公开(公告)号：US20100331379A1

公开(公告)日：2010-12-30

申请号：US12298840

申请日：2007-04-27

申请人： Anthony Murray ,  Jesper Lau ,  Lone Jeppesen ,  Per Vedso ,  Dharma Rao Polisetti ,  Bapu Gaddam ,  Daniel P. Christen ,  Kalpathy Santhosh ,  Jeremy T. Cooper ,  Robert Carl Andrews

发明人： Anthony Murray ,  Jesper Lau ,  Lone Jeppesen ,  Per Vedso ,  Dharma Rao Polisetti ,  Bapu Gaddam ,  Daniel P. Christen ,  Kalpathy Santhosh ,  Jeremy T. Cooper ,  Robert Carl Andrews

IPC分类号： A61K31/426 ,  C07D277/44

CPC分类号： C07D277/46 ,  Y02P20/582

摘要： The present invention relates to N-heteroaryl-benzamides, pharmaceutical compositions comprising the same, and methods of using the same. The N-heteroaryl-benzamides are useful in diseases or medical conditions mediated by glucokinase.

摘要翻译： 本发明涉及N-杂芳基 - 苯甲酰胺，包含它们的药物组合物及其使用方法。 N-杂芳基 - 苯甲酰胺可用于由葡糖激酶介导的疾病或医学病症。

公开(公告)号：US20080119454A1

公开(公告)日：2008-05-22

申请号：US11981997

申请日：2007-10-31

申请人： Dharma Polisetti ,  Janos Kodra ,  Jesper Lau ,  Paw Bloch ,  Maria Valcarce-Lopez ,  Niels Blume ,  Mustafa Guzel ,  Kalpathy Santhosh ,  Adnan Mjalli ,  Robert Andrews ,  Govindan Subramanian ,  Michael Ankersen ,  Per Vedso ,  Anthony Murray ,  Lone Jeppesen

发明人： Dharma Polisetti ,  Janos Kodra ,  Jesper Lau ,  Paw Bloch ,  Maria Valcarce-Lopez ,  Niels Blume ,  Mustafa Guzel ,  Kalpathy Santhosh ,  Adnan Mjalli ,  Robert Andrews ,  Govindan Subramanian ,  Michael Ankersen ,  Per Vedso ,  Anthony Murray ,  Lone Jeppesen

IPC分类号： A61K31/55 ,  A61K31/427 ,  A61K31/454 ,  C07D417/02

CPC分类号： C07D277/38 ,  A61K31/426 ,  A61K31/427 ,  A61K31/454 ,  A61K31/55 ,  A61K45/06 ,  C07D213/75 ,  C07D277/46 ,  C07D277/48 ,  C07D277/52 ,  C07D277/54 ,  C07D277/56 ,  C07D285/135 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D473/38

摘要： This invention relates to aryl carbonyl derivatives which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.

公开(公告)号：US20070054897A1

公开(公告)日：2007-03-08

申请号：US11453330

申请日：2006-06-14

申请人： Anthony Murray ,  Jesper Lau ,  Lone Jeppesen ,  Per Vedso ,  Michael Ankersen ,  Jane Lundbeck ,  Marit Kristiansen ,  Maria Valcarce-Lopez ,  Dharma Polisetti ,  Govindan Subramanian ,  Robert Andrews ,  Daniel Christen ,  Jeremy Cooper ,  Kalpathy Santhosh

发明人： Anthony Murray ,  Jesper Lau ,  Lone Jeppesen ,  Per Vedso ,  Michael Ankersen ,  Jane Lundbeck ,  Marit Kristiansen ,  Maria Valcarce-Lopez ,  Dharma Polisetti ,  Govindan Subramanian ,  Robert Andrews ,  Daniel Christen ,  Jeremy Cooper ,  Kalpathy Santhosh

IPC分类号： A61K31/551 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/454 ,  A61K31/428 ,  C07D417/02

CPC分类号： C07D417/12 ,  A61K31/4168 ,  A61K31/427 ,  A61K31/433 ,  C07D213/75 ,  C07D233/88 ,  C07D241/20 ,  C07D261/14 ,  C07D271/08 ,  C07D277/48 ,  C07D277/56 ,  C07D277/60 ,  C07D277/82 ,  C07D285/08 ,  C07D285/135 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14 ,  C07D513/04

摘要： This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.

摘要翻译： 本发明涉及作为葡萄糖激酶活化剂的式（I）化合物，因此可用于治疗，治疗，控制或辅助治疗疾病，其中增加葡糖激酶活性是有益的。

公开(公告)号：US20080119455A1

公开(公告)日：2008-05-22

申请号：US11982248

申请日：2007-10-31

申请人： Dharma Polisetti ,  Janos Kodra ,  Jesper Lau ,  Paw Bloch ,  Maria Valcarce-Lopez ,  Niels Blume ,  Mustafa Guzel ,  Kalpathy Santhosh ,  Adnan Mjalli ,  Robert Andrews ,  Govindan Subramanian ,  Michael Ankersen ,  Per Vedso ,  Anthony Murray ,  Lone Jeppesen

