公开(公告)号：US07135598B2

公开(公告)日：2006-11-14

申请号：US10656706

申请日：2003-09-05

申请人： Eric J. Beckman ,  Toby M. Chapman ,  Lianjun Shi

发明人： Eric J. Beckman ,  Toby M. Chapman ,  Lianjun Shi

IPC分类号： C07C233/03

CPC分类号： C07C233/03 ,  C07C233/13 ,  C07D209/48 ,  C08F26/02

摘要： A method of synthesizing a compound having the formula: comprising the step of: reacting a N-vinylformamide salt having the formula  with a compound having the formula XR1R2; wherein X is Br, Cl or I, M is an alkali metal or an alkali earth metal, R1 is a C0–C25 alkylene group, a C0–C25 fluroalkylene group or a C0–C25 perfluoro alkylene group, R2 is H, provided R1 is not absent, an alkyl group, a fluroalkyl group, a perfluoroalkyl group, an aryl group, a hydroxy group, a polyether group, a heterocyclic group of 5 or 6 atoms wherein at least one of the atoms is not a carbon and is N, O, or S, —OR3, wherein, R3 is an alkyl group, a fluoroalkyl group, a perfluoroalkyl group, or an aryl group, —C(O)R4, —C(O)OR4, —OC(O)R4, —OC(O)R4, wherein R4 is an H, an alkyl group, a fluoroalkyl group, a perfluoroalkyl group, or an aryl group, a phthalimide group or NR5 R5 wherein R5 and R5 are independently H, —C(O)R4, an alkyl, a fluoroalkyl group, a perfluoroalkyl group or an aryl group.

摘要翻译： 一种合成具有下式的化合物的方法：包括以下步骤：使具有下式的N-乙烯基甲酰胺盐与具有式XR 1 R 2的化合物反应; 其中X是Br，Cl或I，M是碱金属或碱土金属，R 1是C 0 -C 25亚烷基，C 0 -C 25氟代亚烷基或C 0 -C 25全氟亚烷基 基团，R 2是H，条件是R 1不存在，烷基，氟烷基，全氟烷基，芳基，羟基，聚醚 基团，5或6个原子的杂环基，其中至少一个原子不是碳并且是N，O或S，-OR 3，其中，R 3， SUP>是烷基，氟烷基，全氟烷基或芳基，-C（O）R 4，-C（O）OR 4， -OC（O）R 4，-OC（O）R 4，其中R 4是H，烷基，氟代烷基 基团，全氟烷基或芳基，邻苯二甲酰亚胺基或NR 5 R 5，其中R 5和R 5， / O 2独立地是H，-C（O）R 4，烷基，氟代烷基，全氟烷基或芳基。

公开(公告)号：US06562605B1

公开(公告)日：2003-05-13

申请号：US08747474

申请日：1996-11-12

申请人： Eric J. Beckman ,  Eliador J. Ghenciu ,  Nathaniel T. Becker ,  Landon M. Steele

发明人： Eric J. Beckman ,  Eliador J. Ghenciu ,  Nathaniel T. Becker ,  Landon M. Steele

IPC分类号： C07K100

CPC分类号： C12N9/54 ,  C07K1/145 ,  C07K14/465 ,  Y02P20/544 ,  Y10S435/814

摘要： A method is provided for the extraction of water soluble biomaterials such as enzymes or proteins into carbon dioxide utilizing certain carbon dioxide soluble surfactants. The extraction can be performed on an aqueous solution, a fermentation broth or a fluid. The method includes the process steps of forming a carbon dioxide/surfactant mixture which involves dissolving carbon dioxide soluble surfactant(s) in carbon dioxide. The carbon dioxide can be in a liquid or supercritical form and the surfactant includes tail and head groups that interact with the biomaterials. Further, the mixture is added to the aqueous solution, fermentation broth or liquid under conditions to allow for extraction of the biomaterials. The method further includes depressurizing and/or temperature adjusting to remove the water soluble biomaterials. The surfactants include fluroethers, oligomers of propylene-oxide, siloxanes, etc. The biomaterials include proteins or enzymes. The carbon dioxide is suberitical or supercritical.

