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11.发明授权Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors 有权三环化合物作为TNF-α合成的调节剂和PDE4抑制剂公开(公告)号：US08853226B2
公开(公告)日：2014-10-07
申请号：US13040382
申请日：2011-03-04
IPC分类号： A61K31/519 , C07D471/04
CPC分类号： A61K31/519 , C07D471/04 , Y02A50/411
摘要： The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to rheumatoid arthritis.
摘要翻译： 本发明涉及式（I）的化合物如本文所定义，药物组合物和用于治疗由TNF-α或PDE4介导的病症或病症的方法，包括但不限于类风湿性关节炎。
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12.发明申请Tricyclic Compounds as Modulators of TNF-alpha Synthesis and as PDE4 Inhibitors 有权三环化合物作为TNF-α合成的调节剂和PDE4抑制剂公开(公告)号：US20120172381A1
公开(公告)日：2012-07-05
申请号：US13410628
申请日：2012-03-02
IPC分类号： A61K31/519 , A61P11/06
CPC分类号： A61K31/519 , C07D471/04 , Y02A50/411
摘要： The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to rheumatoid arthritis.
摘要翻译： 本发明涉及式（I）的化合物如本文所定义，药物组合物和用于治疗由TNF-α或PDE4介导的病症或病症的方法，包括但不限于类风湿性关节炎。
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公开(公告)号：US20100190808A1
公开(公告)日：2010-07-29
申请号：US12532861
申请日：2009-01-23
申请人： Adnan M. M. Mjalli , Bapu Gaddam , Dharmo Rao , Matthew Kostura , Mustafa Guzel
发明人： Adnan M. M. Mjalli , Bapu Gaddam , Dharmo Rao , Matthew Kostura , Mustafa Guzel
IPC分类号： A61K31/519 , C07D239/70 , A61P29/00 , A61P19/02 , A61P3/10 , A61P1/00 , A61P25/00
CPC分类号： A61K31/519 , C07D471/04 , Y02A50/411
摘要： The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-alpha or by PDE4, including but not limited to rheumatoid arthritis.
摘要翻译： 本发明涉及式（I）的化合物如本文所定义，药物组合物和用于治疗由TNF-α或PDE4介导的病症或病症的方法，包括但不限于类风湿性关节炎。
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14.发明授权Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors 有权三环化合物作为TNF-α合成的调节剂和PDE4抑制剂公开(公告)号：US08329715B2
公开(公告)日：2012-12-11
申请号：US13410628
申请日：2012-03-02
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： A61K31/519 , C07D471/04 , Y02A50/411
摘要： The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to rheumatoid arthritis.
摘要翻译： 本发明涉及式（I）的化合物如本文所定义，药物组合物和用于治疗由TNF-α或PDE4介导的病症或病症的方法，包括但不限于类风湿性关节炎。
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公开(公告)号：US07964608B2
公开(公告)日：2011-06-21
申请号：US12532861
申请日：2009-01-23
IPC分类号： A01N43/54 , A61K31/505 , C07D239/70 , C07D471/00
CPC分类号： A61K31/519 , C07D471/04 , Y02A50/411
摘要： The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-alpha or by PDE4, including but not limited to rheumatoid arthritis.
摘要翻译： 本发明涉及式（I）的化合物如本文所定义，药物组合物和用于治疗由TNF-α或PDE4介导的病症或病症的方法，包括但不限于类风湿性关节炎。
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16.发明申请Tricyclic Compounds as Modulators of TNF-alpha Synthesis and as PDE4 Inhibitors 有权三环化合物作为TNF-α合成的调节剂和PDE4抑制剂公开(公告)号：US20110160234A1
公开(公告)日：2011-06-30
申请号：US13040382
申请日：2011-03-04
IPC分类号： A61K31/519 , A61P11/00 , A61P11/06 , A61P19/02
CPC分类号： A61K31/519 , C07D471/04 , Y02A50/411
摘要： The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to rheumatoid arthritis.
