公开(公告)号：US20200347043A1

公开(公告)日：2020-11-05

申请号：US16863747

申请日：2020-04-30

Applicant: Calico Life Sciences LLC ,  AbbVie Inc. ,  SYGNATURE DISCOVERY LIMITED

Inventor： Kathleen Ann Martin ,  Carmela Sidrauski ,  Lei Shi ,  Kathleen J. Murauski ,  Xiangdong Xu ,  Yunsong Tong ,  John T. Randolph ,  Michael J. Dart ,  Hanae Benelkebir ,  Steven Edeson ,  Kathryn Starbuck

IPC: C07D413/12 ,  A61P25/28 ,  A61K45/06 ,  A61K31/422 ,  C07D405/12 ,  A61K31/4155 ,  A61K31/403 ,  C07D311/24 ,  A61K31/353 ,  C07D311/22 ,  A61K31/4433 ,  A61K31/4245 ,  C07C235/36 ,  A61K31/165 ,  C07D493/08 ,  A61K31/4025 ,  C07C235/40 ,  C07D405/06 ,  A61K31/397 ,  C07D407/12 ,  C07D271/10 ,  C07D471/04 ,  A61K31/437

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

公开(公告)号：US20190284135A1

公开(公告)日：2019-09-19

申请号：US16421006

申请日：2019-05-23

Applicant: AbbVie Inc.

Inventor： Dominique Bonafoux ,  Heather Michele Davis ,  Kristine E. Frank ,  Michael M. Friedman ,  J. Martin Herold ,  Michael Z. Hoemann ,  Raymond Huntley ,  Augustine Osuma ,  George Sheppard ,  Gagandeep Kaur Somal ,  Jennifer Van Camp ,  Stacy Anne Van Epps ,  Anil Vasudevan ,  Grier Allan Wallace ,  Lu Wang ,  Lu Wang ,  Zhi Wang ,  Noel S. Wilson ,  Xiangdong Xu

IPC: C07D209/08 ,  C07D487/04 ,  C07D405/14 ,  C07D231/56 ,  C07D403/14 ,  C07D401/14 ,  C07D417/14 ,  C07D471/04 ,  C07D417/12 ,  A61P35/00 ,  C07D513/04 ,  C07D209/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D209/10 ,  C07D209/12 ,  C07D413/04 ,  C07D209/18 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D401/12

Abstract: The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

公开(公告)号：US20230144871A1

公开(公告)日：2023-05-11

申请号：US17806905

申请日：2022-06-14

Applicant: Calico Life Sciences LLC ,  AbbVie Inc.

Inventor： Kathleen Ann Martin ,  Carmela Sidrauski ,  Marina Pliushchev ,  Yunsong Tong ,  Xiangdong Xu ,  Qingwei Zhang ,  Ramzi Farah Sweis ,  Michael J. Dart

IPC: C07D271/10 ,  A61P25/28 ,  A61K31/4245 ,  A61K31/4355 ,  A61K31/4439 ,  A61K45/06 ,  C07D233/96 ,  C07D271/06 ,  C07D401/12 ,  C07D413/12 ,  C07D491/048

CPC classification number: C07D271/10 ,  A61K31/4245 ,  A61K31/4355 ,  A61K31/4439 ,  A61K45/06 ,  A61P25/28 ,  C07D233/96 ,  C07D271/06 ,  C07D401/12 ,  C07D413/12 ,  C07D491/048

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

公开(公告)号：US20220363678A1

公开(公告)日：2022-11-17

申请号：US17103003

申请日：2020-11-24

Applicant: Calico Life Sciences LLC ,  AbbVie Inc.

Inventor： Carmela Sidrauski ,  Marina Pliushchev ,  Jennifer M. Frost ,  Lawrence A. Black ,  Xiangdong Xu ,  Ramzi Farah Sweis ,  Lei Shi ,  Qingwei Zhang ,  Yunsong Tong ,  Charles W. Hutchins ,  SeungWon Chung ,  Michael J. Dart

IPC: C07D471/04 ,  C07D213/73 ,  C07D317/64 ,  C07D231/56 ,  C07D401/04 ,  C07D405/08 ,  C07D241/18 ,  C07D261/08 ,  C07D261/20 ,  C07D271/113 ,  C07D213/30 ,  C07D213/64 ,  C07D213/66 ,  C07C235/22 ,  C07C311/13 ,  C07D237/14 ,  C07C311/24 ,  C07C317/22 ,  C07D237/16 ,  A61P25/28

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

公开(公告)号：US11149043B2

公开(公告)日：2021-10-19

申请号：US17227071

申请日：2021-04-09

Applicant: Calico Life Sciences LLC ,  AbbVie Inc.

Inventor： Michael J. Dart ,  Jennifer M. Frost ,  Yunsong Tong ,  Xiangdong Xu ,  Lei Shi ,  Kathleen Murauski ,  Marina Pliushchev ,  Brian S. Brown ,  Eric Voight ,  John T. Randolph

IPC: C07F9/12

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

公开(公告)号：US20210269399A1

公开(公告)日：2021-09-02

申请号：US17038179

申请日：2020-09-30

Applicant: Calico Life Sciences LLC ,  AbbVie Inc.