摘要翻译： 提供了一种利用某些二氧化碳可溶性表面活性剂将水溶性生物材料如酶或蛋白质提取到二氧化碳中的方法。 提取可以在水溶液，发酵液或流体上进行。 该方法包括形成二氧化碳/表面活性剂混合物的方法步骤，其包括将二氧化碳可溶性表面活性剂溶解在二氧化碳中。 二氧化碳可以是液体或超临界形式，并且表面活性剂包括与生物材料相互作用的尾部和头部基团。 此外，在允许提取生物材料的条件下将混合物加入到水溶液，发酵液或液体中。 该方法还包括减压和/或温度调节以除去水溶性生物材料。 表面活性剂包括氟醚，环氧丙烷的低聚物，硅氧烷等。生物材料包括蛋白质或酶。 二氧化碳是非常重要的或超临界的。

公开(公告)号：US20120121686A1

公开(公告)日：2012-05-17

申请号：US13296670

申请日：2011-11-15

申请人： Eric J. Beckman ,  Jessica L. Meyers

发明人： Eric J. Beckman ,  Jessica L. Meyers

IPC分类号： A61K9/70 ,  A61P41/00 ,  C08G18/78 ,  A61K31/785

CPC分类号： A61L24/0042 ,  A61K9/70 ,  A61K31/785 ,  A61L24/046 ,  C08G18/12 ,  C08G18/2875 ,  C08G18/3206 ,  C08G18/4277 ,  C08G18/664 ,  C08G18/6674 ,  C08G18/771 ,  C08G2170/40 ,  C08G2230/00 ,  C09J175/04 ,  C08G18/282 ,  C08G18/2865

摘要： A composition comprising the reaction product of (a) an isocyanate group-containing component having an average functionality of at least 2; and (b) an active hydrogen group-containing component having an average functionality of at least 2. The composition is biodegradable, a solid at 22° C. and below, and has pressure sensitive adhesive properties at a temperature of 37° C. and relative humidity of 100%. The composition may be used to adhere polymer meshes or films to biological tissue.

摘要翻译： 一种组合物，其包含（a）平均官能度至少为2的含异氰酸酯基的组分的反应产物; 和（b）平均官能度为至少为2的含活性氢基团的组分。该组合物是可生物降解的，在22℃及以下的固体，并且在37℃的温度下具有压敏粘合剂性质， 相对湿度100％。 组合物可以用于将聚合物网状物或膜粘附到生物组织。

公开(公告)号：US20080161208A1

公开(公告)日：2008-07-03

申请号：US12074435

申请日：2008-03-04

申请人： Eric J. Beckman ,  Ronald A. LoSasso ,  Janice E. LoSasso

发明人： Eric J. Beckman ,  Ronald A. LoSasso ,  Janice E. LoSasso

IPC分类号： C09K8/68

CPC分类号： C08L101/14 ,  Y10S507/903

摘要： A composition includes water having a salinity of at least 1 ppt, at least one hydrophilic polymer containing primary (—NH2) and/or secondary (—NHR) amine groups and at least one saccharide containing a reducible function. A method of changing the permeability of a subterranean formation includes the step of injecting into a subterranean formation a composition comprising water, at least one hydrophilic polymer containing at least two groups which are independently the same or different a primary amine group or a secondary amine group and at least one saccharide containing a reducible function.

公开(公告)号：US06184270B2

公开(公告)日：2001-02-06

申请号：US09157918

申请日：1998-09-21

申请人： Eric J. Beckman ,  Mark O'Niell

发明人： Eric J. Beckman ,  Mark O'Niell

IPC分类号： C08J312

CPC分类号： C09D5/03 ,  C08J3/12 ,  C08J2333/00

摘要： A method for producing a powder comprises the steps of: charging a vessel with a mixture of at least two solid components. At least one of the solid components comprises a polymeric resin. The vessel with charged with a fluid in which the polymeric resin, and preferably the other components of the mixture, are not substantially soluble. The fluid is selected such that the density of the fluid can be adjusted upon adjustment of temperature and pressure in the vessel to enable creation of a suspension of the mixture within the vessel upon agitation of the contents of the vessel. The temperature is maintained above the glass transition temperature of the polymeric resin in the fluid. The pressure of the fluid is adjusted such that the density of the fluid enables creation of the suspension of the mixture within the vessel upon agitation of the contents of the vessel. The contents of the vessel is agitated to create the suspension. The temperature is then reduced to a temperature below the glass transition temperature of the polymeric resin component in the fluid.

