公开(公告)号：US08257918B2

公开(公告)日：2012-09-04

申请号：US11631738

申请日：2005-07-07

Applicant: Na Li ,  Winny Tan

Inventor： Na Li ,  Winny Tan

IPC: C12Q1/68 ,  C07H21/04 ,  C07H21/02

CPC classification number: C12N15/111 ,  A61K47/549 ,  A61K47/62 ,  C12N2320/50

Abstract: A method of controlling the activity of a biologically active compound. The method concerns an oligonucleotide-based compound, comprising a hairpin-forming oligonucleotide, an effector moiety physically associated with the oligonucleotide, where the effector moiety possesses a biological activity, and a regulating moiety physically associated with the oligonucleotide, where the regulating moiety controls the biological activity of the effector moiety by interacting with the effector moiety. The oligonucleotide can assume a hairpin configuration, where the effector and regulating moieties interact, or an open configuration, where the effector and regulating moieties fail to interact. Depending on the nature of the effector and regulating moieties, either configuration can result in the expression of the biological activity of the effector moiety.

Abstract translation: 控制生物活性化合物活性的方法。 该方法涉及基于寡核苷酸的化合物，其包含形成发夹的寡核苷酸，与寡核苷酸物理相关的效应部分，其中效应子部分具有生物活性，以及​​与寡核苷酸物理相关的调节部分，其中调节部分控制 通过与效应部分相互作用，效应部分的生物活性。 寡核苷酸可以呈现发夹构型，其中效应物和调节部分相互作用，或者开放构型，其中效应物和调节部分不能相互作用。 取决于效应物和调节部分的性质，任一构型都可以导致效应子部分的生物学活性的表达。

公开(公告)号：US08149535B2

公开(公告)日：2012-04-03

申请号：US12324778

申请日：2008-11-26

Applicant: Na Li ,  Yongjun Liang ,  Shaoyong Liu ,  Yi Zhao Yao

Inventor： Na Li ,  Yongjun Liang ,  Shaoyong Liu ,  Yi Zhao Yao

IPC: G11B17/02

CPC classification number: G11B33/146

Abstract: A disk device with disk contamination control having a spindle for rotating at least one disk. A spindle hub located on the spindle. A disk clamp for clamping the at least one disk on the hub. A magnetic clamp seal magnetically and removably attached to the disk clamp wherein the magnetic clamp seal encapsulates disk contaminants between the clamp and the clamp seal. The magnetic clamp seal magnetically collects metallic contaminants within a sealed housing.

Abstract translation: 具有盘污染控制的盘装置具有用于旋转至少一个盘的主轴。 位于主轴上的主轴毂。 用于夹紧轮毂上的至少一个盘的盘夹。 磁性夹具密封地磁性地并且可移除地附接到盘夹，其中磁性夹具密封件封装夹具和夹紧密封件之间的盘状污染物。 磁性夹具密封件在密封的外壳内磁性收集金属污染物。

公开(公告)号：US20120072598A1

公开(公告)日：2012-03-22

申请号：US13149031

申请日：2011-05-31

Applicant: Qiu Zhong ,  Na Li

Inventor： Qiu Zhong ,  Na Li

IPC: G06F15/16

CPC classification number: G06F17/30887 ,  H04L29/0809 ,  H04L29/12009

Abstract: Various arrangements for creating and using generic universal resource indicators are presented. To create a generic universal resource indicator, one or more parameters of a universal resource indicator may be identified. An interface that permits a parameter of the one or more parameters to be selected and mapped to a variable may be presented. A selection of the parameter for mapping may be received. An indication of the variable to map to the parameter of the selection may also be received. The generic universal resource indicator having a generic parameter corresponding to the parameter of the selection may be created.

Abstract translation: 介绍了创建和使用通用通用资源指标的各种安排。 为了创建通用的通用资源指示符，可以识别通用资源指示符的一个或多个参数。 可以呈现允许一个或多个参数的参数被选择并映射到变量的接口。 可以接收用于映射的参数的选择。 还可以接收到映射到选择的参数的变量的指示。 可以创建具有与选择的参数相对应的通用参数的通用通用资源指示符。

公开(公告)号：US06980511B1

公开(公告)日：2005-12-27

申请号：US09626400

申请日：2000-07-26

Applicant: Na Li ,  San-qi Li ,  Cathy A. Fulton

Inventor： Na Li ,  San-qi Li ,  Cathy A. Fulton

IPC: H04L12/24 ,  H04L12/56 ,  H04Q11/04 ,  H04J1/16 ,  H04J3/16 ,  H04L12/28

CPC classification number: H04L47/805 ,  H04L41/0896 ,  H04L41/5003 ,  H04L47/11 ,  H04L47/15 ,  H04L47/29 ,  H04L47/50 ,  H04L47/522 ,  H04L47/525 ,  H04L47/6225 ,  H04L47/623 ,  H04L47/70 ,  H04L47/762 ,  H04L47/826 ,  H04L2012/5632 ,  H04L2012/5649 ,  H04L2012/5651 ,  H04L2012/5679 ,  H04Q11/0478

