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公开(公告)号:US07622555B2
公开(公告)日:2009-11-24
申请号:US10706691
申请日:2003-11-12
申请人: Andrew Robert Davids , Richard Joseph Fagan , Christopher Benjamin Phelps , Christine Power , Yolande Chvatchko , Ursula Boschert
发明人: Andrew Robert Davids , Richard Joseph Fagan , Christopher Benjamin Phelps , Christine Power , Yolande Chvatchko , Ursula Boschert
CPC分类号: C07K14/70503
摘要: This invention relates to a novel protein (INSP052), herein identified as an immunoglobulin domain-containing cell surface recognition molecule and to the use of this proteins and nucleic acid sequences from the encoding gene in the diagnosis, prevention and treatment of disease. The invention also relates to the identification of the extracellular domain of INSP052.
摘要翻译: 本发明涉及本文鉴定为含有免疫球蛋白结构域的细胞表面识别分子的新型蛋白质(INSP052),以及来自编码基因的该蛋白质和核酸序列在诊断,预防和治疗疾病中的用途。 本发明还涉及INSP052细胞外结构域的鉴定。
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公开(公告)号:US20090214548A1
公开(公告)日:2009-08-27
申请号:US11721291
申请日:2005-12-08
IPC分类号: A61K39/395 , A61K39/00 , A61K35/00 , A61K38/43 , C12Q1/68 , G01N33/53 , C40B40/06 , A61K38/08 , A61K38/10 , A61K38/16 , A61K31/7088 , C07K14/435 , A01K67/00
CPC分类号: C07K14/71 , A61K38/00 , G01N33/74 , G01N2333/71
摘要: There are provided proteins containing a domain corresponding to the C-terminal half of a ZP domain similar to that identified in TGF-beta Receptor III and the use of the proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of diseases. In particular, the present invention relates to the use of the disclosed proteins for modulating the activity of proteins belonging to the TGF-beta superfamily.
摘要翻译: 提供的蛋白质含有对应于与TGF-β受体III中鉴定的ZP结构域的C末端半部分相关的结构域,以及来自编码基因的蛋白质和核酸序列在诊断,预防和治疗中的用途 疾病 特别地,本发明涉及所公开的蛋白质用于调节属于TGF-β超家族的蛋白质的活性的用途。
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公开(公告)号:US07557079B2
公开(公告)日:2009-07-07
申请号:US10539847
申请日:2003-12-23
申请人: Richard Joseph Fagan , Christopher Benjamin Phelps , Christine Power , Richard James Mitter , Ursula Boschert , Yolande Chvatchko
发明人: Richard Joseph Fagan , Christopher Benjamin Phelps , Christine Power , Richard James Mitter , Ursula Boschert , Yolande Chvatchko
CPC分类号: C12N9/6489 , C12N15/52
摘要: This invention relates to proteins termed INSP005a and INSP005b, herein identified as secreted proteins, in particular members of the metalloprotease family and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.
摘要翻译: 本发明涉及称为INSP005a和INSP005b的蛋白质,在本文中鉴定为分泌蛋白质,特别是金属蛋白酶家族的成员,以及来自编码基因的这些蛋白质和核酸序列在诊断,预防和治疗疾病中的用途。
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公开(公告)号:US20090068173A1
公开(公告)日:2009-03-12
申请号:US11722033
申请日:2005-12-19
IPC分类号: A61K39/395 , C12P21/02 , A61K39/00 , G01N33/536 , G01N33/68 , G01N33/50
CPC分类号: C07K14/43527 , Y10T436/143333
摘要: A novel CC-chemokine binding protein is isolated from the saliva of Rhipicephalus sanguineus. Compounds prepared in accordance with the present invention can be used as anti-inflammatory compounds and in the treatment or prevention of CC-chemokine-related diseases.
