公开(公告)号：US09177770B2

公开(公告)日：2015-11-03

申请号：US12763092

申请日：2010-04-19

申请人： Mark A. Osgood ,  Ching Wu

发明人： Mark A. Osgood ,  Ching Wu

IPC分类号： H01J49/06 ,  G01N27/62 ,  C07B63/00

CPC分类号： H01J49/061 ,  C07B63/00 ,  G01N27/622 ,  Y10T29/49227

摘要： The present invention generally relates to systems and methods for transmitting beams of charged particles, and in particular to such systems and methods that employ defecting at least one set of grid elements into the same plane to form an ion gate. In addition, an operation method of closing a gate involving alternating voltages on the adjacent gate wires is described.

摘要翻译： 本发明一般涉及用于传送带电粒子束的系统和方法，特别涉及这样的系统和方法，该系统和方法使用将至少一组栅格元件缺陷到同一平面中以形成离子门。 此外，描述了在相邻栅极线上闭合涉及交流电压的栅极的操作方法。

公开(公告)号：US09024255B2

公开(公告)日：2015-05-05

申请号：US12764808

申请日：2010-04-21

申请人： Mark A. Osgood ,  Ching Wu

发明人： Mark A. Osgood ,  Ching Wu

IPC分类号： H01J49/00 ,  C07B63/00 ,  G01N27/62

CPC分类号： H01J49/004 ,  C07B63/00 ,  G01N27/622 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0495 ,  H01J49/067

摘要： The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching machenism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used.

摘要翻译： 本发明涉及提高连字的仪器分析从具有第一仪器对相同样品的分析而受益的样品的能力。 快速切换宏观主义可以用作离子迁移谱仪（IMS）和质谱仪（MS）之间的界面，使得所获得的IMS光谱被转换成时序图，其在中性分析期间动态地控制真空入口的尺寸， /或带电的化学和/或生物物质，使得可以使用较小的泵送系统。

公开(公告)号：US11024497B2

公开(公告)日：2021-06-01

申请号：US16808353

申请日：2020-03-03

申请人： Ching Wu ,  Mark A. Osgood

发明人： Ching Wu ,  Mark A. Osgood

IPC分类号： H01J49/06 ,  H01J49/00 ,  C07B63/00 ,  G01N27/622

摘要： An ion mobility spectrometry apparatus and method used to separate ions and select some of the ions using an AC gate; the selected ions are further separated along a drift axis of a drift tube, where the AC gate is controlled using a series of AC voltages and/or frequencies to select different ions for the drift tube.

公开(公告)号：US20190259595A1

公开(公告)日：2019-08-22

申请号：US16396715

申请日：2019-04-28

申请人： Ching Wu ,  Mark A. Osgood

发明人： Ching Wu ,  Mark A. Osgood

IPC分类号： H01J49/06 ,  G01N27/62 ,  C07B63/00 ,  H01J49/00

摘要： An ion mobility spectrometry apparatus and method used to separate ions and select some of the ions using an AC gate; the selected ions are further separated along a drift axis of a drift tube, where the AC gate is controlled using a series of AC voltages and/or frequencies to select different ions for the drift tube.

公开(公告)号：US20160196964A1

公开(公告)日：2016-07-07

申请号：US14992053

申请日：2016-01-11

申请人： Ching Wu ,  Mark A. Osgood

发明人： Ching Wu ,  Mark A. Osgood

IPC分类号： H01J49/06 ,  G01N27/62 ,  H01J49/00

CPC分类号： H01J49/061 ,  C07B63/00 ,  G01N27/622 ,  H01J49/0027

摘要： The present invention uses an AC voltage instead of DC voltage on an ion gate to filter/selectively pass ions. The ions that pass through the AC ion gate can be further separated in a spectrometric instrument. An ion mobility spectrometer using the AC ion gate can achieve better gating performance. For a time of flight ion mobility spectrometer with an AC ion gate, a narrow pulse of selected ions can be passed into a drift tube where they are separated based on their low field ion mobility. Moreover, when the AC voltage at the AC ion gate has a waveform as used for differential ion mobility spectrometry, the time of flight ion mobility spectrometer is converted into a two dimensional separation spectrometer, where ions are first separated based on their high field ion mobility and then further separated based on their low field ion mobility.

