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    Functionalized substrates with ion-exchange properties
    3.
    发明授权
    Functionalized substrates with ion-exchange properties 有权
    具有离子交换性能的功能化底物

    公开(公告)号：US09314712B2

    公开(公告)日：2016-04-19

    申请号：US12118447

    申请日：2008-05-09

    Applicant: Xiaodong Liu ,  Christopher A. Pohl ,  Jinhua Chen ,  L. Andy Woodruff

    Inventor： Xiaodong Liu ,  Christopher A. Pohl ,  Jinhua Chen ,  L. Andy Woodruff

    IPC: B01D15/36 ,  B01D15/32 ,  B01J20/28 ,  B01J20/32 ,  B01J39/26 ,  B01J43/00 ,  B01D15/38

    CPC classification number: B01D15/362 ,  B01D15/325 ,  B01D15/361 ,  B01D15/363 ,  B01D15/3847 ,  B01J20/28097 ,  B01J20/3221 ,  B01J20/3285 ,  B01J20/3295 ,  B01J39/26 ,  B01J43/00 ,  B01J41/20

    Abstract: The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC) and solid-phase extraction (SPE). The compositions include a porous solid support (e.g., silica gels, silica monoliths or synthetic organic resins) having an exterior surface and pore openings defined by “interior walls”. To the solid support are covalently bound organic ion-exchange ligands (e.g., silyl ligands), which incorporate at least one ion-exchange group (e.g., ionic or ionizable group). The compositions further include micro-particles (e.g., latex particles) incorporating ion-exchange groups having a charge that is opposite to the charge found on the support. The micro-particles are bound to the exterior surface of the support (e.g., via electrostatic forces). The micro-particles have a size that is sufficient to minimize the number of particles that can enter the pores of the support thereby reducing or essentially preventing binding of the micro-particles to the interior walls of the pores. While the pores are essentially too small for the micro-particles, they can still be accessed by the analytes present in a chromatographic sample. The physical separation of ion-exchange groups located within the pores and the surface of the micro-particles, respectively, prevents reactions (e.g., formation of salt-bridges) between the oppositely charged groups and provides compositions with both anion-exchange and cation-exchange capabilities within the same stationary phase. The ligands bound to the solid support can optionally include additional (e.g., reverse-phase) functionalities creating multi-modal (e.g., trimodal) stationary phases.

    Abstract translation: 本发明提供了用于各种色谱应用的固定相的组合物，例如高效液相色谱（HPLC）和固相萃取（SPE）。 组合物包括具有由“内壁”限定的外表面和孔开口的多孔固体支持物（例如硅胶，二氧化硅整料或合成有机树脂）。 固体支持物是共价结合的有机离子交换配体（例如，甲硅烷基配体），其结合至少一个离子交换基团（例如离子或可离子化基团）。 组合物还包括结合离子交换基团的微粒（例如胶乳颗粒），其具有与载体上发现的电荷相反的电荷。 微粒子结合到支撑体的外表面（例如通过静电力）。 微粒具有足以使能够进入载体的孔的颗粒数量最小化的尺寸，从而减少或基本上防止微粒与孔内壁的结合。 虽然孔对于微粒基本上太小，但是它们仍然可以通过色谱样品中存在的分析物进行访问。 分别位于孔和微粒表面之间的离子交换基团的物理分离防止相反电荷基团之间的反应（例如，形成盐桥），并提供具有阴离子交换和阳离子交换的组合物， 交换能力在同一个固定阶段。 与固体支持物结合的配体可以任选地包括产生多模态（例如，三峰）固定相的另外的（例如反相）官能团。

    Agglomerated ion exchange particle bed and method
    4.
    发明授权
    Agglomerated ion exchange particle bed and method 有权
    聚集离子交换粒子床和方法

