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公开(公告)号：US10793569B2
公开(公告)日：2020-10-06
申请号：US16865009
申请日：2020-05-01
发明人： Liqi He , Sanjeev Gangwar , Yam B. Poudel , Prasanna Sivaprakasam
IPC分类号： A61K31/52 , A61K31/522 , C07D473/18 , C07D473/04 , A61P37/04 , A61K47/68
摘要： Compounds having a structure according to formula (I) or (II) where R1, R2, R3, R4, Ar and X1 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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2.发明申请公开(公告)号：US20190055245A1
公开(公告)日：2019-02-21
申请号：US16103581
申请日：2018-08-14
IPC分类号： C07D473/18 , A61K47/68
摘要： Compounds having a structure according to formula (I) where R1 and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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公开(公告)号：US09371328B2
公开(公告)日：2016-06-21
申请号：US14191861
申请日：2014-02-27
发明人： Brian E. Fink , Libing Chen , Ashvinikumar V. Gavai , Liqi He , Soong-Hoon Kim , Andrew James Nation , Yufen Zhao , Litai H. Zhang
IPC分类号： C07D487/04 , C07D498/04
CPC分类号： C07D487/04 , C07D498/04
摘要： The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）咪唑并哒嗪抑制蛋白激酶活性，从而使其成为抗癌剂。
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公开(公告)号：US20150210697A1
公开(公告)日：2015-07-30
申请号：US14414152
申请日：2013-07-12
发明人： Ashok Vinayak Purandare , Brian E. Fink , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer Inghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann , Yong Zhang , Libing Chen , Bin Chen , John S. Tokarski , Ashvinikumar V. Gavai
IPC分类号： C07D487/04 , C07F7/18 , C07D487/10 , C07D487/08 , C07D471/10
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
摘要： The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
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公开(公告)号：US08940736B2
公开(公告)日：2015-01-27
申请号：US13940619
申请日：2013-07-12
发明人： Ashok Vinayak Purandare , Brian E. Fink , Ashvinikumar V. Gavai , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer Inghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann
IPC分类号： A61K31/535 , A01N43/00 , A61K31/00 , A01N57/00 , A61K31/675 , C07D413/00 , C07D487/00 , C07D243/08 , A61K31/53 , A61K45/06 , A61K31/5377 , C07D471/10 , C07D487/10 , C07D498/04 , A61K31/551 , C07D487/04 , A61K31/5383 , C07F9/6521
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
摘要： The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）咪唑三嗪抑制蛋白激酶活性，从而使它们用作抗癌剂。
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公开(公告)号：US20140018319A1
公开(公告)日：2014-01-16
申请号：US13940619
申请日：2013-07-12
发明人： Ashok Vinayak Purandare , Brian E. Fink , Ashvinikumar V. Gavai , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer Inghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann
IPC分类号： A61K31/675 , A61K31/53 , A61K31/551 , A61K31/5377 , C07D487/10 , C07F9/6521 , C07D498/04 , A61K31/5383 , A61K45/06 , C07D487/04 , C07D471/10
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
摘要： The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）咪唑三嗪抑制蛋白激酶活性，从而使它们用作抗癌剂。
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![1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor](/abs-image/US/2023/01/17/US11554120B2/abs.jpg.150x150.jpg)
公开(公告)号：US11554120B2
公开(公告)日：2023-01-17
申请号：US16527802
申请日：2019-07-31
发明人： Yam B. Poudel , Sanjeev Gangwar , Liqi He , Prasanna Sivaprakasam , Matthias Broekema , Matthew Cox , Christine M. Tarby , Qian Zhang , Naidu S. Chowdari
IPC分类号： C07D487/04 , A61K31/519 , A61K47/60 , A61K39/395 , A61P35/00 , A61K31/395
摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
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公开(公告)号：US10927114B2
公开(公告)日：2021-02-23
申请号：US16904337
申请日：2020-06-17
IPC分类号： C07D473/16 , C07D473/18 , A61P37/04 , A61K47/60 , A61K47/68 , A61K31/52
摘要： Compounds having a structure according to formula (I) or (II) where R1, R2, and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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公开(公告)号：US10919895B2
公开(公告)日：2021-02-16
申请号：US16902860
申请日：2020-06-16
IPC分类号： C07D473/18 , A61K47/68 , A61P37/04 , A61K47/60
摘要： Compounds having a structure according to formula (I) where R1 and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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公开(公告)号：US20160108050A1
公开(公告)日：2016-04-21
申请号：US14976476
申请日：2015-12-21
发明人： Ashok Vinayak Purandare , Brian E. Fink , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer lnghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann , Yong Zhang , Libing Chen , Bin Chen , John S. Tokarski , Ashvinikumar V. Gavai
IPC分类号： C07D487/04 , C07F9/6561 , C07F7/18 , C07D519/00
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
摘要： The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
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