摘要翻译： 本发明在离子浇口上使用交流电压而不是直流电压来过滤/选择性地通过离子。 通过AC离子浇口的离子可以在光谱仪器中进一步分离。 使用AC离子浇口的离子迁移谱仪可以获得更好的门控性能。 对于具有AC离子浇口的飞行时间离子迁移谱仪，选择的离子的窄脉冲可以被传送到漂移管中，基于它们的低场离子迁移率，它们被分离。 此外，当AC离子浇口处的AC电压具有用于差示离子迁移率光谱法的波形时，将飞行时间离子迁移谱仪转换成二维分离光谱仪，其中离子首先基于它们的高场离子迁移率而被分离 然后基于它们的低场离子迁移率进一步分离。

公开(公告)号：US20100200746A1

公开(公告)日：2010-08-12

申请号：US12764808

申请日：2010-04-21

申请人： Mark A. Osgood ,  Ching Wu

发明人： Mark A. Osgood ,  Ching Wu

IPC分类号： H01J49/26 ,  H01J49/04

CPC分类号： H01J49/004 ,  C07B63/00 ,  G01N27/622 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0495 ,  H01J49/067

摘要： The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used.

摘要翻译： 本发明涉及提高连字的仪器分析从具有第一仪器对相同样品的分析而受益的样品的能力。 可以将快速切换机制用作离子迁移谱仪（IMS）和质谱仪（MS）之间的界面，使得所获得的IMS光谱被转换成时序图，其在中性分析期间动态地控制真空入口的尺寸， /或带电的化学和/或生物物质，使得可以使用较小的泵送系统。

公开(公告)号：US20170365454A1

公开(公告)日：2017-12-21

申请号：US15665421

申请日：2017-07-31

申请人： Ching Wu ,  Mark A. Osgood

发明人： Ching Wu ,  Mark A. Osgood

IPC分类号： H01J49/06 ,  C07B63/00 ,  G01N27/62 ,  H01J49/00

CPC分类号： H01J49/061 ,  C07B63/00 ,  G01N27/622 ,  H01J49/0027

摘要： An ion mobility spectrometry apparatus and method wherein ions are selected using an AC gate, then separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis.

公开(公告)号：US20100224695A1

公开(公告)日：2010-09-09

申请号：US12719831

申请日：2010-03-08

申请人： Ching Wu ,  Mark A. Osgood ,  Christopher Hilton

发明人： Ching Wu ,  Mark A. Osgood ,  Christopher Hilton

IPC分类号： B05B5/025

CPC分类号： B05B5/001 ,  B05B5/0255 ,  H01J49/0468 ,  H01J49/165

摘要： The present invention is a method and apparatus to keep the electrospray ionization at a lower temperature than the heated chamber where the desolvation process occurs. The means to cool the electrosprayer is by actively removing heat from the apparatus through heat transfer methods. This apparatus and method can be used with any ionization apparatus at high temperatures preventing the ionization source from reaching a high temperature that may hinter the normal operation.

摘要翻译： 本发明是一种将电喷雾​​电离保持在比发生去溶剂化过程的加热室低的温度的方法和装置。 冷却电喷雾器的方法是通过热传递方法主动地从装置中去除热量。 该装置和方法可以在高温下与任何电离装置一起使用，防止电离源达到可能使正常操作的高温。

公开(公告)号：US20100132561A1

公开(公告)日：2010-06-03

申请号：US12698047

申请日：2010-02-01

申请人： Leslie Bromberg ,  Ching Wu ,  Mark A. Osgood

发明人： Leslie Bromberg ,  Ching Wu ,  Mark A. Osgood

IPC分类号： B03C3/011 ,  H01J49/02

CPC分类号： G01N1/14 ,  G01N2001/022 ,  G01N2001/028 ,  G01T1/00

摘要： The present invention describes directly using particles collected with an electrostatic precipitator for the detection of explosives and other compounds of interest. The method and apparatus of analyzing particles involves directly measuring particles on the collection electrodes or thermally desorbing them into an ion mobility spectrometer and/or other analytical instruments. One aspect of the present invention is a particulate charging method. Another aspect of the present invention provides a means of high charging of the particulates while minimizing their collection in the charging stage. The present invention also provides a means for efficiently collecting the particulates in a second stage for sampling in a compact electrode.

摘要翻译： 本发明直接使用用静电除尘器收集的颗粒来检测爆炸物和其它感兴趣的化合物。 分析颗粒的方法和装置包括直接测量收集电极上的颗粒或将其热解吸到离子迁移谱仪和/或其他分析仪器中。 本发明的一个方面是颗粒充电方法。 本发明的另一方面提供了一种在充电阶段最小化其收集的微粒的高充电的方法。 本发明还提供了用于在紧凑型电极中进行采样的第二级中有效收集微粒的装置。