic acids encoding the polypeptides, production of the variant polypeptides, and use of the variant polypeptides in various applications, such as screening and synthetic methods. For example, the variant polypeptides, or enzymatically-active fragments thereof, are useful for converting aliphatic keto acids to aliphatic alpha amino acids.
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公开(公告)号：US10316338B1
公开(公告)日：2019-06-11
申请号：US15010557
申请日：2016-01-29
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Angelica B. Kielbus , William T. Riordan , David R. Hill , Sanjay R. Chemburkar , Rajarathnam E. Reddy , Timothy B. Towne , Jianzhang Mei , Gareth J. Brown , Stefan Mix
IPC: C12P7/62
Abstract: Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
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Patent Agency Ranking
公开(公告)号：US20190048326A1
公开(公告)日：2019-02-14
申请号：US16172111
申请日：2018-10-26
Applicant: AbbVie Inc.
IPC: C12N9/06
Abstract: Disclosed are, among other things, variant polypeptides, nucleic acids encoding the polypeptides, production of the variant polypeptides, and use of the variant polypeptides in various applications, such as screening and synthetic methods. For example, the variant polypeptides, or enzymatically-active fragments thereof, are useful for converting aliphatic keto acids to aliphatic alpha amino acids.
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公开(公告)号：US10059969B1
公开(公告)日：2018-08-28
申请号：US14874001
申请日：2015-10-02
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Julie J. Pruyne , Angelica B. Kielbus , John E. Lallaman , Rajarathnam E. Reddy , Sanjay R. Chemburkar
IPC: C12P13/04 , C07C51/377 , C07C67/343
CPC classification number: C12P13/04 , C12Y104/01009
Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
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6.发明申请公开(公告)号：US20200024621A1
公开(公告)日：2020-01-23
申请号：US16435000
申请日：2019-06-07
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Angelica B. Kielbus , William T. Riordan , David R. Hill , Sanjay R. Chemburkar , Rajarathnam E. Reddy , Timothy B. Towne , Jianzhang Mei , Stefan Mix , Gareth J. Brown
Abstract: Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
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公开(公告)号：US10465216B2
公开(公告)日：2019-11-05
申请号：US16113738
申请日：2018-08-27
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Julie J. Pruyne , Angelica B. Kielbus , John E. Lallaman , Rajarathnam E. Reddy , Sanjay R. Chemburkar
IPC: C12P13/04
Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
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公开(公告)号：US20190048372A1
公开(公告)日：2019-02-14
申请号：US16113738
申请日：2018-08-27
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Julie J. Pruyne , Angelica B. Kielbus , John E. Lallaman , Rajarathnam E. Reddy , Sanjay R. Chemburkar
IPC: C12P13/04
CPC classification number: C12P13/04 , C12Y104/01009
Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
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