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公开(公告)号：US20220306630A1
公开(公告)日：2022-09-29
申请号：US17632909
申请日：2020-08-05
发明人： Lalgudi S. Harikrishnan , Peter Kinam Park , Zheming Ruan , Donna D. Wei , Daniel O'Malley , Honghe Wan , Ashok Vinayak Purandare , Brian E. Fink
IPC分类号： C07D471/10 , C07C317/18 , C07D213/73 , C07D213/71 , C07C255/60 , C07D213/82 , C07D231/12 , C07D231/18 , C07D263/24 , C07D213/56 , C07D401/12 , C07C311/16 , C07D213/69 , C07D233/61 , C07D211/34 , C07D235/18 , C07D213/58 , C07D211/96 , C07D295/26
摘要： The present invention is directed to compounds of the formula (I) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US10053454B2
公开(公告)日：2018-08-21
申请号：US14770230
申请日：2014-02-27
发明人： Michael A. Poss , David R. Tortolani , Ashok Vinayak Purandare , John S. Tokarski , Christopher P. Mussari , Muthoni G. Kamau , Dharmpal S. Dodd , Ashvinikumar V. Gavai , Daniel O'Malley , Tram N. Huynh , Wayne Vaccaro , Lalgudi S. Harikrishnan
IPC分类号： C07D413/04 , C07D413/10 , C07D413/14 , C07D417/14 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K31/553
CPC分类号： C07D413/10 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K31/553 , C07D413/04 , C07D413/14 , C07D417/14
摘要： The present invention is directed to carbazole compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：US20160108050A1
公开(公告)日：2016-04-21
申请号：US14976476
申请日：2015-12-21
发明人： Ashok Vinayak Purandare , Brian E. Fink , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer lnghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann , Yong Zhang , Libing Chen , Bin Chen , John S. Tokarski , Ashvinikumar V. Gavai
IPC分类号： C07D487/04 , C07F9/6561 , C07F7/18 , C07D519/00
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
摘要： The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
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公开(公告)号：US10550125B2
公开(公告)日：2020-02-04
申请号：US15769113
申请日：2016-10-19
IPC分类号： A61K31/53 , C07D487/04 , A61P19/02 , A61P17/06 , A61P35/02
摘要： The invention provides pharmaceutically active compounds of formula (I) and prodrugs thereof. The formula (I) 2-(aminophenylamino)-4-amino-7-cyano-imidazo[2,1-f][1,2,4]triazine derivatives inhibit CK2 protein kinase activity, thereby making them useful for treating cancer, psoriasis and rheumatoid arthritis.
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公开(公告)号：US09738630B2
公开(公告)日：2017-08-22
申请号：US15037081
申请日：2014-11-18
IPC分类号： C07D405/12 , C07D401/14 , C07D413/14 , A61K31/4725 , C07D407/14 , C07D417/14 , A61K45/06 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D405/14
CPC分类号： C07D405/12 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/14 , Y02A50/411 , Y02A50/414 , A61K2300/00
摘要： There are disclosed compounds that are inhibitors of EZH2, pharmaceutical compositions containing said compounds and methods of treating hyperproliferative, inflammatory, infectious, and immunoregulatory disorders and diseases, utilizing the compounds of the invention.
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公开(公告)号：US20150210697A1
公开(公告)日：2015-07-30
申请号：US14414152
申请日：2013-07-12
发明人： Ashok Vinayak Purandare , Brian E. Fink , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer Inghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann , Yong Zhang , Libing Chen , Bin Chen , John S. Tokarski , Ashvinikumar V. Gavai
IPC分类号： C07D487/04 , C07F7/18 , C07D487/10 , C07D487/08 , C07D471/10
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
摘要： The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
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公开(公告)号：US08940736B2
公开(公告)日：2015-01-27
申请号：US13940619
申请日：2013-07-12
发明人： Ashok Vinayak Purandare , Brian E. Fink , Ashvinikumar V. Gavai , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer Inghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann
IPC分类号： A61K31/535 , A01N43/00 , A61K31/00 , A01N57/00 , A61K31/675 , C07D413/00 , C07D487/00 , C07D243/08 , A61K31/53 , A61K45/06 , A61K31/5377 , C07D471/10 , C07D487/10 , C07D498/04 , A61K31/551 , C07D487/04 , A61K31/5383 , C07F9/6521
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
摘要： The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）咪唑三嗪抑制蛋白激酶活性，从而使它们用作抗癌剂。
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公开(公告)号：US20140018319A1
公开(公告)日：2014-01-16
申请号：US13940619
申请日：2013-07-12
发明人： Ashok Vinayak Purandare , Brian E. Fink , Ashvinikumar V. Gavai , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer Inghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann
IPC分类号： A61K31/675 , A61K31/53 , A61K31/551 , A61K31/5377 , C07D487/10 , C07F9/6521 , C07D498/04 , A61K31/5383 , A61K45/06 , C07D487/04 , C07D471/10
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
摘要： The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）咪唑三嗪抑制蛋白激酶活性，从而使它们用作抗癌剂。
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公开(公告)号：US20230322803A1
公开(公告)日：2023-10-12
申请号：US17913206
申请日：2021-03-22
发明人： Andrew P. Degnan , Godwin Kwame Kumi , Andrew J. Tebben , Audris Huang , Peter Kinam Park , Donna M. Bilder , Emily Charlotte Cherney , Ashok Vinayak Purandare
IPC分类号： C07D498/04 , C07D471/04 , C07D401/14
CPC分类号： C07D498/04 , C07D401/14 , C07D471/04
摘要： Disclosed are compounds of Formula (I) or a salt thereof, wherein Ring A is a carbon-linked ring; and Ring A, R1, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US11548870B2
公开(公告)日：2023-01-10
申请号：US16950978
申请日：2020-11-18
发明人： Andrew P. Degnan , Godwin Kwame Kumi , Audris Huang , James Aaron Balog , Ashok Vinayak Purandare , Weifang Shan , Guo Li
IPC分类号： C07D407/14 , C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/107 , A61K31/4439 , A61P35/00 , C07D405/14 , C07D498/18
摘要： Disclosed are compounds of Formula (I): or a salt thereof, wherein: Z is CR6R6 or C═O; Ring A is: and R1, R2, R3, R4, R5, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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