公开(公告)号：US20130079313A1

公开(公告)日：2013-03-28

申请号：US13627221

申请日：2012-09-26

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Elisabetta ARMANI ,  Gabriele Amari ,  Carmelida Capaldi ,  Oriana Esposito ,  Ilaria Peretto

IPC: C07D213/89 ,  C07D413/12 ,  A61K31/5377 ,  C07D401/12 ,  A61K31/496 ,  C07D417/12 ,  A61K31/4439 ,  C07D409/12 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/506 ,  A61K31/56 ,  A61P11/00 ,  A61P11/06 ,  A61K31/44

CPC classification number: A61K31/5377 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/496 ,  A61M15/0045 ,  A61M15/009 ,  A61M16/14 ,  C07D213/55 ,  C07D213/56 ,  C07D213/69 ,  C07D213/89 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

Abstract: The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

Abstract translation: 本发明涉及磷酸二酯酶4（PDE4）酶的抑制剂。 更具体地，本发明涉及作为1-苯基-2-吡啶基烷基醇的衍生物的化合物，制备这些化合物的方法，含有它们的组合物及其治疗用途。

公开(公告)号：US10023558B2

公开(公告)日：2018-07-17

申请号：US15712366

申请日：2017-09-22

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Jonathan Mark Sutton ,  Robert Andrew Heald ,  Andrew Stephen Robert Jennings ,  Carmelida Capaldi ,  Elisabetta Armani

IPC: C07D403/04 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  A61K31/454 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4196 ,  C07C309/29 ,  C07D403/14

Abstract: Compounds of formula (I) defined herein exhibit human neutrophil elastase inhibitory properties and are useful for the treatment of disease or conditions in which HNE is implicated.

公开(公告)号：US09944612B2

公开(公告)日：2018-04-17

申请号：US14097445

申请日：2013-12-05

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Elisabetta Armani ,  Gabriele Amari ,  Oriana Esposito ,  Laura Carzaniga ,  Carmelida Capaldi

IPC: A61K31/44 ,  A61K31/435 ,  A61K31/425 ,  C07D295/155 ,  A61M15/00 ,  A61M16/14 ,  C07D213/89 ,  C07D401/12 ,  C07D407/12 ,  C07D417/12 ,  C07D213/61

CPC classification number: C07D295/155 ,  A61M15/0065 ,  A61M15/009 ,  A61M16/14 ,  C07D213/61 ,  C07D213/89 ,  C07D401/12 ,  C07D407/12 ,  C07D417/12

Abstract: Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and are useful for the prevention and/or treatment of an allergic disease state or a disease of the respiratory tract characterized by airway obstruction.

公开(公告)号：US09931327B2

公开(公告)日：2018-04-03

申请号：US14863915

申请日：2015-09-24

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Elisabetta Armani ,  Gabriele Amari ,  Laura Carzaniga ,  Carmelida Capaldi ,  Oriana Esposito ,  Gino Villetti ,  Renato De Fanti

IPC: A61K31/4425 ,  C07D213/89 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  A61K45/06 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  C07D213/30 ,  A61K31/517 ,  A61K31/635 ,  C07D471/04 ,  C07D498/04

CPC classification number: A61K31/4425 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  A61K31/635 ,  A61K45/06 ,  C07D213/30 ,  C07D213/89 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D498/04

Abstract: Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme and the treatment of certain conditions such as COPD.

公开(公告)号：US09862706B2

公开(公告)日：2018-01-09

申请号：US15606064

申请日：2017-05-26

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Carmelida Capaldi ,  Elisabetta Armani ,  Andrew Stephen Robert Jennings

IPC: C07D403/04 ,  C07D233/86 ,  C07C309/29 ,  C07D231/22

CPC classification number: C07D403/04 ,  C07C309/29 ,  C07D231/22 ,  C07D233/86 ,  C07D401/14

Abstract: Imidazolone and pyrazolone derivatives of formula (I) described herein exhibit human neutrophil elastase inhibitory properties and are useful for the therapy of diseases and conditions in which HNE is implicated.

