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公开(公告)号：US10913741B2
公开(公告)日：2021-02-09
申请号：US17003385
申请日：2020-08-26
发明人： Liqi He , Sanjeev Gangwar , Yam B. Poudel , Prasanna Sivaprakasam
IPC分类号： A61K31/52 , A61K31/522 , C07D473/18 , C07D473/04 , A61P37/04 , A61K47/68
摘要： Compounds having a structure according to formula (I) or (II) where R1, R2, R1, R4, Ar and X1 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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公开(公告)号：US10711003B2
公开(公告)日：2020-07-14
申请号：US16659735
申请日：2019-10-22
IPC分类号： A61K31/52 , C07D473/18 , A61P37/04 , A61K47/60 , A61K47/68
摘要： Compounds having a structure according to formula (I) or (II) where R1, R2, and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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![2H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS AND METHODS AND USES THEREFOR](/abs-image/US/2020/02/06/US20200039986A1/abs.jpg.150x150.jpg)
13.发明申请公开(公告)号：US20200039986A1
公开(公告)日：2020-02-06
申请号：US16529457
申请日：2019-08-01
发明人： Yam B. POUDEL , Sanjeev Gangwar , Liqi He , Prasanna Sivaprakasam
IPC分类号： C07D487/04 , A61K39/395 , A61K31/519 , A61K47/60
摘要： Compounds according to formula II are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
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公开(公告)号：US09556178B2
公开(公告)日：2017-01-31
申请号：US14532218
申请日：2014-11-04
发明人： Ashok Vinayak Purandare , Brian E. Fink , Ashvinikumar V. Gavai , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer Inghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann
IPC分类号： C07D487/04 , C07D487/22 , C07D403/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/10 , C07D498/04 , C07F9/6521 , A61K31/541 , A61K31/55 , C07D487/08 , C07D519/00 , C07F9/6561 , C07F7/18
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
摘要： The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）咪唑三嗪抑制蛋白激酶活性，从而使它们用作抗癌剂。
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公开(公告)号：US09273057B2
公开(公告)日：2016-03-01
申请号：US14414152
申请日：2013-07-12
发明人： Ashok Vinayak Purandare , Brian E. Fink , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer Inghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann , Yong Zhang , Libing Chen , Bin Chen , John S. Tokarski , Ashvinikumar V. Gavai
IPC分类号： C07D487/04 , C07D487/08 , C07D487/10 , C07D471/10 , C07D498/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61P19/02 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07F9/6521 , C07D519/00 , C07F9/6561 , C07F7/18
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
摘要： The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
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公开(公告)号：US20150065465A1
公开(公告)日：2015-03-05
申请号：US14532218
申请日：2014-11-04
发明人： Ashok Vinayak Purandare , Brian E. Fink , Ashvinikumar V. Gavai , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer Inghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann
IPC分类号： C07D487/04 , A61K45/06 , A61K31/541 , C07D487/08 , A61K31/5383 , C07D519/00 , A61K31/55 , A61K31/5377 , C07F9/6561 , A61K31/675 , A61K31/53 , A61K31/551
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
摘要： The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）咪唑三嗪抑制蛋白激酶活性，从而使它们用作抗癌剂。
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公开(公告)号：US11485741B2
公开(公告)日：2022-11-01
申请号：US17043886
申请日：2019-04-23
发明人： Ashok V. Purandare , Honghe Wan , Liqi He , Sanjeev Gangwar , Shoshana L. Posy , Yam B. Poudel , Prasanna Sivaprakasam , Naidu S. Chowdari
IPC分类号： C07D487/16 , A61K47/60
摘要： Compounds having a structure according to formula are modulators of TLR7 activity and can be used to treat conditions amenable to treatment by the modulation of TLR7 activity.
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公开(公告)号：US10723736B2
公开(公告)日：2020-07-28
申请号：US16660365
申请日：2019-10-22
IPC分类号： C07D473/18 , A61P37/04 , A61K47/60 , A61K47/68
摘要： Compounds having a structure according to formula (I) where R1 and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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公开(公告)号：US10689382B2
公开(公告)日：2020-06-23
申请号：US16676870
申请日：2019-11-07
发明人： Liqi He , Sanjeev Gangwar , Yam B. Poudel , Prasanna Sivaprakasam
IPC分类号： A61K31/52 , A61K31/522 , C07D473/14 , C07D473/18 , A61P37/04 , A61K47/68
摘要： Compounds having a structure according to formula (I) or (II) where R1, R2, R3, R4, Ar and X1 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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公开(公告)号：US10508115B2
公开(公告)日：2019-12-17
申请号：US16103619
申请日：2018-08-14
发明人： Liqi He , Sanjeev Gangwar , Yam B. Poudel , Prasanna Sivaprakasam
IPC分类号： A61K31/52 , A61K31/522 , C07D473/14 , A61P31/14 , A61P31/20 , C07D473/18 , A61P37/04 , A61K47/68
摘要： Compounds having a structure according to formula (I) or (II) where R1, R2, R3, R4, Ar and X1 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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