摘要翻译: 从R us唾液中分离出一种新型CC-趋化因子结合蛋白。 根据本发明制备的化合物可用作抗炎化合物和用于治疗或预防CC趋化因子相关疾病。
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公开(公告)号:US07341851B2
公开(公告)日:2008-03-11
申请号:US11062093
申请日:2005-02-18
CPC分类号: C07K14/521
摘要: This present invention relates to a novel protein, termed INSP085, herein identified as an IL-8 like protein and to the use of this protein and nucleic acid sequence from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及一种称为INSP085的新型蛋白质,在本文中被鉴定为IL-8样蛋白质,以及来自编码基因的该蛋白质和核酸序列在诊断,预防和治疗疾病中的用途。
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公开(公告)号:US20070224125A1
公开(公告)日:2007-09-27
申请号:US10583218
申请日:2004-12-21
IPC分类号: A61K39/02 , A01K67/027 , A61K49/00 , C07H21/04 , C07K14/195 , C07K16/12 , C12N15/63 , C12N5/10 , C12P21/02 , C12Q1/68
CPC分类号: C07K14/43527
摘要: A novel CC-chemokine binding protein is isolated from the saliva of Rhipicephalus sanguineus. Compounds prepared in accordance with the present invention can be used as anti-inflammatory compounds and in the treatment or prevention of CC-chemokine-related diseases.
摘要翻译: 从R us唾液中分离出一种新型CC-趋化因子结合蛋白。 根据本发明制备的化合物可用作抗炎化合物和用于治疗或预防CC趋化因子相关疾病。
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公开(公告)号:US20060252117A1
公开(公告)日:2006-11-09
申请号:US10539847
申请日:2003-12-23
申请人: Richard Fagan , Christopher Phelps , Christine Power , Richard Mitter , Ursula Boschert , Yolande Chvatchko
发明人: Richard Fagan , Christopher Phelps , Christine Power , Richard Mitter , Ursula Boschert , Yolande Chvatchko
CPC分类号: C12N9/6489 , C12N15/52
摘要: This invention relates to proteins termed INSPOO5a and INSPOO5b, herein identified as secreted proteins, in particular members of the metalloprotease family and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.
摘要翻译: 本发明涉及称为INSPOO5a和INSPOO5b的蛋白质,这里鉴定为分泌蛋白质,特别是金属蛋白酶家族的成员,以及来自编码基因的这些蛋白质和核酸序列在诊断,预防和治疗疾病中的用途。
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公开(公告)号:US20100303760A9
公开(公告)日:2010-12-02
申请号:US11912432
申请日:2006-04-20
IPC分类号: A61K38/21 , A61K38/00 , A61K31/7088 , A61P31/00 , A61P19/00 , A61K39/395 , A61K35/12
CPC分类号: A61K38/191 , A61K38/1793 , A61K2300/00
摘要: The invention relates to the use of INSP163 for treatment and/or prevention of cancer and/or musculoskeletal/connective tissue disorder, in particular of lung cancer and/or osteoarthritis. Combinations of INSP163 with an interferon, a TNF antagonist or a further anti-cancer or anti-arthritis agent are also within the present invention.
摘要翻译: 本发明涉及INSP163用于治疗和/或预防癌症和/或肌肉骨骼/结缔组织病症,特别是肺癌和/或骨关节炎的用途。 INSP163与干扰素,TNF拮抗剂或其它抗癌或抗关节炎药物的组合也在本发明的范围内。
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公开(公告)号:US20090104197A1
公开(公告)日:2009-04-23
申请号:US11718183
申请日:2005-10-28
IPC分类号: A61K39/395 , C12Q1/68 , A61K39/02 , C40B40/08 , G01N33/53 , C07K14/00 , A61K35/00 , A61K31/7088 , A61K38/16
CPC分类号: C07K14/70503 , A61K38/00 , Y02A50/469
摘要: This invention relates to novel proteins (herein termed INSP141, INSP142, INSP143, and INSP144), herein identified as anthrax receptor-like proteins containing von Willebrand factor A (vWFA) and Anthrax receptor extracellular (ANT_IG) domains and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及新型蛋白质(本文称为INSP141,INSP142,INSP143和INSP144),其被鉴定为含有血管性血友病因子A(vWFA)和炭疽芽孢杆菌受体胞外(ANT_IG)结构域的炭疽受体样蛋白质,以及这些蛋白质的使用 和来自编码基因的核酸序列在疾病的诊断,预防和治疗中。
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公开(公告)号:US20090042775A1
公开(公告)日:2009-02-12
申请号:US10539656
申请日:2004-01-13
CPC分类号: C07K14/4723
摘要: This invention relates to novel proteins, termed INSP 108 and INSP 109, herein identified as members of the defensin family of proteins and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及称为INSP 108和INSP 109的新型蛋白质,其在本文中被鉴定为蛋白质防卫素家族的成员,以及来自编码基因的这些蛋白质和核酸序列在诊断,预防和治疗疾病中的用途。
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