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11.发明申请公开(公告)号：US20150152154A1
公开(公告)日：2015-06-04
申请号：US14457897
申请日：2014-08-12
Applicant: BioNTech AG
Inventor： Thorsten Klamp , Ugur Sahin , Ozlem Tureci , Michael Koslowski , Thomas Hiller , Jens Schumacher
IPC: C07K14/47 , A61K39/00 , C12N7/00 , C07K14/005
CPC classification number: C07K14/4748 , A61K39/0011 , A61K2039/5156 , A61K2039/523 , A61K2039/5258 , A61K2039/53 , A61K2039/57 , A61K2039/575 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N2730/10123 , C12N2730/10134 , C12N2730/10143 , C12N2730/10171
Abstract: The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.
Abstract translation: 本发明涉及使用包含全部或部分乙型肝炎病毒核心抗原蛋白的嵌合蛋白和包含衍生自肿瘤相关抗原的细胞外部分的表位的氨基酸序列的肿瘤免疫治疗，特别是肿瘤免疫接种。 特别地，本发明提供了包含所述嵌合蛋白的病毒样颗粒，其可用于在受试者内针对肿瘤相关抗原，特别是针对在其表面上携带所述肿瘤相关抗原的细胞引起体液免疫应答，其中 肿瘤相关抗原是所述受试者的自身蛋白质。
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公开(公告)号：US20240059772A1
公开(公告)日：2024-02-22
申请号：US18339837
申请日：2023-06-22
Applicant: BioNTech AG , Astellas Pharma Inc. , TRON - Translationle Onkologie an der Universitatsmedizin der Johannes Gutenberg-Universitat Mainz
Inventor： Ugur Sahin , Ozlem Tureci , Korden Walter , Meike Wagner , Maria Kreuzberg , Sabine Hacker , Stefan Jacobs
IPC: C07K16/28 , G01N33/574 , A61K47/68 , A61K33/243 , A61K31/337 , A61K31/5365 , A61K31/7048 , A61K31/7064 , A61K39/395 , A61N5/10 , C07K16/30
CPC classification number: C07K16/28 , G01N33/57484 , A61K47/6851 , A61K33/243 , A61K31/337 , A61K31/5365 , A61K31/7048 , A61K31/7064 , A61K39/39558 , A61N5/10 , C07K16/30 , G01N33/57492 , G01N2800/52 , C07K2317/73 , A61K2039/505
Abstract: The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6. Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.
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公开(公告)号：US10604568B2
公开(公告)日：2020-03-31
申请号：US14904011
申请日：2014-07-30
Applicant: BioNTech AG , Astellas Pharma Inc. , TRON-TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN JOHANNES GUTENBERG-UNIVERSITÄT MAINZ GEMEINNÜTZIGE GMBH
Inventor： Ugur Sahin , Ozlem Tureci , Korden Walter , Meike Wagner , Maria Kreuzberg , Sabine Hacker , Stefan Jacobs
IPC: A61K39/395 , A61K47/68 , A61K31/337 , A61K31/5365 , A61K31/7048 , A61K31/7064 , C07K16/28 , G01N33/574 , A61K33/24 , A61N5/10 , C07K16/30 , A61K39/00
Abstract: The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6, Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.
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14.发明授权公开(公告)号：US10106800B2
公开(公告)日：2018-10-23
申请号：US15217555
申请日：2016-07-22
Applicant: BioNTech AG
Inventor： Ugur Sahin , Silke Holtkamp , Ozlem Tureci , Sebastian Kreiter
Abstract: It was the object of the present invention to provide RNA with increased stability and translation efficiency and means for obtaining such RNA. It should be possible to obtain increased grades of expression by using said RNA in gene therapy approaches.
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公开(公告)号：US10093736B2
公开(公告)日：2018-10-09
申请号：US14442445
申请日：2013-11-12
Applicant: Biontech AG , Ganymed Pharmaceuticals AG , TRON—Translationale Onkologie an der Universitatsmedizin der Johannes Gutenberg-Universitat Mainz gemeinnutzige GmbH
Inventor： Ugur Sahin , Ozlem Tureci , Christiane Stadler , Julia Holland , Hayat Bahr-Mahmud , Tim Beissert , Laura Plum , Fabrice Le Gall , Arne Jendretzki , Markus Fiedler
IPC: A61K39/395 , C07K16/28 , C07K16/30 , A61K39/00
Abstract: The present invention provides binding agents that contain a binding domain that is specific for CD3 allowing binding to T cells and a binding domain that is specific for a tumor-associated claudin molecule and methods of using these binding agents or nucleic acids encoding therefor for treating cancer.
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Patent Agency Ranking
公开(公告)号：US09617321B2
公开(公告)日：2017-04-11
申请号：US14457897
申请日：2014-08-12
Applicant: BioNTech AG
Inventor： Thorsten Klamp , Ugur Sahin , Ozlem Tureci , Michael Koslowski , Thomas Hiller , Jens Schumacher
IPC: A61K39/00 , C07K14/47 , C07K14/005 , C12N7/00
CPC classification number: C07K14/4748 , A61K39/0011 , A61K2039/5156 , A61K2039/523 , A61K2039/5258 , A61K2039/53 , A61K2039/57 , A61K2039/575 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N2730/10123 , C12N2730/10134 , C12N2730/10143 , C12N2730/10171
Abstract: The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.
