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公开(公告)号：US08933235B2
公开(公告)日：2015-01-13
申请号：US14347662
申请日：2012-09-24
Applicant: Bristol-Myers Squibb Company
Inventor： Zulan Pi , John Lloyd , Jennifer X. Qiao , Tammy C. Wang , George O. Tora
IPC: A61K31/47 , C07D213/62 , C07D413/04 , C07D213/89 , C07D401/04 , C07D401/12 , C07D213/81 , C07D409/04
CPC classification number: C07D213/81 , C07D213/34 , C07D213/89 , C07D401/04 , C07D401/12 , C07D409/04 , C07D413/04
Abstract: The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供了如说明书中所定义的式（I）化合物和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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12.发明申请AMIDE, UREA OR SULFONE AMIDE LINKED BENZOTHIAZOLE INHIBITORS OF ENDOTHELIAL LIPASE 有权氨基酸，尿素或磺酰胺连接的内皮素的苯并噻唑抑制剂公开(公告)号：US20140045811A1
公开(公告)日：2014-02-13
申请号：US13944921
申请日：2013-07-18
Applicant: Bristol-Myers Squibb Company
Inventor： Heather Finlay , Ji Jiang , Soong-Hoon Kim , Brandon Parkhurst , Jennifer X. Qiao , Tammy C. Wang , Zulan Pi , George O. Tora , John Lloyd , James A. Johnson
IPC: C07D277/64 , C07D417/10 , C07D417/12 , C07D417/04 , C07D417/14
CPC classification number: C07D277/64 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US10508104B2
公开(公告)日：2019-12-17
申请号：US16309161
申请日：2017-06-14
Applicant: Bristol-Myers Squibb Company
Inventor： George O. Tora , Heather Finlay , Wen Jiang , Wei Meng , Xiaojun Zhang
IPC: C07D405/04 , C07D403/12 , C07D401/14 , C07D405/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D239/60 , C07D413/12 , C07D417/12 , C07D471/04 , A61P9/10 , A61P9/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20190194173A1
公开(公告)日：2019-06-27
申请号：US16309161
申请日：2017-06-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： George O. Tora , Heather Finlay , Wen Jiang , Wei Meng , Xiaojun Zhang
IPC: C07D405/04 , A61P9/04 , A61P9/10 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
CPC classification number: C07D405/04 , A61P9/04 , A61P9/10 , C07D239/60 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20170275272A1
公开(公告)日：2017-09-28
申请号：US15468230
申请日：2017-03-24
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zulan Pi , Donna M. Bilder , Robert Paul Brigance , Heather Finlay , Wen Jiang , James A. Johnson , R. Michael Lawrence , Wei Meng , Michael C. Myers , Monique Phillips , George O. Tora , Xiaojun Zhang
IPC: C07D403/06 , C07D471/04 , C07D417/14 , C07D401/14
CPC classification number: C07D403/06 , A61K31/505 , C07D239/54 , C07D239/545 , C07D239/557 , C07D401/06 , C07D401/14 , C07D403/02 , C07D403/14 , C07D417/14 , C07D471/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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Patent Agency Ranking
16.发明授权公开(公告)号：US09139578B2
公开(公告)日：2015-09-22
申请号：US14413370
申请日：2013-07-03
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zulan Pi , Jennifer X. Qiao , George O. Tora , Tammy C. Wang
IPC: C07D417/14 , C07D417/06
CPC classification number: C07D417/14 , C07D417/06
Abstract: The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供了如说明书中所定义的式（I）化合物和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US20150259286A1
公开(公告)日：2015-09-17
申请号：US14418023
申请日：2013-07-30
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Alexandre L'Heureux , Sheldon Hiebert , Carol Hu , Patrick Y.S. Lam , John Lloyd , Zulan Pi , Jennifer X. Qiao , Carl Thibeault , George O. Tora , Wu Yang , Yufeng Wang , Tammy C. Wang , Michael S. Bowsher , Ruel Rejean
IPC: C07D209/26 , C07D401/12 , C07D403/12 , C07D513/04 , C07D413/04 , C07D401/04 , C07D403/04 , C07D498/04 , C07D417/14 , C07D413/14 , C07D409/04 , C07D417/12 , C07D417/04
CPC classification number: C07D209/26 , C07D209/14 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D498/04 , C07D513/04
Abstract: The present invention provides compounds of Formula (I): Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are antagonists of P2Y1 receptor which may be used medicaments.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义的式（I）和包含任何这些新化合物的组合物。 这些化合物是可以使用药物的P2Y1受体的拮抗剂。
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18.发明申请公开(公告)号：US20150158856A1
公开(公告)日：2015-06-11
申请号：US14413370
申请日：2013-07-03
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zulan Pi , Jennifer X. Qiao , George O. Tora , Tammy C. Wang
IPC: C07D417/14 , C07D417/06
CPC classification number: C07D417/14 , C07D417/06
Abstract: The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供了如说明书中所定义的式（I）化合物和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US20140011799A1
公开(公告)日：2014-01-09
申请号：US13936311
申请日：2013-07-08
Applicant: Bristol-Myers Squibb Company
Inventor： James A. Johnson , Ji Jiang , Soong-Hoon Kim , Zulan Pi , Jennifer X. Qiao , George O. Tora , Tammy C. Wang , Heather Finlay
IPC: C07D417/06 , C07D417/14
CPC classification number: C07D417/06 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US10590113B2
公开(公告)日：2020-03-17
申请号：US16122975
申请日：2018-09-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zulan Pi , Donna M. Bilder , Robert Paul Brigance , Heather Finlay , Wen Jiang , James A. Johnson , R. Michael Lawrence , Wei Meng , Michael C. Myers , Monique Phillips , George O. Tora , Xiaojun Zhang
IPC: A61K31/505 , C07D403/06 , C07D401/06 , C07D403/14 , C07D239/557 , C07D239/54 , C07D239/545 , C07D401/14 , C07D403/02 , C07D417/14 , C07D471/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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