公开(公告)号：US20060167416A1

公开(公告)日：2006-07-27

申请号：US11286445

申请日：2005-11-23

Applicant: Mark Mathis ,  David Thompson ,  Bruce Addis ,  David Yankelevitz

Inventor： Mark Mathis ,  David Thompson ,  Bruce Addis ,  David Yankelevitz

IPC: A61B10/00 ,  A61B18/04 ,  A61M5/178

CPC classification number: A61M25/0147 ,  A61B10/0275 ,  A61B10/04 ,  A61B17/2909 ,  A61B17/3403 ,  A61B17/3417 ,  A61B17/3468 ,  A61B17/3478 ,  A61B18/1477 ,  A61B18/1492 ,  A61B2010/045 ,  A61B2017/003 ,  A61B2017/00867 ,  A61B2017/2927 ,  A61B2017/3405 ,  A61F7/00 ,  A61M25/00

Abstract: A variety of steerable needles, lancets, trocars, stylets, cannulas and systems are provided for examining, diagnosing, treating, or removing tissue from a patient. The steerable needles, trocars, stylets, cannulas and systems also provide a platform for delivery of target materials, such as therapeutics, biologics, polymers, glues, etc., to a target site. An embodiment of the invention includes a steerable device for use in accessing target site in a patient comprising: a steerable member adapted to penetrate tissue; and a steering mechanism adapted to be operated by a user to apply a bending force to bend the steerable member to access the target site.

公开(公告)号：US20060041304A1

公开(公告)日：2006-02-23

申请号：US11220227

申请日：2005-09-06

Applicant: Yue-Teh Jang ,  Ross Tsugita ,  Bruce Addis ,  Tracy Maahs ,  Jean Chang

Inventor： Yue-Teh Jang ,  Ross Tsugita ,  Bruce Addis ,  Tracy Maahs ,  Jean Chang

IPC: A61F2/06

CPC classification number: A61B17/22 ,  A61B2017/22067 ,  A61B2217/005 ,  A61B2217/007 ,  A61M25/007 ,  A61M25/1011 ,  A61M2206/16

Abstract: A catheter system comprising a guidewire, an endovascular catheter, and an aspiration catheter. The guidewire has an expandable occluder mounted on a distal end. The guidewire and the endovascular catheter are insertable into a lumen of the aspiration catheter. The aspiration catheter also includes infusion and aspiration lumen(s) and port(s). Methods of using the catheter system for treating a vascular lesion and removing embolic material during the procedure are also disclosed.

Abstract translation: 导管系统，其包括导丝，血管内导管和抽吸导管。 导丝具有安装在远端上的可扩张封堵器。 引导线和血管内导管可插入到吸引导管的内腔中。 抽吸导管还包括输注和抽吸腔和端口。 还公开了在手术期间使用导管系统来治疗血管病变并去除栓塞物质的方法。

公开(公告)号：US06706033B1

公开(公告)日：2004-03-16

申请号：US09365650

申请日：1999-08-02

Applicant: Lorraine Mangosong Martinez ,  Jobert Balceta ,  Kevin Hahnen ,  Bruce Addis ,  Timothy J. Wood ,  Roman Turovskiy ,  Richard O. Murphy ,  Tracy D. Maahs

Inventor： Lorraine Mangosong Martinez ,  Jobert Balceta ,  Kevin Hahnen ,  Bruce Addis ,  Timothy J. Wood ,  Roman Turovskiy ,  Richard O. Murphy ,  Tracy D. Maahs

IPC: A61M2900

CPC classification number: A61B17/3415 ,  A61B17/3421 ,  A61B2017/00243 ,  A61B2017/22067 ,  A61B2017/3445 ,  A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0065 ,  A61F2230/0067 ,  A61F2230/008

Abstract: Modular systems comprising a cannula and at least one access port adjacent to a distal end of the cannula provide insertion of one or more therapeutic or diagnostic devices into a vessel or cardiac tissue through a single incision site. Other embodiments include a vessel introducer or multi-port introducer. The devices can be operated in combination or independently. The systems can be employed to provide multiple therapies, including blood perfusion, filtration, aspiration, vessel occlusion, atherectomy, and endoscopic devices. Methods of using the system for vessel cannulation are also disclosed herein.

