公开(公告)号：US11344637B2

公开(公告)日：2022-05-31

申请号：US16987277

申请日：2020-08-06

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Christopher John Brown ,  Michael Edward Prime ,  Peter David Johnson ,  Thomas Martin Krulle ,  Daniel Clark-Frew ,  Duane Higgins ,  Matthew Robert Mills ,  Richard Waldron Marston ,  Samuel Coe ,  Samantha Brown ,  Sarah Hayes

IPC: A61K51/04 ,  C07D513/04 ,  C07D487/04 ,  C07D513/14 ,  C07B59/00

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US20170283436A1

公开(公告)日：2017-10-05

申请号：US15507208

申请日：2015-08-28

Applicant: Celia DOMINGUEZ ,  John WITYAK ,  Jonathan BARD ,  Alex KISELYOV ,  Christopher John BROWN ,  Sebastien Rene Gabriel GALAN ,  Michael Edward PRIME ,  Paul Richard GILES ,  Elise Luciennen Paulette GADOULEAU ,  Thomas Martin KRÜLLE ,  Daniel CLARKFREW ,  Peter David JOHNSON ,  Sabinc SCHAERTI ,  Steffen Kaspar GRIMM ,  Jan Dirk KAHMANN ,  Christoph SCHEICH ,  Samuel COE ,  Sarah HAYES ,  CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Alex Kiselyov ,  Christopher John Brown ,  Sébastien René Gabriel Galan ,  Michael Edward Prime ,  Paul Richard Giles ,  Elise Luciennen Paulette Gadouleau ,  Thomas Martin Krülle ,  Daniel Clark-Frew ,  Peter David Johnson ,  Samuel Coe ,  Sarah Hayes

IPC: C07D513/04 ,  C07D413/04 ,  C07D413/14 ,  A61K51/04 ,  C07D498/04 ,  C07D405/14 ,  C07D471/04 ,  C07D263/57 ,  C07D413/12

CPC classification number: C07D513/04 ,  A61K51/0455 ,  A61K51/0459 ,  A61K51/0463 ,  C07D263/57 ,  C07D405/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D498/04

Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US12036291B2

公开(公告)日：2024-07-16

申请号：US17353611

申请日：2021-06-21

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Christopher John Brown ,  Thomas Martin Krülle ,  Daniel Clark-Frew ,  Sarah Hayes

IPC: A61K51/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D487/04 ,  C07D513/04 ,  C07D513/14

CPC classification number: A61K51/0455 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D487/04 ,  C07D513/04 ,  C07D513/14 ,  C07B2200/05

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US11992535B2

公开(公告)日：2024-05-28

申请号：US17125905

申请日：2020-12-17

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Matthew Lee ,  Celia Dominguez ,  Peter David Johnson ,  Christopher John Brown ,  Sarah Hayes ,  Adrian Kotey ,  Matthew Robert Mills ,  Michael Edward Prime

IPC: A61K51/04 ,  C07B59/00 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/107

CPC classification number: A61K51/0455 ,  A61K51/0459 ,  A61K51/0468 ,  C07B59/00 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/107 ,  C07B2200/05

Abstract: Provided herein are certain compounds and imaging agents useful for detecting a condition or disorder associated with protein aggregation, compositions thereof, and methods of their use.

公开(公告)号：US20220372045A1

公开(公告)日：2022-11-24

申请号：US17729881

申请日：2022-04-26

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Celia Dominguez ,  Jonathan Bard ,  Vinod Khetarpal ,  Ashley Jarvis ,  Sarah Hayes ,  John E. Mangette

IPC: C07D498/04 ,  A61K51/04

Abstract: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.

公开(公告)号：US20210379211A1

公开(公告)日：2021-12-09

申请号：US17353611

申请日：2021-06-21

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Christopher John Brown ,  Thomas Martin Krulle ,  Daniel Clark-Frew ,  Sarah Hayes

IPC: A61K51/04 ,  C07D401/14 ,  C07D403/04 ,  C07D401/04 ,  C07D487/04 ,  C07D513/04 ,  C07D513/14

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US20170056535A1

公开(公告)日：2017-03-02

申请号：US15249223

申请日：2016-08-26

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Christopher John Brown ,  Michael Edward Prime ,  Peter David Johnson ,  Thomas Martin Krulle ,  Daniel Clark-Frew ,  Duane Higgins ,  Matthew Robert Mills ,  Richard Waldron Marston ,  Samuel Coe ,  Samantha Louise Jones Green ,  Sarah Hayes

IPC: A61K51/04 ,  C07D487/04 ,  C07D513/14 ,  C07D513/04

CPC classification number: A61K51/0455 ,  A61K51/0459 ,  C07B59/002 ,  C07D487/04 ,  C07D513/04 ,  C07D513/14

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

Abstract translation: 提供了包含式I化合物或其药学上可接受的盐的成像剂及其使用方法。 （一世）。