公开(公告)号：US10519458B2

公开(公告)日：2019-12-31

申请号：US13265205

申请日：2010-04-22

申请人： Huihua Fu ,  Jeffrey A. Brown ,  Kirk Francis ,  Hee-Sook Song

发明人： Huihua Fu ,  Jeffrey A. Brown ,  Kirk Francis ,  Hee-Sook Song

IPC分类号： C12N15/82 ,  C12N15/113

摘要： The present invention is concerned with the provision of means and methods for gene expression. Specifically, it relates to a polynucleotide comprising an expression control sequence which allows for seed specific of a nucleic acid of interest being operatively linked thereto in plants. Furthermore, vectors, host cells, transgenic plants and methods for expressing nucleic acids of interest are provided which are based on the said polynucleotide.

公开(公告)号：US20130326727A1

公开(公告)日：2013-12-05

申请号：US13992259

申请日：2011-12-08

申请人： Lahoucine Achnine ,  Jill Stevenson-Paulik ,  Suzy M. Cocciolone ,  Durba Ghoshal ,  Jeffrey A. Brown ,  Libby Bernal

发明人： Lahoucine Achnine ,  Jill Stevenson-Paulik ,  Suzy M. Cocciolone ,  Durba Ghoshal ,  Jeffrey A. Brown ,  Libby Bernal

IPC分类号： C07K14/415 ,  G06F19/10

CPC分类号： C07K14/415 ,  C07K14/425 ,  C12N15/625 ,  C12N15/8251 ,  G16B99/00

摘要： The present invention belongs to genetic engineering technical field and discloses modified protein body tags, a system for evaluating the efficacy of the modified polypeptides, and methods for targeting proteins to protein bodies or for forming protein bodies. The present invention also discloses modified protein body tags with reduced allergenicity and methods for making and using the modified protein body tags.

摘要翻译： 本发明属于遗传工程技术领域，并公开了修饰的蛋白质体标签，用于评估修饰多肽的功效的系统，以及将蛋白质靶向蛋白质体或用于形成蛋白质体的方法。 本发明还公开了具有降低的过敏原性的修饰的蛋白质体标签以及制备和使用修饰的蛋白体标签的方法。

公开(公告)号：US08452928B1

公开(公告)日：2013-05-28

申请号：US11427749

申请日：2006-06-29

申请人： Adi Ofer ,  Kiran Madnani ,  Jeffrey A. Brown

发明人： Adi Ofer ,  Kiran Madnani ,  Jeffrey A. Brown

IPC分类号： G06F12/00

CPC分类号： G06F3/0605 ,  G06F3/0647 ,  G06F3/0664 ,  G06F3/067

摘要： Described are a storage network and method of migrating data from a source virtual array to a destination virtual array transparently with respect to a storage application executing on a host. The storage application provides particular storage functionality at a source storage array while using metadata during its execution. The metadata used by the storage application are associated with the source virtual array and forwarded, during a data migration event in which data resident in logical units of storage (LUNs) of the source virtual array are copied to LUNs of the destination virtual array, to a destination storage array where the metadata is associated with the destination virtual array.

摘要翻译： 描述了相对于在主机上执行的存储应用，将数据从源虚拟阵列迁移到目的虚拟阵列的存储网络和方法。 存储应用程序在源存储阵列中提供特定的存储功能，同时在其执行期间使用元数据。 存储应用程序使用的元数据与源虚拟阵列相关联，并在数据迁移事件期间将源虚拟阵列的存储逻辑单元（LUN）中的数据复制到目标虚拟阵列的LUN中的数据转发到 元数据与目标虚拟阵列相关联的目标存储阵列。

公开(公告)号：US08107467B1

公开(公告)日：2012-01-31

申请号：US11318756

申请日：2005-12-27

申请人： Kiran Madnani ,  Adi Ofer ,  Jeffrey A. Brown

发明人： Kiran Madnani ,  Adi Ofer ,  Jeffrey A. Brown

IPC分类号： H04L12/50 ,  G06F7/00

CPC分类号： H04L49/557 ,  G06F3/0635 ,  G06F3/065 ,  G06F3/067 ,  H04L29/12047 ,  H04L29/12886 ,  H04L49/357 ,  H04L61/15 ,  H04L61/6045 ,  H04L67/1097

