公开(公告)号：US12216343B2

公开(公告)日：2025-02-04

申请号：US18508894

申请日：2023-11-14

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Philip M. Buscemi ,  Pascal Loser ,  Ben Crook ,  Massimo Pinazza ,  Jim Niebanck ,  James Phillips ,  Stefan Bauer

IPC: G02C11/00 ,  G02C5/14 ,  G02C7/08

Abstract: An electronic case for electronic spectacles may include a base comprising a cavity formed therein. A first spectacle retention device may be located within the cavity. The first spectacle retention device may be configured to retain spectacles. An electrical control system may be included. An electrical connector may be configured to couple the electrical control system in electronic communication with the spectacles.

公开(公告)号：US11896308B2

公开(公告)日：2024-02-13

申请号：US18064422

申请日：2022-12-12

Applicant: ACUCELA INC.

Inventor： Christian Oggenfuss ,  Karim Haroud ,  Lukas Scheibler ,  Matthias Pfister ,  Urban Schnell ,  Stefan Troller ,  Ryo Kubota ,  Philip Buscemi

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/13

CPC classification number: A61B3/102 ,  A61B3/0008 ,  A61B3/1005 ,  A61B3/132 ,  A61B2560/0431 ,  A61B2562/0214 ,  A61B2562/0257 ,  A61B2562/223

Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

公开(公告)号：US11890053B2

公开(公告)日：2024-02-06

申请号：US18177993

申请日：2023-03-03

Applicant: ACUCELA INC.

Inventor： Lukas Scheibler ,  Matthias Pfister ,  Urban Schnell ,  Stefan Troller ,  Ryo Kubota

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/12 ,  A61B5/00 ,  G01B9/02

CPC classification number: A61B3/102 ,  A61B3/0008 ,  A61B3/0025 ,  A61B3/10 ,  A61B3/1005 ,  A61B3/1225 ,  A61B5/0013 ,  G01B9/02 ,  A61B2505/07 ,  A61B2560/0425 ,  A61B2560/0431 ,  A61B2560/0456 ,  A61B2576/00

Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

公开(公告)号：US11627874B2

公开(公告)日：2023-04-18

申请号：US17248850

申请日：2021-02-10

Applicant: ACUCELA INC.

Inventor： Lukas Scheibler ,  Matthias Pfister ,  Urban Schnell ,  Stefan Troller ,  Ryo Kubota

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/12 ,  A61B5/00 ,  G01B9/02

Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

公开(公告)号：US11467428B2

公开(公告)日：2022-10-11

申请号：US17657036

申请日：2022-03-29

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Amitava Gupta

IPC: G02C7/08 ,  G02F1/29

Abstract: An apparatus to treat refractive error of an eye comprises an electroactive component configured to switch between a light scattering or optical power providing configuration to treat refractive error of the eye and a substantially transparent configuration to allow normal viewing. The electroactive component can be located on the lens away from a central axis of the lens to provide light to a peripheral region of the retina to decrease the progression of myopia. The electroactive component can be located on the lens away from the central axis of the lens in order for the wearer to view objects through an optical zone while the electroactive component scatters light. The electroactive component can be configured to switch to the substantially transparent configuration to allow light to pass through the electroactive component and to allow the lens to refract light to correct vision and allow normal viewing through the lens.

公开(公告)号：US10952607B2

公开(公告)日：2021-03-23

申请号：US16805267

申请日：2020-02-28

Applicant: ACUCELA INC.

Inventor： Lukas Scheibler ,  Matthias Pfister ,  Urban Schnell ,  Stefan Troller ,  Ryo Kubota

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/12 ,  A61B5/00 ,  G01B9/02

Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

公开(公告)号：US10201545B2

公开(公告)日：2019-02-12

申请号：US14631711

申请日：2015-02-25

Applicant: Acucela Inc.