发明人： Dharma Polisetti ,  Janos Kodra ,  Jesper Lau ,  Paw Bloch ,  Maria Valcarce-Lopez ,  Niels Blume ,  Mustafa Guzel ,  Kalpathy Santhosh ,  Adnan Mjalli ,  Robert Andrews ,  Govindan Subramanian ,  Michael Ankersen ,  Per Vedso ,  Anthony Murray ,  Lone Jeppesen

IPC分类号： A61K31/55 ,  A61K31/454 ,  A61K31/427 ,  C07D417/02

CPC分类号： C07D277/38 ,  A61K31/426 ,  A61K31/427 ,  A61K31/454 ,  A61K31/55 ,  A61K45/06 ,  C07D213/75 ,  C07D277/46 ,  C07D277/48 ,  C07D277/52 ,  C07D277/54 ,  C07D277/56 ,  C07D285/135 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D473/38

摘要： This invention relates to aryl carbonyl derivatives which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.

公开(公告)号：US20060183783A1

公开(公告)日：2006-08-17

申请号：US11365534

申请日：2006-03-01

申请人： Dharma Polisetti ,  Janos Kodra ,  Jesper Lau ,  Paw Bloch ,  Maria Lopez ,  Niels Blume ,  Mustafa Guzel ,  Kalpathy Santhosh ,  Adnan Mjalli ,  Robert Andrews ,  Govindan Subramanian ,  Michael Ankersen ,  Per Vedso ,  Anthony Murray ,  Lone Jeppesen

发明人： Dharma Polisetti ,  Janos Kodra ,  Jesper Lau ,  Paw Bloch ,  Maria Lopez ,  Niels Blume ,  Mustafa Guzel ,  Kalpathy Santhosh ,  Adnan Mjalli ,  Robert Andrews ,  Govindan Subramanian ,  Michael Ankersen ,  Per Vedso ,  Anthony Murray ,  Lone Jeppesen

IPC分类号： A61K31/426 ,  C07D277/18

CPC分类号： C07D213/75 ,  C07D277/48 ,  C07D277/52 ,  C07D277/54 ,  C07D277/56 ,  C07D285/135 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D473/38

摘要： This invention relates to aryl carbonyl derivativeswhich are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.

摘要翻译： 本发明涉及芳基羰基衍生物，其是可用于治疗，治疗，控制或辅助治疗疾病的葡糖激酶的活化剂，其中增加葡糖激酶活性是有益的。

公开(公告)号：US08383644B2

公开(公告)日：2013-02-26

申请号：US12825631

申请日：2010-06-29

申请人： Adnan M. M. Mjalli ,  Christopher Behme ,  Daniel P. Christen ,  Devi Reddy Gohimukkula ,  Dharma Rao Polisetti ,  James Quada ,  Jennifer L. R. Freeman ,  Kalpathy Santhosh ,  Muralidhar Bondlela ,  Mustafa Guzel ,  Ravindra Reddy Yarragunta ,  Robert Carl Andrews ,  Stephen Thomas Davis ,  Thomas Scott Yokum

发明人： Adnan M. M. Mjalli ,  Christopher Behme ,  Daniel P. Christen ,  Devi Reddy Gohimukkula ,  Dharma Rao Polisetti ,  James Quada ,  Jennifer L. R. Freeman ,  Kalpathy Santhosh ,  Muralidhar Bondlela ,  Mustafa Guzel ,  Ravindra Reddy Yarragunta ,  Robert Carl Andrews ,  Stephen Thomas Davis ,  Thomas Scott Yokum

IPC分类号： C07D491/056 ,  A61K31/436

CPC分类号： C07D491/056 ,  C07D319/20 ,  C07D491/06

摘要： The present invention is directed to substituted azoanthracene derivatives or pharmaceutically acceptable salts thereof that modulate the human GLP-1 receptor and that may be useful in the treatment of diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial, such as diabetes mellitus type 2. The invention is also directed to pharmaceutical compositions comprising these compounds and to the use of these compounds and compositions in the treatment of such diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial.

公开(公告)号：US20110160198A1

公开(公告)日：2011-06-30

申请号：US12825631

申请日：2010-06-29

申请人： Adnan M.M. Mjalli ,  Christopher Behme ,  Daniel P. Christen ,  Devi Reddy Gohimukkula ,  Dharma Rao Polisetti ,  James Quada ,  Jennifer L.R. Freeman ,  Kalpathy Santhosh ,  Muralidhar Bondlela ,  Mustafa Guzel ,  Ravindra Reddy Yarragunta ,  Robert Carl Andrews ,  Stephen Thomas Davis ,  Thomas Scott Yokum

发明人： Adnan M.M. Mjalli ,  Christopher Behme ,  Daniel P. Christen ,  Devi Reddy Gohimukkula ,  Dharma Rao Polisetti ,  James Quada ,  Jennifer L.R. Freeman ,  Kalpathy Santhosh ,  Muralidhar Bondlela ,  Mustafa Guzel ,  Ravindra Reddy Yarragunta ,  Robert Carl Andrews ,  Stephen Thomas Davis ,  Thomas Scott Yokum

IPC分类号： A61K31/4741 ,  C07D491/056 ,  C07D498/04 ,  A61K31/497 ,  A61K31/5383 ,  A61K31/5377 ,  A61P3/00 ,  A61P3/06 ,  A61P3/10 ,  A61P3/04 ,  A61P9/10 ,  A61P9/12

CPC分类号： C07D491/056 ,  C07D319/20 ,  C07D491/06

摘要： The present invention is directed to substituted azoanthracene derivatives or pharmaceutically acceptable salts thereof that modulate the human GLP-1 receptor and that may be useful in the treatment of diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial, such as diabetes mellitus type 2. The invention is also directed to pharmaceutical compositions comprising these compounds and to the use of these compounds and compositions in the treatment of such diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial.