摘要翻译： 制备粉末的方法包括以下步骤：用至少两种固体组分的混合物装入容器。 固体组分中的至少一种包含聚合物树脂。 装有流体的容器，其中聚合物树脂，优选混合物的其它组分基本上不溶。 选择流体使得可以在调节容器中的温度和压力时调节流体的密度，以便在搅动容器的内容物时能够在容器内产生混合物的悬浮液。 温度保持在流体中聚合物树脂的玻璃化转变温度以上。 调节流体的压力，使得流体的密度能够在搅动容器的内容物时产生混合物在容器内的悬浮液。 搅动容器的内容物以产生悬浮液。 然后将温度降低至低于流体中聚合物树脂组分的玻璃化转变温度的温度。

公开(公告)号：US5977252A

公开(公告)日：1999-11-02

申请号：US612270

申请日：1996-03-07

申请人： William R. Wagner ,  Christopher R. Deible ,  Eric J. Beckman ,  Alan Russell

发明人： William R. Wagner ,  Christopher R. Deible ,  Eric J. Beckman ,  Alan Russell

IPC分类号： A61L33/00 ,  C08G63/48 ,  A01N1/00 ,  C08G63/91

CPC分类号： A61L33/0088

摘要： Described herein is a technique for covalently modifying tissue and cellular surfaces to inhibit cell adhesion. The process described herein is conducted under conditions tolerable in vivo and employs a biocompatible polymer having a reactive group attached to at least one end that reacts with groups present or on tissue and cellular surfaces under aqueous and mild conditions and thereby covalently attaches the polymer to the tissue or cellular surface. Preferably, the reactive group attached to the polymer reacts with amines and hydroxyls present on tissue and cellular surfaces. In one preferred embodiment, the methods described herein provide for the covalent modification of tissue and cellular surfaces using a PEG-diisocyanate solution. The methods described herein are particularly useful in impairing platelet and leukocyte deposition in blood vessels and thereby thwarting thrombosis and restenosis, a common complication of vascular procedures including PTCA and vascular surgery. Furthermore, by masking the tissue surface proteins from blood elements, the methods described herein are useful in decreasing graft thrombogenicity and reducing the complications of vascular surgery. Finally the methods described herein reduce the immunogenicity of transplanted tissues and cells and thereby reduce the need for immunosuppressive therapy.

摘要翻译： 本文描述了共价修饰组织和细胞表面以抑制细胞粘附的技术。 本文描述的方法在体内可耐受的条件下进行，并且使用生物相容性聚合物，其具有连接至至少一个末端的反应性基团，所述反应性基团在水溶液和温和条件下与存在的或与组织和细胞表面上的基团反应，从而将聚合物共价连接到 组织或细胞表面。 优选地，连接到聚合物的反应性基团与存在于组织和细胞表面上的胺和羟基反应。 在一个优选的实施方案中，本文所述的方法使用PEG-二异氰酸酯溶液提供组织和细胞表面的共价修饰。 本文描述的方法特别可用于损害血管中的血小板和白细胞沉积，从而阻止血栓形成和再狭窄，包括PTCA和血管手术的血管手术的常见并发症。 此外，通过从血液元件掩蔽组织表面蛋白质，本文所述的方法可用于降低移植物血栓形成和减少血管手术的并发症。 最后，本文所述的方法降低了移植组织和细胞的免疫原性，从而减少了免疫抑制治疗的需要。