Inventor： Ian Leslie Scott ,  Vladimir Aleksandrovich Kuksa ,  Anna Gall ,  Mark W. Orme ,  Jennifer Gage ,  Thomas L. Little, Jr. ,  Qin Jiang ,  Lana Michele Rossiter ,  Kevin F. McGee, Jr. ,  Ryo Kubota

IPC: A61K31/137 ,  A61K31/5375 ,  C07C217/18 ,  C07C211/27 ,  C07C211/28 ,  C07C211/29 ,  C07C215/08 ,  C07C215/30 ,  C07C215/42 ,  C07C215/46 ,  C07C217/16 ,  C07C217/48 ,  C07C217/54 ,  C07C217/62 ,  C07C217/72 ,  C07C225/18 ,  C07C233/05 ,  C07C237/04 ,  C07C317/28 ,  C07C323/25 ,  C07C323/32 ,  C07D295/03 ,  C07C217/10 ,  C07C225/06 ,  C07C323/33 ,  C07D207/06 ,  C07D211/14 ,  A61K31/145 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/495

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

公开(公告)号：US20160229831A1

公开(公告)日：2016-08-11

申请号：US14849859

申请日：2015-09-10

Applicant: Acucela Inc.

Inventor： Vladimir A. Kuksa ,  Mark W. Orme ,  Feng Hong ,  Ryo Kubota

IPC: C07D335/02 ,  C07D213/38 ,  C07D211/26 ,  C07D307/81 ,  C07D307/14 ,  C07D211/60 ,  C07D233/96 ,  C07D311/04 ,  C07D207/09 ,  C07D211/76 ,  C07D333/12 ,  C07D207/26 ,  C07D279/02 ,  C07D211/96 ,  C07D209/08 ,  C07D233/64 ,  C07D309/06

CPC classification number: C07D335/02 ,  A61K31/341 ,  A61K31/343 ,  A61K31/351 ,  A61K31/382 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/505 ,  C07D207/08 ,  C07D207/09 ,  C07D207/26 ,  C07D209/08 ,  C07D209/14 ,  C07D211/22 ,  C07D211/26 ,  C07D211/60 ,  C07D211/76 ,  C07D211/96 ,  C07D213/30 ,  C07D213/38 ,  C07D233/64 ,  C07D233/96 ,  C07D239/26 ,  C07D279/02 ,  C07D307/12 ,  C07D307/14 ,  C07D307/80 ,  C07D307/81 ,  C07D309/04 ,  C07D309/06 ,  C07D311/04 ,  C07D311/58 ,  C07D333/12 ,  C07D333/16 ,  C07D333/20

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted 3-phenylpropylamine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

公开(公告)号：US20160193160A1

公开(公告)日：2016-07-07

申请号：US15072250

申请日：2016-03-16

Applicant: Acucela Inc.

Inventor： Ian Leslie Scott ,  Vladimir Aleksandrovich Kuksa ,  Anna Gall ,  Mark W. Orme ,  Jennifer Gage ,  Thomas L. Little, JR. ,  Qin Jiang ,  Lana Michele Rossiter ,  Kevin F. McGee ,  Ryo Kubota

IPC: A61K31/137

CPC classification number: A61K31/5375 ,  A61K31/137 ,  A61K31/145 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/495 ,  C07C211/27 ,  C07C211/28 ,  C07C211/29 ,  C07C215/08 ,  C07C215/30 ,  C07C215/42 ,  C07C215/46 ,  C07C217/10 ,  C07C217/16 ,  C07C217/18 ,  C07C217/48 ,  C07C217/54 ,  C07C217/62 ,  C07C217/72 ,  C07C225/06 ,  C07C225/18 ,  C07C233/05 ,  C07C237/04 ,  C07C317/28 ,  C07C323/25 ,  C07C323/32 ,  C07C323/33 ,  C07C2602/14 ,  C07C2602/16 ,  C07D207/06 ,  C07D211/14 ,  C07D295/03

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

公开(公告)号：US12210225B2

公开(公告)日：2025-01-28

申请号：US18160200

申请日：2023-01-26

Applicant: ACUCELA INC.

Inventor： Beat Wyss ,  Jean-Noel Fehr ,  Glenn Noronha ,  Karim Haroud ,  Julien Sauvet ,  Hans Bernhard ,  Christian Oggenfuss ,  Amitava Gupta ,  Ryo Kubota

IPC: G02C7/04 ,  G02C7/14 ,  G02C11/04

Abstract: A soft contact lens comprises a plurality of light sources coupled to a plurality of optical elements. The plurality of light sources and the plurality of optical elements are embedded in a soft contact lens material. Each of said plurality of optical elements generates an image focused in front of a peripheral retina of a wearer. In some embodiments, each of the images is focused at a distance in front of the peripheral retina at a location, and each of the images comprises a depth of focus and a spatial resolution. The depth of focus can be less than the distance, and the spatial resolution greater than a spatial resolution of the peripheral retina at the location.