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11.发明授权Benzothiophene compounds, intermediates, processes, compositions, and methods 失效苯并噻吩化合物，中间体，工艺，组合物和方法
公开(公告)号：US5843963A
公开(公告)日：1998-12-01
申请号：US933800
申请日：1997-09-19
IPC分类号： A61K31/38 , A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/4433 , A61K31/445 , A61K31/4535 , A61K31/535 , A61K31/55 , A61P3/06 , A61P9/00 , A61P15/08 , A61P19/10 , A61P43/00 , C07D333/66 , C07D409/12 , C07D333/64 , C07D409/10
CPC分类号： C07D333/66
摘要： The invention provides benzothiophene compounds, of formula I, ##STR1## wherein R1, R2, R3, R4 and n are as defined in the specification, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological conditions, including hyperlipidemia, and other cardiovascular pathologies.
摘要翻译： 本发明提供式I的苯并噻吩化合物，其中R1，R2，R3，R4和n如说明书中所定义，制剂和抑制骨丢失或骨吸收，特别是骨质疏松症和心血管相关病理学的方法 病情，包括高脂血症和其他心血管病变。
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12.发明授权Compounds, methods and formulations for the oral delivery of a glucagon-like peptide (GLP-1) compound or a melanocortin-4 receptor (MC4) agonist peptide 有权用于口服递送胰高血糖素样肽（GLP-1）化合物或黑皮质素-4受体（MC4）激动剂肽的化合物，方法和制剂公开(公告)号：US08552039B2
公开(公告)日：2013-10-08
申请号：US12636244
申请日：2009-12-11
申请人： Robert Jason Herr , Louis Nickolaus Jungheim , John McNeil McGill , Kenneth Jeff Thrasher , Muralikrishna Valluri
发明人： Robert Jason Herr , Louis Nickolaus Jungheim , John McNeil McGill , Kenneth Jeff Thrasher , Muralikrishna Valluri
IPC分类号： A61K31/421 , C07D263/34
CPC分类号： C07D263/48 , A61K31/4164 , A61K38/22 , A61K38/26 , A61K47/22 , C07D233/64 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/24 , C07D285/12 , C07D409/04 , C07D413/04
摘要： The present invention relates to novel compounds, methods, and formulations useful for the oral delivery of a GLP-1 compound or an MC4 agonist peptide.
摘要翻译： 本发明涉及可用于口服递送GLP-1化合物或MC4激动剂肽的新化合物，方法和制剂。
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13.发明授权Compounds, methods and formulations for the oral delivery of a glucagon-like peptide (Glp)-1 compound or a melanocortin-4 receptor (Mc4) agonist peptide 有权用于口服递送胰高血糖素样肽（Glp）-1化合物或黑皮质素-4受体（Mc4）激动剂肽的化合物，方法和制剂公开(公告)号：US08546581B2
公开(公告)日：2013-10-01
申请号：US13087255
申请日：2011-04-14
申请人： Louis Nickolaus Jungheim , John Mcneill McGill, III , Kenneth Jeff Thrasher , Robert Jason Herr , Muralikrishna Valluri
发明人： Louis Nickolaus Jungheim , John Mcneill McGill, III , Kenneth Jeff Thrasher , Robert Jason Herr , Muralikrishna Valluri
IPC分类号： C07D271/06 , C07D401/00 , C07D409/00
CPC分类号： C07D233/64 , A61K47/22 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/24 , C07D285/12 , C07D409/04 , C07D413/04
摘要： The present application relates to novel compounds, methods and formulations useful for the oral delivery of a glucagon like peptide-1 compound or a melanocortin 4 receptor agonist peptide.
