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公开(公告)号：US20190240208A1
公开(公告)日：2019-08-08
申请号：US16124407
申请日：2018-09-07
Applicant: CLEARSIDE BIOMEDICAL, INC.
Inventor： Vladimir ZARNITSYN , Samirkumar PATEL , Daniel WHITE , Glenn NORONHA , Brian BURKE
IPC: A61K31/4439 , A61K47/26 , A61K9/00 , A61K9/10 , A61K47/38 , A61K45/06 , A61K47/12 , A61M37/00 , A61K9/16 , C07K16/22 , A61K31/573
CPC classification number: A61K31/4439 , A61K9/0019 , A61K9/0048 , A61K9/10 , A61K9/16 , A61K31/573 , A61K45/06 , A61K47/12 , A61K47/26 , A61K47/38 , A61K2039/505 , A61K2039/54 , A61K2300/00 , A61M37/0015 , A61M2037/0023 , A61M2037/0061 , C07K16/22
Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.
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公开(公告)号：US20180333297A1
公开(公告)日：2018-11-22
申请号：US15946838
申请日：2018-04-06
Applicant: CLEARSIDE BIOMEDICAL, INC.
Inventor： Rafael Victor ANDINO , Vladimir ZARNITSYN , Jesse YOO , Christopher John BROOKS , Trent John KAHUTE , Justin William ARSENAULT , David Jackson TRETTIN , Andrew Kent BAUER , Stephanie Elaine LEWIS
Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.
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公开(公告)号：US20150051581A1
公开(公告)日：2015-02-19
申请号：US14523243
申请日：2014-10-24
Applicant: Clearside Biomedical, Inc.
Inventor： Rafael Victor ANDINO , Vladimir ZARNITSYN , Christopher John BROOKS , Jesse YOO
CPC classification number: A61F9/0017 , A61F2250/0007 , A61F2250/0069 , A61J1/201 , A61J1/2055 , A61J1/2096 , A61M5/2033 , A61M5/2053 , A61M5/31 , A61M5/3293 , A61M5/34 , A61M5/344 , A61M5/346 , A61M5/347 , A61M5/348 , A61M5/349 , A61M5/46 , A61M5/482 , A61M37/0015 , A61M2005/31508 , A61M2037/0023 , A61M2037/0061 , A61M2210/0612
Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.
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公开(公告)号：US20150038905A1
公开(公告)日：2015-02-05
申请号：US14268687
申请日：2014-05-02
Applicant: Clearside Biomedical, Inc.
Inventor： Rafael Victor ANDINO , Vladimir ZARNITSYN , Christopher John BROOKS
CPC classification number: A61F9/0017 , A61F2250/0007 , A61F2250/0069 , A61J1/201 , A61J1/2055 , A61J1/2096 , A61M5/2033 , A61M5/2053 , A61M5/31 , A61M5/3293 , A61M5/34 , A61M5/344 , A61M5/346 , A61M5/347 , A61M5/348 , A61M5/349 , A61M5/46 , A61M5/482 , A61M37/0015 , A61M2005/31508 , A61M2037/0023 , A61M2037/0061 , A61M2210/0612
Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.
Abstract translation: 一种装置包括联接到药物容器的壳体，其联接到针上。 注射组件设置在壳体内并且包括能量存储构件和致动杆。 致动杆的远端部分设置在药物容器内。 能量存储构件可以在致动杆的近端部分上产生足以将致动杆的远端部分移动到药物容器内的力。 当针的远端设置在目标位置的第一区域内时，这可以经由针从药物容器中传送至少一部分物质。 当针的远端设置在目标位置的第二区域内时，力不足以将致动杆的远端部分移动到药物容器内。
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公开(公告)号：US20210260047A1
公开(公告)日：2021-08-26
申请号：US17314272
申请日：2021-05-07
Applicant: CLEARSIDE BIOMEDICAL, INC.
Inventor： Vladimir ZARNITSYN , Samirkumar PATEL , Daniel WHITE , Glenn NORONHA , Brian BURKE
IPC: A61K31/4439 , A61K9/00 , A61K9/10 , A61K47/38 , A61K45/06 , C07K16/22 , A61K31/573 , A61K9/16 , A61M37/00 , A61K47/12 , A61K47/26
Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.
