公开(公告)号：US09228016B2

公开(公告)日：2016-01-05

申请号：US14732082

申请日：2015-06-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Changyu Wang ,  Nils Lonberg ,  Alan J. Korman ,  Mark J. Selby ,  Mohan Srinivasan ,  Karla Henning ,  Michelle Minhua Han ,  Guodong Chen ,  Richard Huang ,  Indrani Chakraborty ,  Haichun Huang ,  Susan Wong ,  Huiming Li

IPC: C07K16/00 ,  C07H21/00 ,  C07K16/28 ,  A61K39/395 ,  G01N33/68 ,  G01N33/574 ,  A61K39/00

CPC classification number: C07K16/2878 ,  A61K39/3955 ,  A61K47/48569 ,  A61K47/6851 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2818 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57492 ,  G01N33/6872 ,  G01N2333/70578

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

Abstract translation: 本文提供了结合糖皮质激素诱导型TNF受体（GITR）的抗体或其抗原结合部分。 还提供了这些蛋白质在治疗应用中的用途，例如在癌症的治疗中。 还提供了产生抗体的细胞，编码抗体的重链和/或轻链可变区的多核苷酸，以及包含编码抗体的重链和/或轻链可变区的多核苷酸的载体。

公开(公告)号：US20150218279A1

公开(公告)日：2015-08-06

申请号：US14692948

申请日：2015-04-22

Applicant: Pfizer Inc. ,  Bristol-Myers Squibb Company

Inventor： Jing Min ,  Yanli Wu ,  Rory F. Finn ,  Barrett R. Thiele ,  Wei Liao ,  Ronald P. Gladue ,  Arvind Rajpal ,  Timothy J. Paradis ,  Peter Brams ,  Brigitte Devaux ,  Yi Wu ,  Kristopher Toy ,  Heidi N. LeBlanc ,  Haichun Huang

IPC: C07K16/28

CPC classification number: C07K16/2878 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/92

Abstract: The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.

Abstract translation: 本公开提供了结合人OX40R的分离的结合分子，编码结合分子的氨基酸序列的核酸分子，包含核酸分子的载体，含有载体的宿主细胞，制备结合分子的方法，含有 结合分子，以及使用结合分子或组合物的方法。

公开(公告)号：US08846037B2

公开(公告)日：2014-09-30

申请号：US13857867

申请日：2013-04-05

Applicant: Pfizer Inc. ,  Bristol-Myers Squibb Company

Inventor： Arvind Rajpal ,  Madhav Narasimha Devalaraja ,  Kristopher Toy ,  Lan Yang ,  Haichun Huang ,  Jun Zhang ,  Peter Brams ,  Brigitte Devaux ,  David B. Passmore

IPC: A61K39/395 ,  A61K39/00 ,  C07K16/24

CPC classification number: C07K16/248 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/92

Abstract: Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions.

Abstract translation: 提供了结合人IL-6的抗体及其抗原结合部分。 还提供了编码此类抗体和抗原结合部分的核酸，制备此类抗体和抗原结合部分的方法，包含此类抗体或抗原结合部分的组合物，以及此类抗体或抗原结合部分的用途。

公开(公告)号：US11802162B2

公开(公告)日：2023-10-31

申请号：US16663583

申请日：2019-10-25

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Changyu Wang ,  Nils Lonberg ,  Alan J. Korman ,  Mark J. Selby ,  Mohan Srinivasan ,  Karla A. Henning ,  Michelle Minhua Han ,  Guodong Chen ,  Richard Huang ,  Indrani Chakraborty ,  Haichun Huang ,  Susan Wong ,  Huiming Li

IPC: C07K16/28 ,  A61K47/68 ,  A61K39/395 ,  G01N33/68 ,  G01N33/574 ,  A61K39/00

CPC classification number: C07K16/2878 ,  A61K39/3955 ,  C07K16/2818 ,  C07K16/2863 ,  G01N33/57492 ,  G01N33/6863 ,  G01N33/6872 ,  A61K47/6851 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/70578 ,  G01N2333/7151

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

公开(公告)号：US20230051701A1

公开(公告)日：2023-02-16

申请号：US17737403

申请日：2022-05-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Nils Lonberg ,  Alan J. Korman ,  Bryan C. Barnhart ,  Aaron P. Yamniuk ,  Mohan Srinivasan ,  Karla A. Henning ,  Ming Lei ,  Emanuela Sega ,  Angela Goodenough ,  Maria N. Jure-Kunkel ,  Guodong Chen ,  John S. Sack ,  Richard Huang ,  Martin J. Corbett ,  Joseph E. Myers, JR. ,  Liang Schweizer ,  Sandra V. Hatcher ,  Haichun Huang ,  Pingping Zhang

IPC: C07K16/40 ,  C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  G01N33/573 ,  A61K47/68 ,  A61K45/06 ,  G01N33/574

Abstract: The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers.