公开(公告)号：US5886061A

公开(公告)日：1999-03-23

申请号：US028372

申请日：1993-03-09

申请人： Eric J. Beckman

发明人： Eric J. Beckman

IPC分类号： B29C44/34 ,  C08J9/12 ,  C08F14/00

CPC分类号： B29C44/3446 ,  C08J9/122

摘要： Polymers capable of reversibly complexing carbon dioxide and other acid gases and a method of producing such polymers are disclosed. In a preferred embodiment, the present polymers incorporate amine groups capable of reversibly complexing carbon dioxide to produce an environmentally safe foamed polymer product. Because the reaction of an amine and CO.sub.2 is a reversible reaction, and because the amines are incorporated into the polymer backbone, the foamed polymers can be reverted to foamable polymers simply by collection, washing, granulating, and re-exposure to CO.sub.2. The polymers are environmentally desirable as carbon dioxide is non-toxic and is easily isolated from the atmosphere. Moreover, the process recycles the gas continually, rather than generating new gases.

摘要翻译： 公开了能够可逆地络合二氧化碳和其它酸性气体的聚合物和制备这种聚合物的方法。 在优选的实施方案中，本发明的聚合物包含能够可逆地络合二氧化碳的胺基，以产生环境安全的泡沫聚合物产物。 因为胺和CO 2的反应是可逆反应，并且因为胺被引入到聚合物主链中，所以发泡聚合物可以简单地通过收集，洗涤，制粒和再暴露于CO 2而还原成可发泡聚合物。 这些聚合物是环保的，因为二氧化碳是无毒的并且易于与大气隔离。 此外，该方法不断产生新气体，而是循环再循环气体。

公开(公告)号：US20110301639A1

公开(公告)日：2011-12-08

申请号：US13116571

申请日：2011-05-26

申请人： Eric J. Beckman

发明人： Eric J. Beckman

IPC分类号： A61B17/03 ,  A61L15/26 ,  C08G65/48 ,  C08G77/18 ,  C08G77/26

CPC分类号： A61L24/046 ,  A61B17/00491 ,  A61B17/0057 ,  A61B2017/0065 ,  A61L24/0042 ,  C08L83/04 ,  C08L71/02

摘要： A tissue sealant is described that includes the reaction product of (a) a polyol having at least two groups capable of reacting with an alkoxy silane and (b) an alkoxy silane having the formula: (R1R2R3)—Si—CH2—Z where (i) Z is an —OH, —SH, —NCO, or —NHR4 group, where R4 is hydrogen or an alkyl group; and (ii) each R1, R2, and R3, independently, is H, an alkoxy group, an alkyl group, a heteroalkyl group other than an alkoxy group, an aryl group, or a heteroaryl group, with the proviso that at least two of R1, R2, and R3 are alkoxy groups. The tissue sealant is moisture-curable and biodegradable in a physiological environment.

摘要翻译： 描述了一种组织密封剂，其包括（a）具有至少两个能够与烷氧基硅烷反应的基团的多元醇的反应产物和（b）具有下式的烷氧基硅烷：（R1R2R3）-Si-CH2-Z其中（ i）Z是-OH，-SH，-NCO或-NHR 4基团，其中R 4是氢或烷基; 和（ii）每个R 1，R 2和R 3独立地是H，烷氧基，烷基，除烷氧基，芳基或杂芳基以外的杂烷基，条件是至少两个 R 1，R 2和R 3为烷氧基。 组织密封剂在生理环境中是可湿固化的和可生物降解的。

公开(公告)号：US07628888B2

公开(公告)日：2009-12-08

申请号：US11450999

申请日：2006-06-12

申请人： Eric J. Beckman ,  W. Eamon Carroll ,  Toby Chapman ,  Kristen E. Minnich ,  Dennis Sagl ,  Richard J. Goddard

发明人： Eric J. Beckman ,  W. Eamon Carroll ,  Toby Chapman ,  Kristen E. Minnich ,  Dennis Sagl ,  Richard J. Goddard

