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公开(公告)号：US20200338344A1
公开(公告)日：2020-10-29
申请号：US16855421
申请日：2020-04-22
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Devon N. Arnholt , Benjamin Keith Stein , Keith R. Maile , William J. Linder , Ron A. Balczewski , Jacob M. Ludwig , Aleksandra Kharam
Abstract: Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system is included having at least one electric field generating circuit configured to generate one or more electric fields; control circuitry in communication with the electric field generating circuit, the control circuitry configured to control delivery of the one or more electric fields from the at least one electric field generating circuit; and two or more electrodes to deliver the electric fields to the site of a cancerous tumor within a patient. At least one electrode can be configured to be implanted. At least one electrode can be configured to be external. The control circuitry can cause the electric field generating circuit to generate one or more electric fields at frequencies selected from a range of between 10 kHz to 1 MHz.
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公开(公告)号：US20200330756A1
公开(公告)日：2020-10-22
申请号：US16850712
申请日：2020-04-16
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Devon N. Arnholt , Benjamin Keith Stein , Keith R. Maile , William J. Linder , Ron A. Balczewski , Aleksandra Kharam
Abstract: Embodiments herein relate to a medical device for treating a cancerous tumor, the medical device having a first lead including a first wire and second wire; a second lead can include a third wire and fourth wire; and a first electrode in electrical communication with the first wire, a second electrode in electrical communication with the second wire, a third electrode in electrical communication with the third wire, and a fourth electrode in electrical communication with the fourth wire. The first and third electrodes form a supply electrode pair configured to deliver one or more electric fields to the cancerous tumor. The second and fourth electrodes form a sensing electrode pair configured to measure an impedance of the cancerous tumor independent of an impedance of the first electrode, the first wire, the third electrode, the third wire, and components in electrical communication therewith. Other embodiments are also included herein.
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公开(公告)号：US20190151640A1
公开(公告)日：2019-05-23
申请号：US16196934
申请日：2018-11-20
Applicant: Boston Scientific Scimed, Inc.
Inventor： Jan Weber , Keith R. Maile , Deepa Mahajan , Jeffrey E. Stahmann , James M. Peck
Abstract: A system for monitoring one or more respiratory conditions is disclosed. The system comprises a medical device and an e-tattoo configured to attach to the subject's skin. The medical device is configured to monitor at least one respiratory parameter of a subject and transmit a signal in response to monitoring a trigger event in the at least one respiratory parameter. The e-tattoo is configured to: receive the signal from the medical device; sense at least one environmental parameter in response to receiving the signal; and transmit the at least one environmental parameter.
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公开(公告)号：US12109412B2
公开(公告)日：2024-10-08
申请号：US16850728
申请日：2020-04-16
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Benjamin Keith Stein , Keith R. Maile , Ron A. Balczewski , Aleksandra Kharam
CPC classification number: A61N1/36002 , A61B10/02 , A61N5/0601 , A61P35/00
Abstract: Embodiments herein relate to a method for treating a cancerous tumor located within a subject. The method can include applying one or more electric fields at or near a site of the cancerous tumor, where the cancerous tumor can include a cancerous cell population. The one or more applied electric fields are effective to delay mitosis and cause mitotic synchronization within a proportion of the cancerous cell population. The method can include removing the one or more electric fields to allow mitosis to proceed within the cancerous cell population. The method can include administering a chemotherapeutic agent to the subject after the one or more electric fields have been removed. Other embodiments are also included herein.
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公开(公告)号：US11691006B2
公开(公告)日：2023-07-04
申请号：US16850712
申请日：2020-04-16
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Devon N. Arnholt , Benjamin Keith Stein , Keith R. Maile , William J. Linder , Ron A. Balczewski , Aleksandra Kharam
IPC: A61N1/36 , A61B5/0538 , A61N1/05
CPC classification number: A61N1/36002 , A61B5/0538 , A61N1/05
Abstract: Embodiments herein relate to a medical device for treating a cancerous tumor, the medical device having a first lead including a first wire and second wire; a second lead can include a third wire and fourth wire; and a first electrode in electrical communication with the first wire, a second electrode in electrical communication with the second wire, a third electrode in electrical communication with the third wire, and a fourth electrode in electrical communication with the fourth wire. The first and third electrodes form a supply electrode pair configured to deliver one or more electric fields to the cancerous tumor. The second and fourth electrodes form a sensing electrode pair configured to measure an impedance of the cancerous tumor independent of an impedance of the first electrode, the first wire, the third electrode, the third wire, and components in electrical communication therewith. Other embodiments are also included herein.
