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公开(公告)号：US20100167391A1
公开(公告)日：2010-07-01
申请号：US12107571
申请日：2008-04-22
申请人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberty E. Shoemaker , Debra G. Gilbertson , James W. West
发明人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberty E. Shoemaker , Debra G. Gilbertson , James W. West
IPC分类号： C12N5/071
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US07387885B2
公开(公告)日：2008-06-17
申请号：US11021088
申请日：2004-12-22
申请人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
发明人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
IPC分类号： C12N15/12
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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13.发明授权Methods for promoting growth of bone, ligament, and cartilage using zvegf4 有权使用zvegf4促进骨，韧带和软骨生长的方法公开(公告)号：US07192592B2
公开(公告)日：2007-03-20
申请号：US10910938
申请日：2004-08-03
CPC分类号： C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective amount of zvegf4 in combination with a pharmaceutically acceptable delivery vehicle. Also disclosed are methods for promoting proliferation or differentiation of osteoblasts, osteoclasts, chondrocytes, or bone marrow stem cells comprising culturing the cells in an effective amount of zvegf4.
摘要翻译： 公开了促进哺乳动物骨，韧带或软骨生长的方法。 所述方法包括向所述哺乳动物施用包含药理学有效量的zvegf4与药学上可接受的递送载体组合的组合物。 还公开了促进成骨细胞，破骨细胞，软骨细胞或骨髓干细胞的增殖或分化的方法，包括以有效量的zvegf4培养细胞。
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公开(公告)号：US06962802B2
公开(公告)日：2005-11-08
申请号：US09876813
申请日：2001-06-06
IPC分类号： A61K38/00 , A61K38/18 , A61K38/19 , C07K14/52 , C12N15/09 , A61K38/24 , A61K38/27 , C07H21/04 , C12N15/00
CPC分类号： C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基52-179或SEQ ID NO：2的残基258-370至少70％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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15.发明授权Methods for promoting growth of bone, ligament, and cartilage using zvegf4 有权使用zvegf4促进骨，韧带和软骨生长的方法公开(公告)号：US06866991B2
公开(公告)日：2005-03-15
申请号：US10226559
申请日：2002-08-23
CPC分类号： C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective amount of zvegf4 in combination with a pharmaceutically acceptable delivery vehicle. Also disclosed are methods for promoting proliferation or differentiation of osteoblasts, osteoclasts, chondrocytes, or bone marrow stem cells comprising culturing the cells in an effective amount of zvegf4.
摘要翻译： 公开了促进哺乳动物骨，韧带或软骨生长的方法。 所述方法包括向所述哺乳动物施用包含药理学有效量的zvegf4与药学上可接受的递送载体组合的组合物。 还公开了促进成骨细胞，破骨细胞，软骨细胞或骨髓干细胞的增殖或分化的方法，包括以有效量的zvegf4培养细胞。
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公开(公告)号：US08052976B2
公开(公告)日：2011-11-08
申请号：US12107571
申请日：2008-04-22
申请人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberty E. Shoemaker , Debra G. Gilbertson , James W. West
发明人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberty E. Shoemaker , Debra G. Gilbertson , James W. West
IPC分类号： A61K38/18
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US07597883B2
公开(公告)日：2009-10-06
申请号：US11552848
申请日：2006-10-25
CPC分类号： C07K14/52 , A01K2217/05 , A61K9/2027 , A61K38/1858 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44 , A61L24/108 , A61L27/02 , A61L27/14 , A61L27/227 , A61L27/52 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2300/43 , A61L2430/02 , A61L2430/10 , A61L2430/12 , C07K14/475 , C12N2799/022 , G01N2001/2223 , A61K2300/00
摘要： Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective amount of a zvegf3 protein in combination with a pharmaceutically acceptable delivery vehicle. Also disclosed are methods for promoting proliferation or differentiation of osteoblasts, osteoclasts, chondrocytes, or bone marrow stem cells comprising culturing the cells in an effective amount of a zvegf3 protein.
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公开(公告)号：US07323446B2
公开(公告)日：2008-01-29
申请号：US11550246
申请日：2006-10-17
CPC分类号： C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基52-179或SEQ ID NO：2的残基258-370至少70％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US06663870B2
公开(公告)日：2003-12-16
申请号：US09823033
申请日：2001-03-29
IPC分类号： A61K3818
CPC分类号： C07K14/52 , A01K2217/05 , A61K9/2027 , A61K38/1858 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44 , A61L24/108 , A61L27/02 , A61L27/14 , A61L27/227 , A61L27/52 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2300/43 , A61L2430/02 , A61L2430/10 , A61L2430/12 , C07K14/475 , C12N2799/022 , G01N2001/2223 , A61K2300/00
摘要： Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective amount of a zvegf3 protein in combination with a pharmaceutically acceptable delivery vehicle. Also disclosed are methods for promoting proliferation or differentiation of osteoblasts, osteoclasts, chondrocytes, or bone marrow stem cells comprising culturing the cells in an effective amount of a zvegf3 protein.
摘要翻译： 公开了促进哺乳动物骨，韧带或软骨生长的方法。 所述方法包括向所述哺乳动物施用包含药理学有效量的zvegf3蛋白与药学上可接受的递送载体组合的组合物。 还公开了促进成骨细胞，破骨细胞，软骨细胞或骨髓干细胞的增殖或分化的方法，包括以有效量的zvegf3蛋白培养细胞。
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公开(公告)号：US06528050B1
公开(公告)日：2003-03-04
申请号：US09706968
申请日：2000-11-06
申请人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
发明人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
IPC分类号： A61K4500
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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