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公开(公告)号：US20140235608A1
公开(公告)日：2014-08-21
申请号：US14347683
申请日：2012-09-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： John Lloyd , Jeniffer X. Qiao , Heather Finlay , James Neels , Zulan Pi , Carol Hui Hu , Tammy C. Wang
IPC: C07D417/12 , C07D401/12 , C07D413/12 , C07D213/81
CPC classification number: C07D213/81 , C07D213/79 , C07D401/12 , C07D413/12 , C07D417/12
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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12.发明申请AMIDE, UREA OR SULFONE AMIDE LINKED BENZOTHIAZOLE INHIBITORS OF ENDOTHELIAL LIPASE 有权氨基酸，尿素或磺酰胺连接的内皮素的苯并噻唑抑制剂公开(公告)号：US20140045811A1
公开(公告)日：2014-02-13
申请号：US13944921
申请日：2013-07-18
Applicant: Bristol-Myers Squibb Company
Inventor： Heather Finlay , Ji Jiang , Soong-Hoon Kim , Brandon Parkhurst , Jennifer X. Qiao , Tammy C. Wang , Zulan Pi , George O. Tora , John Lloyd , James A. Johnson
IPC: C07D277/64 , C07D417/10 , C07D417/12 , C07D417/04 , C07D417/14
CPC classification number: C07D277/64 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US11008306B2
公开(公告)日：2021-05-18
申请号：US16864825
申请日：2020-05-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , John Lloyd , Heather Finlay , James Neels , Naveen Kumar Dhondi , Prashantha Gunaga , Abhisek Banerjee , Ashokkumar Adisechan
IPC: C07D401/14 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D405/12 , C07D471/04 , C07D513/04
Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
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公开(公告)号：US09403834B2
公开(公告)日：2016-08-02
申请号：US14772403
申请日：2014-03-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Heather Finlay , Ashok Kumar Adisechan , Prashantha Gunaga , John Lloyd , Srinivasu Pothukanuri
IPC: C07D487/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/14 , A61K31/53 , A61P9/06 , A61P9/04
CPC classification number: C07D487/04 , A61K31/53 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D413/04 , C07D413/14
Abstract: A compound of formula (I), wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
Abstract translation: 式（I）化合物，其中A，R 1，R 3和R 24在本文中描述。 这些化合物可用作钾通道功能的抑制剂和治疗和预防心律失常，IKur相关疾病以及由离子通道功能介导的其它病症。
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公开(公告)号：US20160016961A1
公开(公告)日：2016-01-21
申请号：US14772152
申请日：2014-03-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Heather Finlay , Ashok Kumar Adisechan , Prashantha Gunaga , John Lloyd , Srinivasu Pothukanuri
IPC: C07D487/04 , A61K31/5025
CPC classification number: C07D487/04 , A61K31/5025
Abstract: A compound of formula (I) wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
Abstract translation: 其中A，R1，R3和R24的式（I）化合物在此描述。 该化合物可用作钾通道功能的抑制剂和治疗心律不齐，IKur相关疾病以及由离子通道功能介导的其它病症。
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Patent Agency Ranking
公开(公告)号：US20160009719A1
公开(公告)日：2016-01-14
申请号：US14772403
申请日：2014-03-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Heather Finlay , Ashok Kumar Adisechan , Prashantha Gunaga , John Lloyd , Srinivasu Pothukanuri
IPC: C07D487/04 , A61K31/53
CPC classification number: C07D487/04 , A61K31/53 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D413/04 , C07D413/14
Abstract: A compound of formula (I), wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
Abstract translation: 式（I）化合物，其中A，R 1，R 3和R 24在本文中描述。 这些化合物可用作钾通道功能的抑制剂和治疗和预防心律失常，IKur相关疾病以及由离子通道功能介导的其它病症。
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公开(公告)号：US10676460B2
公开(公告)日：2020-06-09
申请号：US16243400
申请日：2019-01-09
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , John Lloyd , Heather Finlay , James Neels , Naveen Kumar Dhondi , Prashantha Gunaga , Abhisek Banerjee , Ashokkumar Adisechan
IPC: C07D401/14 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D405/12 , C07D471/04 , C07D513/04
Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
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公开(公告)号：US20180030034A1
公开(公告)日：2018-02-01
申请号：US15724566
申请日：2017-10-04
Applicant: Bristol-Myers Squibb Company
Inventor： John Lloyd , Heather Finlay , Prashantha Gunaga , Abhisek Banerjee , Ashokkumar Adisechan
IPC: C07D401/14 , A61K31/549 , C07D513/04 , A61K45/06 , C07D239/94 , C07D405/12 , C07D471/04 , A61K31/517 , C07D417/14 , C07D417/12 , C07D413/14 , C07D407/12 , C07D403/12 , C07D403/04 , C07D401/12 , A61K31/5377 , C07D239/95
CPC classification number: C07D401/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
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公开(公告)号：US09458133B2
公开(公告)日：2016-10-04
申请号：US14771902
申请日：2014-03-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Heather Finlay , Ashok Kumar Adisechan , Naveen Kumar Dhondi , Prashantha Gunaga , John Lloyd , Srinivasu Pothukanuri
IPC: C07D217/12 , C07D401/04 , C07D405/04 , A61K31/4709 , C07D401/12 , C07D401/14 , C07D405/14 , C07D405/12 , A61K31/4725 , A61K31/497 , A61K31/5377 , C07D417/14
CPC classification number: C07D401/12 , A61K31/4725 , A61K31/497 , A61K31/5377 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D417/14
Abstract: A compound of formula (I) (I) wherein A, R1, R1a, R3 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
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公开(公告)号：US09458114B2
公开(公告)日：2016-10-04
申请号：US14038814
申请日：2013-09-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , John Lloyd , Heather Finlay , Ji Jiang , James Neels , Naveen Kumar Dhondi , Prashantha Gunaga , Abhisek Banerjee , Ashokkumar Adisechan
IPC: C07D239/94 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D405/12 , C07D471/04 , C07D513/04
CPC classification number: C07D401/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
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