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11.发明申请公开(公告)号：US20150158856A1
公开(公告)日：2015-06-11
申请号：US14413370
申请日：2013-07-03
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zulan Pi , Jennifer X. Qiao , George O. Tora , Tammy C. Wang
IPC: C07D417/14 , C07D417/06
CPC classification number: C07D417/14 , C07D417/06
Abstract: The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供了如说明书中所定义的式（I）化合物和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US20150065505A1
公开(公告)日：2015-03-05
申请号：US14390172
申请日：2013-03-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jennifer X. Qiao , Carol Hui Hu , Tammy C. Wang , Ji Jiang
IPC: C07D239/557 , C07D495/04 , C07D487/04 , C07D417/12 , C07D401/14 , C07D401/12 , C07D403/12
CPC classification number: C07D239/557 , A61K31/4709 , A61K31/505 , C07D239/60 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D495/04
Abstract: The present invention provides compounds of Formula (I), as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供了如说明书中所定义的式（I）化合物和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US20140011799A1
公开(公告)日：2014-01-09
申请号：US13936311
申请日：2013-07-08
Applicant: Bristol-Myers Squibb Company
Inventor： James A. Johnson , Ji Jiang , Soong-Hoon Kim , Zulan Pi , Jennifer X. Qiao , George O. Tora , Tammy C. Wang , Heather Finlay
IPC: C07D417/06 , C07D417/14
CPC classification number: C07D417/06 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US09540323B2
公开(公告)日：2017-01-10
申请号：US14418023
申请日：2013-07-30
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Alexandre L'Heureux , Sheldon Hiebert , Carol Hu , Patrick Y. S. Lam , John Lloyd , Zulan Pi , Jennifer X. Qiao , Carl Thibeault , George O. Tora , Wu Yang , Yufeng Wang , Tammy C. Wang , Michael S. Bowsher , Ruel Rejean
IPC: C07D209/26 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/14 , C07D409/04 , C07D413/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D498/04 , C07D209/14 , C07D513/04 , C07D403/12 , C07D413/14 , C07D417/04
CPC classification number: C07D209/26 , C07D209/14 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D498/04 , C07D513/04
Abstract: The present invention provides compounds of Formula (I): Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are antagonists of P2Y1 receptor which may be used medicaments.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义的式（I）和包含任何这些新化合物的组合物。 这些化合物是可以使用药物的P2Y1受体的拮抗剂。
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公开(公告)号：US20160326125A1
公开(公告)日：2016-11-10
申请号：US15108584
申请日：2015-01-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , Zulan Pi , Jennifer X. Qiao , Soong-Hoon Kim , Tammy C. Wang , Ji Jiang , Heather Finlay , John Lloyd
IPC: C07D277/64 , C07D417/12 , C07D417/14 , C07D417/04 , C07D417/10
CPC classification number: C07D277/64 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used medicaments.
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Patent Agency Ranking
16.发明授权公开(公告)号：US09249096B2
公开(公告)日：2016-02-02
申请号：US14346747
申请日：2012-09-26
Applicant: Bristol-Myers Squibb Company
Inventor： Lynn Abell , Leonard Adam , Cullen L. Cavallaro , Heather Finlay , Todd J. Friends , Jon J. Hangeland , Ji Jiang , R. Michael Lawrence , Jennifer X. Qiao , Carol Hui Hu , Tammy C. Wang
IPC: C07D207/38 , C07D403/12 , C07D401/12 , C07D207/277 , C07D401/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D417/04 , C07D417/06 , C07D207/28 , C07D233/61 , C07D413/06
CPC classification number: C07D207/277 , C07D207/28 , C07D207/38 , C07D233/61 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/06 , C07D409/04 , C07D413/06 , C07D417/04 , C07D417/06
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments. The disclosure also provides a novel method of treating diseases or conditions related to the activity of endothelial lipase by use of compounds according to Formula (II): as defined in the specification and compositions comprising any of the compounds.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。 本公开还提供了一种通过使用根据式（II）的化合物来治疗与内皮脂肪酶活性相关的疾病或病症的新方法：如说明书中所定义和包含任何化合物的组合物。
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公开(公告)号：US09169240B2
公开(公告)日：2015-10-27
申请号：US14427105
申请日：2013-09-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： George O. Tora , Heather Finlay , Carol Hui Hu , Ji Jiang , James A. Johnson , Soong-Hoon Kim , John Lloyd , Brandon Parkhurst , Zulan Pi , Jennifer X. Qiao , Tammy C. Wang
IPC: C07D417/06 , C07D417/14
CPC classification number: C07D417/06 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicament.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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18.发明申请公开(公告)号：US20150105378A1
公开(公告)日：2015-04-16
申请号：US14575171
申请日：2014-12-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Lynn Abell , Leonard Adam , Cullen L. Cavallaro , Heather Finlay , Todd J. Friends , Jon J. Hangeland , Ji Jiang , R. Michael Lawrence , John Lloyd , Zulan Pi , George O. Tora , Jennifer X. Qiao , Carol Hui Hu , Tammy C. Wang
IPC: C07D471/04 , C07D487/04 , C07D413/06 , C07D403/06 , C07D401/12 , C07D207/38 , C07D417/12
CPC classification number: C07D471/04 , C07D207/28 , C07D207/38 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12 , C07D487/04
Abstract: The present invention provides compounds of Formula (I) or Formula (III): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）或式（III）的化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US08993557B2
公开(公告)日：2015-03-31
申请号：US14347683
申请日：2012-09-26
Applicant: Bristol-Myers Squibb Company
Inventor： John Lloyd , Jennifer X. Qiao , Heather Finlay , James Neels , Zulan Pi , Carol Hui Hu , Tammy C. Wang
IPC: A61K31/00 , C07D213/62 , C07D213/81 , C07D213/79 , C07D401/12 , C07D413/12 , C07D417/12
CPC classification number: C07D213/81 , C07D213/79 , C07D401/12 , C07D413/12 , C07D417/12
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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20.发明授权公开(公告)号：US08952180B2
公开(公告)日：2015-02-10
申请号：US14346745
申请日：2012-09-25
Applicant: Bristol-Myers Squibb Company
Inventor： Lynn Abell , Leonard Adam , Cullen L. Cavallaro , Heather Finlay , Todd J. Friends , Jon J. Hangeland , Ji Jiang , R. Michael Lawrence , John Lloyd , Zulan Pi , George O. Tora , Jennifer X. Qiao , Carol Hui Hu , Tammy C. Wang
IPC: A61K31/44 , A61K31/40 , C07D221/02 , C07D205/00 , C07D207/38 , C07D403/12 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/06 , C07D405/12 , C07D417/04 , C07D417/06 , C07D471/04 , C07D207/28 , C07D417/12 , C07D487/04
CPC classification number: C07D471/04 , C07D207/28 , C07D207/38 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12 , C07D487/04
Abstract: The present invention provides compounds of Formula (I) or Formula (III): [INSERT CHEMICAL STRUCTURE HERE] (I) [INSERT CHEMICAL STRUCTURE HERE] (III) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）或式（III）的化合物：[INSERT CHEMICAL Structure这里]（I）如本说明书中定义的[INSERT CHEMICAL STRUCTURE HERE]（III）和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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