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    BLOOD TRANSCRIPTIONAL SIGNATURE OF ACTIVE VERSUS LATENT MYCOBACTERIUM TUBERCULOSIS INFECTION
    13.
    发明申请
    BLOOD TRANSCRIPTIONAL SIGNATURE OF ACTIVE VERSUS LATENT MYCOBACTERIUM TUBERCULOSIS INFECTION 审中-公开
    活动性血清MYCOBACTERIUM TUBCCOSOS感染的血液转录水平

    公开(公告)号：US20140080732A1

    公开(公告)日：2014-03-20

    申请号：US14024142

    申请日：2013-09-11

    Applicant: Baylor Research Institute ,  Imperial College Healthcare NHS Trust ,  Medical Research Council

    Inventor： Jacques F. Banchereau ,  Damien Chaussabel ,  Anne O'Garra ,  Matthew Berry ,  Onn Min Kon

    IPC: C12Q1/68

    CPC classification number: C12Q1/689 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158

    Abstract: The present invention includes methods, systems and kits for distinguishing between active and latent mycobacterium tuberculosis infection in a patient suspected of being infected with Mycobacterium tuberculosis, the method including the steps of obtaining a patient gene expression dataset from a patient suspected of being infected with Mycobacterium tuberculosis; sorting the patient gene expression dataset into one or more gene modules associated with Mycobacterium tuberculosis infection; and comparing the patient gene expression dataset for each of the one or more gene modules to a gene expression dataset from a non-patient; wherein an increase or decrease in the totality of gene expression in the patient gene expression dataset for the one or more gene modules is indicative of active Mycobacterium tuberculosis infection.

    Abstract translation: 本发明包括用于区分疑似感染结核分枝杆菌的患者的活性和潜在结核分枝杆菌感染的方法，系统和试剂盒，所述方法包括以下步骤：从疑似感染分枝杆菌的患者获得患者基因表达数据集 结核; 将患者基因表达数据集分类成与结核分枝杆菌感染相关的一个或多个基因模块; 以及将所述一个或多个基因模块中的每一个的患者基因表达数据集与来自非患者的基因表达数据集进行比较; 其中所述一个或多个基因模块的患者基因表达数据集中基因表达的总和的增加或减少指示活动性结核分枝杆菌感染。

    BLOOD TRANSCRIPTIONAL SIGNATURES OF ACTIVE PULMONARY TUBERCULOSIS AND SARCOIDOSIS
    17.
    发明申请
    BLOOD TRANSCRIPTIONAL SIGNATURES OF ACTIVE PULMONARY TUBERCULOSIS AND SARCOIDOSIS 审中-公开
    活动性肺结核和肺结核的血液转录征

    公开(公告)号：US20150315643A1

    公开(公告)日：2015-11-05

    申请号：US14651989

    申请日：2013-12-13

    Applicant: BAYLOR RESEARCH INSTITUTE ,  MEDICAL RESEARCH COUNCIL ,  IMPERIAL COLLEGE HEALTHCARE NHS TRUST

    Inventor： Anne O'Garra ,  Chloe Bloom ,  Matthew Paul Reddoch Berry ,  Jacques F. Banchereau ,  Damien Chaussabel ,  Viginia Maria Pascual

    IPC: C12Q1/68

    CPC classification number: C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16

    Abstract: The present invention includes a method of determining a lung disease from a patient suspected of sarcoidosis, tuberculosis, lung cancer or pneumonia comprising: obtaining a sample from whole blood of the patient suspected of sarcoidosis, tuberculosis, lung cancer or pneumonia; detecting expression of (although not exclusive) six or more disease genes, markers, or probes selected from SEQ ID NOS.: 1 to 1446, wherein increased expression of mRNA of upregulated sarcoidosis, tuberculosis, lung cancer and pneumonia markers of SEQ ID NOS.: 1 to 1446 and/or decreased expression of mRNA of downregulated sarcoidosis, tuberculosis, lung cancer or pneumonia markers of SEQ ID NOS.: 1 to 1446 relative to the expression of the mRNAs from a normal sample; and determining the lung disease based on the expression level of the six or more disease markers of SEQ ID NOS.: 1 to 1446 based on a comparison of the expression level of sarcoidosis, tuberculosis, lung cancer, and pneumonia.

    Abstract translation: 本发明包括从疑似结节病，肺结核，肺癌或肺炎的患者中确定肺部疾病的方法，包括从疑似结节病，肺结核，肺癌或肺炎的患者的全血中获得样品; 检测选自SEQ ID NO：1至1446的（但不排除）六种或更多种疾病基因，标记或探针的表达，其中增加SEQ ID NO：1至1446的上调的结节病，结核病，肺癌和肺炎标记物的mRNA的表达。 ：1至1446和/或相对于来自正常样品的mRNA表达的SEQ ID NO：1至1446的下调的结节病，结核病，肺癌或肺炎标记物的mRNA的表达降低; 以及基于结节病，结核病，肺癌和肺炎的表达水平的比较，基于SEQ ID NO：1至1446的六种或更多种疾病标志物的表达水平确定肺部疾病。

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