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    Method and mould for casting articles with a pre-determined crytalline orientation
    12.
    发明申请
    Method and mould for casting articles with a pre-determined crytalline orientation 有权
    用预先确定的crytalline取向铸造制品的方法和模具

    公开(公告)号：US20080282972A1

    公开(公告)日：2008-11-20

    申请号：US12219801

    申请日：2008-07-29

    申请人： Neil J. D'Souza ,  Philip A. Jennings ,  Keerthi Devendra

    发明人： Neil J. D'Souza ,  Philip A. Jennings ,  Keerthi Devendra

    IPC分类号： C30B28/10

    CPC分类号： C30B11/14 ,  C30B29/52 ,  F01D5/28 ,  F05D2230/211 ,  F05D2300/606 ,  F05D2300/607 ,  Y10T117/10 ,  Y10T117/1016 ,  Y10T117/1036

    摘要： Previously a number of techniques have been used in order to form single crystal or pre-determined crystallography components and articles. Each one of these techniques has its own particular problems, including susceptibility to error. By utilisation of a bi-crystal experiment to determine melt-back length LM and by consideration of the ingress distance d from potential initiation nucleation points on a perimeter of a seed crystal, it is possible to determine a maximum ingress length d. By ensuring that the maximum ingress length d is less than or equal to a seed crystal diameter R, it is possible to project locus from potential nucleation points C1, C2 in terms of potential radii for stray grain propagation. As the seed crystal will have a known crystalline orientation, it will be possible to consider two divergent growth curves of the crystal in terms of the stray grains propagating from the point C1, C2. In such circumstances, a connector channel can be provided with a radius r=R/4 in an area between the periphery of the seed and the locus of the stray grain maximum ingress distances d. In situations where it is found d exceeds the crystal radius R, it will be understood that the actual crystal diameter R used may be increased or adjustment made with regard to the melt-back length LM in order to alter the maximum ingress distance d.

    摘要翻译： 以前已经使用许多技术来形成单晶或预定的晶体学组件和制品。 这些技术中的每一种都有自己的特殊问题，包括对误差的敏感性。 通过利用双晶实验来确定熔体回缩长度LM，并且考虑到晶种周边上潜在的起始成核点的入口距离d，可以确定最大入口长度d。 通过确保最大入口长度d小于或等于籽晶直径R，可以将位点从潜在成核点C 1，C 2 2投影到 杂散粒子传播的潜在半径条件。 由于晶种将具有已知的晶体取向，所以可以考虑晶体的两个发散生长曲线，就是从点C 1，C 2 2传播的杂散晶粒， / SUB>。 在这种情况下，连接器通道可以在种子周边与杂散颗粒最大进入距离d的轨迹之间的区域中具有半径r = R / 4。 在发现d超过晶体半径R的情况下，可以理解，为了改变最大入口距离d，所使用的实际晶体直径R可以增加或相对于熔体返回长度LM进行调整。

    Endonucleases
    13.
    发明授权
    Endonucleases 失效
    核酸内切酶

    公开(公告)号：US5298612A

    公开(公告)日：1994-03-29

    申请号：US717602

    申请日：1991-06-19

    申请人： Philip A. Jennings ,  Masine J. McCall ,  Philip Hendry

    发明人： Philip A. Jennings ,  Masine J. McCall ,  Philip Hendry

    IPC分类号： A61K38/46 ,  A61K38/00 ,  A61P17/00 ,  A61P31/12 ,  C12N9/00 ,  C12N9/22 ,  C12N15/113 ,  C12N15/10

    CPC分类号： C12N15/113 ,  C12N9/22 ,  A61K38/00 ,  C12N2310/111 ,  C12N2310/121 ,  C12N2310/322

    摘要： This invention provides catalytic molecules capable of cleaving target nucleotide sequences. More specifically, the invention provides an endonuclease having nucleotide sequences which are of sufficient length to allow hybridisation to a target nucleotide sequence desired to be cleaved. The endonuclease contains a catalytic region comprising ribonucleotides and/or deoxyribonucleotides, or derivatives thereof which act to cleave a phosphodiester bond of the substrate nucleotide sequence. The catalytic region comprises nucleotides or derivatives thereof which are linked by linking groups which may comprise ribonucleotides, deoxyribonucleotides or combinations thereof.The endonucleases of the invention are useful in the cleavage of target RNAs associated with disease in humans and animals and in the inactivation of RNA transcripts in eukaryotic and prokaryotic cells, as well as the cleavage of RNA transcripts in-vitro.

    摘要翻译： 本发明提供能够切割靶核苷酸序列的催化分子。 更具体地，本发明提供了具有足够长度的核苷酸序列的核酸内切核酸酶，以允许与期望切割的靶核苷酸序列杂交。 核酸内切酶含有包含核糖核苷酸和/或脱氧核糖核苷酸或其衍生物的催化区，其作用是切割底物核苷酸序列的磷酸二酯键。 催化区域包含通过可包含核糖核苷酸，脱氧核糖核苷酸或其组合的连接基团连接的核苷酸或其衍生物。 本发明的核酸内切酶可用于在人类和动物中与疾病相关的靶RNA的切割和真核和原核细胞中的RNA转录物的失活以及在体外切割RNA转录物。

    Casting method
    18.
    发明授权
    Casting method 有权
    铸造方法

    公开(公告)号：US07204294B2

    公开(公告)日：2007-04-17

    申请号：US11065442

    申请日：2005-02-25

    申请人： Philip A. Jennings ,  Neil J. D'Souza

    发明人： Philip A. Jennings ,  Neil J. D'Souza

    IPC分类号： B22C9/04

    CPC分类号： F01D5/12 ,  C30B11/002 ,  F05D2230/21 ,  F05D2300/607

    摘要： In order to more effectively utilise seed crystals 35, 55 to achieve a single crystal grain orientation for a component without the problems of utilising a helix constriction previously necessary to avoid epitaxial grain competition and growth. The present invention creates a wax component pattern 30. This pattern 30 comprises integral sections of wax for a mould component section and for a spacer section with the seed crystal 35 or holder for that crystal therebetween. This pattern 30 is then utilised in order to form a final refractory mould within which the component is formed. By appropriate choice of the spacer section 32, an appropriate spacing between an upper surface of the seed 55 which will be the initial interface with molten castable material to form the component and a chiller surface through which heat is transferred can be determined in order to achieve successful transfer of the seed 55 orientation to the formed component.

    摘要翻译： 为了更有效地利用晶种35,55来实现组分的单晶晶粒取向，而没有利用先前必要的避免外延晶粒竞争和生长的螺旋收缩的问题。 本发明产生蜡组分图案30。 该图案30包括用于模具部件部分的蜡的整体部分和用于其间晶体的种子晶体35或保持器的间隔部分。 然后使用该图案30以形成其中形成部件的最终耐火模具。 通过适当选择间隔部分32，可以确定作为初始界面的种子55的上表面与熔融浇铸材料形成部件之间的适当间隔，以及通过其传送热量的冷却器表面，以便实现 将种子55取向成功地转移到形成的部件上。