公开(公告)号：US20060183943A1

公开(公告)日：2006-08-17

申请号：US11352887

申请日：2006-02-13

Applicant: Baihua Hu

Inventor： Baihua Hu

IPC: C07C211/00

CPC classification number: C07C279/22 ,  C07C279/24

Abstract: The present invention provides terphenyl guanidine compounds of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.

Abstract translation: 本发明提供式I的三联苯胍化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的方法。

公开(公告)号：US06410734B1

公开(公告)日：2002-06-25

申请号：US09904157

申请日：2001-07-12

Applicant: Baihua Hu

Inventor： Baihua Hu

IPC: C07D41700

CPC classification number: C07D417/14 ,  A61K31/4412 ,  A61K31/4709 ,  A61K31/5377 ,  C07D277/54 ,  C07D417/10 ,  C07D417/12

Abstract: This invention provides compounds of Formula I having the structure wherein: A, X, Y, Z, R1, R2, R3, R4, R5, and R6 are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.

Abstract translation: 本发明提供具有结构的式I化合物，其中A，X，Y，Z，R 1，R 2，R 3，R 4，R 5和R 6如上所定义，或其药学上可接受的盐，其可用于治疗或抑制代谢 与胰岛素抵抗或高血糖相关的疾病（通常与肥胖或葡萄糖不耐受相关），动脉粥样硬化，胃肠道疾病，神经源性炎症和尿频; 并且特别可用于治疗或抑制II型糖尿病。

公开(公告)号：US08951993B2

公开(公告)日：2015-02-10

申请号：US13402335

申请日：2012-02-22

Applicant: Baihua Hu ,  Kan He ,  Minsheng Zhang

Inventor： Baihua Hu ,  Kan He ,  Minsheng Zhang

IPC: A61K31/675 ,  A61K31/685 ,  C07F9/58 ,  C07F9/6509 ,  C07F9/6558

CPC classification number: C07F9/58 ,  C07F9/650952 ,  C07F9/65583

Abstract: The present invention relates to compounds represented by formula (I), which can modulate the activity of protein kinases. The invention also relates to a composition containing a compound of formula (I), and a method for synthesizing and using such compound for preventing or treating ALK or cMet mediated disorders or conditions.

Abstract translation: 本发明涉及可以调节蛋白激酶活性的由式​​（I）表示的化合物。 本发明还涉及包含式（I）化合物的组合物，以及用于合成和使用该化合物以预防或治疗ALK或cMet介导的病症或病症的方法。

公开(公告)号：US07713964B2

公开(公告)日：2010-05-11

申请号：US10302171

申请日：2002-11-22

Applicant: John C. McKew ,  Steven Y. Tam ,  Katherine L. Lee ,  Lihren Chen ,  Paresh Thakker ,  Fuk-Wah Sum ,  Mark Behnke ,  Baihua Hu ,  James D. Clark

Inventor： John C. McKew ,  Steven Y. Tam ,  Katherine L. Lee ,  Lihren Chen ,  Paresh Thakker ,  Fuk-Wah Sum ,  Mark Behnke ,  Baihua Hu ,  James D. Clark

IPC: A61K31/54 ,  A61K31/535 ,  A61K31/497 ,  A61K31/44 ,  A61K31/425 ,  A61K31/41 ,  A61K31/415 ,  A61K31/40

CPC classification number: C07D401/12 ,  C07D209/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08 ,  C07D491/10 ,  Y10S514/826

Abstract: This invention provides methods for treating in mammals asthma and asthmatic conditions using substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.

Abstract translation: 本发明提供使用以下通式的取代吲哚化合物及其药学上可接受的盐形式来治疗哺乳动物哮喘和哮喘病症的方法，以及使用该化合物作为各种磷脂酶，特别是磷脂酶A2酶的活性的抑制剂的方法，以及 用于治疗，预防和抑制疼痛和炎症。

公开(公告)号：US07683091B2

公开(公告)日：2010-03-23

申请号：US11505527

申请日：2006-08-16

Applicant: Baihua Hu ,  James W. Jetter

Inventor： Baihua Hu ,  James W. Jetter

IPC: A61K31/404 ,  A61K31/445 ,  C07D209/04 ,  C07D401/02

CPC classification number: C07D209/08 ,  C07D209/26

Abstract: The present invention relates generally to substituted indoles and methods of using them.