Abstract translation: 包括套管和邻近套管远端的至少一个进入口的模块化系统通过单个切口部位将一个或多个治疗或诊断装置插入血管或心脏组织。 其他实施例包括血管引入器或多端口引导器。 设备可以组合或独立运行。 该系统可用于提供多种疗法，包括血液灌注，过滤，抽吸，血管闭塞，粥样斑块切除术和内窥镜装置。 本文还公开了使用该系统用于血管插管的方法。

公开(公告)号：US06500191B2

公开(公告)日：2002-12-31

申请号：US10043869

申请日：2001-11-01

Applicant: Bruce Addis

Inventor： Bruce Addis

IPC: A61M2900

CPC classification number: A61B17/1204 ,  A61B17/12109 ,  A61B17/12136 ,  A61B2017/00557 ,  A61B2017/22051 ,  A61B2017/22062 ,  A61B2017/22067 ,  A61B2017/22069 ,  A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067

Abstract: An expansion mechanism that includes an elongate instrument and a plurality of struts arranged around the elongate instrument provides radial expansion of a medical device. Each strut has a first end pivotally connected to the elongate instrument and a second strut that expands radially outward. Each strut further carries a flexible line which has a proximal end and a distal end. The distal end of each line passes beyond the second end of the strut which carries it and is attached to the strut immediately adjacent the strut which carries it. Methods of using such an expansion mechanism are also disclosed, particularly to provide deployment of medical devices within a patient's blood vascular system.

Abstract translation: 包括细长器械和布置在细长器械周围的多个支柱的膨胀机构提供医疗器械的径向膨胀。 每个支柱具有枢转地连接到细长器械的第一端和径向向外膨胀的第二支柱。 每个支柱还具有柔性线，其具有近端和远端。 每条线的远端超过承载该支柱的支柱的第二端，并且与支承它的支柱紧邻的支柱相连。 还公开了使用这种膨胀机构的方法，特别是提供在患者的血管系统内部署医疗装置。

公开(公告)号：US06245087B1

公开(公告)日：2001-06-12

申请号：US09365991

申请日：1999-08-03

Applicant: Bruce Addis

Inventor： Bruce Addis

IPC: A61M2900

CPC classification number: A61F2/013 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/221 ,  A61B2017/1205 ,  A61B2017/2215 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2230/008

Abstract: An expansion frame system for deploying medical devices in a patient's body cavity. The system typically includes an inner wire disposed within a lumen of an outer wire. Distal ends of the inner and outer wires are attached to a substantially circular frame at first and second points. During use, the outer wire is displaced relative to the inner wire, causing the circular frame to rotate about an axis perpendicular to the line defined by the first and second points. Medical devices, such as a filter, a stent, an occluder or a manometer, can be mounted on the circular frame. The diameter of the expansion frame can be varied to achieve optimal contact with the luminal wall of the body cavity. Methods of using the expansion frame system for temporary or permanent placement of a medical device is disclosed.

Abstract translation: 一种用于在患者体腔中部署医疗装置的扩展框架系统。 该系统通常包括设置在外部线的内腔内的内部线。 内部和外部电线的末端在第一和第二点附接到基本圆形的框架。 在使用期间，外部线材相对于内部线材移位，使得圆形框架围绕垂直于由第一和第二点限定的线条的轴线旋转。 诸如过滤器，支架，闭塞器或压力计的医疗装置可以安装在圆形框架上。 可以改变膨胀框架的直径以实现与体腔的腔壁的最佳接触。 公开了使用扩展框架系统临时或永久性地放置医疗装置的方法。

公开(公告)号：US06171328B2

公开(公告)日：2001-01-09

申请号：US09437097

申请日：1999-11-09

Applicant: Bruce Addis

Inventor： Bruce Addis

IPC: A61M2900

CPC classification number: A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2230/0093

Abstract: A filter device for temporary placement of a filter in an artery or vein is disclosed. The device includes an expandable filter mounted on a distal end of a catheter. The filter comprises a plurality of circumferentially adjacent porous segments which are arranged generally about the surface of a cone having an open base, and the segments are engaged to one another by means, such as a hook. The filter conforms to the interior of a vessel wall when expanded and contracts to a consistent diameter without bunching when stowed. Methods of using the filter device to entrap and remove embolic material from a vessel during endovascular procedures are also disclosed.

Abstract translation: 公开了一种用于将过滤器临时放置在动脉或静脉中的过滤装置。 该装置包括安装在导管的远端上的可扩张过滤器。 过滤器包括多个周向相邻的多孔区段，其大致围绕具有开放底座的锥体的表面布置，并且通过诸如钩子的方式将段彼此接合。 过滤器在膨胀时符合血管壁的内部，并收缩到一致的直径，而不会在收起时聚束。 还公开了使用过滤装置在血管内手术期间从血管中捕获和去除栓塞物质的方法。

公开(公告)号：US6146357A

公开(公告)日：2000-11-14

申请号：US307092

申请日：1999-05-07

Applicant: Bruce Addis

Inventor： Bruce Addis

IPC: A61F2/958 ,  A61M29/00

CPC classification number: A61M25/10184 ,  A61M25/1018 ,  A61M25/10187 ,  A61M2025/0001 ,  A61M2025/1059 ,  A61M2025/1068

Abstract: The invention provides a device having first and second balloons. Each of the first and second balloons communicates with an inflation lumen. A differential pressure gauge communicates with both inflation lumens. Each of the inflation lumens also communicates independently with a pump for inflating the balloon. The pressure gauge may include a shut-off valve for terminating inflation in the second balloon when the pressure within the first balloon exceeds the pressure in the second balloon. The pressure gauge may also include a pressure limiter. Methods of using the devices for measuring diameter and pressure of a balloon occluder deployed in a vessel or body cavity are disclosed.