摘要： Failover is provided from a primary Fiber Channel device to a secondary Fiber Channel device. Source and secondary Fiber Channel devices are coupled to a Fiber Channel fabric having a database that associates Fiber Channel names and Fiber Channel addresses of Fiber Channel ports coupled to it. All data is copied from the primary Fiber Channel device to the secondary Fiber Channel device. In response to a failure, secondary port names and LUN names are replaced with the primary port names and LUN names, and the fabric updates its database so that the database associates the secondary port and LUN addresses with the primary port and LUN names. The secondary Fiber Channel device thereby assumes the primary Fiber Channel device's identity.

摘要翻译： 从主光纤通道设备向辅助光纤通道设备提供故障转移。 源和辅助光纤通道设备耦合到具有将光纤通道名称和耦合到其的光纤通道端口的光纤通道地址相关联的数据库的光纤通道结构。 所有数据从主光纤通道设备复制到辅助光纤通道设备。 为了响应故障，备用端口名称和LUN名称将替换为主端口名称和LUN名称，并且Fabric更新其数据库，以便数据库将辅助端口和LUN地址与主端口和LUN名称相关联。 因此，次级光纤通道设备假设主要光纤通道设备的身份。

公开(公告)号：US07989678B2

公开(公告)日：2011-08-02

申请号：US11661703

申请日：2005-08-31

申请人： Luke Mankin ,  Dwight-Steven Hill ,  Paula Olhoft ,  Effie Toren ,  Jeffrey A. Brown ,  Liqun Xing ,  Huihua Fu ,  Lesley Ireland ,  Hongmei Jia ,  Hee-Sook Song ,  Allan Richard Wenck ,  Larry Nea

发明人： Luke Mankin ,  Dwight-Steven Hill ,  Paula Olhoft ,  Effie Toren ,  Jeffrey A. Brown ,  Liqun Xing ,  Huihua Fu ,  Lesley Ireland ,  Hongmei Jia ,  Hee-Sook Song ,  Allan Richard Wenck ,  Larry Nea

IPC分类号： C12N15/84 ,  C12N1/20 ,  C12N1/21 ,  C12N15/31

CPC分类号： C07K14/195 ,  C12N15/8205

摘要： The present invention relates “disarmed” strain variants of Agrobacterium strain K599 (NCPPB 2659), “disarmed” plasmid variants of the Ri-plasmid pRi2659, and derivatives thereof, and methods employing these strains and plasmids in plant transformation.

摘要翻译： 本发明涉及农杆菌菌株K599（NCPPB2659）的“撤防”菌株变体，Ri质粒pRi2659的“解除武装”质粒变体及其衍生物，以及在植物转化中使用这些菌株和质粒的方法。

公开(公告)号：US07757059B1

公开(公告)日：2010-07-13

申请号：US11427724

申请日：2006-06-29

申请人： Adi Ofer ,  Kiran Madnani ,  Jeffrey A. Brown

发明人： Adi Ofer ,  Kiran Madnani ,  Jeffrey A. Brown

IPC分类号： G06F12/00

CPC分类号： G06F3/0665 ,  G06F3/0626 ,  G06F3/0647 ,  G06F3/067 ,  H04L67/1097

摘要： Described are systems and methods of migrating data from a source virtual array to a destination virtual array transparently with respect to a management application program executing on a host and using management information to send management messages to the virtual arrays. Data from the source virtual array are copied to the destination virtual array during a data migration event. First and second virtual array management interfaces are associated with the source and destination virtual arrays, respectively. The first and second virtual array management interfaces are exchanged during the data migration event so that the virtual array management interface associated with the destination virtual array becomes associated with the source virtual array and the virtual array management interface associated with the source virtual array becomes associated with the destination virtual array.

