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    Hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors
    16.
    发明授权
    Hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors 失效
    可用作HIV整合酶抑制剂的羟基萘啶酮甲酰胺

    公开(公告)号：US07279487B2

    公开(公告)日：2007-10-09

    申请号：US10500972

    申请日：2003-01-13

    申请人： Melissa Egbertson ,  Jeffrey Y. Melamed ,  H. Marie Langford ,  Steven D. Young

    发明人： Melissa Egbertson ,  Jeffrey Y. Melamed ,  H. Marie Langford ,  Steven D. Young

    IPC分类号： A61K31/44 ,  C07F5/02 ,  C07D471/02

    CPC分类号： C07D471/04 ,  A61K31/4353 ,  A61K45/06 ,  A61K2300/00

    摘要： Hydroxynaphthyridinone carboxamides of formula: are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein L, R1a, R1b, R1c, R2a, R2b, R3, R4, and R5 are defined herein. These compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

    摘要翻译： 下式的羟基萘啶酮甲酰胺被描述为HIV整合酶的抑制剂和HIV复制抑制剂，其中L，R 1a，R 1b，R 1c， R 2a，R 2b，R 3，R 4和R 5，以及R 5， >在本文中定义。 这些化合物可用于预防和治疗艾滋病毒感染以及艾滋病的预防，延迟发作和治疗。 这些化合物用作抗感染和艾滋病作为化合物本身或以药学上可接受的盐的形式。 化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。 还描述了预防，治疗或延缓AIDS发病的方法以及预防或治疗HIV感染的方法。

    Aza-and polyaza-naphthalenyl carboxamides useful as HIV intergrase inhibitors
    17.
    发明授权
    Aza-and polyaza-naphthalenyl carboxamides useful as HIV intergrase inhibitors 失效
    可用作HIV中间体抑制剂的氮杂和多氮萘甲酰胺

    公开(公告)号：US06841558B2

    公开(公告)日：2005-01-11

    申请号：US10398988

    申请日：2001-10-09

    申请人： Neville J. Anthony ,  Robert P. Gomez ,  Steven D. Young ,  Jennifer J. Bennett

    发明人： Neville J. Anthony ,  Robert P. Gomez ,  Steven D. Young ,  Jennifer J. Bennett

    IPC分类号： A61K31/4375 ,  A61P31/18 ,  A61P43/00 ,  C07D471/04 ,  C07D471/02

    CPC分类号： C07D471/04

    摘要： Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating, or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

    摘要翻译： 包括某些喹啉羧酰胺和萘啶甲酰胺衍生物的氮杂和多氮萘甲酰胺衍生物被描述为HIV整合酶的抑制剂和HIV复制抑制剂。 这些化合物可用于预防或治疗HIV的感染和治疗AIDS，作为化合物或药学上可接受的盐，或作为药物组合物中的成分，任选地与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合。 还描述了预防，治疗或延迟AIDS发病的方法以及预防或治疗HIV感染的方法。