公开(公告)号：US07608087B1

公开(公告)日：2009-10-27

申请号：US10293030

申请日：2002-11-12

Applicant: Bruce Addis

Inventor： Bruce Addis

IPC: A61M29/00

CPC classification number: A61F2/013 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/221 ,  A61B2017/1205 ,  A61B2017/2215 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2230/008

Abstract: An expansion frame system for deploying medical devices in a patient's body cavity. The system typically includes an inner wire disposed within a lumen of an outer wire. Distal ends of the inner and outer wires are attached to a substantially circular frame at first and second points. During use, the outer wire is displaced relative to the inner wire, causing the circular frame to rotate about an axis perpendicular to the line defined by the first and second points. Medical devices, such as a filter, a stent, an occluder or a manometer, can be mounted on the circular frame. The diameter of the expansion frame can be varied to achieve optimal contact with the luminal wall of the body cavity. Methods of using the expansion frame system for temporary or permanent placement of a medical device is disclosed.

公开(公告)号：US20080038313A1

公开(公告)日：2008-02-14

申请号：US11973526

申请日：2007-10-09

Applicant: Bruce Addis ,  Charles Milo ,  Olexander Hnojewyj

Inventor： Bruce Addis ,  Charles Milo ,  Olexander Hnojewyj

IPC: A61K31/74 ,  A61F2/06 ,  A61K9/00 ,  A61M31/00 ,  A61P17/02 ,  C07K1/107

CPC classification number: A61B17/0057 ,  A61B17/00491 ,  A61B2017/00004 ,  A61B2017/00495 ,  A61B2017/00637 ,  A61B2017/0065

Abstract: A method of treating tissue lyophilizes a biocompatible polymer having a functionality equal to or greater than three. The method provides a protein solution. The method mixes the protein solution with the lyophilized polymer to reconstitute the polymer and form a mixture, wherein, upon mixing, the protein solution and the polymer cross-link to form a material composition. The method applies the material composition to a tissue region. The biocompatible polymer can comprise, e.g., poly(ethylene glycol) PEG. The protein solution can comprise, e.g., albumin.

Abstract translation: 治疗组织的方法将具有等于或大于3的功能的生物相容性聚合物冻干。 该方法提供蛋白质溶液。 该方法将蛋白质溶液与冻干聚合物混合以重构聚合物并形成混合物，其中在混合时，蛋白质溶液和聚合物交联以形成材料组成。 该方法将材料组合物应用于组织区域。 生物相容性聚合物可以包括例如聚（乙二醇）PEG。 蛋白质溶液可以包含例如白蛋白。

公开(公告)号：US07279001B2

公开(公告)日：2007-10-09

申请号：US10141510

申请日：2002-05-08

Applicant: Bruce Addis ,  Charles Milo ,  Olexander Hnojewyj

Inventor： Bruce Addis ,  Charles Milo ,  Olexander Hnojewyj

IPC: A61B17/08 ,  A61D1/00

CPC classification number: A61B17/0057 ,  A61B17/00491 ,  A61B2017/00004 ,  A61B2017/00495 ,  A61B2017/00637 ,  A61B2017/0065

Abstract: Systems and methods convey a closure material into a catheter, e.g., to seal a puncture site in a blood vessel. The closure material comprises a mixture of first and second components, which, upon mixing, undergo a reaction to form solid closure material composition. The first component may be a lyophilized polyethylene glycol (PEG) material contained within a vial. The second component may be a buffered albumin solution plus water contained within a syringe. An applicator provides easy and effective mixing of the components and delivery of the mixture to the puncture site.

Abstract translation: 系统和方法将封闭材料输送到导管中，例如以密封血管中的穿刺部位。 封闭材料包括第一和第二组分的混合物，其在混合时经历反应以形成固体封闭材料组合物。 第一组分可以是包含在小瓶内的冻干聚乙二醇（PEG）材料。 第二组分可以是缓冲的白蛋白溶液和加在注射器内的水。 施用器提供容易且有效地混合组分并将混合物输送到穿刺部位。