    公开(公告)号：US09283494B2

    公开(公告)日：2016-03-15

    申请号：US11229057

    申请日：2005-09-16

    Applicant: Christopher A. Pohl ,  Charanjit Saini

    Inventor： Christopher A. Pohl ,  Charanjit Saini

    IPC: B01D15/36 ,  B01J20/32 ,  B01J39/26 ,  B01J41/20 ,  B01J47/00

    CPC classification number: B01D15/361 ,  B01J20/3221 ,  B01J39/26 ,  B01J41/20 ,  B01J47/016

    Abstract: A liquid chromatography agglomerated bed comprising component A comprising (a) substrate particles and polymer chains (e.g. a condensation polymer) bound to the substrate particles and projecting therefrom, and (b) component B comprising substrate particles having external surfaces of opposite charge to that of the charged polymer chains, components A and B being bound at least in part by electrostatic forces between the component A charged polymer chains and the component B external surfaces to form in composite an agglomerated bed of ion exchange particles packed in a chromatography column.

    Abstract translation: 包含组分A的液相色谱附聚床包含（a）底物颗粒和与基底颗粒结合并从其中突出的聚合物链（例如缩合聚合物），和（b）组分B，其包含具有与 带电聚合物链，组分A和B至少部分地由组分A带电的聚合物链和组分B外表面之间的静电力结合，以形成填充在色谱柱中的离子交换颗粒的聚集床。

    Chemical suppressors and method of use
    6.
    发明授权
    Chemical suppressors and method of use 有权
    化学抑制剂及其使用方法

    公开(公告)号：US08636963B2

    公开(公告)日：2014-01-28

    申请号：US13368663

    申请日：2012-02-08

    Applicant: Kannan Srinivasan ,  Christopher A. Pohl

    Inventor： Kannan Srinivasan ,  Christopher A. Pohl

    IPC: G01N30/84

    CPC classification number: G01N30/96 ,  B01D15/367 ,  B01D61/48 ,  Y10T436/25

    Abstract: A non-electrolytic method and apparatus for treating an aqueous sample stream including analyte ions and matrix ions of opposite charge, for pretreatment or suppression. The apparatus includes an ion exchange membrane capable of passing only ions of opposite charge to the analyte ions, a sample stream flow channel, a first aqueous stream ion receiving flow channel adjacent one side of the sample stream flow channel and separated therefrom by the first ion exchange membrane, and stationary flow-through ion exchange packing disposed in the sample stream flow channel. The ion receiving channel has an ion exchange capacity for the matrix ions less than about 25% of the ion exchange capacity for the matrix ions.

    Abstract translation: 一种用于处理包含分析物离子和相反电荷的基质离子的水样品流的非电解方法和装置，用于预处理或抑制。 该装置包括能够仅将相反电荷的离子通过到分析物离子的离子交换膜，样品流流动通道，邻近样品流流动通道的一侧的第一含水流离子接收流动通道，并由第一离子 交换膜和设置在样品流流动通道中的固定流通离子交换填料。 离子接收通道对于基质离子的离子交换容量小于基质离子的离子交换容量的约25％。

    Capillary ion chromatography
    8.
    发明授权
    Capillary ion chromatography 有权
    毛细管离子色谱

    公开(公告)号：US08415168B2

    公开(公告)日：2013-04-09

    申请号：US13479119

    申请日：2012-05-23

    Applicant: Yan Liu ,  Victor Manuel Berber Barreto ,  Christopher A. Pohl ,  Nebojsa Avdalovic

    Inventor： Yan Liu ,  Victor Manuel Berber Barreto ,  Christopher A. Pohl ,  Nebojsa Avdalovic

    IPC: G01N30/84

    CPC classification number: B01D15/363 ,  B01D15/361 ,  B01D15/367 ,  G01N30/96 ,  G01N2030/965

    Abstract: An apparatus for capillary ion chromatography comprising a suppressor comprising flow-through ion exchange packing in a housing and capillary tubing formed of a permselective ion exchange membrane, and at least partially disposed in said ion exchange packing. Also, a recycle conduit for aqueous liquid from the detector to the packing. Further, the capillary tubing may have weakly acidic or weakly basic functional groups. Also, a method for using the apparatus.

