公开(公告)号：US6013631A

公开(公告)日：2000-01-11

申请号：US99725

申请日：1998-06-19

申请人： Arnold Horwitz ,  Stephen Fitzhugh Carroll ,  David Burke

发明人： Arnold Horwitz ,  Stephen Fitzhugh Carroll ,  David Burke

IPC分类号： C12N15/09 ,  A01N37/18 ,  A61K38/00 ,  A61K38/16 ,  A61P31/04 ,  C07H21/04 ,  C07K14/00 ,  C07K14/47 ,  C12N5/00 ,  C12N5/10 ,  C12N9/48 ,  C12N15/31 ,  C12N15/74 ,  C12P21/02 ,  C12P21/06 ,  C12R1/91 ,  C07K1/00

CPC分类号： A61K38/17 ,  C07K14/4742

摘要： Novel BPI deletion analogs are provided that consist of amino acid residues 10 through 193 of mature human BPI wherein the cysteine residue at BPI amino acid position 132 is replaced by another amino acid. Fusion proteins comprising these analogs are also provided, as are polynucleotides encoding these products, materials and methods for their recombinant production, compositions and medicaments of these products, and therapeutic uses for these products.

公开(公告)号：US5827816A

公开(公告)日：1998-10-27

申请号：US466822

申请日：1995-06-06

申请人： Georgia Theofan ,  Arnold Horwitz ,  David Burke ,  Manik Baltaian ,  Lynn Grinna

发明人： Georgia Theofan ,  Arnold Horwitz ,  David Burke ,  Manik Baltaian ,  Lynn Grinna

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P7/02 ,  A61P7/06 ,  A61P9/02 ,  A61P11/00 ,  A61P13/12 ,  A61P31/00 ,  A61P31/04 ,  A61P39/02 ,  C07H21/04 ,  C07K14/47 ,  C07K14/52 ,  C07K16/00 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/02 ,  C12N5/10 ,  C12N15/12 ,  C12N15/85 ,  C12P21/02 ,  C12R1/91 ,  A61K38/17

CPC分类号： C07K19/00 ,  C07K14/4742 ,  C12N15/85 ,  A61K38/00 ,  C07K2319/00 ,  C12N2830/00 ,  C12N2830/15 ,  C12N2830/30 ,  C12N2830/60 ,  C12N2830/85 ,  C12N2840/44

摘要： Disclosed are novel bactericidal/permeability-increasing (BPI) protein products wherein cysteine residue number 132 or 135 is replaced by another amino acid residue, preferably an alanine or serine residue and/or wherein the leucine residue at position 193 is the carboxy terminal residue. Also disclosed are DNA sequences encoding methods for the production of the same in appropriate host cells, and stable homogeneous pharmaceutical compositions containing the analogs suitable for use treatment of gram negative bacterial infection and its sequelae.

公开(公告)号：US20060009383A1

公开(公告)日：2006-01-12

申请号：US10980722

申请日：2004-11-03

申请人： Georgia Theofan ,  Arnold Horwitz ,  David Burke ,  Manik Baltaian ,  Lynn Grinna

发明人： Georgia Theofan ,  Arnold Horwitz ,  David Burke ,  Manik Baltaian ,  Lynn Grinna

IPC分类号： A61K38/16 ,  C07K14/195

CPC分类号： C07K19/00 ,  A61K38/00 ,  C07K14/4742 ,  C07K2319/00 ,  C12N15/85 ,  C12N2830/00 ,  C12N2830/15 ,  C12N2830/30 ,  C12N2830/60 ,  C12N2830/85 ,  C12N2840/44

摘要： Disclosed are novel bactericidal/permeability-increasing (BPI) protein products wherein cysteine residue number 132 or 135 is replaced by another amino acid residue, preferably an alanine or serine residue and/or wherein the leucine residue at position 193 is the carboxy terminal residue. Also disclosed are DNA sequences encoding methods for the production of the same in appropriate host cells, and stable homogeneous pharmaceutical compositions containing the analogs suitable for use treatment of gram negative bacterial infection and its sequelae.