公开(公告)号：US10690674B2

公开(公告)日：2020-06-23

申请号：US15578874

申请日：2016-06-02

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Xi-Tao Wang ,  Olufemi A. Adelakun ,  Anne C. Lewin ,  Alan J. Korman ,  Mark J. Selby ,  Changyu Wang ,  Haichun Huang ,  Karla A. Henning ,  Nils Lonberg ,  Mohan Srinivasan ,  Michelle Minhua Han ,  Guodong Chen ,  Richard Y. Huang ,  Indrani Chakraborty ,  Susan Chien-Szu Wong ,  Huiming Li

IPC: G01N33/566 ,  G01N33/574 ,  C07K16/28

Abstract: Provided herein are diagnostic antibodies that bind to glucocorticoid-induced tumor necrosis factor receptor (GITR). Such antibodies are useful for methods of detecting the expression of GITR in biological samples, for example, tumor tissue, and identifying a cancer patient likely to respond to anti-GITR immunotherapy or predicting whether a cancer patient will respond to anti-GITR immunotherapy.

公开(公告)号：US10196452B2

公开(公告)日：2019-02-05

申请号：US15807351

申请日：2017-11-08

Applicant: Pfizer Inc. ,  Bristol-Myers Squibb Company

Inventor： Jing Min ,  Yanli Wu ,  Rory F. Finn ,  Barrett R. Thiele ,  Wei Liao ,  Ronald P. Gladue ,  Arvind Rajpal ,  Timothy J. Paradis ,  Peter Brams ,  Brigitte Devaux ,  Yi Wu ,  Kristopher Toy ,  Heidi N. Leblanc ,  Haichun Huang

IPC: C07K16/28 ,  A61K39/00

Abstract: The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.

公开(公告)号：US12110337B2

公开(公告)日：2024-10-08

申请号：US17045143

申请日：2019-04-03

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Li-Sheng Lu ,  Mark J. Selby ,  Alan J. Korman ,  Shrikant Deshpande ,  Mohan Srinivasan ,  Jun Zhang ,  Haichun Huang ,  Guodong Chen ,  Richard Y. Huang ,  Ekaterina Deyanova

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  A61K39/00

CPC classification number: C07K16/2878 ,  A61K39/39541 ,  A61P35/00 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/92

Abstract: This disclosure provides isolated antibodies that bind specifically to CD27 with high affinity. The disclosure provides methods for treating a subject afflicted with a cancer comprising administering to the subject a therapeutically effective amount of an anti-CD27 antibody as monotherapy or in combination with a checkpoint inhibitor, such as an anti-PD-1, anti-PD-L1, or anti-CTLA-4 antibody.

公开(公告)号：US11084881B2

公开(公告)日：2021-08-10

申请号：US16578987

申请日：2019-09-23

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Changyu Wang ,  Nils Lonberg ,  Alan J. Korman ,  Mark J. Selby ,  Mohan Srinivasan ,  Karla Henning ,  Michelle Minhua Han ,  Guodong Chen ,  Richard Huang ,  Indrani Chakraborty ,  Haichun Huang ,  Susan Wong ,  Huiming Li

IPC: C12N15/13 ,  C07K16/28 ,  A61K39/395 ,  G01N33/68 ,  G01N33/574 ,  A61K39/00 ,  A61K47/68

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

公开(公告)号：US10465010B2

公开(公告)日：2019-11-05

申请号：US15646558

申请日：2017-07-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Changyu Wang ,  Nils Lonberg ,  Alan J. Korman ,  Mark J. Selby ,  Mohan Srinivasan ,  Karla Henning ,  Michelle Minhua Han ,  Guodong Chen ,  Richard Huang ,  Indrani Chakraborty ,  Haichun Huang ,  Susan Wong ,  Huiming Li

IPC: C07K16/00 ,  C07H21/00 ,  C07K16/28 ,  A61K39/395 ,  G01N33/68 ,  G01N33/574 ,  A61K39/00 ,  A61K47/68

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.