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公开(公告)号：US12031981B2
公开(公告)日：2024-07-09
申请号：US17053522
申请日：2019-05-08
Inventor： Stuart Lindsay , Bintian Zhang
IPC: G01N27/327 , G01N33/487 , G01N33/543 , G01N33/68
CPC classification number: G01N33/5438 , G01N33/48721 , G01N33/6854 , G01N2469/20
Abstract: The present disclosure relates to a sensing device and methods for detecting, and quantifying the amount of, a target protein in a sample.
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公开(公告)号：US20210325379A1
公开(公告)日：2021-10-21
申请号：US17232631
申请日：2021-04-16
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , RECOGNITION ANALYTIX INC.
Inventor： Stuart Lindsay , Karen Anderson , Mark Knappenberger , Sepideh Afsari Mamaghani , Jacob L. Swett
Abstract: The present disclosure provides devices, systems, and methods related to single molecule detection. In particular, the present disclosure provides devices and methods for sequence-specific detection of a nucleic acid target using current fluctuations as a readout for protein binding to the nucleic acid target. As described herein, certain aspects of the bioelectronic devices and method can be used to detect and identify any nucleic acid target for the purpose of diagnosis and/or treatment.
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公开(公告)号：US11119089B2
公开(公告)日：2021-09-14
申请号：US16327232
申请日：2017-08-21
Inventor： Peiming Zhang , Sovan Biswas , Suman Sen , Stuart Lindsay
IPC: G01N33/48 , G01N33/487 , C12Q1/6869 , C07C321/10 , C12Q1/68
Abstract: The present disclosure provides apparatus and methods for determining the sequence of a nucleic acid. The apparatus comprises electrodes that form a tunnel gap through which the nucleic acid can pass. The electrodes comprise a reagent that is capable of selectively interacting with a nucleobase of the nucleic acid sequence. When the reagent interacts with a nucleobase, a detectable signal is produced and used to identify the nucleobase of the nucleic acid. Advantageously, the apparatus of this disclosure is specific to identifying nucleic acids.
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公开(公告)号：US20200033320A1
公开(公告)日：2020-01-30
申请号：US16537232
申请日：2019-08-09
Inventor： Stuart Lindsay , Peiming Zhang , Yanan Zhao
IPC: G01N33/487
Abstract: A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length L1 and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than L2, but less than or equal to the sum of L1 and L2.
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公开(公告)号：US10442771B2
公开(公告)日：2019-10-15
申请号：US15417903
申请日：2017-01-27
Inventor： Stuart Lindsay , Peiming Zhang
IPC: C07D235/24 , G01N33/487 , G01N27/447 , C12Q1/6869
Abstract: The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer.
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Patent Agency Ranking
公开(公告)号：US10422787B2
公开(公告)日：2019-09-24
申请号：US15797052
申请日：2017-10-30
Inventor： Stuart Lindsay , Peiming Zhang , Yanan Zhao
IPC: G01N27/327 , G01N33/487 , G01N27/447
Abstract: A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length L1 and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than 2L1, but less than or equal to the sum of 2L1 and L2.
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公开(公告)号：US09952198B2
公开(公告)日：2018-04-24
申请号：US14773072
申请日：2014-03-05
Inventor： Stuart Lindsay , Peiming Zhang
IPC: G01N33/68 , G01N33/487 , G01N27/447 , G01N27/26 , G01N33/543 , G01N15/12 , C12Q1/37
CPC classification number: G01N33/48721 , C12Q1/37 , G01N15/12 , G01N27/44704 , G01N27/44747 , G01N27/44756 , G01N33/5438 , G01N33/6803 , G01N33/6848 , G01N2333/952 , G01N2570/00 , Y10T436/255
Abstract: Embodiments of the present disclosure are directed to methods, systems and devices, for analyzing the molecules. For example, in some embodiments, a system is provided which includes a first volume of conducting fluid, a second volume of conducting fluid, an orifice in communication with the first and second volumes of fluid, and means for applying an electric potential difference between the first and second volumes of fluid. In some embodiments, a conjugate product is provided which includes charged polymers each having attached thereto at least one first molecule for analysis, where the product carries a predetermined charge greater than the charge on the first molecule, and upon dissolving a product in the first volume of fluid, the product is directed into the orifice.
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公开(公告)号：US12298300B2
公开(公告)日：2025-05-13
申请号：US17232631
申请日：2021-04-16
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , RECOGNITION ANALYTIX INC.
Inventor： Stuart Lindsay , Karen Anderson , Mark Knappenberger , Sepideh Afsari Mamaghani , Jacob L. Swett
Abstract: The present disclosure provides devices, systems, and methods related to single molecule detection. In particular, the present disclosure provides devices and methods for sequence-specific detection of a nucleic acid target using current fluctuations as a readout for protein binding to the nucleic acid target. As described herein, certain aspects of the bioelectronic devices and method can be used to detect and identify any nucleic acid target for the purpose of diagnosis and/or treatment.
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公开(公告)号：US12276653B2
公开(公告)日：2025-04-15
申请号：US17333087
申请日：2021-05-28
Inventor： Stuart Lindsay
IPC: G01N33/487 , C12Q1/00 , G01N27/327
Abstract: The present disclosure provides devices, systems, and methods related to bioelectronic devices. In particular, the present disclosure provides bioelectronic devices, and methods of making bioelectronic devices, comprising adjustable adaptor polypeptides with repeatable motifs and enhanced conductive properties. The bioelectronic devices and methods of the present disclosure are useful for a variety of applications, including the direct measurement of protein activity (e.g., when sequencing a biopolymer).
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公开(公告)号：US11630098B2
公开(公告)日：2023-04-18
申请号：US16917474
申请日：2020-06-30
Inventor： Stuart Lindsay , Peiming Zhang , Yanan Zhao
IPC: G01N33/487
Abstract: A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length LI and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than L2, but less than or equal to the sum of LI and L2.
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