Abstract: A method of adaptive resource allocation in transmitting data is provided. In particular, the method of the present invention is applicable to scheduling bandwidths using a modified and dynamic weighted round robin process. The method includes the steps of allocating a resource to each of a plurality of data transmitting active connections, the plurality of active connections belonging to more than one class of service. Then the method determines a lender class of service for each active connection from which resources may be reallocated to the active connection, and periodically comparing the resource usage of an active connection to an upper threshold and a lower threshold. Borrowing action for resources from the lender class of service for the active connection is carried out in response to the current usage exceeding the upper threshold, and returning action for borrowed resources to the lender class of service from the active connection in response to the current usage being less than the lower threshold is carried out.

Abstract translation: 提供了一种在传输数据中自适应资源分配的方法。 特别地，本发明的方法适用于使用修改和动态加权循环过程调度带宽。 该方法包括以下步骤：向属于多于一类服务的多个活动连接的多个数据传输活动连接中的每一个分配资源。 然后，该方法为资源可以从其重新分配到活动连接的每个活动连接确定贷款人服务等级，并且周期性地比较活动连接的资源使用量与上限阈值和下限阈值。 响应于当前使用超过上限阈值，执行来自用于活动连接的贷款人服务类别的资源的资源的借用动作，并且响应于当前使用从活动连接向借出者服务等级返回借用资源的动作 小于下限阈值。

公开(公告)号：US09056916B2

公开(公告)日：2015-06-16

申请号：US13354341

申请日：2012-01-20

Applicant: Ge Lin ,  Jiang Zheng ,  Na Li

Inventor： Ge Lin ,  Jiang Zheng ,  Na Li

IPC: C07K16/00 ,  C07K1/04 ,  C07K16/44 ,  G01N33/53 ,  G01N33/567

CPC classification number: C07K16/44 ,  C07K2317/33 ,  G01N33/53 ,  G01N33/5308 ,  G01N33/567

Abstract: An antibody, which specifically recognizes adducts between pyrrole and cellular macromolecules. Such adducts are likely to occur in mammals suffering an incident of pyrrolizidine alkaloid poisoning. The antibody can be produced using a synthetic immunogen conjugated with a pyrrole as a hapten and it can be used, for example in an assay kit and/or by itself, as a novel means for detecting or diagnosing pyrrolizidine alkaloid poisoning both clinics and research laboratories.

Abstract translation: 抗体，其特异性识别吡咯和细胞大分子之间的加合物。 这种加合物很可能发生在遭受吡咯烷酮生物碱中毒事件的哺乳动物中。 可以使用与吡咯缀合的合成免疫原作为半抗原来产生抗体，并且其可以用于例如测定试剂盒和/或其本身，作为用于检测或诊断吡咯烷酮生物碱中毒两种诊所和研究实验室的新手段 。

公开(公告)号：US20130227640A1

公开(公告)日：2013-08-29

申请号：US13821867

申请日：2011-09-08

Applicant: Da Zhou ,  Xiaoming Wang ,  Ming Lv ,  Hui Jiang ,  Guangxu Liu ,  Xiaohai Lu ,  Na Li ,  Liang Lu ,  Jingjing Zeng

Inventor： Da Zhou ,  Xiaoming Wang ,  Ming Lv ,  Hui Jiang ,  Guangxu Liu ,  Xiaohai Lu ,  Na Li ,  Liang Lu ,  Jingjing Zeng

IPC: H04L29/06

CPC classification number: H04L63/1433 ,  H04L63/1483 ,  H04L67/02

Abstract: Described is a website scanning apparatus comprising a policy analysis device for determining whether a link in a target website belongs to a known web application used by the target website. If the link belongs to the identified web application, then a vulnerability scanning is not performed on the link; a crawler device for obtaining the link content that the link points to; a web application identification device for determining whether the link belongs to a known web application; a full scan device for performing a full vulnerability scanning on a link determined as not belonging to the known web application; and a known web application vulnerability detection device for performing vulnerability detection for the identified web application according to known vulnerabilities to determine whether the known vulnerabilities exist in the website. A website scanning method employed by the website scanning apparatus is also described.

