公开(公告)号：US11971615B2

公开(公告)日：2024-04-30

申请号：US17821079

申请日：2022-08-19

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Amitava Gupta

IPC: G02C7/08 ,  G02F1/29

CPC classification number: G02C7/083 ,  G02F1/294 ,  G02C2202/24

Abstract: An apparatus to treat refractive error of an eye comprises an electroactive component configured to switch between a light scattering or optical power providing configuration to treat refractive error of the eye and a substantially transparent configuration to allow normal viewing. The electroactive component can be located on the lens away from a central axis of the lens to provide light to a peripheral region of the retina to decrease the progression of myopia. The electroactive component can be located on the lens away from the central axis of the lens in order for the wearer to view objects through an optical zone while the electroactive component scatters light. The electroactive component can be configured to switch to the substantially transparent configuration to allow light to pass through the electroactive component and to allow the lens to refract light to correct vision and allow normal viewing through the lens.

公开(公告)号：US11860454B2

公开(公告)日：2024-01-02

申请号：US18175648

申请日：2023-02-28

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Philip M. Buscemi ,  Pascal Loser ,  Ben Crook ,  Massimo Pinazza ,  Jim Niebanck ,  James Phillips ,  Stefan Bauer

IPC: G02C5/14 ,  G02C7/08 ,  G02C11/00

CPC classification number: G02C7/083 ,  G02C5/146 ,  G02C11/10 ,  G02C2200/08

Abstract: An electronic case for electronic spectacles may include a base comprising a cavity formed therein. A first spectacle retention device may be located within the cavity. The first spectacle retention device may be configured to retain spectacles. An electrical control system may be included. An electrical connector may be configured to couple the electrical control system in electronic communication with the spectacles.

公开(公告)号：US11719957B2

公开(公告)日：2023-08-08

申请号：US17823208

申请日：2022-08-30

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Philip M. Buscemi ,  Amitava Gupta ,  Stefan Bauer ,  Benjamin Crook ,  Julien Sauvet

IPC: G02C7/08 ,  G02C7/06 ,  G02C7/14 ,  G02C7/10 ,  G02C7/02

CPC classification number: G02C7/08 ,  G02C7/022 ,  G02C7/06 ,  G02C7/10 ,  G02C7/14 ,  G02C2202/24

Abstract: An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure is located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.

公开(公告)号：US11619831B2

公开(公告)日：2023-04-04

申请号：US17806326

申请日：2022-06-10

Applicant: ACUCELA INC.

Inventor： Beat Wyss ,  Jean-Noël Fehr ,  Glenn Noronha ,  Karim Haroud ,  Julien Sauvet ,  Hans Bernhard ,  Christian Oggenfuss ,  Amitava Gupta ,  Ryo Kubota

IPC: G02C7/04 ,  G02C7/14 ,  G02C11/04

Abstract: A soft contact lens comprises a plurality of light sources coupled to a plurality of optical elements. The plurality of light sources and the plurality of optical elements are embedded in a soft contact lens material. Each of said plurality of optical elements generates an image focused in front of a peripheral retina of a wearer. In some embodiments, each of the images is focused at a distance in front of the peripheral retina at a location, and each of the images comprises a depth of focus and a spatial resolution. The depth of focus can be less than the distance, and the spatial resolution greater than a spatial resolution of the peripheral retina at the location.

公开(公告)号：US11497931B2

公开(公告)日：2022-11-15

申请号：US17304666

申请日：2021-06-24

Applicant: ACUCELA INC.

Inventor： Philip M. Buscemi ,  Ryo Kubota

IPC: A61N5/06

Abstract: A stimulus is configured to treat astigmatism with changes in retinal thickness, independently of, or in combination with, treatment for myopia. In some embodiments, a stimulus pattern is arranged with respect to an astigmatic axis of the eye to decrease ocular growth in relation to the astigmatic axis. In some embodiments, the apparatus is configured to direct light to regions of retina outside the macula in relation to the astigmatic axis of the eye. In some embodiments, the intensity is modulated to provide the effect. A lens, such as a contact lens or spectacle lens may be configured with a plurality of light sources, such as projection units having a light source and focusing optics that work together to project anteriorly or posteriorly defocused images onto the retina at locations eccentric to the fovea.