Abstract translation: 本发明一般涉及取代的吲哚及其使用方法。

公开(公告)号：US20070299126A1

公开(公告)日：2007-12-27

申请号：US11881514

申请日：2007-07-27

Applicant: Baihua Hu

Inventor： Baihua Hu

IPC: A61K31/404 ,  A61P11/00 ,  A61P25/28 ,  A61P3/10 ,  A61P35/00 ,  A61P9/00 ,  C07D209/04

CPC classification number: C07D403/04 ,  C07D209/42

Abstract: The present invention relates generally to substituted pyrrole-indoles such as substituted pyrrole-indoles, and methods of using them.

公开(公告)号：US20050113439A1

公开(公告)日：2005-05-26

申请号：US10947727

申请日：2004-09-23

Applicant: Baihua Hu

Inventor： Baihua Hu

IPC: A61P7/02 ,  C07D209/42 ,  C07D403/04 ,  C07D43/02 ,  A61K31/405

CPC classification number: C07D403/04 ,  C07D209/42

Abstract: The present invention relates generally to substituted pyrrole-indoles such as substituted pyrrole-indoles, and methods of using them.

Abstract translation: 本发明一般涉及取代的吡咯 - 吲哚，例如取代的吡咯 - 吲哚，以及使用它们的方法。

公开(公告)号：US06635771B2

公开(公告)日：2003-10-21

申请号：US10302634

申请日：2002-11-22

Applicant: John C. McKew ,  Steven Y. Tam ,  Katherine L. Lee ,  Lihren Chen ,  Paresh Thakker ,  Fuk-Wah Sum ,  Mark Behnke ,  Baihua Hu ,  James D. Clark

Inventor： John C. McKew ,  Steven Y. Tam ,  Katherine L. Lee ,  Lihren Chen ,  Paresh Thakker ,  Fuk-Wah Sum ,  Mark Behnke ,  Baihua Hu ,  James D. Clark

IPC: C07D20916

CPC classification number: C07D401/12 ,  C07D209/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08 ,  C07D491/10

Abstract: Compounds of the formula in which R, R′, R7-R11, X, n1 and n3 are as defined herein. These compounds are useful as intermediates for preparing pharmaceutical compounds having pharmacological activity as chemical inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes.

Abstract translation: R，R'，R 7 -R 11，X，n 1和n 3如本文所定义的化合物。 这些化合物可用作制备具有作为各种磷脂酶，特别是磷脂酶A2酶的活性的化学抑制剂的具有药理活性的药物化合物的中间体。

公开(公告)号：US06583140B2

公开(公告)日：2003-06-24

申请号：US10132483

申请日：2002-04-25

Applicant: Baihua Hu

Inventor： Baihua Hu

IPC: C07D41302

CPC classification number: C07D417/14 ,  A61K31/4412 ,  A61K31/4709 ,  A61K31/5377 ,  C07D277/54 ,  C07D417/10 ,  C07D417/12

Abstract: This invention provides compounds of Formula I having the structure wherein: A, X, Y, Z, R1, R2, R3, R4, R5, and R6 are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.

公开(公告)号：US06498170B2

公开(公告)日：2002-12-24

申请号：US09904158

申请日：2001-07-12

Applicant: Fuk-Wah Sum ,  Baihua Hu

Inventor： Fuk-Wah Sum ,  Baihua Hu

IPC: A61K31445

CPC classification number: C07D401/12 ,  C07D205/04 ,  C07D207/48 ,  C07D211/96 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14

Abstract: This invention provides compounds of Formula I having the structure wherein R1, R2, R3, W, X, and Z are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.

Abstract translation: 本发明提供具有其中R 1，R 2，R 3，W，X和Z如上文所定义的结构的式I化合物或其药学上可接受的盐，其可用于治疗与胰岛素抵抗或高血糖相关的代谢紊乱。