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公开(公告)号：US10689675B2
公开(公告)日：2020-06-23
申请号：US15886318
申请日：2018-02-01
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Sanjay R. Chemburkar , Angelica B. Kielbus , Russell D. Cink
IPC: C12P7/62 , C12P7/40 , C12N9/18 , C07C67/343
Abstract: Disclosed are methods of synthesizing racemic 2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and 2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and their salts, such as the dicyclohexylamine salt. Also disclosed are methods for preparing enantioenriched (1R,2R)-1-((tert-butoxycarbonyl)amino)-2-(difluoromethyl)cyclopropane-1-carboxylic acid and esters of the same. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
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公开(公告)号：US20180258451A1
公开(公告)日：2018-09-13
申请号：US15886318
申请日：2018-02-01
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Sanjay R. Chemburkar , Angelica B. Kielbus , Russell D. Cink
Abstract: Disclosed are methods of synthesizing racemic 2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and 2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and their salts, such as the dicyclohexylamine salt. Also disclosed are methods for preparing enantioenriched (1R,2R)-1-((tert-butoxycarbonyl)amino)-2-(difluoromethyl)cyclopropane-1-carboxylic acid and esters of the same. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
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公开(公告)号：US09809576B1
公开(公告)日：2017-11-07
申请号：US14802372
申请日：2015-07-17
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07C69/74 , C07D241/44 , C07D405/06 , C07C271/34 , C07C67/08 , C07D405/14 , C07D487/04 , C07C269/06 , C07C269/04 , C07C41/26 , C07C43/196
CPC classification number: C07D403/12 , C07C41/26 , C07C43/196 , C07C67/08 , C07C68/02 , C07C69/74 , C07C211/35 , C07C269/04 , C07C269/06 , C07C271/34 , C07C2601/08 , C07D241/44 , C07D405/06 , C07D405/14 , C07D487/04 , C12P1/00 , C07C69/96 , C07C69/14
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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公开(公告)号：US20210087592A1
公开(公告)日：2021-03-25
申请号：US16871848
申请日：2020-05-11
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Sanjay R. Chemburkar , Angelica B. Kielbus , Russell D. Cink
IPC: C12P7/62 , C12N9/18 , C07C67/343
Abstract: Disclosed are methods of synthesizing racemic 2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and 2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and their salts, such as the dicyclohexylamine salt. Also disclosed are methods for preparing enantioenriched (1R,2R)-1-((tert-butoxycarbonyl)amino)-2-(difluoromethyl)cyclopropane-1-carboxylic acid and esters of the same. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
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公开(公告)号：US20200095230A1
公开(公告)日：2020-03-26
申请号：US16586401
申请日：2019-09-27
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07D405/14 , C07D241/44 , C07D405/06 , C07C271/34 , C07C69/74 , C07C43/196 , C07D487/04 , C07C269/06 , C07C269/04 , C07C41/26 , C07C67/08 , C07C68/02 , C07C211/35 , C12P1/00 , C12P41/00
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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Patent Agency Ranking
公开(公告)号：US10077256B2
公开(公告)日：2018-09-18
申请号：US15804485
申请日：2017-11-06
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07C67/08 , C07C41/26 , C07C269/04 , C07C269/06 , C07D487/04 , C07C43/196 , C07C69/74 , C07C271/34 , C07D405/06 , C07D241/44 , C07D405/14
CPC classification number: C07D403/12 , C07C41/26 , C07C43/196 , C07C67/08 , C07C68/02 , C07C69/74 , C07C211/35 , C07C269/04 , C07C269/06 , C07C271/34 , C07C2601/08 , C07D241/44 , C07D405/06 , C07D405/14 , C07D487/04 , C12P1/00 , C12P41/005 , C07C69/96 , C07C69/14
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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7.发明申请公开(公告)号：US20200024621A1
公开(公告)日：2020-01-23
申请号：US16435000
申请日：2019-06-07
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Angelica B. Kielbus , William T. Riordan , David R. Hill , Sanjay R. Chemburkar , Rajarathnam E. Reddy , Timothy B. Towne , Jianzhang Mei , Stefan Mix , Gareth J. Brown
Abstract: Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
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公开(公告)号：US10465216B2
公开(公告)日：2019-11-05
申请号：US16113738
申请日：2018-08-27
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Julie J. Pruyne , Angelica B. Kielbus , John E. Lallaman , Rajarathnam E. Reddy , Sanjay R. Chemburkar
IPC: C12P13/04
Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
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公开(公告)号：US20190084966A1
公开(公告)日：2019-03-21
申请号：US16132997
申请日：2018-09-17
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07C269/06 , C07C68/02 , C07C67/08 , C07C211/35 , C07C271/34 , C12P1/00 , C07C69/74 , C07C43/196 , C07C41/26 , C07D405/14 , C07D241/44 , C07D405/06 , C07D487/04 , C07C269/04
CPC classification number: C07D403/12 , C07C41/26 , C07C43/196 , C07C67/08 , C07C68/02 , C07C69/74 , C07C211/35 , C07C269/04 , C07C269/06 , C07C271/34 , C07C2601/08 , C07D241/44 , C07D405/06 , C07D405/14 , C07D487/04 , C12P1/00 , C12P41/005 , C07C69/96 , C07C69/14
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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公开(公告)号：US20190048372A1
公开(公告)日：2019-02-14
申请号：US16113738
申请日：2018-08-27
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Julie J. Pruyne , Angelica B. Kielbus , John E. Lallaman , Rajarathnam E. Reddy , Sanjay R. Chemburkar
IPC: C12P13/04
CPC classification number: C12P13/04 , C12Y104/01009
Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
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