公开(公告)号：US20220409615A1

公开(公告)日：2022-12-29

申请号：US17318693

申请日：2021-05-12

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Elizabeth M. Doherty ,  Longbin Liu ,  Matthew Lee ,  Mark Stuart Chambers ,  Karine Fabienne Malagu ,  Perla Breccia ,  Alan F. Haughan ,  Huw D. Vater ,  Andrew J. Stott ,  William R. K. Esmieu ,  Stephen John Webster ,  Amanda J. Van De Poël

IPC: A61K31/497 ,  C07D471/04 ,  C07D519/00 ,  A61K31/4985 ,  C07D487/04 ,  C07D403/14 ,  A61K31/506 ,  A61K31/501 ,  C07D413/14 ,  A61P25/28

Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.

公开(公告)号：US20190185463A1

公开(公告)日：2019-06-20

申请号：US16046268

申请日：2018-07-26

Applicant: CHDI Foundation, Inc.

Inventor： Michel C. Maillard ,  Perla Breccia ,  Celia Dominguez ,  Alan F. Haughan ,  Rebecca E. Jarvis ,  Christopher A. Luckhurst ,  Elizabeth A. Saville-Stones ,  Andrew J. Stott ,  Amanda Van de Poël ,  Michael Wall ,  Grant Wishart

IPC: C07D413/12 ,  C07D491/107

CPC classification number: C07D413/12 ,  C07D491/107

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

公开(公告)号：US10053434B2

公开(公告)日：2018-08-21

申请号：US15148907

申请日：2016-05-06

Applicant: CHDI Foundation, Inc.

Inventor： Michel C. Maillard ,  Perla Breccia ,  Celia Dominguez ,  Alan F. Haughan ,  Amanda Van de Poël ,  Andrew J. Stott ,  Christopher A. Luckhurst ,  Elizabeth A. Saville-Stones ,  Grant Wishart ,  Michael Wall ,  Rebecca E. Jarvis

IPC: C07D413/12 ,  C07D271/06 ,  C07D471/04

CPC classification number: C07D271/06 ,  C07D413/12 ,  C07D471/04

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

公开(公告)号：US20170101402A1

公开(公告)日：2017-04-13

申请号：US15315713

申请日：2015-06-01

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Ignacio Muñoz-Sanjuán ,  Christopher A. Luckhurst ,  Daniel R. Allen ,  Gilles Raphy ,  Roland W. Bürli ,  Perla Breccia ,  Alan F. Haughan ,  Grant Wishart ,  Samantha J. Hughes ,  Rebeca E. Jarvis ,  Huw D. Vater ,  Stephen D. Penrose ,  Michael Wall ,  Andrew J. Stott ,  Elizabeth A. Saville-Stones

IPC: C07D417/04 ,  C07D401/04 ,  C07D403/04 ,  C07C259/08 ,  C07D239/88 ,  C07D277/60 ,  C07D239/70 ,  C07D231/54 ,  C07D231/56

CPC classification number: C07D417/04 ,  C07C259/08 ,  C07D231/54 ,  C07D231/56 ,  C07D239/70 ,  C07D239/74 ,  C07D239/88 ,  C07D275/04 ,  C07D277/60 ,  C07D401/04 ,  C07D403/04

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, or pharmaceutically acceptable salts thereof, compositions thereof, and methods of their use. The condition or disorder mediated by HDAC comprises a neurodegenerative pathology. Accordingly, also provided is a method of treating a neurodegenerative pathology mediated by HDAC in a subject in need of such a treatment, comprising administering to the subject a therapeutically effective amount of at least one compound, or pharmaceutically acceptable salt thereof, described herein.

公开(公告)号：US09617259B2

公开(公告)日：2017-04-11

申请号：US14776320

申请日：2014-03-10

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Ignacio Muñoz-Sanjuán ,  Michel Maillard ,  Christopher A. Luckhurst ,  Rebecca E. Jarvis ,  Roland W. Bürli ,  Daniel R. Allen ,  Alan F. Haughan ,  Perla Breccia ,  Huw D. Vater ,  Andrew J. Stott ,  Stephen D. Penrose ,  Michael Wall ,  Elizabeth A. Saville-Stones ,  Grant Wishart ,  Samantha J. Hughes

IPC: C07D471/04 ,  C07D277/64 ,  C07D241/12 ,  C07D213/64 ,  C07C259/08 ,  C07D277/62 ,  C07D261/20 ,  C07D275/04 ,  C07D333/60 ,  C07D213/56 ,  C07D213/61 ,  C07D239/26 ,  C07D241/42 ,  C07D231/12 ,  C07D231/56