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Patent Agency Ranking
公开(公告)号：US20190350755A1
公开(公告)日：2019-11-21
申请号：US16510238
申请日：2019-07-12
Applicant: CLEARSIDE BIOMEDICAL, INC.
Inventor： Rafael Victor ANDINO , Vladimir ZARNITSYN , Jesse YOO , Christopher John BROOKS , Trent John KAHUTE , Justin William ARSENAULT , David Jackson TRETTIN , Andrew Kent BAUER , Stephanie Elaine LEWIS
IPC: A61F9/00 , A61M5/32 , A61M5/34 , A61M37/00 , A61M5/31 , A61J1/20 , A61M5/48 , A61M5/20 , A61M5/46
Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.
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公开(公告)号：US20190231592A1
公开(公告)日：2019-08-01
申请号：US16381213
申请日：2019-04-11
Applicant: CLEARSIDE BIOMEDICAL, INC.
Inventor： Rafael Victor ANDINO , Vladimir ZARNITSYN , Jesse YOO , Christopher John BROOKS , Trent John KAHUTE , Justin William ARSENAULT , David Jackson TRETTIN , Andrew Kent BAUER , Stephanie Elaine LEWIS
IPC: A61F9/00 , A61M5/32 , A61M5/34 , A61M37/00 , A61M5/31 , A61J1/20 , A61M5/48 , A61M5/20 , A61M5/46
Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.
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公开(公告)号：US20190133933A1
公开(公告)日：2019-05-09
申请号：US16097303
申请日：2017-05-01
Applicant: CLEARSIDE BIOMEDICAL, INC.
Inventor： Richard BECKMAN , Jesse YOO , Rafael Victor ANDINO , Glenn NORONHA , Samirkumar PATEL , Donna TARABORELLI , Vladimir ZARNITSYN
Abstract: The current disclosure relates to formulations and methods for reducing intraocular pressure (IOP) in the eye of a subject in need thereof. The disclosure also relates to formulations and methods for reducing intraocular pressure (IOP) related to glaucoma in a subject. The methods provided include non-surgically administering a non-pharmacologically active injectable formulation to the eye of the subject by using an apparatus that is suitable for delivering the formulations. The methods provided also include placing a solid implant into the eye of the subject to create a controlled space in the suprachoroidal space (SCS) or the supraciliary space of the eye of the subject in need thereof. The present disclosure further comprises facilitating and improving the aqueous outflows in the eye through the trabecular meshwork outflow pathway and/or uveoscleral outflow pathway and thereby decreasing the intraocular pressure.
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公开(公告)号：US20170224534A1
公开(公告)日：2017-08-10
申请号：US15472551
申请日：2017-03-29
Applicant: Clearside Biomedical, Inc.
Inventor： Rafael Victor ANDINO , Vladimir ZARNITSYN , Jesse YOO , Christopher John BROOKS , Trent John KAHUTE , Justin William ARSENAULT , David Jackson TRETTIN , Andrew Kent BAUER , Stephanie Elaine LEWIS
CPC classification number: A61F9/0017 , A61F2250/0007 , A61F2250/0069 , A61J1/201 , A61J1/2055 , A61J1/2096 , A61M5/2033 , A61M5/2053 , A61M5/31 , A61M5/3293 , A61M5/34 , A61M5/344 , A61M5/346 , A61M5/347 , A61M5/348 , A61M5/349 , A61M5/46 , A61M5/482 , A61M37/0015 , A61M2005/31508 , A61M2037/0023 , A61M2037/0061 , A61M2210/0612
Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.
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公开(公告)号：US20160213662A1
公开(公告)日：2016-07-28
申请号：US15086485
申请日：2016-03-31
Applicant: Clearside Biomedical, Inc.
Inventor： Vladimir ZARNITSYN , Samirkumar PATEL , Daniel WHITE , Glenn NORONHA , Brian BURKE
IPC: A61K31/4439 , A61K9/16 , A61K9/00
CPC classification number: A61K31/4439 , A61K9/0019 , A61K9/0048 , A61K9/10 , A61K9/16 , A61K31/573 , A61K45/06 , A61K47/12 , A61K47/26 , A61K47/38 , A61K2039/505 , A61K2039/54 , A61K2300/00 , A61M37/0015 , A61M2037/0023 , A61M2037/0061 , C07K16/22
Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.
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