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公开(公告)号：US12005076B2
公开(公告)日：2024-06-11
申请号：US15538330
申请日：2014-12-26
发明人： Baohua Qiao , Long Pan , Gregory Szewczyk , Ravi Subramanyam
IPC分类号： A61K33/42 , A61K6/20 , A61K6/74 , A61K8/24 , A61K8/27 , A61K9/00 , A61K33/30 , A61Q11/00 , A61Q15/00 , C01B25/37
CPC分类号： A61K33/42 , A61K6/20 , A61K6/74 , A61K8/24 , A61K8/27 , A61K9/0063 , A61K33/30 , A61Q11/00 , A61Q15/00 , C01B25/37 , A61K2800/262 , A61K2800/58 , A61K33/42 , A61K2300/00 , A61K33/30 , A61K2300/00
摘要： A soluble zinc polyphosphate complex made by combining ingredients which include an inorganic zinc salt and a plurality of long chain polyphosphates having 6 or more phosphate polymer units, the relative amount of inorganic zinc salt and long chain polyphosphates providing a phosphorus to zinc mole ratio of at least 6:1. Further provided is a method of making this soluble zinc polyphosphate.
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公开(公告)号：US11344486B2
公开(公告)日：2022-05-31
申请号：US16425122
申请日：2019-05-29
发明人： Baohua Qiao , Long Pan , Gregory Szewczyk , Ravi Subramanyam , Shiri Nawrocki , Viktor Dubovoy
摘要： A soluble zinc polyphosphate complex made by combining ingredients which include an organic zinc salt and a plurality of long chain polyphosphates having 6 or more phosphate polymer units, the organic zinc salt and long chain polyphosphates being mixed in amounts that provide a phosphorus to zinc mole ratio of 15:1 to about 55:1. Further provided is a method of making this soluble zinc polyphosphate.
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公开(公告)号：US11033594B2
公开(公告)日：2021-06-15
申请号：US14648715
申请日：2013-03-07
发明人： Shashank Potnis , Ravi Subramanyam , Rajitha Nair
IPC分类号： A61K36/61 , A61K9/00 , A61K31/125 , A61K47/18 , A61K47/32 , A61K31/085 , A61K9/06 , A61K31/045 , A61K36/48 , A61K36/185
摘要： Disclosed herein are orally acceptable topical analgesic gels comprising a mixture of analgesic oils comprising (a) clove oil and/or eugenol, (b) a cooling agent, and (c) camphor, in an orally acceptable gel base, the gel base comprising an anionic polymer and a basic amino acid, and the analgesic gel providing controlled release of the mixture of analgesic oils following application to a tooth together with a methods of making and using the same.
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公开(公告)号：US10532016B2
公开(公告)日：2020-01-14
申请号：US16213871
申请日：2018-12-07
发明人： Zhigang Hao , Dennis Zhang , Donghui Wu , Ravi Subramanyam , Chi-Yuan Cheng , Long Pan , Stanislav Jaracz
摘要： Disclosed herein are zinc-amino acid-tripolyphosphate complexes, oral care and personal care compositions comprising zinc-amino acid-tripolyphosphate complexes, and methods of making and using the same.
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公开(公告)号：US10251823B2
公开(公告)日：2019-04-09
申请号：US15525381
申请日：2015-11-13
发明人： Ravi Subramanyam , Suzanne Jogun , Mahmoud Hassan , Navin Lewis , Xiao Yi Huang , Shao Peng Xu
IPC分类号： A61K8/27 , A61K8/25 , A61K8/365 , A61Q11/00 , A61K8/02 , A61K8/04 , A61K8/19 , A61K8/21 , A61K8/37
摘要： The present invention provides an oral care composition comprising: (a) a first composition comprising a silica abrasive and a first zinc compound selected from zinc citrate, zinc chloride, zinc acetate, zinc lactate, zinc salicylate, zinc sulfate, and zinc nitrate; and (b) a second composition comprising a calcium carbonate abrasive; wherein the first composition and/or the second composition further comprises a second zinc compound selected from zinc oxide, zinc carbonate and zinc tartrate; and wherein the oral care composition optionally further comprises from 0.1 to 1.75 weight % of a tartar control agent, based on the total weight of the oral care composition.
