公开(公告)号：US20060009383A1

公开(公告)日：2006-01-12

申请号：US10980722

申请日：2004-11-03

申请人： Georgia Theofan ,  Arnold Horwitz ,  David Burke ,  Manik Baltaian ,  Lynn Grinna

发明人： Georgia Theofan ,  Arnold Horwitz ,  David Burke ,  Manik Baltaian ,  Lynn Grinna

IPC分类号： A61K38/16 ,  C07K14/195

CPC分类号： C07K19/00 ,  A61K38/00 ,  C07K14/4742 ,  C07K2319/00 ,  C12N15/85 ,  C12N2830/00 ,  C12N2830/15 ,  C12N2830/30 ,  C12N2830/60 ,  C12N2830/85 ,  C12N2840/44

摘要： Disclosed are novel bactericidal/permeability-increasing (BPI) protein products wherein cysteine residue number 132 or 135 is replaced by another amino acid residue, preferably an alanine or serine residue and/or wherein the leucine residue at position 193 is the carboxy terminal residue. Also disclosed are DNA sequences encoding methods for the production of the same in appropriate host cells, and stable homogeneous pharmaceutical compositions containing the analogs suitable for use treatment of gram negative bacterial infection and its sequelae.

公开(公告)号：US20050009097A1

公开(公告)日：2005-01-13

申请号：US10816276

申请日：2004-03-31

申请人： Marc Better ,  Arnold Horwitz

发明人： Marc Better ,  Arnold Horwitz

IPC分类号： C07K16/30 ,  G01N33/574 ,  G01N33/53 ,  C07K16/40 ,  C12P21/04

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/73 ,  G01N33/57492

摘要： Human engineered anti-Ep-CAM antibodies and various uses therefore are disclosed. These human engineered anti-Ep-CAM antibodies have high affinity binding to Ep-CAM with low immunogenicity.

摘要翻译： 因此公开了人工抗Ep-CAM抗体和各种用途。 这些人工构建的抗Ep-CAM抗体与Ep-CAM具有高亲和力结合，免疫原性低。

公开(公告)号：US06828418B2

公开(公告)日：2004-12-07

申请号：US10196460

申请日：2002-07-16

申请人： Georgia Theofan ,  Arnold Horwitz ,  David Burke ,  Manik Baltaian ,  Lynn Grinna

发明人： Georgia Theofan ,  Arnold Horwitz ,  David Burke ,  Manik Baltaian ,  Lynn Grinna

IPC分类号： A61K3800

CPC分类号： C07K19/00 ,  A61K38/00 ,  C07K14/4742 ,  C07K2319/00 ,  C12N15/85 ,  C12N2830/00 ,  C12N2830/15 ,  C12N2830/30 ,  C12N2830/60 ,  C12N2830/85 ,  C12N2840/44

摘要： Disclosed are novel bactericidal/permeability-increasing (BPI) protein products wherein cysteine residue number 132 or 135 is replaced by another amino acid residue, preferably an alanine or serine residue and/or wherein the leucine residue at position 193 is the carboxy terminal residue. Also disclosed are DNA sequences encoding methods for the production of the same in appropriate host cells, and stable homogeneous pharmaceutical compositions containing the analogs suitable for use treatment of gram negative bacterial infection and its sequelae.

摘要翻译： 公开了新的杀菌/渗透性增加（BPI）蛋白产物，其中半胱氨酸残基132或135被另一个氨基酸残基，优选丙氨酸或丝氨酸残基替代，和/或其中第193位的亮氨酸残基是羧基末端残基。 还公开了编码在合适的宿主细胞中制备其的方法的DNA序列，以及含有适合用于治疗革兰氏阴性细菌感染及其后遗症的类似物的稳定的均匀药物组合物。