摘要翻译： 本发明涉及调节人GLP-1受体并且可用于治疗人GLP-1受体调节有益的疾病，病症或病症的取代的偶氮蒽衍生物或其药学上可接受的盐， 例如2型糖尿病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗人GLP-1受体调节有益的疾病，病症或病症中的用途 。

公开(公告)号：US07790714B2

公开(公告)日：2010-09-07

申请号：US12759010

申请日：2010-04-13

申请人： Adnan M.M. Mjalli ,  Dharma Rao Polisetti ,  Thomas Scott Yokum ,  Kalpathy Santhosh ,  Mustafa Guzel ,  Christopher Behme ,  Stephen Thomas Davis

发明人： Adnan M.M. Mjalli ,  Dharma Rao Polisetti ,  Thomas Scott Yokum ,  Kalpathy Santhosh ,  Mustafa Guzel ,  Christopher Behme ,  Stephen Thomas Davis

IPC分类号： C07D498/02 ,  A61K31/5365

CPC分类号： C07D498/04 ,  C07D498/14

摘要： The present invention provides methods of use of oxadiazoanthracene derivatives of the formula (I) and pharmaceutically acceptable salts thereof, wherein A, B, C, R, R1, R2, R3, R4 and R5 are as herein described, and wherein said methods of use include uses for the treatment and/or prevention of disorders and diseases, such as diabetes.

摘要翻译： 本发明提供使用式（I）的恶二唑衍生物及其药学上可接受的盐的方法，其中A，B，C，R，R 1，R 2，R 3，R 4和R 5如本文所述，并且其中所述方法 包括用于治疗和/或预防疾病和疾病如糖尿病的用途。

公开(公告)号：US20100197677A1

公开(公告)日：2010-08-05

申请号：US12759010

申请日：2010-04-13

申请人： Adnan M.M. Mjalli ,  Dharma Rao Polisetti ,  Thomas Scott Yokum ,  Kalpathy Santhosh ,  Mustafa Guzel ,  Christopher Behme ,  Stephen Thomas Davis

发明人： Adnan M.M. Mjalli ,  Dharma Rao Polisetti ,  Thomas Scott Yokum ,  Kalpathy Santhosh ,  Mustafa Guzel ,  Christopher Behme ,  Stephen Thomas Davis

IPC分类号： A61K31/5383 ,  A61P3/10

CPC分类号： C07D498/04 ,  C07D498/14

摘要： The present invention provides methods of use of oxadiazoanthracene derivatives of the formula (I) and pharmaceutically acceptable salts thereof, wherein A, B, C, R, R1, R2, R3, R4 and R5 are as herein described, and wherein said methods of use include uses for the treatment and/or prevention of disorders and diseases, such as diabetes.

公开(公告)号：US07727983B2

公开(公告)日：2010-06-01

申请号：US12399504

申请日：2009-03-06

申请人： Adnan M. M. Mjalli ,  Dharma Rao Polisetti ,  Thomas Scott Yokum ,  Kalpathy Santhosh ,  Mustafa Guzel ,  Christopher Behme ,  Stephen Thomas Davis

发明人： Adnan M. M. Mjalli ,  Dharma Rao Polisetti ,  Thomas Scott Yokum ,  Kalpathy Santhosh ,  Mustafa Guzel ,  Christopher Behme ,  Stephen Thomas Davis

IPC分类号： C07D498/02 ,  A61K31/5365

CPC分类号： C07D498/04 ,  C07D498/14

摘要： The present invention provides oxadiazoanthracene derivatives of the formula (I), wherein A, B, C, R, R1, R2, R3, R4 and R5 are as herein described, pharmaceutical compositions comprising oxadiazoanthracene derivatives, use of the oxadiazoanthracene derivatives for the preparation of pharmaceutical compositions, methods of use thereof for the treatment and/or prevention of disorders and diseases, such as diabetes, and intermediates useful for the preparation of oxadiazoanthracene derivatives of Formula (I).

摘要翻译： 本发明提供式（I）的恶二唑并蒽衍生物，其中A，B，C，R，R 1，R 2，R 3，R 4和R 5如本文所述，包含恶二唑并蒽衍生物的药物组合物，使用恶二唑衍生物用于制备 的药物组合物，其用于治疗和/或预防疾病和疾病的方法，例如糖尿病，以及可用于制备式（I）的恶二唑衍生物的中间体。