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公开(公告)号：US10689675B2
公开(公告)日：2020-06-23
申请号：US15886318
申请日：2018-02-01
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Sanjay R. Chemburkar , Angelica B. Kielbus , Russell D. Cink
IPC: C12P7/62 , C12P7/40 , C12N9/18 , C07C67/343
Abstract: Disclosed are methods of synthesizing racemic 2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and 2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and their salts, such as the dicyclohexylamine salt. Also disclosed are methods for preparing enantioenriched (1R,2R)-1-((tert-butoxycarbonyl)amino)-2-(difluoromethyl)cyclopropane-1-carboxylic acid and esters of the same. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
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公开(公告)号：US20180258451A1
公开(公告)日：2018-09-13
申请号：US15886318
申请日：2018-02-01
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Sanjay R. Chemburkar , Angelica B. Kielbus , Russell D. Cink
Abstract: Disclosed are methods of synthesizing racemic 2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and 2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and their salts, such as the dicyclohexylamine salt. Also disclosed are methods for preparing enantioenriched (1R,2R)-1-((tert-butoxycarbonyl)amino)-2-(difluoromethyl)cyclopropane-1-carboxylic acid and esters of the same. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
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3.发明申请公开(公告)号：US20200024621A1
公开(公告)日：2020-01-23
申请号：US16435000
申请日：2019-06-07
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Angelica B. Kielbus , William T. Riordan , David R. Hill , Sanjay R. Chemburkar , Rajarathnam E. Reddy , Timothy B. Towne , Jianzhang Mei , Stefan Mix , Gareth J. Brown
Abstract: Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
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公开(公告)号：US10465216B2
公开(公告)日：2019-11-05
申请号：US16113738
申请日：2018-08-27
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Julie J. Pruyne , Angelica B. Kielbus , John E. Lallaman , Rajarathnam E. Reddy , Sanjay R. Chemburkar
IPC: C12P13/04
Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
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公开(公告)号：US20190048372A1
公开(公告)日：2019-02-14
申请号：US16113738
申请日：2018-08-27
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Julie J. Pruyne , Angelica B. Kielbus , John E. Lallaman , Rajarathnam E. Reddy , Sanjay R. Chemburkar
IPC: C12P13/04
CPC classification number: C12P13/04 , C12Y104/01009
Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
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Patent Agency Ranking
公开(公告)号：US20210087592A1
公开(公告)日：2021-03-25
申请号：US16871848
申请日：2020-05-11
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Sanjay R. Chemburkar , Angelica B. Kielbus , Russell D. Cink
IPC: C12P7/62 , C12N9/18 , C07C67/343
Abstract: Disclosed are methods of synthesizing racemic 2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and 2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and their salts, such as the dicyclohexylamine salt. Also disclosed are methods for preparing enantioenriched (1R,2R)-1-((tert-butoxycarbonyl)amino)-2-(difluoromethyl)cyclopropane-1-carboxylic acid and esters of the same. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
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公开(公告)号：US20200325506A1
公开(公告)日：2020-10-15
申请号：US16673326
申请日：2019-11-04
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Julie J. Pruyne , Angelica B. Kielbus , John E. Lallaman , Rajarathnam E. Reddy , Sanjay R. Chemburkar
IPC: C12P13/04
Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
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公开(公告)号：US10113152B1
公开(公告)日：2018-10-30
申请号：US14873706
申请日：2015-10-02
Applicant: AbbVie Inc.
Abstract: Disclosed are, among other things, variant polypeptides, nucleic acids encoding the polypeptides, production of the variant polypeptides, and use of the variant polypeptides in various applications, such as screening and synthetic methods. For example, the variant polypeptides, or enzymatically-active fragments thereof, are useful for converting aliphatic keto acids to aliphatic alpha amino acids.
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公开(公告)号：US09255092B2
公开(公告)日：2016-02-09
申请号：US14053311
申请日：2013-10-14
Applicant: AbbVie Inc.
Inventor： John F. Bauer , Azita Saleki-Gerhardt , Bikshandarkoil A. Narayanan , Sanjay R. Chemburkar , Ketan M. Patel , Harry O. Spiwek , Philip E. Bauer , Kimberly A. Allen
IPC: C07D417/12 , C07D277/28
CPC classification number: C07D417/12 , C07D277/28
Abstract: A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed.
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公开(公告)号：US20150031731A1
公开(公告)日：2015-01-29
申请号：US14053311
申请日：2013-10-14
Applicant: AbbVie Inc.
Inventor： John F. Bauer , Azita Saleki-Gerhardt , Bikshandarkoil A. Narayanan , Sanjay R. Chemburkar , Ketan M. Patel , Harry O. Spiwek , Philip E. Bauer , Kimberly A. Allen
IPC: C07D417/12
CPC classification number: C07D417/12 , C07D277/28
Abstract: A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed.
Abstract translation: 公开了利托那韦的新结晶多晶型物及其使用和制备方法。
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