公开(公告)号：US6013631A

公开(公告)日：2000-01-11

申请号：US99725

申请日：1998-06-19

申请人： Arnold Horwitz ,  Stephen Fitzhugh Carroll ,  David Burke

发明人： Arnold Horwitz ,  Stephen Fitzhugh Carroll ,  David Burke

IPC分类号： C12N15/09 ,  A01N37/18 ,  A61K38/00 ,  A61K38/16 ,  A61P31/04 ,  C07H21/04 ,  C07K14/00 ,  C07K14/47 ,  C12N5/00 ,  C12N5/10 ,  C12N9/48 ,  C12N15/31 ,  C12N15/74 ,  C12P21/02 ,  C12P21/06 ,  C12R1/91 ,  C07K1/00

CPC分类号： A61K38/17 ,  C07K14/4742

摘要： Novel BPI deletion analogs are provided that consist of amino acid residues 10 through 193 of mature human BPI wherein the cysteine residue at BPI amino acid position 132 is replaced by another amino acid. Fusion proteins comprising these analogs are also provided, as are polynucleotides encoding these products, materials and methods for their recombinant production, compositions and medicaments of these products, and therapeutic uses for these products.

公开(公告)号：US5783561A

公开(公告)日：1998-07-21

申请号：US758116

申请日：1996-11-25

申请人： Arnold Horwitz ,  Lewis H. Lambert, Jr. ,  Roger G. Little, II

发明人： Arnold Horwitz ,  Lewis H. Lambert, Jr. ,  Roger G. Little, II

IPC分类号： C12N15/09 ,  A01N37/18 ,  A61K31/70 ,  A61K38/00 ,  A61K38/17 ,  A61K45/06 ,  A61P3/00 ,  A61P31/04 ,  C07H21/04 ,  C07K14/47 ,  C12P21/02 ,  A61K38/16

CPC分类号： C07K14/4742 ,  A61K38/00

摘要： The present invention relates to methods of treating gram-positive bacterial infections by administration of a BPI protein product alone, or in combination with an antibiotic. BPI protein product alone has a bactericidal or growth inhibitory effect on selected gram-positive organisms. BPI protein product also increases the susceptibility of gram-positive organisms to antibiotics and can even reverse resistance of gram-positive organisms to antibiotic.

公开(公告)号：US5643570A

公开(公告)日：1997-07-01

申请号：US64693

申请日：1993-05-19

申请人： Georgia Theofan ,  Lynn S. Grinna ,  Arnold Horwitz

发明人： Georgia Theofan ,  Lynn S. Grinna ,  Arnold Horwitz

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K19/00 ,  C12N1/21 ,  C12N15/12 ,  C12N15/13 ,  C12N15/63 ,  C12N15/85 ,  C12P21/00 ,  A61K39/395 ,  C12N15/00

CPC分类号： C12N15/85 ,  C07K14/4742 ,  A61K38/00 ,  C07K2319/033 ,  C07K2319/30

摘要： Disclosed are novel hybrid fusion proteins comprising at their amino terminus, bactericidal/permeability-increasing protein or a biologically active fragment thereof and, at their carboxy terminus, at least one immunoglobulin heavy chain constant domain useful in treating bacterial infection. Also disclosed are DNA sequences encoding such proteins, recombinant methods for production of the proteins, and pharmaceutical preparations containing the recombinant products.

摘要翻译： 公开了在其氨基末端包含杀菌/增加渗透性蛋白质或其生物活性片段的新型杂合融合蛋白，并且在其羧基末端包含至少一个可用于治疗细菌感染的免疫球蛋白重链恒定结构域。 还公开了编码这种蛋白质的DNA序列，用于生产蛋白质的重组方法和含有重组产物的药物制剂。

公开(公告)号：US5578572A

公开(公告)日：1996-11-26

申请号：US372783

申请日：1995-01-13

申请人： Arnold Horwitz ,  Lewis H. Lambert, Jr. ,  Roger G. Little, II

发明人： Arnold Horwitz ,  Lewis H. Lambert, Jr. ,  Roger G. Little, II

IPC分类号： C12N15/09 ,  A01N37/18 ,  A61K31/70 ,  A61K38/00 ,  A61K38/17 ,  A61K45/06 ,  A61P3/00 ,  A61P31/04 ,  C07H21/04 ,  C07K14/47 ,  C12P21/02 ,  A61K38/16

CPC分类号： C07K14/4742 ,  A61K38/00

摘要： The present invention relates to methods of treating gram-positive bacterial infections by administration of a BPI protein product alone, or in combination with an antibiotic. BPI protein product alone has a bactericidal or growth inhibitory effect on selected gram-positive organisms. BPI protein product also increases the susceptibility of gram-positive organisms to antibiotics and can even reverse resistance of gram-positive organisms to antibiotic.

