公开(公告)号：US07585679B1

公开(公告)日：2009-09-08

申请号：US12036147

申请日：2008-02-22

Applicant: Yan Liu ,  Kannan Srinivasan ,  Christopher A. Pohl ,  Sheetal Bhardwaj ,  Zhongqing Lu

Inventor： Yan Liu ,  Kannan Srinivasan ,  Christopher A. Pohl ,  Sheetal Bhardwaj ,  Zhongqing Lu

IPC: G01N30/02

CPC classification number: B01D15/10 ,  G01N30/26 ,  G01N30/96 ,  G01N2030/965

Abstract: A chromatographic method including chromatographically separating sample ionic species in an eluent stream, detecting the separated sample ionic species, catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide in a catalytic gas elimination chamber, and recycling the effluent stream from the chamber to the chromatography separation column. The residence time between the detector and the chamber is at least about one minute. Also, flowing the recycle sequentially through two detector effluent flow channels of an electrolytic membrane suppressor. Also, applying heat or UV energy between the detector and the chamber. Also, detecting bubbles after the chamber. Also, a Platinum group metal catalyst and ion exchange medium in the chamber. Apparatus for performing the methods.

Abstract translation: 一种色谱方法，包括在洗脱液流中色谱分离样品离子物质，检测分离的样品离子物质，催化结合氢气和氧气，或催化分解催化气体消除室中的过氧化氢，并将来自室的流出物流再循环至色谱 分离柱。 检测器和腔室之间的停留时间至少约1分钟。 此外，使循环物依次流过电解膜抑制器的两个检测器流出物流动通道。 此外，在检测器和室之间施加热或UV能量。 另外，在室后检测气泡。 此外，铂族金属催化剂和离子交换介质在室内。 用于执行方法的装置。

公开(公告)号：US07473354B2

公开(公告)日：2009-01-06

申请号：US11229022

申请日：2005-09-16

Applicant: Yan Liu ,  Victor Manuel Berber Barreto ,  Christopher A. Pohl ,  John M. Riviello

Inventor： Yan Liu ,  Victor Manuel Berber Barreto ,  Christopher A. Pohl ,  John M. Riviello

IPC: B01D15/08

CPC classification number: G01N30/96 ,  G01N2030/965

Abstract: A suppressed ion chromatographic apparatus using a regenerant recycle loop, comprising (a) an ion separation device, (b) a membrane suppressor, (c) a detector, (d) a container for regenerant solution, (e) a first conduit between the ion separation device and the suppressor, (f) a second conduit between the regenerant solution container and the suppressor, (g) a third conduit between the suppressor and the regenerant solution container, and (h) a regenerant solution recycle loop out of fluid communication with the detector outlet.

Abstract translation: 一种使用再生剂循环回路的抑制离子色谱装置，包括（a）离子分离装置，（b）膜抑制剂，（c）检测器，（d）用于再生剂溶液的容器，（e） 离子分离装置和抑制器，（f）再生剂溶液容器和抑制剂之间的第二导管，（g）抑制剂和再生剂溶液容器之间的第三导管，和（h）流体连通的再生剂溶液循环回路 与检测器出口。

公开(公告)号：US20080116139A1

公开(公告)日：2008-05-22

申请号：US11955083

申请日：2007-12-12

Applicant: Yan Liu ,  Christopher A. Pohl ,  Nebojsa Avdalovic ,  John M. Riviello ,  Archava Siriraks

Inventor： Yan Liu ,  Christopher A. Pohl ,  Nebojsa Avdalovic ,  John M. Riviello ,  Archava Siriraks

IPC: B01D15/08

CPC classification number: G01N30/96 ,  G01N30/62 ,  G01N2030/965

Abstract: A liquid chromatographic system is provided including catalytically combining hydrogen and oxygen gases in the chromatography eluent stream in a catalytic gas elimination chamber, to form water and thereby reduce the gas content in the eluent stream. Also, a liquid ion chromatographic system in which the effluent from the detector is recycled to a membrane suppressor and then is mixed with a source of eluent for recycle to the chromatographic column.