CPC classification number: C07D471/04 ,  C07C259/08 ,  C07C2601/02 ,  C07C2601/10 ,  C07D213/56 ,  C07D213/61 ,  C07D213/64 ,  C07D231/12 ,  C07D231/56 ,  C07D239/26 ,  C07D241/12 ,  C07D241/42 ,  C07D261/20 ,  C07D275/04 ,  C07D277/62 ,  C07D277/64 ,  C07D333/60

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

公开(公告)号：US20170042892A1

公开(公告)日：2017-02-16

申请号：US15335279

申请日：2016-10-26

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Perla Breccia ,  Christopher A. Luckhurst ,  Roland W. Bürli ,  Andrew J. Stott

IPC: A61K31/505 ,  A61K31/426 ,  A61K31/4418 ,  A61K31/421 ,  A61K31/165 ,  A61K31/357

CPC classification number: A61K31/505 ,  A61K31/165 ,  A61K31/357 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4418 ,  C07B2200/07 ,  C07C259/08 ,  C07C2601/02 ,  C07D213/56 ,  C07D213/61 ,  C07D213/74 ,  C07D215/18 ,  C07D237/08 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D241/12 ,  C07D263/32 ,  C07D263/56 ,  C07D277/30 ,  C07D277/64 ,  C07D295/155 ,  C07D311/58 ,  C07D319/18 ,  C07D401/04 ,  C07D417/04

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

Abstract translation: 提供式I的组蛋白脱乙酰酶（HDAC）抑制剂，其组合物及其使用方法。

公开(公告)号：US09505736B2

公开(公告)日：2016-11-29

申请号：US14414149

申请日：2013-07-16

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Perla Breccia ,  Christopher A. Luckhurst ,  Roland W. Bürli ,  Andrew J. Stott

IPC: C07D319/18 ,  C07D213/74 ,  C07D311/58 ,  C07D401/04 ,  C07D237/08 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D241/12 ,  C07D417/04 ,  C07D263/32 ,  C07D277/30 ,  C07D213/56 ,  C07D213/61 ,  C07D263/56 ,  C07D215/18 ,  C07D277/64 ,  C07D295/155 ,  C07C259/08

CPC classification number: A61K31/505 ,  A61K31/165 ,  A61K31/357 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4418 ,  C07B2200/07 ,  C07C259/08 ,  C07C2601/02 ,  C07D213/56 ,  C07D213/61 ,  C07D213/74 ,  C07D215/18 ,  C07D237/08 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D241/12 ,  C07D263/32 ,  C07D263/56 ,  C07D277/30 ,  C07D277/64 ,  C07D295/155 ,  C07D311/58 ,  C07D319/18 ,  C07D401/04 ,  C07D417/04

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

Abstract translation: 提供式I的组蛋白脱乙酰酶（HDAC）抑制剂，其组合物及其使用方法。

公开(公告)号：US11806346B2

公开(公告)日：2023-11-07

申请号：US17318693

申请日：2021-05-12

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Elizabeth M. Doherty ,  Longbin Liu ,  Matthew Lee ,  Mark Stuart Chambers ,  Karine Fabienne Malagu ,  Perla Breccia ,  Alan F. Haughan ,  Huw D. Vater ,  Andrew J. Stott ,  William R. K. Esmieu ,  Stephen John Webster ,  Amanda J. Van De Poël

IPC: A61K31/497 ,  A61P25/28 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  C07D403/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

CPC classification number: A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61P25/28 ,  C07D403/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.

公开(公告)号：US20210188827A1

公开(公告)日：2021-06-24

申请号：US17111307

申请日：2020-12-03

Applicant: CHDI Foundation, Inc.

Inventor： Leticia M. Toledo-Sherman ,  Celia Dominguez ,  Perla Breccia ,  Amanda J. Van De Poël ,  Grant Wishart ,  Huw D. Vater ,  William R. K. Esmieu ,  Cole Clissold ,  Wesley P. Blackaby

IPC: C07D413/14 ,  C07D471/08 ,  C07D498/08

Abstract: Provided are certain ATM kinase inhibitors of Formula I: Also provided herein are compositions of such compounds, and methods of their use.

公开(公告)号：US20190202795A1

公开(公告)日：2019-07-04

申请号：US16046254

申请日：2018-07-26

Applicant: CHDI Foundation, Inc.

Inventor： Michel C. Maillard ,  Perla Breccia ,  Celia Dominguez ,  Alan F. Haughan ,  Amanda Van de Poël ,  Andrew J. Stott ,  Christopher A. Luckhurst ,  Elizabeth A. Saville-Stones ,  Grant Wishart ,  Michael Wall ,  Rebecca E. Jarvis

IPC: C07D271/06 ,  C07D413/12 ,  C07D471/04

CPC classification number: C07D271/06 ,  C07D413/12 ,  C07D471/04

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.