公开(公告)号：US07695717B2

公开(公告)日：2010-04-13

申请号：US12218997

申请日：2008-07-18

申请人： Linda Masat ,  Mary Haak-Frendscho ,  Gang Chen ,  Arnold Horwitz ,  Marina Roell

发明人： Linda Masat ,  Mary Haak-Frendscho ,  Gang Chen ,  Arnold Horwitz ,  Marina Roell

IPC分类号： A61K39/395

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K16/245 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  Y10S514/885

摘要： Methods of treating or preventing an IL-1 related disease or condition in a mammal comprising administering an effective amount of an IL-1β binding antibody or IL-1β binding fragment thereof. An IL-1β binding antibody or IL-1β binding fragment thereof is provided comprising the amino acid sequence of SEQ ID NO:28, and related nucleic acids, vectors, cells, and compositions, and a method of preparing an affinity matured IL-1β binding polypeptide is provided. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.

摘要翻译： 治疗或预防哺乳动物中IL-1相关疾病或病症的方法，包括给予有效量的IL-1和bgr; 结合抗体或IL-1和bgr; 其结合片段。 IL-1和bgr 结合抗体或IL-1和bgr; 提供了包含SEQ ID NO：28的氨基酸序列及相关核酸，载体，细胞和组合物的结合片段，以及制备亲和力成熟的IL-1和bgr的方法。 提供了结合多肽。 IL-1和bgr 结合抗体或IL-1和bgr; 提供其结合片段，其具有期望的亲和力和效力。

公开(公告)号：US20100055110A1

公开(公告)日：2010-03-04

申请号：US12464323

申请日：2009-05-12

申请人： Linda Masat ,  Mary Haak-Frendscho ,  Gang Chen ,  Arnold Horwitz ,  Marina Roell

发明人： Linda Masat ,  Mary Haak-Frendscho ,  Gang Chen ,  Arnold Horwitz ,  Marina Roell

IPC分类号： A61K39/395 ,  A61P9/00

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K16/245 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  Y10S514/885

摘要： An IL-1β binding antibody or IL-1β binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 2, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease, and a method of preparing an affinity matured IL-1β binding polypeptide. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.

摘要翻译： IL-1和bgr 结合抗体或IL-1和bgr; 包含SEQ ID NO：2的氨基酸序列的结合片段，以及相关的核酸，载体，细胞和组合物，以及其用于治疗或预防疾病的方法，以及制备亲和力成熟的IL的方法 -1＆bgr 结合多肽。 IL-1和bgr 结合抗体或IL-1和bgr; 提供其结合片段，其具有期望的亲和力和效力。

公开(公告)号：US20090246210A1

公开(公告)日：2009-10-01

申请号：US12463844

申请日：2009-05-11

申请人： Linda Masat ,  Mary Haak-Frendscho ,  Gang Chen ,  Arnold Horwitz ,  Marina Roell

发明人： Linda Masat ,  Mary Haak-Frendscho ,  Gang Chen ,  Arnold Horwitz ,  Marina Roell

IPC分类号： A61K39/395 ,  C07K16/18

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K16/245 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  Y10S514/885

摘要： An IL-1β binding antibody or IL-1β binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 26 and SEQ ID NO: 11, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.

摘要翻译： 包含SEQ ID NO：26和SEQ ID NO：11的氨基酸序列的IL-1β结合抗体或IL-1β结合片段，以及相关的核酸，载体，细胞和组合物，以及其使用方法 治疗或预防疾病。 提供具有期望的亲和力和效力的IL-1β结合抗体或其IL-1β结合片段。