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Patent Agency Ranking
公开(公告)号：US11420049B2
公开(公告)日：2022-08-23
申请号：US16850720
申请日：2020-04-16
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Benjamin Keith Stein , Keith R. Maile , William J. Linder , Ron A. Balczewski , Sarah Melissa Gruba , Tucker James Nelson , Aleksandra Kharam
Abstract: Embodiments herein relate to a medical device for treating a cancerous tumor, including an electric field generating circuit configured to generate one or more electric fields at or near a site of the cancerous tumor and control circuitry in communication with the electric field generating circuit. The medical device includes one or more supply wires in electrical communication with the electric field generating circuit and one or more supply electrodes. The supply electrodes are configured to deliver an electric field at or near the site of the cancerous tumor. The medical device can include one or more sensing wires in electrical communication with the control circuitry and one or more sensing electrodes. The sensing electrodes can be configured to measure an impedance of the cancerous tumor at at least two different electric field strengths. Other embodiments are also included herein.
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公开(公告)号：US20220218355A1
公开(公告)日：2022-07-14
申请号：US17575154
申请日：2022-01-13
Applicant: BOSTON SCIENTIFIC SCIMED, INC.
Inventor： Eric Wedul , Keith R. Maile
IPC: A61B17/12
Abstract: A medical system may include a left atrial appendage closure device including an expandable framework and a proximal hub disposed along a central longitudinal axis of the expandable framework, the expandable framework being configured to shift between a collapsed delivery configuration and an expanded deployed configuration; wherein the left atrial appendage closure device includes a sensor at least partially disposed within an interior of the expandable framework and axially movable relative to the proximal hub; wherein the proximal hub includes a first threaded connection structure; and a delivery catheter including a core wire extending axially within a lumen of the delivery catheter, the core wire having a second threaded connection structure at a distal end thereof configured to releasably engage the first threaded connection structure in an unreleased configuration and the second threaded connection structure is disengaged from the first threaded connection structure in a released configuration.
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公开(公告)号：US20210298763A1
公开(公告)日：2021-09-30
申请号：US17209938
申请日：2021-03-23
Applicant: BOSTON SCIENTIFIC SCIMED, INC.
Inventor： Jeffrey E. Stahmann , Bin Mi , Eric Wedul , Keith R. Maile
IPC: A61B17/12
Abstract: A medical system may include a left atrial appendage closure device including an expandable framework and a proximal hub centered on a central longitudinal axis of the framework. An insert may be disposed within the proximal hub and include a collar configured to engage the proximal hub, a recess extending into the insert from a proximal end, and a post member disposed within the recess. The post member may be radially spaced apart from the collar and may extend proximally from a distal end of the recess to a proximal surface. The insert may include a first connection structure disposed distal of the proximal surface. The medical system may include a delivery catheter having a second connection structure configured to engage the first connection structure in a delivery configuration. The distal end of the delivery catheter includes a hollow portion configured to receive the post member in the delivery configuration.
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公开(公告)号：US20200338346A1
公开(公告)日：2020-10-29
申请号：US16855448
申请日：2020-04-22
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Benjamin Keith Stein , Keith R. Maile , William J. Linder , Aleksandra Kharam
Abstract: Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system is included having an electric field generating circuit configured to generate one or more electric fields and a control circuit in communication with the electric field generating circuit. The control circuit configured to control delivery of the one or more electric fields from the electric field generating circuit. The system can include two or more electrodes to deliver the electric fields to a site of a cancerous tumor within a patient and a temperature sensor to measure the temperature of tissue at the site of the cancerous tumor. The control circuit can cause the electric field generating circuit to generate one or more electric fields at frequencies selected from a range of between 10 kHz to 1 MHz. Other embodiments are also included herein.
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公开(公告)号：US20200215266A1
公开(公告)日：2020-07-09
申请号：US16732796
申请日：2020-01-02
Applicant: Boston Scientific Scimed, Inc.
Inventor： Vijay Koya , Bryan Allen Clark , Keith R. Maile , Michael J. Kane , Jeffrey E. Stahmann , Elizabeth Mary Annoni
Abstract: A system may include an input device configured to receive a signal indicative of elevated glucose in a patient, and an electrical stimulator configured to electrically stimulate at least one skeletal muscle. The system may further include a controller operably connected to the electrical stimulator. The controller may be configured for delivering a glucose therapy in response to the signal by controlling the electrical stimulator. The system may be configured to deliver the therapy in combination with other glucose therapies, and the therapy may be titrated based on a sensed parameter or patient feedback.
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