公开(公告)号：US06828418B2

公开(公告)日：2004-12-07

申请号：US10196460

申请日：2002-07-16

申请人： Georgia Theofan ,  Arnold Horwitz ,  David Burke ,  Manik Baltaian ,  Lynn Grinna

发明人： Georgia Theofan ,  Arnold Horwitz ,  David Burke ,  Manik Baltaian ,  Lynn Grinna

IPC分类号： A61K3800

CPC分类号： C07K19/00 ,  A61K38/00 ,  C07K14/4742 ,  C07K2319/00 ,  C12N15/85 ,  C12N2830/00 ,  C12N2830/15 ,  C12N2830/30 ,  C12N2830/60 ,  C12N2830/85 ,  C12N2840/44

摘要： Disclosed are novel bactericidal/permeability-increasing (BPI) protein products wherein cysteine residue number 132 or 135 is replaced by another amino acid residue, preferably an alanine or serine residue and/or wherein the leucine residue at position 193 is the carboxy terminal residue. Also disclosed are DNA sequences encoding methods for the production of the same in appropriate host cells, and stable homogeneous pharmaceutical compositions containing the analogs suitable for use treatment of gram negative bacterial infection and its sequelae.

摘要翻译： 公开了新的杀菌/渗透性增加（BPI）蛋白产物，其中半胱氨酸残基132或135被另一个氨基酸残基，优选丙氨酸或丝氨酸残基替代，和/或其中第193位的亮氨酸残基是羧基末端残基。 还公开了编码在合适的宿主细胞中制备其的方法的DNA序列，以及含有适合用于治疗革兰氏阴性细菌感染及其后遗症的类似物的稳定的均匀药物组合物。

公开(公告)号：US20050130889A1

公开(公告)日：2005-06-16

申请号：US10629516

申请日：2003-07-29

申请人： Arnold Horwitz ,  Stephen Carroll ,  David Burke

发明人： Arnold Horwitz ,  Stephen Carroll ,  David Burke

IPC分类号： C12N15/09 ,  A01N37/18 ,  A61K38/00 ,  A61K38/16 ,  A61P31/04 ,  C07H21/04 ,  C07K14/00 ,  C07K14/47 ,  C12N5/00 ,  C12N5/10 ,  C12N9/48 ,  C12N15/31 ,  C12N15/74 ,  C12P21/02 ,  C12P21/06 ,  C12R1/91

CPC分类号： A61K38/17 ,  C07K14/4742

摘要： Novel BPI deletion analogs are provided that consist of amino acid residues 10 through 193 of mature human BPI wherein the cysteine residue at BPI amino acid position 132 is replaced by another amino acid. Fusion proteins comprising these analogs are also provided, as are polynucleotides encoding these products, materials and methods for their recombinant production, compositions and medicaments of these products, and therapeutic uses for these products.

摘要翻译： 提供了由成熟人BPI的氨基酸残基10至193组成的新型BPI缺失类似物，其中BPI氨基酸位置132处的半胱氨酸残基被另一个氨基酸替代。 还提供了包含这些类似物的融合蛋白，编码这些产物的多核苷酸，其重组生产的材料和方法，这些产品的组合物和药物以及这些产品的治疗用途。

公开(公告)号：US06433140B1

公开(公告)日：2002-08-13

申请号：US09425034

申请日：1999-10-19

申请人： Georgia Theofan ,  Arnold Horwitz ,  David Burke ,  Manik Baltaian ,  Lynn Grinna

发明人： Georgia Theofan ,  Arnold Horwitz ,  David Burke ,  Manik Baltaian ,  Lynn Grinna

