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公开(公告)号：US20170283439A1
公开(公告)日：2017-10-05
申请号：US15507203
申请日：2015-08-28
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , John Wityak , Jonathan Bard , Alex Kiselyov , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Daniel CLark-Frew
IPC: C07D519/00 , A61K51/04 , C07D471/04
CPC classification number: C07D519/00 , A61K51/0455 , A61K51/0459 , C07D471/04
Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号：US11104691B2
公开(公告)日：2021-08-31
申请号：US15507203
申请日：2015-08-28
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , John Wityak , Jonathan Bard , Alex Kiselyov , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Daniel Clark-Frew
IPC: A61K51/00 , A61M36/14 , C07D519/00 , C07D471/04 , A61K51/04
Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号：US10765764B2
公开(公告)日：2020-09-08
申请号：US16172425
申请日：2018-10-26
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , John Wityak , Jonathan Bard , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Thomas Martin Krulle , Daniel Clark-Frew , Duane Higgins , Matthew Robert Mills , Richard Waldron Marston , Samuel Coe , Samantha Brown , Sarah Hayes
IPC: A61K51/04 , C07D513/04 , C07D487/04 , C07D513/14 , C07B59/00
Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号：US20200276176A1
公开(公告)日：2020-09-03
申请号：US16799651
申请日：2020-02-24
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Jonathan Bard , Matthew R. Lee , Longbin Liu , Michael Edward Prime , Samuel Coe
IPC: A61K31/454 , A61K31/427 , A61K31/165 , A61K47/54
Abstract: The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenerative disorders caused by aggregation of mHTT.
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公开(公告)号：US20190167821A1
公开(公告)日：2019-06-06
申请号：US16172425
申请日：2018-10-26
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , John Wityak , Jonathan Bard , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Thomas Martin Krulle , Daniel Clark-Frew , Duane Higgins , Matthew Robert Mills , Richard Waldron Marston , Samuel Coe , Samantha Brown , Sarah Hayes
IPC: A61K51/04 , C07B59/00 , C07D513/04 , C07D487/04 , C07D513/14
Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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Patent Agency Ranking
公开(公告)号：US10137211B2
公开(公告)日：2018-11-27
申请号：US15249223
申请日：2016-08-26
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , John Wityak , Jonathan Bard , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Thomas Martin Krulle , Daniel Clark-Frew , Duane Higgins , Matthew Robert Mills , Richard Waldron Marston , Samuel Coe , Samantha Brown , Sarah Hayes
IPC: A61K51/04 , C07D513/04 , C07D487/04 , C07D513/14 , C07B59/00
Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use
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公开(公告)号：US11992535B2
公开(公告)日：2024-05-28
申请号：US17125905
申请日：2020-12-17
Applicant: CHDI Foundation, Inc.
Inventor： Longbin Liu , Matthew Lee , Celia Dominguez , Peter David Johnson , Christopher John Brown , Sarah Hayes , Adrian Kotey , Matthew Robert Mills , Michael Edward Prime
IPC: A61K51/04 , C07B59/00 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/107
CPC classification number: A61K51/0455 , A61K51/0459 , A61K51/0468 , C07B59/00 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/107 , C07B2200/05
Abstract: Provided herein are certain compounds and imaging agents useful for detecting a condition or disorder associated with protein aggregation, compositions thereof, and methods of their use.
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公开(公告)号：US11851446B2
公开(公告)日：2023-12-26
申请号：US17353627
申请日：2021-06-21
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , John Wityak , Jonathan Bard , Alex Kiselyov , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Daniel Clark-Frew
IPC: C07D519/00 , C07D471/04 , A61K51/04
CPC classification number: C07D519/00 , A61K51/0455 , A61K51/0459 , C07D471/04
Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号：US20210380608A1
公开(公告)日：2021-12-09
申请号：US17353627
申请日：2021-06-21
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , John Wityak , Jonathan Bard , Alex Kiselyov , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Daniel Clark-Frew
IPC: C07D519/00 , C07D471/04 , A61K51/04
Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号：US20170056535A1
公开(公告)日：2017-03-02
申请号：US15249223
申请日：2016-08-26
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , John Wityak , Jonathan Bard , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Thomas Martin Krulle , Daniel Clark-Frew , Duane Higgins , Matthew Robert Mills , Richard Waldron Marston , Samuel Coe , Samantha Louise Jones Green , Sarah Hayes
IPC: A61K51/04 , C07D487/04 , C07D513/14 , C07D513/04
CPC classification number: A61K51/0455 , A61K51/0459 , C07B59/002 , C07D487/04 , C07D513/04 , C07D513/14
Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
Abstract translation: 提供了包含式I化合物或其药学上可接受的盐的成像剂及其使用方法。 （一世）。
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