IPC分类号： C09K8/68 ,  C09K8/90 ,  C08L101/00 ,  D21H17/24 ,  D21H17/56

CPC分类号： D21H21/18 ,  C08L39/00 ,  C08L39/02 ,  C09D133/14 ,  C09D139/02 ,  D21H17/06 ,  D21H17/36 ,  D21H17/56

摘要： A composition includes at least one hydrophilic polymer containing primary (—NH2) and/or secondary (—NHR) amine groups and at least one saccharide containing a reducible function. A method of increasing the strength of paper includes the step of contacting the paper with a composition comprising (i) at least one hydrophilic polymer containing at least two groups which are independently the same or different a primary amine group or a secondary amine group and at least one saccharide containing a reducible function. A hydrogel composition is formed from a mixture of at least one hydrophilic polymer containing at least two groups which are independently the same or different a primary amine group or a secondary amine group and at least one saccharide containing a reducible function.

摘要翻译： 组合物包含至少一种含有伯（-NH 2）和/或仲（-NHR）胺基团的至少一种亲水性聚合物和至少一种含有可还原功能的糖。 提高纸张强度的方法包括使纸与包含（i）至少一种亲水性聚合物的步骤，所述组合物含有至少两个独立地相同或不同的伯胺基或仲胺基的基团，并且在 至少一种含有可还原功能的糖。 水凝胶组合物由至少一种含有至少两个独立地相同或不同的伯胺基或仲胺基的亲水性聚合物和至少一种含有还原性功能的糖的亲水性聚合物的混合物形成。

公开(公告)号：US07494566B2

公开(公告)日：2009-02-24

申请号：US10799793

申请日：2004-03-12

申请人： William Eamon Carroll ,  Christian Jehn Rendu ,  Eric J. Beckman

发明人： William Eamon Carroll ,  Christian Jehn Rendu ,  Eric J. Beckman

IPC分类号： D21H21/20

CPC分类号： D21H21/18 ,  C08L39/00 ,  C08L39/02 ,  C08L39/04 ,  C08L2312/00 ,  C09D133/02 ,  C09D133/14 ,  C09D139/02 ,  D21H17/06 ,  D21H17/36 ,  D21H17/56 ,  D21H21/20 ,  C08L2666/26

摘要： A composition includes water; at least one hydrophilic polymer containing at least two groups which are independently the same or different a primary amine group or a secondary amine group and at least one saccharide containing a reducible function as described above. The hydrophilic polymer and the saccharide are mixed to form a reaction mixture and reacted to increase the viscosity of the reaction mixture. The reaction is then substantially terminated by reducing the pH of the composition. A method of increasing the strength of a cellulosic pulp product includes the steps of: contacting wet cellulosic pulp with a composition comprising (i) at least one hydrophilic polymer containing at least two groups which are independently the same or different a primary amine group or a secondary amine group and at least one saccharide containing a reducible function, the hydrophilic polymer and the saccharide of the composition having been reacted in a crosslinking reaction prior to contacting the composition with the cellulosic pulp product to increase the viscosity the composition; and, after contacting the cellulosic pulp with the composition, causing the crosslinking reaction between the hydrophilic polymer and the saccharide of the composition to proceed further.

摘要翻译： 组合物包括水; 至少一种含有至少两个独立地相同或不同的伯胺基或仲胺基的亲水性聚合物和至少一种含有如上所述的还原性功能的糖。 将亲水性聚合物和糖混合以形成反应混合物并反应以增加反应混合物的粘度。 然后通过降低组合物的pH基本上终止反应。 提高纤维素纸浆产品的强度的方法包括以下步骤：使湿纤维素纸浆与组合物接触，所述组合物包含（i）至少一种亲水性聚合物，所述亲水性聚合物含有至少两个独立地相同或不同的伯胺基或 仲胺基团和至少一种含有可还原功能的糖类，亲水性聚合物和组合物的糖类在使组合物与纤维素纸浆产物接触之前已经在交联反应中反应以增加组合物的粘度; 并且在将纤维素纸浆与组合物接触之后，使亲水性聚合物与组合物的糖类之间的交联反应进一步进行。