Abstract translation: 提供液相色谱系统，其包括在催化气体消除室中的色谱洗脱液流中催化结合氢气和氧气，形成水，从而降低洗脱液流中的气体含量。 此外，液体离子色谱系统将来自检测器的流出物再循环至膜抑制剂，然后与洗脱液混合以再循环至色谱柱。

公开(公告)号：US07291395B2

公开(公告)日：2007-11-06

申请号：US10782366

申请日：2004-02-18

Applicant: Christopher A. Pohl ,  Charanjit Saini

Inventor： Christopher A. Pohl ,  Charanjit Saini

IPC: B32B5/16 ,  B05D7/00

CPC classification number: B01J41/20 ,  B01D15/362 ,  B01D15/363 ,  B01J20/28014 ,  B01J20/28042 ,  B01J20/3221 ,  B01J20/3293 ,  B01J39/26 ,  B01J47/016 ,  B01J2220/54 ,  Y10T428/2998 ,  Y10T428/31725

Abstract: A method for making an ion exchange coating (e.g., a chromatographic medium) on a substrate comprising (a) reacting at least a first amine compound comprising amino groups, with at least a first polyfunctional compound, in the presence of a substrate to form a first condensation polymer reaction product, with a first unreacted excess of either at least said first amino group or polyfunctional compound functional moieties, irreversibly attached to the substrate, and (b) reacting at least a second amine compound or at least a second polyfunctional compound with unreacted excess in the first condensation polymer reaction product to form a second condensation polymer reaction product, and repeating the steps to produce the desired coating. A coated ion exchange substrate so made.

Abstract translation: 一种用于在基材上制备离子交换涂层（例如，色谱介质）的方法，包括（a）使至少含有氨基的第一种胺化合物与至少第一多官能化合物在底物存在下反应，形成 第一缩合聚合物反应产物，具有至少所述第一氨基或多官能化合物官能部分的第一未反应过量，不可逆地附着于所述底物，和（b）使至少第二种胺化合物或至少第二种多官能化合物与 在第一缩聚物反应产物中的未反应过量以形成第二缩聚物反应产物，并重复以产生所需涂层的步骤。 如此制成的涂覆的离子交换衬底。

公开(公告)号：US07147891B2

公开(公告)日：2006-12-12

申请号：US10778007

申请日：2004-02-11

Applicant: Andrei V. Bordunov ,  Maria Rey ,  Christopher A. Pohl

Inventor： Andrei V. Bordunov ,  Maria Rey ,  Christopher A. Pohl

IPC: C08J3/24

CPC classification number: B01D15/362 ,  B01J20/28097 ,  B01J20/3208 ,  B01J20/3268 ,  B01J20/327 ,  B01J20/3282 ,  B01J39/26 ,  B01J47/018 ,  Y10T428/2998 ,  Y10T428/31536 ,  Y10T428/31931

Abstract: A method for making a weak cation-exchange (carboxylic acid) medium comprising contacting a solution of a functional organic polymer having carbon to carbon double bond unsaturation and having weak cationic exchange functional moieties or precursors thereof in a solvent with a substrate having an organic polymer surface, evaporating said solvent and breaking said double bond under conditions to cause the functional organic polymer to covalently bond to the substrate surface and to cross-link to form a cross-linked functional polymer layer covalently bound to the substrate surface. The medium produced by the method.

Abstract translation: 一种制备弱阳离子交换（羧酸）培养基的方法，包括使具有碳 - 碳双键不饱和键的官能有机聚合物溶液和具有弱阳离子交换官能团或其前体的溶液与具有有机聚合物 表面，蒸发所述溶剂并在条件下破坏所述双键以使功能性有机聚合物共价键合到基材表面并交联以形成共价结合到基材表面的交联官能聚合物层。 该方法生产的培养基。

公开(公告)号：US06248798B1

公开(公告)日：2001-06-19

申请号：US09198203

申请日：1998-11-23

Applicant: Rosanne W. Slingsby ,  Christopher A. Pohl ,  Jacek J. Jagodzinski ,  Latha P. Narayanan ,  Michael Weitzhandler

Inventor： Rosanne W. Slingsby ,  Christopher A. Pohl ,  Jacek J. Jagodzinski ,  Latha P. Narayanan ,  Michael Weitzhandler

IPC: B01J4702

CPC classification number: B01D15/363 ,  B01J41/05 ,  B01J41/20 ,  B01J47/016

Abstract: Anion-exchange compositions are provided comprising anion-exchange functional groups comprising at least a first and a second nitrogen group, wherein the first nitrogen group is a quaternary amine and the second nitrogen group is selected from the group consisting of primary, secondary, tertiary or quaternary amines. Methods of making and using the compositions are also provided.