Inventor： Carmela Sidrauski ,  Marina Pliushchev ,  Jennifer M. Frost ,  Lawrence A. Black ,  Xiangdong Xu ,  Ramzi Farah Sweis ,  Lei Shi ,  Qingwei Zhang ,  Yunsong Tong ,  Charles W. Hutchins ,  SeungWon Chung ,  Michael J. Dart

IPC: C07D213/42 ,  C07D231/12 ,  C07D237/08 ,  C07D239/34 ,  C07D241/12 ,  C07D471/04 ,  C07D261/08 ,  C07D263/32 ,  C07D277/28 ,  C07D209/14 ,  C07C235/22 ,  C07D213/40 ,  C07D213/64 ,  C07D307/52 ,  C07D271/07 ,  A61K31/18 ,  A61K31/197 ,  A61K31/341 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/415 ,  A61K31/417 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/505 ,  C07C311/16 ,  C07C323/09 ,  C07D213/89 ,  C07D235/00 ,  C07D271/10 ,  C07D307/36 ,  C07D333/20

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

公开(公告)号：US20210169892A1

公开(公告)日：2021-06-10

申请号：US16761354

申请日：2018-11-02

Applicant: Calico Life Sciences LLC ,  AbbVie Inc.

Inventor： Kathleen Ann Martin ,  Carmela Sidrauski ,  Jennifer M. Frost ,  Yunsong Tong ,  Xiangdong Xu ,  SeungWon Chung ,  Qingwei I. Zhang ,  Lei Shi ,  Kathleen J. Murauski ,  Michael J. Dart ,  John T. Randolph

IPC: A61K31/538 ,  A61K45/06 ,  C07D317/46 ,  C07D209/08 ,  C07D413/06 ,  C07D265/36 ,  C07D217/16 ,  C07D311/66 ,  C07D413/12 ,  C07D319/20 ,  C07D307/85 ,  C07D209/42 ,  C07D493/04 ,  C07D405/12 ,  C07C235/22 ,  A61K31/36 ,  A61K31/4045 ,  A61K31/472 ,  A61K31/353 ,  A61K31/357 ,  A61K31/343 ,  A61K31/404

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

公开(公告)号：US10913727B2

公开(公告)日：2021-02-09

申请号：US16098679

申请日：2017-05-05

Applicant: Calico Life Sciences LLC ,  AbbVie Inc.

Inventor： Marina Pliushchev ,  Jennifer M. Frost ,  Lawrence A. Black ,  Xiangdong Xu ,  Ramzi Farah Sweis ,  Lei Shi ,  Qingwei I. Zhang ,  Yunsong Tong ,  Charles W. Hutchins ,  Seungwon Chung ,  Michael J. Dart

IPC: C07D307/82 ,  C07D213/74 ,  C07D231/14 ,  C07D237/10 ,  C07D241/12 ,  C07D241/44 ,  C07D261/08 ,  C07D277/32 ,  C07D213/57 ,  C07D307/56 ,  C07C233/74 ,  C07D213/54 ,  C07C235/54 ,  C07C233/79 ,  C07C255/41 ,  C07C255/57 ,  C07C235/14

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

公开(公告)号：US20190142806A1

公开(公告)日：2019-05-16

申请号：US16098950

申请日：2017-05-05

Applicant: Calico Life Sciences LLC ,  AbbVie Inc.

Inventor： Carmela Sidrauski ,  Marina Pliushchev ,  Jennifer M. Frost ,  Lawrence A. Black ,  Xiangdong Xu ,  Ramzi Farah Sweis ,  Lei Shi ,  Qingwei I. Zhang ,  Yunsong Tong ,  Charles W. Hutchins ,  Seungwon Chung ,  Michael J. Dart

IPC: A61K31/42 ,  A61P35/00 ,  A61P3/08 ,  A61P25/28 ,  A61P9/00

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

公开(公告)号：US20170174624A1

公开(公告)日：2017-06-22

申请号：US15398978

申请日：2017-01-05

Applicant: AbbVie Inc.

Inventor： Dominique Bonafoux ,  Heather M. Davis ,  Kristine E. Frank ,  Michael M. Friedman ,  J. Martin Herold ,  Michael Z. Hoemann ,  Raymond Huntley ,  Augustine Osuma ,  George Sheppard ,  Gagandeep K. Somal ,  Jennifer Van Camp ,  Stacy A. Van Epps ,  Anil Vasudevan ,  Grier A. Wallace ,  Lu Wang ,  Lu Wang ,  Zhi Wang ,  Noel S. Wilson ,  Xiangdong Xu

IPC: C07D209/08 ,  C07D405/14 ,  C07D403/04 ,  C07D401/04 ,  C07D209/18 ,  C07D405/04 ,  C07D209/12 ,  C07D209/10 ,  C07D209/14 ,  C07D417/14 ,  C07D401/14 ,  C07D409/14 ,  C07D403/10 ,  C07D409/04 ,  C07D409/12 ,  C07D403/14 ,  C07D413/04

CPC classification number: C07D209/08 ,  A61P35/00 ,  C07D209/10 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D231/56 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

Abstract: The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.