Abstract translation: 描述了一种网站扫描装置，包括用于确定目标网站中的链接是否属于目标网站使用的已知网络应用的策略分析装置。 如果链接属于所识别的Web应用程序，则不会在链接上执行漏洞扫描; 用于获得链接指向的链接内容的履带装置; 用于确定所述链路是否属于已知网络应用的网络应用识别装置; 用于在被确定为不属于已知网络应用的链路上执行完整的漏洞扫描的全扫描设备; 以及已知的Web应用漏洞检测设备，用于根据已知的漏洞执行针对所识别的Web应用的漏洞检测，以确定网站中是否存在已知的漏洞。 还描述了网站扫描装置采用的网站扫描方法。

公开(公告)号：US20120072918A1

公开(公告)日：2012-03-22

申请号：US13149017

申请日：2011-05-31

Applicant: Qiu Zhong ,  Na Li

Inventor： Qiu Zhong ,  Na Li

IPC: G06F9/46

CPC classification number: G06F17/30887 ,  H04L29/0809 ,  H04L29/12009

Abstract: Various arrangements for creating and using generic universal resource indicators are presented. To create a generic universal resource indicator, one or more parameters of a universal resource indicator may be identified. An interface that permits a parameter of the one or more parameters to be selected and mapped to a variable may be presented. A selection of the parameter for mapping may be received. An indication of the variable to map to the parameter of the selection may also be received. The generic universal resource indicator having a generic parameter corresponding to the parameter of the selection may be created.

Abstract translation: 介绍了创建和使用通用通用资源指标的各种安排。 为了创建通用的通用资源指示符，可以识别通用资源指示符的一个或多个参数。 可以呈现允许一个或多个参数的参数被选择并映射到变量的接口。 可以接收用于映射的参数的选择。 还可以接收到映射到选择的参数的变量的指示。 可以创建具有与选择的参数相对应的通用参数的通用通用资源指示符。

公开(公告)号：US20110030077A1

公开(公告)日：2011-02-03

申请号：US12865579

申请日：2009-02-02

Applicant: Nazzareno Ballatori ,  Na Li

Inventor： Nazzareno Ballatori ,  Na Li

IPC: A01K67/027 ,  A61K39/395 ,  A61K38/16 ,  A61P3/06 ,  A61K31/7088 ,  C07K14/00

CPC classification number: A01K67/0276 ,  A01K2217/056 ,  A01K2227/105 ,  A01K2267/03 ,  C12N15/8509

Abstract: The present invention is directed to methods of modulating bile acid and lipid transport via the organic solute and steroid transporter Ostα-Ostβ. The present invention is further directed to methods of treating a patient having dyslipidemia or a condition associated with altered bile acid homeostasis. Therapeutic agents and pharmaceutical compositions that modulate Ostα-Ostβ heteromeric complex formation and/or transport activity are also disclosed.

Abstract translation: 本发明涉及通过有机溶质和类固醇转运蛋白Ostα-Ost和bgr调节胆汁酸和脂质转运的方法。 本发明还涉及治疗患有血脂异常的患者或与胆汁酸体内平衡变化相关的病症的方法。 调节Ostα-Ost＆bgr的治疗剂和药物组合物 异聚体复合物形成和/或转运活性也被公开。

公开(公告)号：US20100168183A1

公开(公告)日：2010-07-01

申请号：US11993440

申请日：2006-06-21

Applicant: Mingwei Wang ,  Na Li ,  Xin Xie ,  Qing Liu ,  Caihong Zhou ,  Fajun Nan

Inventor： Mingwei Wang ,  Na Li ,  Xin Xie ,  Qing Liu ,  Caihong Zhou ,  Fajun Nan

IPC: A61K31/381 ,  C07D409/12 ,  A61K31/4439 ,  A61P3/04 ,  A61P5/50 ,  A61P3/10

CPC classification number: C07D333/38

Abstract: The present invention provides a substituted cyclic compound of the following general formula I or II: its preparation process and its use as a glucagon-like peptide-1 receptor regulator for preventing or treating metabolic disorders including, but not limited to, diabetes, insulin resistance and obesity, etc.

Abstract translation: 本发明提供以下通式I或II的取代的环状化合物：其制备方法及其作为胰高血糖素样肽-1受体调节剂用于预防或治疗代谢紊乱的用途，包括但不限于糖尿病，胰岛素抵抗 肥胖等

公开(公告)号：US20100128388A1

公开(公告)日：2010-05-27

申请号：US12324778

申请日：2008-11-26

Applicant: Na Li ,  Yongjun Liang ,  Shaoyong Liu ,  Yi Zhao Yao

Inventor： Na Li ,  Yongjun Liang ,  Shaoyong Liu ,  Yi Zhao Yao

IPC: G11B33/14

CPC classification number: G11B33/146

Abstract: A disk device with disk contamination control having a spindle for rotating at least one disk. A spindle hub located on the spindle. A disk clamp for clamping the at least one disk on the hub. A magnetic clamp seal magnetically and removably attached to the disk clamp wherein the magnetic clamp seal encapsulates disk contaminants between the clamp and the clamp seal. The magnetic clamp seal magnetically collects metallic contaminants within a sealed housing.

Abstract translation: 具有盘污染控制的盘装置具有用于旋转至少一个盘的主轴。 位于主轴上的主轴毂。 用于夹紧轮毂上的至少一个盘的盘夹。 磁性夹具密封地磁性地并且可移除地附接到盘夹，其中磁性夹具密封件封装夹具和夹紧密封件之间的盘状污染物。 磁性夹具密封件在密封的外壳内磁性收集金属污染物。