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公开(公告)号：US09809576B1
公开(公告)日：2017-11-07
申请号：US14802372
申请日：2015-07-17
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07C69/74 , C07D241/44 , C07D405/06 , C07C271/34 , C07C67/08 , C07D405/14 , C07D487/04 , C07C269/06 , C07C269/04 , C07C41/26 , C07C43/196
CPC classification number: C07D403/12 , C07C41/26 , C07C43/196 , C07C67/08 , C07C68/02 , C07C69/74 , C07C211/35 , C07C269/04 , C07C269/06 , C07C271/34 , C07C2601/08 , C07D241/44 , C07D405/06 , C07D405/14 , C07D487/04 , C12P1/00 , C07C69/96 , C07C69/14
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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公开(公告)号：US20180194721A1
公开(公告)日：2018-07-12
申请号：US15789133
申请日：2017-10-20
Applicant: AbbVie Inc.
Inventor： Kirill A. Lukin , Jianzhang Mei , David R. Hill , Michael J. Abrahamson
IPC: C07C271/24 , C12P7/62 , C07C269/06 , C07C67/333 , C07C67/347 , C07C69/74
Abstract: The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.
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公开(公告)号：US09809534B1
公开(公告)日：2017-11-07
申请号：US14802392
申请日：2015-07-17
Applicant: AbbVie Inc.
Inventor： Kirill A. Lukin , Jianzhang Mei , David R. Hill , Michael J. Abrahamson
IPC: C07C271/24 , C07C269/06 , C07C69/74 , C07C67/333 , C07C67/347 , C12P7/62
CPC classification number: C07C271/24 , C07B2200/07 , C07C67/333 , C07C67/347 , C07C69/65 , C07C69/74 , C07C211/27 , C07C211/35 , C07C269/00 , C07C269/06 , C07C269/08 , C07C2601/02 , C07C2601/14 , C12P7/62
Abstract: The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.
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4.发明申请公开(公告)号：US20200024621A1
公开(公告)日：2020-01-23
申请号：US16435000
申请日：2019-06-07
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Angelica B. Kielbus , William T. Riordan , David R. Hill , Sanjay R. Chemburkar , Rajarathnam E. Reddy , Timothy B. Towne , Jianzhang Mei , Stefan Mix , Gareth J. Brown
Abstract: Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
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公开(公告)号：US20190084966A1
公开(公告)日：2019-03-21
申请号：US16132997
申请日：2018-09-17
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07C269/06 , C07C68/02 , C07C67/08 , C07C211/35 , C07C271/34 , C12P1/00 , C07C69/74 , C07C43/196 , C07C41/26 , C07D405/14 , C07D241/44 , C07D405/06 , C07D487/04 , C07C269/04
CPC classification number: C07D403/12 , C07C41/26 , C07C43/196 , C07C67/08 , C07C68/02 , C07C69/74 , C07C211/35 , C07C269/04 , C07C269/06 , C07C271/34 , C07C2601/08 , C07D241/44 , C07D405/06 , C07D405/14 , C07D487/04 , C12P1/00 , C12P41/005 , C07C69/96 , C07C69/14
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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Patent Agency Ranking
公开(公告)号：US20200095230A1
公开(公告)日：2020-03-26
申请号：US16586401
申请日：2019-09-27
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07D405/14 , C07D241/44 , C07D405/06 , C07C271/34 , C07C69/74 , C07C43/196 , C07D487/04 , C07C269/06 , C07C269/04 , C07C41/26 , C07C67/08 , C07C68/02 , C07C211/35 , C12P1/00 , C12P41/00
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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公开(公告)号：US10077256B2
公开(公告)日：2018-09-18
申请号：US15804485
申请日：2017-11-06
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07C67/08 , C07C41/26 , C07C269/04 , C07C269/06 , C07D487/04 , C07C43/196 , C07C69/74 , C07C271/34 , C07D405/06 , C07D241/44 , C07D405/14
CPC classification number: C07D403/12 , C07C41/26 , C07C43/196 , C07C67/08 , C07C68/02 , C07C69/74 , C07C211/35 , C07C269/04 , C07C269/06 , C07C271/34 , C07C2601/08 , C07D241/44 , C07D405/06 , C07D405/14 , C07D487/04 , C12P1/00 , C12P41/005 , C07C69/96 , C07C69/14
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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公开(公告)号：US09309279B2
公开(公告)日：2016-04-12
申请号：US14170199
申请日：2014-01-31
Applicant: AbbVie, Inc. , Enanta Pharmaceuticals, Inc.
Inventor： Yiyin Ku , Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , Dale J. Kempf , David J. Grampovnik , Ying Sun , Dong Liu , Yonghua Gai , Yat Sun Or , Seble H. Wagaw , Kenneth Engstrom , Tim Grieme , Ahmad Sheikh , Jianzhang Mei
IPC: C07K1/113 , C07D487/04
CPC classification number: C07K1/113 , C07D487/04
Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
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公开(公告)号：US20140148573A1
公开(公告)日：2014-05-29
申请号：US14170199
申请日：2014-01-31
Applicant: Enanta Pharmaceuticals, Inc. , AbbVie, Inc.
Inventor： Yiyin Ku , Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , Dale J. Kempf , David J. Grampovnik , Ying Sun , Dong Liu , Yonghua Gai , Yat Sun Or , Seble H. Wagaw , Kenneth Engstrom , Tim Grieme , Ahmad Sheikh , Jianzhang Mei
IPC: C07K1/113
CPC classification number: C07K1/113 , C07D487/04
Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
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公开(公告)号：US10442792B2
公开(公告)日：2019-10-15
申请号：US16132997
申请日：2018-09-17
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07D405/14 , C07D241/44 , C07D405/06 , C07C271/34 , C07C43/196 , C07D487/04 , C07C269/06 , C07C41/26 , C07C67/08 , C07C68/02 , C12P1/00 , C07C211/35 , C12P41/00 , C07C69/74 , C07C269/04
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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