IPC分类号： C07K100

CPC分类号： C07K19/00 ,  A61K38/00 ,  C07K14/4742 ,  C07K2319/00 ,  C12N15/85 ,  C12N2830/00 ,  C12N2830/15 ,  C12N2830/30 ,  C12N2830/60 ,  C12N2830/85 ,  C12N2840/44

摘要： Disclosed are novel bactericidal/permeability-increasing (BPI) protein products wherein cysteine residue number 132 or 135 is replaced by another amino acid residue, preferably an alanine or serine residue and/or wherein the leucine residue at position 193 is the carboxy terminal residue. Also disclosed are DNA sequences encoding methods for the production of the same in appropriate host cells, and state homogeneous pharmaceutical compositions containing the analogs suitable for use treatment of gram negative bacterial infection and in sequelae.

摘要翻译： 公开了新的杀菌/渗透性增加（BPI）蛋白产物，其中半胱氨酸残基132或135被另一个氨基酸残基，优选丙氨酸或丝氨酸残基替代，和/或其中第193位的亮氨酸残基是羧基末端残基。 还公开了编码在合适的宿主细胞中制备其的方法的DNA序列，以及含有适合用于治疗革兰氏阴性细菌感染和后遗症的类似物的均匀的药物组合物。

公开(公告)号：US5420019A

公开(公告)日：1995-05-30

申请号：US13801

申请日：1993-02-02

申请人： Georgia Theofan ,  Arnold Horwitz ,  David Burke ,  Manik Baltaian ,  Lynn Grinna

发明人： Georgia Theofan ,  Arnold Horwitz ,  David Burke ,  Manik Baltaian ,  Lynn Grinna

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P7/02 ,  A61P7/06 ,  A61P9/02 ,  A61P11/00 ,  A61P13/12 ,  A61P31/00 ,  A61P31/04 ,  A61P39/02 ,  C07H21/04 ,  C07K14/47 ,  C07K14/52 ,  C07K16/00 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/02 ,  C12N5/10 ,  C12N15/12 ,  C12N15/85 ,  C12P21/02 ,  C12R1/91 ,  C12P21/06 ,  C07K14/435 ,  C12N15/00

CPC分类号： C07K19/00 ,  C07K14/4742 ,  C12N15/85 ,  A61K38/00 ,  C07K2319/00 ,  C12N2830/00 ,  C12N2830/15 ,  C12N2830/30 ,  C12N2830/60 ,  C12N2830/85 ,  C12N2840/44

摘要： Disclosed are novel bactericidal/permeability-increasing (BPI) protein products wherein cysteine residue number 132 or 135 is replaced by another amino acid residue, preferably an alanine or serine residue and/or wherein the leucine residue at position 193 is the carboxy terminal residue. Also disclosed are DNA sequences encoding methods for the production of the same in appropriate host cells, and stable homogeneous pharmaceutical compositions containing the analogs suitable for use treatment of gram negative bacterial infection and its sequelae.

摘要翻译： 公开了新的杀菌/渗透性增加（BPI）蛋白产物，其中半胱氨酸残基132或135被另一个氨基酸残基，优选丙氨酸或丝氨酸残基替代，和/或其中第193位的亮氨酸残基是羧基末端残基。 还公开了编码在合适的宿主细胞中制备其的方法的DNA序列，以及含有适合用于治疗革兰氏阴性细菌感染及其后遗症的类似物的稳定的均匀药物组合物。

公开(公告)号：US06599880B1

公开(公告)日：2003-07-29

申请号：US09579403

申请日：2000-05-25

申请人： Arnold Horwitz ,  Stephen F. Carroll ,  David Burke

发明人： Arnold Horwitz ,  Stephen F. Carroll ,  David Burke

IPC分类号： A61K3800

CPC分类号： A61K38/17 ,  C07K14/4742

摘要： Novel BPI deletion analogs are provided that consist of amino acid residues 10 through 193 of mature human BPI wherein the cysteine residue at BPI amino acid position 132 is replaced by another amino acid. Fusion proteins comprising these analogs are also provided, as are polynucleotides encoding these products, materials and methods for their recombinant production, compositions and medicaments of these products, and therapeutic uses for these products.

