Patent search ap:("BRISTOL-MYERS SQUIBB COMPANY") AND inv:"Yi Xiao" Page 2

11.

发明申请
METHODS FOR THE PREPARATION OF HIV ATTACHMENT INHIBITOR PIPERAZINE PRODRUG COMPOUND 审中-公开

公开(公告)号：US20150038709A1

公开(公告)日：2015-02-05

申请号：US14516636

申请日：2014-10-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao

IPC: C07F9/6561

CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561

Abstract: A method for making the compound is set forth utilizing the starting material

12.

发明申请
PROCESS FOR THE PREPARATION OF N,N-DICYCLOPROPYL-4-(1,5-DIMETHYL-1H-PYRAZOL-3-YLAMINO)-6-ETHYL-1-METHYL-1,6-DIHYDROIMIDAZO[4,5-d]PYRROLO[2,3-b]PYRIDINE-7-CARBOXAMIDE 审中-公开
Title translation: 制备N，N-二异丙基-4-（1,5-二甲基-1H-吡唑-3-基氨基）-6-乙基-1-甲基-1,6-二氢吲哚并[4,5-d]吡咯的方法 [2,3-b]吡啶-7-羧酰胺

公开(公告)号：US20160229854A1

公开(公告)日：2016-08-11

申请号：US14914330

申请日：2014-08-28

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Martin D. Eastgate , Gregory L. Beutner , Benjamin Cohen , Nicolas Cuniere , Lopa V. Desai , Monica Fitzgerald , Qi Gao , Michael Bryan Hay , Michael Joseph Lawler , Paul C. Lobben , Christopher S. Regens , Thorsten Rosner , Neil Strotman , Carolyn S. Wei , Yi Xiao , Bin Zheng , Keming Zhu

IPC: C07D471/14 , C07D403/04 , C07D231/16 , C07D207/42

CPC classification number: C07D471/14 , C07D207/42 , C07D231/16 , C07D403/04

Abstract: The invention relates to an improved process for synthesizing N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide of the formula: (I) Compound (I) is currently in clinical trials for the treatment of myeloproliferative disorders, such as polycythaemia vera, thrombocythaemia and primary myelofibrosis.

Abstract translation: 本发明涉及一种合成N，N-二环丙基-4-（1,5-二甲基-1H-吡唑-3-基氨基）-6-乙基-1-甲基-1,6-二氢咪唑并[4,5 d]吡咯并[2,3-b]吡啶-7-甲酰胺，其化学式（I）化合物（I）目前正在临床试验中用于治疗骨髓增生性疾病，如多发性红血球病，血小板减少症和原发性骨髓纤维化。

13.

发明申请
METHODS FOR THE PREPARATION OF HIV ATTACHMENT INHIBITOR PIPERAZINE PRODRUG COMPOUND 审中-公开

公开(公告)号：US20160152644A1

公开(公告)日：2016-06-02

申请号：US14986816

申请日：2016-01-04

Applicant: Bristol-Myers Squibb Company

Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao

IPC: C07F9/6561 , C07C213/08

CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561

Abstract: A method for making the compound is set forth utilizing the starting material

14.

发明申请
METHODS FOR THE PREPARATION OF HIV ATTACHMENT INHIBITOR PIPERAZINE PRODRUG COMPOUND 有权
Title translation: 制备HIV连接抑制剂哌嗪类化合物的方法

公开(公告)号：US20150038712A1

公开(公告)日：2015-02-05

申请号：US14516661

申请日：2014-10-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao

IPC: C07F1/02 , C07D471/04

CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561

Abstract: A method for making the compound is set forth utilizing the starting material

Abstract translation: 使用原料制备化合物的方法

15.

发明授权
Process for the preparation of N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide 有权
Title translation: 制备N，N-二环丙基-4-（1,5-二甲基-1H-吡唑-3-基氨基）-6-乙基-1-甲基-1,6-二氢咪唑并[4,5-d]吡咯的方法 [2,3-b]吡啶-7-甲酰胺

公开(公告)号：US09518058B2

公开(公告)日：2016-12-13

申请号：US14914330

申请日：2014-08-28

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Martin D. Eastgate , Gregory L. Beutner , Benjamin Cohen , Nicolas Cuniere , Lopa V. Desai , Monica Fitzgerald , Qi Gao , Michael Bryan Hay , Michael Joseph Lawler , Paul C. Lobben , Christopher S. Regens , Thorsten Rosner , Neil Strotman , Carolyn S. Wei , Yi Xiao , Bin Zheng , Keming Zhu

IPC: C07D471/14 , C07D207/42 , C07D403/04 , C07D231/16

CPC classification number: C07D471/14 , C07D207/42 , C07D231/16 , C07D403/04

Abstract: The invention relates to an improved process for synthesizing N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide of the formula: (I) Compound (I) is currently in clinical trials for the treatment of myeloproliferative disorders, such as polycythaemia vera, thrombocythaemia and primary myelofibrosis.

16.

发明授权
Methods for the Preparation of HIV attachment inhibitor piperazine prodrug compound 有权
Title translation: 制备HIV附着抑制剂哌嗪前药化合物的方法

公开(公告)号：US09255113B2

公开(公告)日：2016-02-09

申请号：US14516655

申请日：2014-10-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao

IPC: C07D471/04 , C07F9/09 , C07F9/6561 , C07C213/08 , C07F1/02 , C07D207/333 , C07D405/04

CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561

Abstract: A method for making the compound is set forth utilizing the starting material wherein R7═—H, alkyl, aryl, —SO2R, —C(O)OR, and —C(O)NR2; where R═—H, C1-C6 alkyl, -aryl, and —CH2Aryl.

Abstract translation: 使用其中R 7 = -H，烷基，芳基，-SO 2 R，-C（O）OR和-C（O）NR 2的起始物质来阐述制备该化合物的方法。其中R = -H，C 1 -C 6烷基， - 芳基和-CH 2芳基。