摘要翻译： 本申请涉及可用于胰高血糖素样肽-1化合物或黑皮质素4受体激动剂肽的口服递送的新化合物，方法和制剂。
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14.发明授权Compounds, methods and formulations for the oral delivery of a glucagon-like peptide (GLP)-1 compound or a melanocortin-4 receptor (MC4) agonist peptide 有权胰高血糖素样肽（GLP）-1化合物或黑皮质素-4受体（MC4）激动剂肽的口服递送的化合物，方法和制剂公开(公告)号：US07947841B2
公开(公告)日：2011-05-24
申请号：US12263722
申请日：2008-11-03
申请人： Louis Nickolaus Jungheim , John McNeill McGill, III , Kenneth Jeff Thrasher , Robert Jason Herr , Valluri Muralikrishna
发明人： Louis Nickolaus Jungheim , John McNeill McGill, III , Kenneth Jeff Thrasher , Robert Jason Herr , Valluri Muralikrishna
IPC分类号： C07D263/34 , C07D213/00 , C07D409/00
CPC分类号： C07D233/64 , A61K47/22 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/24 , C07D285/12 , C07D409/04 , C07D413/04
摘要： The present application relates to novel compounds, methods and formulations useful for the oral delivery of a glucagon like peptide-1 compound or a melanocortin 4 receptor agonist peptide.
摘要翻译： 本申请涉及可用于胰高血糖素样肽-1化合物或黑皮质素4受体激动剂肽的口服递送的新化合物，方法和制剂。
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15.发明授权公开(公告)号：US06258826B1
公开(公告)日：2001-07-10
申请号：US09388340
申请日：1999-09-01
IPC分类号： A61K31445
CPC分类号： A61K31/381 , A61K31/38 , A61K31/40 , A61K31/445 , A61K2300/00
摘要： Formulations and applications thereof are described which are useful for the inhibition of various medical conditions associated with estrogen deprivation syndrome including osteoporosis and hyperlipidemia utilizing compounds of structure I represented by the following structure in combination with compounds of formula II represented by the following structure where X, Y, R, R′, R6, R7 and R8 are as defined herein.
摘要翻译： 描述了其制剂和应用，其可用于抑制与雌激素剥夺综合征（包括骨质疏松症和高脂血症）相关的各种医学病症，其利用由以下结构表示的结构I的化合物与由以下结构表示的式II化合物组合，其中X，Y， R，R'，R 6，R 7和R 8如本文所定义。
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16.发明申请Compounds, Methods and Formulations for the Oral Delivery of a Glucagon-Like Peptide (Glp)-1 Compound or a Melanocortin-4 Receptor (Mc4) Agonist Peptide 有权口服胰岛素样肽（Glp）-1化合物或黑皮质素-4受体（Mc4）激动剂肽的口服递送的化合物，方法和制剂公开(公告)号：US20090239798A1
公开(公告)日：2009-09-24
申请号：US12263722
申请日：2008-11-03
申请人： Louis Nickolaus Jungheim , John McNeill McGill, III , Kenneth Jeff Thrasher , Robert Jason Herr , Muralikrishna Valluri
发明人： Louis Nickolaus Jungheim , John McNeill McGill, III , Kenneth Jeff Thrasher , Robert Jason Herr , Muralikrishna Valluri
IPC分类号： A61K38/22 , C07D413/04 , A61K38/12
CPC分类号： C07D233/64 , A61K47/22 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/24 , C07D285/12 , C07D409/04 , C07D413/04
摘要： The present application relates to novel compounds, methods and formulations useful for the oral delivery of a glucagon like peptide-1 compound or a melanocortin 4 receptor agonist peptide.
摘要翻译： 本申请涉及可用于胰高血糖素样肽-1化合物或黑皮质素4受体激动剂肽的口服递送的新化合物，方法和制剂。
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17.发明申请Compounds, Methods and Formulations for the Oral Delivery of a Glucagon-Like Peptide (Glp)-1 Compound or a Melanocortin-4 Receptor (Mc4) Agonist Peptide 有权口服胰岛素样肽（Glp）-1化合物或黑皮质素-4受体（Mc4）激动剂肽的口服递送的化合物，方法和制剂公开(公告)号：US20080214448A1
公开(公告)日：2008-09-04
申请号：US10566342
申请日：2004-08-18
申请人： Robert Jason Herr , Louis Nickolaus Jungheim , John McNeill McGill , Kenneth Jeff Thrasher , Muralikrishna Valluri
发明人： Robert Jason Herr , Louis Nickolaus Jungheim , John McNeill McGill , Kenneth Jeff Thrasher , Muralikrishna Valluri
IPC分类号： A61K38/22 , C07D277/30 , C07D263/44 , C07D233/56 , A61P43/00
CPC分类号： C07D263/48 , A61K31/4164 , A61K38/22 , A61K38/26 , A61K47/22 , C07D233/64 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/24 , C07D285/12 , C07D409/04 , C07D413/04
摘要： The present invention relates to novel compounds, methods, and formulations useful for the oral delivery of a GLP-1 compound or an MC4 agonist peptide.