摘要翻译： 提供了由成熟人BPI的氨基酸残基10至193组成的新型BPI缺失类似物，其中BPI氨基酸位置132处的半胱氨酸残基被另一个氨基酸替代。 还提供了包含这些类似物的融合蛋白，编码这些产物的多核苷酸，其重组生产的材料和方法，这些产品的组合物和药物以及这些产品的治疗用途。

公开(公告)号：US6087126A

公开(公告)日：2000-07-11

申请号：US336402

申请日：1999-06-18

申请人： Arnold Horwitz ,  Stephen F. Carroll ,  David Burke

发明人： Arnold Horwitz ,  Stephen F. Carroll ,  David Burke

IPC分类号： C12N15/09 ,  A01N37/18 ,  A61K38/00 ,  A61K38/16 ,  A61P31/04 ,  C07H21/04 ,  C07K14/00 ,  C07K14/47 ,  C12N5/00 ,  C12N5/10 ,  C12N9/48 ,  C12N15/31 ,  C12N15/74 ,  C12P21/02 ,  C12P21/06 ,  C12R1/91 ,  C12N5/06 ,  C12N15/00

CPC分类号： A61K38/17 ,  C07K14/4742

摘要： Novel BPI deletion analogs are provided that consist of amino acid residues 10 through 193 of mature human BPI wherein the cysteine residue at BPI amino acid position 132 is replaced by another amino acid. Fusion proteins comprising these analogs are also provided, as are polynucleotides encoding these products, materials and methods for their recombinant production, compositions and medicaments of these products, and therapeutic uses for these products.

公开(公告)号：US5674834A

公开(公告)日：1997-10-07

申请号：US430417

申请日：1995-04-28

申请人： Georgia Theofan ,  Arnold Horwitz ,  David Burke ,  Manik Baltaian ,  Lynn Grinna

发明人： Georgia Theofan ,  Arnold Horwitz ,  David Burke ,  Manik Baltaian ,  Lynn Grinna

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P7/02 ,  A61P7/06 ,  A61P9/02 ,  A61P11/00 ,  A61P13/12 ,  A61P31/00 ,  A61P31/04 ,  A61P39/02 ,  C07H21/04 ,  C07K14/47 ,  C07K14/52 ,  C07K16/00 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/02 ,  C12N5/10 ,  C12N15/12 ,  C12N15/85 ,  C12P21/02 ,  C12R1/91 ,  A61K38/17

CPC分类号： C07K19/00 ,  C07K14/4742 ,  C12N15/85 ,  A61K38/00 ,  C07K2319/00 ,  C12N2830/00 ,  C12N2830/15 ,  C12N2830/30 ,  C12N2830/60 ,  C12N2830/85 ,  C12N2840/44

摘要： Disclosed are novel bactericidal/permeability-increasing (BPI) protein products wherein cysteine residue number 132 or 135 is replaced by another amino acid residue, preferably an alanine or serine residue and/or wherein the leucine residue at position 193 is the carboxy terminal residue. Also disclosed are DNA sequences encoding methods for the production of the same in appropriate host cells, and stable homogeneous pharmaceutical compositions containing the analogs suitable for use treatment of gram negative bacterial infection and its sequelae.

摘要翻译： 公开了新的杀菌/渗透性增加（BPI）蛋白产物，其中半胱氨酸残基132或135被另一个氨基酸残基，优选丙氨酸或丝氨酸残基替代，和/或其中第193位的亮氨酸残基是羧基末端残基。 还公开了编码在合适的宿主细胞中制备其的方法的DNA序列，以及含有适合用于治疗革兰氏阴性细菌感染及其后遗症的类似物的稳定的均匀药物组合物。