公开(公告)号：US09573955B2

公开(公告)日：2017-02-21

申请号：US14571755

申请日：2014-12-16

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Lilian Alcaraz ,  Jonathan Mark Sutton ,  Elisabetta Armani ,  Carmelida Capaldi

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Heterocyclic compounds and salts according to formula (I), which are pyrimidinone derivatives, described herein exhibit human neutrophil elastase inhibitory properties, and useful for treating diseases or conditions in which HNE is implicated.

Abstract translation: 本文所述的作为嘧啶酮衍生物的式（I）的杂环化合物和盐表现出人嗜中性粒细胞弹性蛋白酶抑制性质，并且可用于治疗涉及HNE的疾病或病症。

公开(公告)号：US09409870B2

公开(公告)日：2016-08-09

申请号：US14953183

申请日：2015-11-27

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Elisabetta Armani ,  Carmelida Capaldi ,  Jonathan Mark Sutton ,  Robert Andrew Heald

IPC: A61K31/513 ,  C07D233/70 ,  C07D403/04 ,  C07D405/14 ,  C07D403/14 ,  C07C309/29 ,  C07C53/06 ,  C07D401/14

CPC classification number: C07D233/70 ,  C07C53/06 ,  C07C309/29 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14

Abstract: Compounds of formula (I) described herein are imidazolone derivatives having human neutrophil elastase (HNE) inhibitory properties and are useful for the treatment of diseases and conditions in which HNE is implicated.

Abstract translation: 本文所述的式（I）化合物是具有人嗜中性粒细胞弹性蛋白酶（HNE）抑制性质的咪唑啉酮衍生物，可用于治疗涉及HNE的疾病和病症。

公开(公告)号：US09359354B2

公开(公告)日：2016-06-07

申请号：US14296730

申请日：2014-06-05

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Chi-Kit Woo ,  Lilian Alcaraz ,  Carmelida Capaldi

IPC: A61K31/44 ,  C07D471/02 ,  C07D471/10 ,  C07D471/04

CPC classification number: C07D471/10 ,  C07D471/04

Abstract: Compounds of formula (I) described herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

公开(公告)号：US20160008338A1

公开(公告)日：2016-01-14

申请号：US14863915

申请日：2015-09-24

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Elisabetta ARMANI ,  Gabriele Amari ,  Laura Carzaniga ,  Carmelida Capaldi ,  Oriana Esposito ,  Gino Villetti ,  Renato De Fanti

IPC: A61K31/4425 ,  C07D401/12 ,  A61K31/4439 ,  C07D417/12 ,  C07D413/12 ,  A61K31/5377 ,  A61K31/4545 ,  A61K31/541 ,  A61K31/496 ,  C07D405/14 ,  C07D417/14 ,  A61K31/517 ,  A61K31/538 ,  C07D498/04 ,  C07D471/04 ,  A61K31/635 ,  A61K45/06 ,  C07D213/89

CPC classification number: A61K31/4425 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  A61K31/635 ,  A61K45/06 ,  C07D213/30 ,  C07D213/89 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D498/04

Abstract: Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme and the treatment of certain conditions such as COPD.

公开(公告)号：US20130324501A1

公开(公告)日：2013-12-05

申请号：US13909222

申请日：2013-06-04

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Elisabetta ARMANI ,  Carmelida Capaldi ,  Laura Carzaniga ,  Oriana Esposito

IPC: C07D401/12 ,  A61K45/06 ,  A61K31/4436 ,  A61K31/5377 ,  C07D409/12 ,  A61K31/4439

CPC classification number: C07D401/12 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/5377 ,  A61K45/06 ,  C07D409/12

Abstract: Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols according to formula (I) are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme.

Abstract translation: 根据式（I）的1-苯基-2-吡啶基烷基醇的衍生物可用作磷酸二酯酶4（PDE4）酶的抑制剂。