摘要翻译： 本发明涉及可用于口服递送GLP-1化合物或MC4激动剂肽的新化合物，方法和制剂。
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公开(公告)号：US07125840B2
公开(公告)日：2006-10-24
申请号：US10380867
申请日：2001-10-09
申请人： Jeffrey Alan Dodge , Britta Evers , Louis Nickolaus Jungheim , Brian Stephen Muehl , Gerd Ruehter , Kenneth Jeff Thrasher
发明人： Jeffrey Alan Dodge , Britta Evers , Louis Nickolaus Jungheim , Brian Stephen Muehl , Gerd Ruehter , Kenneth Jeff Thrasher
IPC分类号： A01N37/18
CPC分类号： C07D275/06 , A61K31/4015 , A61K31/4025 , A61K31/404 , A61K31/425 , C07D209/54 , C07D401/10 , C07D409/04 , C07D409/10 , C07D417/04 , C07D417/06 , C07D417/10
摘要： This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
摘要翻译： 本发明涉及可用于调节哺乳动物内源性生长激素水平的新化合物。 本发明还涉及用于合成所述化合物的新中间体，以及在这些合成中使用的新方法。 还包括治疗哺乳动物的方法，其包括施用所述化合物。
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公开(公告)号：US06743794B2
公开(公告)日：2004-06-01
申请号：US10130800
申请日：2002-05-21
申请人： Rosanne Bonjouklian , Jeffrey Daniel Cohen , Joseph Michael Gruber , Douglas Webb Johnson , Louis Nickolaus Jungheim , Julian Stanley Kroin , Peter Ambrose Lander , Ho-Shen Lin , Mark Christopher Lohman , Brian Stephen Muehl , Bryan Hurst Norman , Vinod Francis Patel , Michael Enrico Richett , Kenneth Jeff Thrasher , Sreenivasarao Vepachedu , Wesley Todd White , Yongping Xie , Jeremy Schulenburg York , Brandon Lee Parkhurst , Qiupang Wang
发明人： Rosanne Bonjouklian , Jeffrey Daniel Cohen , Joseph Michael Gruber , Douglas Webb Johnson , Louis Nickolaus Jungheim , Julian Stanley Kroin , Peter Ambrose Lander , Ho-Shen Lin , Mark Christopher Lohman , Brian Stephen Muehl , Bryan Hurst Norman , Vinod Francis Patel , Michael Enrico Richett , Kenneth Jeff Thrasher , Sreenivasarao Vepachedu , Wesley Todd White , Yongping Xie , Jeremy Schulenburg York , Brandon Lee Parkhurst , Qiupang Wang
IPC分类号： A61K31496
CPC分类号： C07D471/04
摘要： The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).
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20.发明授权
公开(公告)号：US6087378A
公开(公告)日：2000-07-11
申请号：US388307
申请日：1999-09-01
IPC分类号： C07D333/62 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/445 , A61K31/4453 , A61P3/06 , A61P5/30 , A61P19/10 , A61P25/28 , C07D333/64 , A61K31/44
CPC分类号： A61K31/381 , A61K31/38 , A61K31/40 , A61K31/445
摘要： Formulations and applications thereof are described which are useful for the inhibition of various medical conditions associated with estrogen deprivation syndrome including osteoporosis and hyperlipidemia utilizing compounds represented by the following structure where X is a halogen. ##STR1##
摘要翻译： 描述了其制备和应用，其可用于利用由以下结构表示的化合物抑制与雌激素剥夺综合征（包括骨质疏松症和高脂血症）相关的各种医学病症，其中X为卤素。
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