摘要翻译： 描述了相对于在主机上执行的管理应用程序透明地将数据从源虚拟阵列迁移到目的地虚拟阵列的系统和方法，并且使用管理信息将管理消息发送到虚拟阵列。 在数据迁移事件期间，源虚拟阵列的数据将复制到目标虚拟阵列。 第一和第二虚拟阵列管理接口分别与源虚拟阵列和目标虚拟阵列相关联。 在数据迁移事件期间交换第一和第二虚拟阵列管理接口，使得与目标虚拟阵列相关联的虚拟阵列管理接口与源虚拟阵列相关联，并且与源虚拟阵列相关联的虚拟阵列管理接口变为与 目标虚拟阵列。

公开(公告)号：US20100162428A1

公开(公告)日：2010-06-24

申请号：US12600902

申请日：2008-05-30

申请人： Jeffrey A. Brown ,  Fang-Ming Lai ,  Christina E. Roche ,  Hee-Sook Song

发明人： Jeffrey A. Brown ,  Fang-Ming Lai ,  Christina E. Roche ,  Hee-Sook Song

IPC分类号： A01H1/00 ,  A01H5/00

CPC分类号： C12N15/8201 ,  C12N9/22

摘要： The present invention relates to a method for excising a nucleic acid sequence from the genome of a plant or a plant cell. This method is based on the steps of transforming a plant cell with a construct encoding a DNA double strand break inducing enzyme (DSBI), generating a transgenic plant line, performing a transient assay to analyze the functionality of the transgenic enzyme, crossing the plant line with a line containing a nucleic acid sequence to be excised and performing an immature embryo conversion or a tissue culture regeneration through callus formation. The method can also be reversed, which means that a plant cell is transformed with a construct encoding a nucleic acid sequence to be excised, and the crossing is performed with a plant line containing a DSBI. As an alternative to the crossing step, a re-transformation of a transgenic plant line with a second construct can also be performed. The invention is also directed to a plant obtained by this method, or progeny, propagation material, part, tissue, cell or cell culture, derived from such a plant. Finally, the invention relates to the use of a plant or progeny, propagation material, part, tissue, cell or cell culture, derived from this method, as aliment, fodder or seeds or for the production of pharmaceuticals or chemicals.

摘要翻译： 本发明涉及从植物或植物细胞的基因组中切除核酸序列的方法。 该方法基于用编码DNA双链断裂诱导酶（DSBI）的构建体转化植物细胞的步骤，产生转基因植物系，进行瞬时测定以分析转基因酶的功能，穿过植物系 含有要切除的核酸序列的线，并通过愈伤组织形成进行未成熟胚转化或组织培养再生。 该方法也可以相反，这意味着用编码待切除的核酸序列的构建体转化植物细胞，并且用含有DSBI的植物系进行杂交。 作为交叉步骤的替代方案，也可以进行具有第二构建体的转基因植物系的再转化。 本发明还涉及通过该方法获得的植物，或从这种植物衍生的后代，繁殖材料，部分，组织，细胞或细胞培养物。 最后，本发明涉及来源于该方法的植物或后代，繁殖材料，部分，组织，细胞或细胞培养物作为营养物，饲料或种子或用于生产药物或化学品的用途。

公开(公告)号：US07685395B1

公开(公告)日：2010-03-23

申请号：US11427646

申请日：2006-06-29

申请人： Jeffrey A. Brown ,  Kiran Madnani ,  Adi Ofer

发明人： Jeffrey A. Brown ,  Kiran Madnani ,  Adi Ofer

IPC分类号： G06F12/00

CPC分类号： G06F3/0664 ,  G06F3/0605 ,  G06F3/0637 ,  G06F3/067 ,  G06F3/0689 ,  H04L67/1097

摘要： Described are a storage network and method of presenting a virtual array in the storage network. The storage network includes a first storage array and a second storage array. At least one of the first and second storage arrays has one or more logical units of storage assigned to a virtual array that spans the first and second storage arrays. In addition, at least one of the first and second storage arrays has one or more physical ports coupled to the virtual array. The virtual array is assigned a unique virtual port identifier (ID) for each physical port coupled to the virtual array. A host coupled to a switch can communicate with the virtual array using a virtual port ID assigned to the virtual array.