摘要翻译： 本发明涉及式（I）的化合物如本文所定义，药物组合物和用于治疗由TNF-α或PDE4介导的病症或病症的方法，包括但不限于类风湿性关节炎。
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公开(公告)号：US20100331379A1
公开(公告)日：2010-12-30
申请号：US12298840
申请日：2007-04-27
申请人： Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedso , Dharma Rao Polisetti , Bapu Gaddam , Daniel P. Christen , Kalpathy Santhosh , Jeremy T. Cooper , Robert Carl Andrews
发明人： Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedso , Dharma Rao Polisetti , Bapu Gaddam , Daniel P. Christen , Kalpathy Santhosh , Jeremy T. Cooper , Robert Carl Andrews
IPC分类号： A61K31/426 , C07D277/44
CPC分类号： C07D277/46 , Y02P20/582
摘要： The present invention relates to N-heteroaryl-benzamides, pharmaceutical compositions comprising the same, and methods of using the same. The N-heteroaryl-benzamides are useful in diseases or medical conditions mediated by glucokinase.
摘要翻译： 本发明涉及N-杂芳基 - 苯甲酰胺，包含它们的药物组合物及其使用方法。 N-杂芳基 - 苯甲酰胺可用于由葡糖激酶介导的疾病或医学病症。
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18.发明申请SUBSTITUTED PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE TO TREAT OXIDATIVE STRESS 审中-公开取代的吡啶衍生物，药物组合物和用于治疗氧化应激的方法公开(公告)号：US20120071505A1
公开(公告)日：2012-03-22
申请号：US13278515
申请日：2011-10-21
IPC分类号： A61K31/47 , C07D215/24 , A61P9/00 , A61P9/10 , A61P9/12 , A61P3/10 , A61P13/12 , A61P25/28 , A61P25/16 , A61P25/00 , A61P11/06 , A61P11/00 , A61P17/00 , A61P27/02 , A61P27/12 , A61P35/00 , C07D215/54
CPC分类号： A61K31/443 , A61K31/44
摘要： Substituted pyridine derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted pyridine derivative, and methods of use in treating inflammation are provided. The substituted pyridine derivatives may control of the activity or the amount or both the activity and the amount of heme-oxygenase.
摘要翻译： 提供了取代的吡啶衍生物，其制备方法，包含取代的吡啶衍生物的药物组合物和用于治疗炎症的方法。 取代的吡啶衍生物可以控制血红素加氧酶的活性或活性和量的量。
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公开(公告)号：US20050261294A1
公开(公告)日：2005-11-24
申请号：US11110499
申请日：2005-04-20
申请人： Adnan Mjalli , Bapu Gaddam , Ghassan Qabaja , Govindan Subramanian , Jeff Zhu , John Dankwardt , Murty Arimilli , Robert Andrews , Samuel Victory , Ye Tian
发明人： Adnan Mjalli , Bapu Gaddam , Ghassan Qabaja , Govindan Subramanian , Jeff Zhu , John Dankwardt , Murty Arimilli , Robert Andrews , Samuel Victory , Ye Tian
IPC分类号： A61K31/426 , A61K31/505 , A61K31/53 , C07D239/42 , C07D277/42 , C07D277/46 , C07D277/52 , C07D277/56 , C07D403/12 , C07D409/12 , C07D417/12 , C07D417/14
CPC分类号： C07D277/52 , C07D239/42 , C07D277/26 , C07D277/42 , C07D277/50 , C07D277/56 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention provides substituted heteroaryl derivatives of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I), and methods of use in treating human or animal disorders. The compounds of the invention can be useful as inhibitors of action of AgRP on a melanocortin receptor and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.
摘要翻译： 本发明提供式（I）的取代杂芳基衍生物，其制备方法，包含式（I）化合物的药物组合物，以及用于治疗人或动物病症的方法。 本发明的化合物可用作AgRP对黑皮质素受体的作用抑制剂，因此可用于治疗，治疗，控制或辅助治疗可能对黑皮质素受体的调节（包括肥胖症 - 相关疾病。
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