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17.发明申请Identification of Surface-Associated Antigens for Tumor Diagnosis and Therapy 审中-公开鉴定表面相关抗原的肿瘤诊断和治疗公开(公告)号：US20170052187A1
公开(公告)日：2017-02-23
申请号：US14887979
申请日：2016-03-07
Applicant: BioNTech AG
Inventor： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Gerd Helftenbein , Dirk Usener , Volker Schluter
IPC: G01N33/574 , G06F19/22 , C12Q1/68
CPC classification number: G01N33/57492 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G06F19/22
Abstract: The invention relates to identifying tumor-associated genetic products and encoding nucleic acids thereof. A therapy and diagnosis of diseases in which the tumor-associated genetic products are aberrantly expressed, proteins, polypeptides and peptides which are expressed in association with tumor and the encoding nucleic acids for said proteins, polypeptides and peptides are also disclosed.
Abstract translation: 本发明涉及鉴定肿瘤相关基因产物并编码其核酸。 还公开了与肿瘤相关表达的肿瘤相关遗传产物异常表达的疾病的治疗和诊断，以及用于所述蛋白质，多肽和肽的编码核酸的蛋白质，多肽和肽。
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公开(公告)号：US20150099302A1
公开(公告)日：2015-04-09
申请号：US14571425
申请日：2014-12-16
Inventor： Ugur Sahin , Ozlem Tureci , Torsten Seppmann , Holger Hoff , Jens Schumacher
IPC: C07K14/705 , C12N5/0781 , C07K16/00
CPC classification number: C07K14/70578 , C07K16/00 , C07K2319/30 , C12N5/0635
Abstract: The present invention provides recombinant proteins comprising the amino acid sequence of an intracellular segment of CD40 and an amino acid sequence mediating the association of the recombinant protein with the constant region of an immunoglobulin heavy chain. The recombinant proteins according to the present invention are useful for inducing clonal expansion of a B cell having a predetermined antigen-specificity without the need for T cell or CD40L mediated co-stimulation. Thus, the present invention provides tools for clonal expansion of B cells specific for an antigen of interest and the production of B cells secreting antibodies specific for an antigen of interest. The recombinant proteins of the present invention may also be used for generating fully human monoclonal antibodies with a predetermined antigen-specificity from the B cell repertoire of a human subject.
Abstract translation: 本发明提供重组蛋白，其包含CD40的细胞内节段的氨基酸序列和介导重组蛋白与免疫球蛋白重链的恒定区的缔合的氨基酸序列。 根据本发明的重组蛋白质可用于诱导具有预定抗原特异性的B细胞的克隆扩增，而不需要T细胞或CD40L介导的共刺激。 因此，本发明提供了用于针对感兴趣的抗原特异性的B细胞的克隆扩增的工具，以及产生分泌针对感兴趣的抗原的抗体的B细胞。 本发明的重组蛋白还可用于从人受试者的B细胞库中产生具有预定抗原特异性的完全人单克隆抗体。
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公开(公告)号：US20140134201A1
公开(公告)日：2014-05-15
申请号：US14152597
申请日：2014-01-10
Applicant: BioNTech AG
Inventor： Ozlem Tureci , Ugur Sahin , Sebastian Kreiter
IPC: A61K47/48
CPC classification number: A61K47/64 , A61K48/00 , C07K14/4748 , C07K14/70539 , C07K2319/02 , C07K2319/03
Abstract: The present invention relates to fusion molecules of antigens, the nucleic acids coding therefor and the use of such fusion molecules and nucleic acids. In particular, said invention relates to fusion molecules, comprising an antigen and the trans-membrane region and cytoplasmic region of a MHC molecule and/or the cytoplasmic region of a MHC or a SNARE molecule.
Abstract translation: 本发明涉及抗原的融合分子，其编码的核酸以及这种融合分子和核酸的使用。 特别地，本发明涉及融合分子，其包含MHC或SNARE分子的MHC分子和/或细胞质区域的抗原和跨膜区域和胞质区域。
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20.发明申请IDENTIFICATION OF SURFACE-ASSOCIATED ANTIGENS FOR TUMOR DIAGNOSIS AND THERAPY 有权用于肿瘤诊断和治疗的表面相关抗原的鉴定公开(公告)号：US20140017679A1
公开(公告)日：2014-01-16
申请号：US13864411
申请日：2013-04-17
Applicant: BioNTech AG
Inventor： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Gerd Helftenbein , Dirk Usener , Volker Schluter
IPC: C12Q1/68
CPC classification number: G01N33/57492 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G06F19/22
Abstract: The invention relates to identifying tumor-associated genetic products and encoding nucleic acids thereof. A therapy and diagnosis of diseases in which the tumor-associated genetic products are aberrantly expressed, proteins, polypeptides and peptides which are expressed in association with tumor and the encoding nucleic acids for said proteins, polypeptides and peptides are also disclosed.
Abstract translation: 本发明涉及鉴定肿瘤相关基因产物并编码其核酸。 还公开了与肿瘤相关表达的肿瘤相关遗传产物异常表达的疾病的治疗和诊断，以及用于所述蛋白质，多肽和肽的编码核酸的蛋白质，多肽和肽。
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