摘要翻译： 描述了在存储网络中呈现虚拟阵列的存储网络和方法。 存储网络包括第一存储阵列和第二存储阵列。 第一和第二存储阵列中的至少一个具有分配给跨越第一和第二存储阵列的虚拟阵列的一个或多个存储逻辑单元。 另外，第一和第二存储阵列中的至少一个具有耦合到虚拟阵列的一个或多个物理端口。 虚拟阵列为与虚拟阵列耦合的每个物理端口分配唯一的虚拟端口标识符（ID）。 耦合到交换机的主机可以使用分配给虚拟阵列的虚拟端口ID与虚拟阵列进行通信。

公开(公告)号：US07539838B1

公开(公告)日：2009-05-26

申请号：US11324646

申请日：2006-01-03

申请人： Stephen J. Todd ,  Jeffrey A. Brown ,  James W. Espy

发明人： Stephen J. Todd ,  Jeffrey A. Brown ,  James W. Espy

IPC分类号： G06F12/00

CPC分类号： G06F3/0635 ,  G06F3/0607 ,  G06F3/0617 ,  G06F3/0632 ,  G06F3/067 ,  G06F11/2069 ,  G06F11/2071 ,  G06F11/2089

摘要： One embodiment is directed to an object addressable storage (OAS) system that has a plurality of storage devices to store a plurality of content units. The OAS system provides an OAS interface so that each one of the content units stored on the OAS system can be accessed using an object identifier. The OAS system is capable of discovering the addition of newly added storage devices to the plurality of storage devices after the OAS system has been at least partially populated so that at least some of the plurality of storage devices have content units already stored thereon, and in response to the discovery of newly added storage devices, configuring the newly discovered storage devices to increase the storage capacity of the OAS system and to enable content units to be stored thereon.

摘要翻译： 一个实施例涉及具有存储多个内容单元的多个存储设备的对象可寻址存储（OAS）系统。 OAS系统提供OAS接口，使得可以使用对象标识符来访问存储在OAS系统上的每个内容单元。 OAS系统能够在OAS系统至少部分地填充之后发现向多个存储设备添加新增的存储设备，使得多个存储设备中的至少一些具有已经存储在其上的内容单元，并且在 响应于发现新添加的存储设备，配置新发现的存储设备以增加OAS系统的存储容量并使内容单元能够被存储在其上。

公开(公告)号：US07529972B2

公开(公告)日：2009-05-05

申请号：US11324728

申请日：2006-01-03

申请人： Mikhail Zelikov ,  Stephen J. Todd ,  Jeffrey A. Brown ,  James W. Espy

发明人： Mikhail Zelikov ,  Stephen J. Todd ,  Jeffrey A. Brown ,  James W. Espy

IPC分类号： G06F11/00

CPC分类号： G06F11/2089 ,  G06F11/201

摘要： One embodiment relates to a computer system comprising at least one host, at least one object addressable storage (OAS) system and at least one communication medium that couples the at least one host to the at least one OAS system. The at least one OAS system has a plurality of storage devices and stores a plurality of content units on the plurality of storage devices. Each of the at least one host and the at least one OAS system has software that provides a OAS interface so that each one of the content units stored on the OAS system may be identified between the at least one host and the at least one OAS using an object identifier. The computer system maps the object identifier for a first of the plurality of content units to at least one of the plurality of storage devices over at least one first path. In response to a failure that prevents the at least one host from accessing the first content unit via the at least one first path, the computer system is automatically reconfigured to establish at least one previously non-established second path that enables the at least one host to access the first content unit using the object identifier for the first content unit.

摘要翻译： 一个实施例涉及包括至少一个主机，至少一个对象可寻址存储（OAS）系统和将至少一个主机耦合到至少一个OAS系统的至少一个通信介质的计算机系统。 至少一个OAS系统具有多个存储设备，并且在多个存储设备上存储多个内容单元。 所述至少一个主机和所述至少一个OAS系统中的每一个具有提供OAS接口的软件，使得可以在所述至少一个主机和所述至少一个OAS之间识别存储在所述OAS系统上的每个内容单元，所述内容单元使用 对象标识符。 计算机系统通过至少一个第一路径将多个内容单元中的第一个的对象标识符映射到多个存储设备中的至少一个。 响应于防止至少一个主机经由至少一个第一路径访问第一内容单元的故障，计算机系统被自动重新配置以建立至少一个先前未建立的第二路径，其使能至少一个主机 使用第一内容单元的对象标识符访问第一内容单元。