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公开(公告)号：US09913784B2
公开(公告)日：2018-03-13
申请号：US15385054
申请日：2016-12-20
CPC分类号： A61K8/27 , A61K8/21 , A61K8/24 , A61K8/44 , A61K8/8176 , A61K8/8182 , A61K2800/58 , A61Q11/00 , A61Q11/02
摘要： Disclosed herein are oral care compositions comprising a zinc amino acid halide complex, and linear polyvinylpyrrolidone and/or sodium tripolyphosphate, which compositions have improved rheological stability. Methods of making and using the compositions are also provided.
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公开(公告)号：US09676690B2
公开(公告)日：2017-06-13
申请号：US14762998
申请日：2013-01-23
IPC分类号： C07C41/30 , C07C41/36 , C07C37/055 , A61Q11/00 , C07C37/00 , C07C41/16 , A61K8/33 , C07C41/06
CPC分类号： C07C37/055 , A61K8/33 , A61Q11/00 , C07C37/003 , C07C41/06 , C07C41/16 , C07C43/215 , C07C39/21 , C07C39/15
摘要： Described herein are high yield methods for making magnolol derivatives, together with novel intermediates and uses thereof.
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公开(公告)号：US20150361017A1
公开(公告)日：2015-12-17
申请号：US14762998
申请日：2013-01-23
IPC分类号： C07C37/055 , C07C37/00 , C07C41/06
CPC分类号： C07C37/055 , A61K8/33 , A61Q11/00 , C07C37/003 , C07C41/06 , C07C41/16 , C07C43/215 , C07C39/21 , C07C39/15
摘要： Described herein are high yield methods for making magnolol derivatives, together with novel intermediates and uses thereof.
摘要翻译： 本文描述了制备厚朴酚衍生物的高产率方法，以及新的中间体及其用途。
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公开(公告)号：US20150313955A1
公开(公告)日：2015-11-05
申请号：US14648868
申请日：2013-03-07
发明人： Shashank Potnis , Ravi Subramanyam , Rajitha Nair
IPC分类号： A61K36/61 , A61K31/125 , A61K31/085
CPC分类号： A61K9/0053 , A61K8/042 , A61K8/34 , A61K8/347 , A61K8/35 , A61K8/922 , A61K31/085 , A61K31/125 , A61K36/61 , A61K47/34 , A61Q11/00 , A61K2300/00
摘要： Disclosed herein are orally acceptable topical analgesic gels comprising a mixture of analgesic oils comprising (a) clove oil and/or eugenol, (b) a cooling agent, and (c) camphor; in an orally acceptable gel base, the gel base providing controlled release of the mixture of analgesic oils following application to a tooth; together with methods of making and using the same.
摘要翻译： 本文公开了口服可接受的局部止痛凝胶，其包含镇痛油的混合物，其包含（a）丁香油和/或丁子香油，（b）冷却剂和（c）樟脑; 在口服可接受的凝胶基质中，凝胶基质在施用于牙齿后提供镇痛油混合物的控制释放; 以及制作和使用方法。
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公开(公告)号：US08895929B2
公开(公告)日：2014-11-25
申请号：US14322897
申请日：2014-07-02
CPC分类号： G01N21/33 , A46B15/0002 , A46B15/0004 , A46B15/0034 , A46B2200/1066 , A61B5/0075 , A61B5/4547 , A61B5/4552 , A61B5/6887 , G01N21/359
摘要： Improved analytical, diagnostic, monitoring, and other methods (and their associated devices) for evaluating the extent of deposition of an agent onto a substrate are described. Exemplary methods may be used in the in the monitoring of the dental health of patients or in the fast, efficient screening and/or characterization of formulations in terms of their use for depositing oral actives onto tooth surfaces. The methods involve the direct or in situ analysis of substrates, onto which agents are deposited, using Near-IR spectroscopy and/or UV spectroscopy.
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