Abstract:
Systems for nerve and tissue modulation are disclosed. An illustrative system may include an intravascular nerve modulation system including a catheter shaft, a first flexible mount, and a cylindrical ablation transducer. The ablation transducer may be affixed to the catheter shaft through the flexible mount to allow an infusion fluid to pass through a lumen of the transducer. Another illustrative system may include an intravascular nerve modulation system including an expandable basket for centering an ablation tra7nsducer within a lumen.
Abstract:
Systems for nerve and tissue modulation are disclosed. An example system may include a first elongate element having a distal end and a proximal end and having at least one nerve modulation element disposed adjacent the distal end. The nerve modulation element may be positioned or moveable to target a particular tissue region. The nerve modulation element may be an ultrasound transducer.
Abstract:
Medical devices and methods for making and using the same are disclosed. An example medical device may include an ablative catheter for nerve modulation through a wall of a blood vessel. The catheter may include a catheter sheath having a proximal end, a distal end, and a lumen extending from the proximal to the distal end. An elongate member may extend along a central elongate axis within the lumen of the catheter sheath. The elongate member having a proximal end and a distal end. An expandable ablative member may be coupled to the distal end of the elongate member having an insulative section connected to a bare electrode section. The ablative member may be configured to switch between a collapsed position and an expanded position.
Abstract:
Medical devices and methods for making and using medical devices are disclosed. An example medical device may be a renal nerve modulation catheter. The catheter may include an elongate catheter shaft. The catheter shaft may have a plurality of cuts formed therein define a plurality of electrode assemblies. The electrode assemblies may each include a main strut, one or more branched spacer struts extending from the main strut, and an electrode extending from the main strut and positioned radially inward from the spacer struts.
Abstract:
Systems and methods for monitoring and performing tissue modulation are disclosed. An example system may include an elongate shaft having a distal end region and a proximal end and having at least one modulation element and one sensing electrode disposed adjacent to the distal end region. The sensing electrode may be used to determine and monitor changes in tissue adjacent to the modulation element.
Abstract:
A metallic tube arrangement includes an electrode region configured to expand radially and contract radially in response to increasing and decreasing a temperature at the electrode region, respectively. The electrode region is configured for intravascular deployment and delivery of high frequency energy to target tissue of a target vessel of the body. The electrode region is configured to expand radially to a diameter sufficient to contact an inner wall of the target vessel in response to a decrease in electrode region temperature and to contract radially to a diameter smaller than a diameter of the target vessel in response to an increase in electrode region temperature.
Abstract:
Systems for nerve and tissue modulation are disclosed. An illustrative system may include an intravascular nerve modulation system including a catheter shaft, an expandable basket and one or more energy delivery regions. The one or more energy delivery regions may be defined by regions of the basket free from an insulating material.
Abstract:
Systems for nerve and tissue modulation are disclosed. An example system may include an intravascular nerve modulation system including an elongated shaft having a first tubular member and a second tubular member. Each of the tubular members may have a proximal end a distal end. The distal end of the second tubular member may be extended distally beyond the distal end of the first tubular member. The system may further include at least one transducer affixed to the distal end region of the second tubular member. In addition, the system may include an infusion sheath having a proximal end and a distal end and the proximal end of the infusion sheath may be fixedly secured to the catheter shaft adjacent the distal end of the first tubular member.
Abstract:
Medical devices including catheters for renal nerve ablation and/or modulation as well as methods for making and using such devices are disclosed. An example catheter may, have a proximal region and a distal region. The catheter may be configured to shift between a first straightened configuration and a second deflected configuration. The catheter may also include an ablation member coupled to the distal region and a handle coupled to the proximal region. The handle may include an actuation member for shifting the catheter between the first configuration and the second configuration. A lock may be coupled to the handle that maintains the catheter in either the first configuration or the second configuration.
Abstract:
A catheter is disclosed including an elongated shaft having a distal end and a proximal end, where the catheter includes a thermal element at the distal end thereof. The thermal element may be used in an ablation procedure or other procedure to heat a tissue adjacent a vessel. The configuration of the distal end of the elongated shaft at or near the distal tip may encourage the cooling of or transferring of heat from the vessel wall. The configurations may include protrusions extending from and indentations extending into the shaft, which may manipulate the flow of fluid through a vessel in which the catheter has been inserted. Alternatively or additionally, a cap or thin insulative layer may be placed at or near the distal tip of the catheter shaft to cool the wall of the vessel.