    Abstract translation: 一种用于毛细管离子色谱的装置，包括抑制器，该抑制器包括在壳体中的流通离子交换填料和由选择性选择性离子交换膜形成的毛细管，并且至少部分地设置在所述离子交换填料中。 另外，从检测器到包装的水性液体循环管道。 此外，毛细管可具有弱酸性或弱碱性官能团。 另外，使用该装置的方法。

    Electrochemically Driven Pump
    9.
    发明申请
    Electrochemically Driven Pump 有权
    电动泵

    公开(公告)号：US20100038245A1

    公开(公告)日：2010-02-18

    申请号：US12192781

    申请日：2008-08-15

    Applicant: Hamish Small ,  Yan Liu ,  Christopher A. Pohl

    Inventor： Hamish Small ,  Yan Liu ,  Christopher A. Pohl

    IPC: B01D59/42

    CPC classification number: G01N30/96 ,  B01D61/427 ,  F04B17/00 ,  G01N30/32 ,  G01N30/34 ,  G01N30/6095

    Abstract: A continuous electrochemical pump comprising a water generator compartment, an anode compartment on one side of said generator compartment, a cation exchange barrier, separating the generator compartment from the anode compartment, a first electrode in electrical communication with the anode compartment, a cathode compartment adjacent the generator chamber, an anion exchange barrier, separating the generation compartment from the cathode compartment, and a second electrode in electrical communication with the cathode compartment. Use of the pump as a sample concentrator. A feedback loop for the pump. A reservoir, with or without an intermediate piston, on the output side of the pump.

    Abstract translation: 一种连续电化学泵，包括水发生器室，在所述发生器室的一侧上的阳极室，阳离子交换屏障，将发生器室与阳极室分开，与阳极室电连通的第一电极，邻近的阴极室 所述发生器室，阴离子交换屏障，将所述发电室与所述阴极室分开，以及与所述阴极室电连通的第二电极。 使用泵作为样品浓缩器。 泵的反馈回路。 在泵的输出侧具有或不具有中间活塞的储存器。

    Membrane suppressor with an outlet substantially non-retentive for ionic species
    10.
    发明授权
    Membrane suppressor with an outlet substantially non-retentive for ionic species 有权
    具有离子物质基本上非保持性的出口的膜抑制器

    公开(公告)号：US07618826B2

    公开(公告)日：2009-11-17

    申请号：US11524513

    申请日：2006-09-19

    Applicant: Yan Liu ,  Victor Barreto ,  Christopher A. Pohl

    Inventor： Yan Liu ,  Victor Barreto ,  Christopher A. Pohl

    IPC: G01N30/02 ,  G01N33/00

    CPC classification number: G01N30/96 ,  G01N2030/965

    Abstract: An apparatus for ion chromatography comprising a suppressor comprising a housing and a liquid conduit segment disposed in the housing, the liquid conduit segment including a membrane, the membrane having an inlet section adjacent the inlet of the conduit segment and an outlet section adjacent the outlet of the conduit segment, the inlet section having ion exchange sites capable of transmitting ions of one charge, positive or negative, and the outlet section being substantially non-retentive electrostatically for charged ionic species. Also, the method of using the apparatus.

    Abstract translation: 一种用于离子色谱的装置，其包括抑制器，该抑制器包括壳体和设置在壳体中的液体导管段，液体导管段包括膜，该膜具有邻近导管段入口的入口部分和邻近出口部分的出口部分 导管部分，入口部分具有能够传输一个电荷的离子的正离子或负离子的离子交换位置，并且对于带电离子物质，出口部分静电地基本上是非保持性的。 另外，使用该装置的方法。

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