公开(公告)号：US12083108B2

公开(公告)日：2024-09-10

申请号：US17752683

申请日：2022-05-24

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Jonathan Bard ,  Matthew R. Lee ,  Longbin Liu ,  Michael Edward Prime ,  Samuel Coe

IPC: A61K31/454 ,  A61K31/165 ,  A61K31/427 ,  A61K47/54

CPC classification number: A61K31/454 ,  A61K31/165 ,  A61K31/427 ,  A61K47/555

Abstract: The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenerative disorders caused by aggregation of mHTT.

公开(公告)号：US11344637B2

公开(公告)日：2022-05-31

申请号：US16987277

申请日：2020-08-06

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Christopher John Brown ,  Michael Edward Prime ,  Peter David Johnson ,  Thomas Martin Krulle ,  Daniel Clark-Frew ,  Duane Higgins ,  Matthew Robert Mills ,  Richard Waldron Marston ,  Samuel Coe ,  Samantha Brown ,  Sarah Hayes

IPC: A61K51/04 ,  C07D513/04 ,  C07D487/04 ,  C07D513/14 ,  C07B59/00

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US20170283436A1

公开(公告)日：2017-10-05

申请号：US15507208

申请日：2015-08-28

Applicant: Celia DOMINGUEZ ,  John WITYAK ,  Jonathan BARD ,  Alex KISELYOV ,  Christopher John BROWN ,  Sebastien Rene Gabriel GALAN ,  Michael Edward PRIME ,  Paul Richard GILES ,  Elise Luciennen Paulette GADOULEAU ,  Thomas Martin KRÜLLE ,  Daniel CLARKFREW ,  Peter David JOHNSON ,  Sabinc SCHAERTI ,  Steffen Kaspar GRIMM ,  Jan Dirk KAHMANN ,  Christoph SCHEICH ,  Samuel COE ,  Sarah HAYES ,  CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Alex Kiselyov ,  Christopher John Brown ,  Sébastien René Gabriel Galan ,  Michael Edward Prime ,  Paul Richard Giles ,  Elise Luciennen Paulette Gadouleau ,  Thomas Martin Krülle ,  Daniel Clark-Frew ,  Peter David Johnson ,  Samuel Coe ,  Sarah Hayes

IPC: C07D513/04 ,  C07D413/04 ,  C07D413/14 ,  A61K51/04 ,  C07D498/04 ,  C07D405/14 ,  C07D471/04 ,  C07D263/57 ,  C07D413/12

CPC classification number: C07D513/04 ,  A61K51/0455 ,  A61K51/0459 ,  A61K51/0463 ,  C07D263/57 ,  C07D405/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D498/04

Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.