公开(公告)号：US20190083262A1

公开(公告)日：2019-03-21

申请号：US16135447

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： LLIA HARITON ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC: A61F2/24

Abstract: A heart valve delivery system may be provided. The heart valve delivery system may include at least a first catheter movable relative to second and third catheters, arranged in a telescoping configuration. The second catheter may be movable relative to and extend from the distal end of the third catheter. The delivery system may include a first adjustable flexure radius associated with the second catheter, and a second flexure radius. The delivery system may include at one control handle assembly configured to permit the catheters to rotate together, independently adjust the first and second flexure radii, cause relative axial movement between the catheters, and permit the ejector to cause relative movement between a heart valve and a capsule connected to the first catheter.

公开(公告)号：US20240423796A1

公开(公告)日：2024-12-26

申请号：US18765724

申请日：2024-07-08

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz Harari ,  Maxim Karalnik ,  Michael Albitov ,  Meni Iamberger

IPC: A61F2/24 ,  A61F2/958 ,  A61F2/966

Abstract: A method includes delivering an implant to a heart of a patient using a delivery tool that includes a nosepiece that is fixed to a shaft and distal to an implant, and an expandable element proximal to the nosepiece. Maximally-expanded, the expandable element (i) has an expanded external diameter at its widest part that is smaller than the expanded internal diameter of a lumen of the frame of the implant and (ii) tapers proximally away from the widest part and from the nosepiece. In a compressed state of the implant a portion of the expandable element is disposed within the lumen of the frame. The method includes, following implantation of the implant, withdrawing the expandable element proximally through the lumen of the implant, between leaflets of the implant, and out of the lumen. Other applications are also described.

公开(公告)号：US12053379B2

公开(公告)日：2024-08-06

申请号：US17181722

申请日：2021-02-22

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Boaz Harari ,  Maxim Karalnik ,  Michael Albitov ,  Meni Iamberger

IPC: A61F2/24 ,  A61F2/966 ,  A61F2/958

CPC classification number: A61F2/2436 ,  A61F2/2433 ,  A61F2/966 ,  A61F2002/9583

Abstract: A delivery tool includes a nosepiece that is fixed to a shaft, and distal to an implant, and an expandable element proximal to the nosepiece. Maximally-expanded, the expandable element (i) has an expanded external diameter at its widest part that is smaller than the expanded internal diameter of a lumen of the frame of the implant, (ii) tapers proximally away from the widest part and from the nosepiece, and (iii) is dimensioned to slide proximally through the lumen of the implant in its expanded state, between leaflets of the implant, and out of the lumen. When non-expanded, the widest part of the expandable element has a non-expanded external diameter that is smaller than the expanded external diameter of the expandable element. In a compressed state of the implant a portion of the expandable element is disposed within the lumen of the frame. Other applications are also described.

公开(公告)号：US12023243B2

公开(公告)日：2024-07-02

申请号：US17010886

申请日：2020-09-03

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC: A61F2/24

CPC classification number: A61F2/2427 ,  A61F2/243 ,  A61F2/2436 ,  A61F2/2445 ,  A61F2/2454 ,  A61F2/2463 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/246 ,  A61F2/2466 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2250/007

Abstract: A prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may include an annular valve body. The prosthetic valve may also include a plurality of tissue anchors arranged about the valve body and configured to extend from connection points on the valve body. The prosthetic valve may also include at least one protective fabric covering extending over each of the connection points between each tissue anchor and the valve body.

公开(公告)号：US11793638B2

公开(公告)日：2023-10-24

申请号：US16896858

申请日：2020-06-09

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Boaz Harari

IPC: A61F2/24 ,  A61F2/95 ,  A61F2/915

CPC classification number: A61F2/2436 ,  A61F2/243 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/9517 ,  A61F2002/91575 ,  A61F2220/0016 ,  A61F2220/0025

Abstract: Prosthetic heart valves and methods of use of prosthetic heart valves may be provided. In one implementation, a prosthetic heart valve may include an annular valve body and atrial anchors and ventricular anchors extending from the valve body. An atrial anchor may include a pivoting portion configured to extend in an upstream direction when the prosthetic heart valve is in a delivery configuration and in a downstream direction when the prosthetic heart valve is in a deployed-anchor configuration. A portion of a ventricular anchor may be configured to abut the annular valve body when the prosthetic heart valve is arranged in the delivery configuration.