公开(公告)号：US11480813B2

公开(公告)日：2022-10-25

申请号：US17650134

申请日：2022-02-07

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Nabin Joshi ,  Arkady Selenow ,  Steven Ali ,  Stefan Bauer ,  Jean-Noël Fehr ,  Moritz Haeberli ,  Patrizia Weber ,  Julien Sauvet ,  Amitava Gupta

IPC: G02C7/02 ,  G02C7/04 ,  A61B3/00 ,  A61F9/00 ,  G02C7/06 ,  G02C11/04

Abstract: An apparatus to treat refractive error of the eye comprises one or more optics configured to project stimuli comprising out of focus images onto the peripheral retina outside the macula. While the stimuli can be configured in many ways, in some embodiments the stimuli are arranged to decrease interference with central vison such as macular vision. The stimuli can be out of focus images may comprise an amount of defocus within a range from about 3 Diopters (“D”) to about 6 D. In some embodiments, the brightness of the stimuli is greater than a brightness of background illumination by an appropriate amount such as at least 3 times the background brightness. In some embodiments, each of a plurality of stimuli comprises a spatial frequency distribution with an amplitude profile having spatial frequencies within a range from about range of 1×10−1 to 2.5×101 cycles per degree.

公开(公告)号：US11460720B1

公开(公告)日：2022-10-04

申请号：US17662805

申请日：2022-05-10

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Philip M. Buscemi ,  Pascal Loser ,  Ben Crook ,  Massimo Pinazza ,  Jim Niebanck ,  James Phillips ,  Stefan Bauer

IPC: G02C11/00 ,  G02C7/08 ,  G02C5/14

Abstract: An electronic case for electronic spectacles may include a base comprising a cavity formed therein. A first spectacle retention device may be located within the cavity. The first spectacle retention device may be configured to retain spectacles. An electrical control system may be included. An electrical connector may be configured to couple the electrical control system in electronic communication with the spectacles.

公开(公告)号：US11366341B1

公开(公告)日：2022-06-21

申请号：US17302479

申请日：2021-05-04

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Philip M. Buscemi ,  Pascal Loser ,  Ben Crook ,  Massimo Pinazza ,  Jim Niebanck ,  James Phillips ,  Stefan Bauer

IPC: G02C5/14 ,  G02C7/08 ,  G02C11/00

Abstract: An electronic case for electronic spectacles may include a base comprising a cavity formed therein. A first spectacle retention device may be located within the cavity. The first spectacle retention device may be configured to retain spectacles. An electrical control system may be included. An electrical connector may be configured to couple the electrical control system in electronic communication with the spectacles.

公开(公告)号：US10730825B2

公开(公告)日：2020-08-04

申请号：US15967080

申请日：2018-04-30

Applicant: Acucela Inc.

Inventor： Claes Olof Bavik ,  Susan Hayes Henry ,  Ryo Kubota ,  Vladimir A. Kuksa

IPC: A61K31/138 ,  A61K45/06 ,  A61K31/137 ,  A61K31/35 ,  A61K31/765 ,  C07C215/08 ,  C07C211/27 ,  C07C217/20 ,  C07C323/32 ,  C07D309/06

Abstract: Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.

公开(公告)号：US20150238497A1

公开(公告)日：2015-08-27

申请号：US14631711

申请日：2015-02-25

Applicant: Acucela Inc.

Inventor： Ian Leslie Scott ,  Vladimir Aleksandrovich Kuksa ,  Anna Gall ,  Mark W. Orme ,  Jennifer Gage ,  Thomas L. Little, JR. ,  Qin Jiang ,  Lana Michele Rossiter ,  Kevin F. McGee, JR. ,  Ryo Kubota

IPC: A61K31/5375 ,  A61K31/40 ,  A61K31/145 ,  A61K31/495 ,  A61K31/167 ,  A61K31/137 ,  A61K31/4453

CPC classification number: A61K31/5375 ,  A61K31/137 ,  A61K31/145 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/495 ,  C07C211/27 ,  C07C211/28 ,  C07C211/29 ,  C07C215/08 ,  C07C215/30 ,  C07C215/42 ,  C07C215/46 ,  C07C217/10 ,  C07C217/16 ,  C07C217/18 ,  C07C217/48 ,  C07C217/54 ,  C07C217/62 ,  C07C217/72 ,  C07C225/06 ,  C07C225/18 ,  C07C233/05 ,  C07C237/04 ,  C07C317/28 ,  C07C323/25 ,  C07C323/32 ,  C07C323/33 ,  C07C2602/14 ,  C07C2602/16 ,  C07D207/06 ,  C07D211/14 ,  C07D295/03

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Abstract translation: 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供了苯乙烯衍生物化合物，包括但不限于二苯乙烯衍生物化合物，以及包含这些化合物的组合物，其可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。