Abstract translation: 提供阴离子交换组合物，其包含至少包含第一和第二氮基团的阴离子交换官能团，其中第一氮基团为季胺，第二氮基团选自伯，仲，叔或 季胺。 还提供了制备和使用组合物的方法。

公开(公告)号：US5472584A

公开(公告)日：1995-12-05

申请号：US406764

申请日：1995-03-17

Applicant: Roy D. Rocklin ,  Christopher A. Pohl ,  John Stillian ,  Nebojsa Avdalovic

Inventor： Roy D. Rocklin ,  Christopher A. Pohl ,  John Stillian ,  Nebojsa Avdalovic

IPC: G01N27/447 ,  G01N30/60 ,  G01N30/96 ,  G01N27/26

CPC classification number: G01N27/4473 ,  G01N2030/965

Abstract: Apparatus and methods are provided for increasing the sensitivity of detection of ionic species separated by capillary electrophoresis. The apparatus includes capillary electrophoretic separating means, suppressor means and detector means.

Abstract translation: 提供了提高通过毛细管电泳分离的离子物质检测灵敏度的装置和方法。 该装置包括毛细管电泳分离装置，抑制装置和检测装置。

公开(公告)号：US10802000B2

公开(公告)日：2020-10-13

申请号：US13834883

申请日：2013-03-15

Applicant: Christopher A. Pohl

Inventor： Christopher A. Pohl

IPC: G01N30/02 ,  G01N30/86

Abstract: A method of calibrating, a chromatography system is described. The method includes injecting a standard into a chromatographic separator. The standard including a first analyte having a first calibrant concentration and a second analyte having a second calibrant concentration. The standard can be separated in the chromatographic separator and measured with a detector. The method automatically identifies whether the first peak corresponds to the first analyte or the second analyte and whether the second peak corresponds to the first analyte or the second analyte, based on either an area or a peak height of the first peak and the second peak, and a ratio based on the first calibrant concentration and the second calibrant concentration.

公开(公告)号：US08925374B2

公开(公告)日：2015-01-06

申请号：US13689885

申请日：2012-11-30

Applicant: Jun Cheng ,  Petr Jandik ,  Christopher A. Pohl

Inventor： Jun Cheng ,  Petr Jandik ,  Christopher A. Pohl

IPC: G01N30/00 ,  G01N27/30 ,  G01N27/416 ,  G01N30/64

CPC classification number: G01N27/30 ,  G01N27/301 ,  G01N27/4166 ,  G01N30/64

Abstract: A detection cell for a chromatography system includes a cell body having an inlet, an outlet, and a counter electrode, a working electrode, a sample flow passageway extending between the inlet and the outlet and in fluid contact with the counter and working electrodes, and a palladium/noble metal reference electrode system. A method of using the detection cell is also described.

Abstract translation: 用于色谱系统的检测电池包括具有入口，出口和对电极的电池体，工作电极，在入口和出口之间延伸并与计数器和工作电极流体接触的样品流动通道，以及 钯/贵金属参考电极系统。 还描述了使用检测单元的方法。

公开(公告)号：US08628652B2

公开(公告)日：2014-01-14

申请号：US13364078

申请日：2012-02-01

Applicant: Hamish Small ,  Yan Liu ,  Christopher A. Pohl

Inventor： Hamish Small ,  Yan Liu ,  Christopher A. Pohl

IPC: B01D61/44

CPC classification number: G01N30/96 ,  B01D61/427 ,  F04B17/00 ,  G01N30/32 ,  G01N30/34 ,  G01N30/6095

Abstract: A continuous electrochemical pump comprising a water generator compartment, an anode compartment on one side of said generator compartment, a cation exchange barrier, separating the generator compartment from the anode compartment, it first electrode in electrical communication with the anode compartment, a cathode compartment adjacent the generator chamber, an anion exchange barrier, separating the generation compartment from the cathode compartment, and a second electrode in electrical communication with the cathode compartment. Use of the pump as a sample concentrator. A feedback loop for the pump. A reservoir, with or without an intermediate piston, on the output side of the pump.

Abstract translation: 一种连续电化学泵，包括水发生器室，在所述发生器室的一侧上的阳极室，阳离子交换屏障，将发电机室与阳极隔室分离，第一电极与阳极室电连通，阴极室相邻 所述发生器室，阴离子交换屏障，将所述发电室与所述阴极室分开，以及与所述阴极室电连通的第二电极。 使用泵作为样品浓缩器。 泵的反馈回路。 在泵的输出侧具有或不具有中间活塞的储存器。