公开(公告)号：US11793635B2

公开(公告)日：2023-10-24

申请号：US17004693

申请日：2020-08-27

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Boaz Harari

IPC: A61F2/24 ,  A61F2/95 ,  A61F2/915

CPC classification number: A61F2/2436 ,  A61F2/243 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/9517 ,  A61F2002/91575 ,  A61F2220/0016 ,  A61F2220/0025

Abstract: Prosthetic valves and methods of use of prosthetic valves may be provided. In one implementation, a prosthetic valve may include an annular outer frame formed of struts intersecting at outer frame junctions, an inner frame situated within the outer frame and formed of struts intersecting at inner frame junctions, and a plurality of tissue anchors extending from the outer frame. The junctions along a downstream end of the outer frame may be spaced apart circumferentially from the junctions along a downstream end of the inner frame. The outer frame may include an anchor support strut extending between a downstream junction of the outer frame and a point of connection between one of the tissue anchors and the outer frame. The anchor support strut may be configured for placement parallel to a longitudinal axis of the prosthetic valve.

公开(公告)号：US11318015B2

公开(公告)日：2022-05-03

申请号：US16135663

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC: A61F2/24

Abstract: A prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may include an annular valve body, a plurality of atrial anchoring arms configured to extend radially outward from the annular valve body, and a plurality of ventricular anchoring legs configured to extend radially outward from the annular valve body. The arms may be configured to engage an atrial portion of the native mitral valve and the ventricular anchoring legs may be configured to engage a ventricular portion of the native mitral valve. The atrial anchoring arms and the ventricular anchoring legs may be positioned relative to each other such that when the atrial anchoring arms and ventricular anchoring legs engage the native mitral valve, a volume between the atrial anchoring arms and ventricular anchoring legs is configured to be substantially filled with tissue.

公开(公告)号：US11065122B2

公开(公告)日：2021-07-20

申请号：US16756235

申请日：2018-01-08

Applicant: CARDIOVALVE LTD.

Inventor： Boaz Harari ,  Ilia Hariton

IPC: A61F2/24 ,  G01N3/04 ,  G01L1/24 ,  G01B11/02 ,  H04N7/18 ,  A61F2/76 ,  G01B11/14

Abstract: A prosthetic valve leaflet is placed across a bar, and the bar is positioned such that the leaflet drapes over the bar and blocks a beam of light emitted by a light source. While the leaflet remains draped over the bar, the bar is elevated at least until the leaflet stops blocking the beam. An elevation of the bar from the beam at which the leaflet stopped blocking the beam is identified. Other embodiments are also described.

公开(公告)号：US20210145578A1

公开(公告)日：2021-05-20

申请号：US17141853

申请日：2021-01-05

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Boaz Harari ,  Maxim Karalnik ,  Meni Iamberger

IPC: A61F2/24

Abstract: A method includes percutaneously advancing an implant to a native heart valve of a subject, the implant being housed in a compressed state within a delivery tool. Next, the method includes unhousing a longitudinally-intermediate portion of the implant, the longitudinally-intermediate portion being longitudinally between a longitudinally-proximal portion of the implant and a longitudinally distal portion of the implant. Subsequently, the longitudinally-proximal portion of the implant is unhoused. Subsequently, the longitudinally-distal portion of the implant is unhoused. Other applications are also described.

公开(公告)号：US10952850B2

公开(公告)日：2021-03-23

申请号：US16318025

申请日：2017-08-01

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Boaz Harari ,  Michael Albitov ,  Paul Kaye

IPC: A61F2/24 ,  A61F2/966 ,  A61F2/958

Abstract: A tool (410) for use with an implant (20) includes a housing (426) and a controller (440). The housing includes a tubular wall (428) that circumscribes a longitudinal axis; is dimensioned to house at least part of the implant; and defines a track (430) that follows a generally-helical path around the longitudinal axis. The controller includes a rod (442) that extends from a proximal part of the tool to the housing; and an actuator (444). The actuator is fixedly coupled to the rod, includes an engaging element (446) that engages the track, and is rotatable with respect to the housing. The controller and the housing mechanically cooperate such that rotation of the actuator with respect to the housing slides the housing longitudinally with respect to the actuator. Other embodiments are also described.