中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

43 records (took 0.025 seconds)

    MAGNETIC MICROCARRIERS
    11.
    发明申请
    MAGNETIC MICROCARRIERS 审中-公开
    磁性微型机

    公开(公告)号：US20160145600A1

    公开(公告)日：2016-05-26

    申请号：US14950771

    申请日：2015-11-24

    Applicant: Corning Incorporated

    Inventor： Stephen Joseph Caracci ,  Ye Fang ,  Ann MeeJin Ferrie ,  Yan Jin ,  Lingyan Wang ,  Yue Zhou

    IPC: C12N13/00 ,  H01F1/147 ,  H01F1/20 ,  C12N5/00 ,  G01N1/40

    CPC classification number: C12N13/00 ,  C12N1/02 ,  H01F1/26 ,  H01F1/37

    Abstract: Magnetic microcarrier beads have a particle size of 1 to 1000 micrometers and include a composite core and a polymer coating that surrounds and encapsulates the core. The composite core includes magnetic particles embedded within an indigestible polymer matrix. The coating is a digestible or indigestible polymer that facilitates cell adhesion to the surface of the beads during cell culture. Magnetic force can be used to agitate the microcarrier beads during cell culture as well as to separate the beads from cultured cells or processed bio-media.

    Abstract translation: 磁性微载体珠具有1至1000微米的粒度，并且包括复合芯和围绕并封装芯的聚合物涂层。 复合芯包括嵌入在难消化的聚合物基质内的磁性颗粒。 该涂层是可消化或消化不良的聚合物，其在细胞培养期间促进细胞与珠表面的粘附。 可以使用磁力在细胞培养过程中搅动微载体珠，以及将珠与培养的细胞或加工的生物培养基分离。

    FLOW CELLS WITH STABLE POLYMER COATING AND THEIR USES FOR GENE SEQUENCING
    14.
    发明申请
    FLOW CELLS WITH STABLE POLYMER COATING AND THEIR USES FOR GENE SEQUENCING 有权

    公开(公告)号：US20210301335A1

    公开(公告)日：2021-09-30

    申请号：US17266245

    申请日：2019-08-05

    Applicant: CORNING INCORPORATED

    Inventor： Ye Fang ,  Jeffrey Glenn Lynn ,  Wei Sun ,  Ying Wei

    IPC: C12Q1/6869 ,  B01L3/00 ,  C12Q1/6853

    Abstract: A flow cell article is provided where the flow cell article includes a substrate having one or more layers; a fluidic channel disposed in the substrate wherein the fluidic channel includes at least one reactive surface comprising: a coupling agent having a first functional group covalently attached to the substrate of the fluidic channel and a second imide functional group covalently attached to a polymer of formula (I), where R1 is a residue of an unsaturated monomer that has been copolymerized with maleic anhydride; R2 is H, an alkyl group, an oligo(ethylene glycol), and/or a dialkyl amine; m, n, and o are each from 1 to 10,000; X is a divalent NH, O, and/or S; and Z is the first functional group.

    FLOW CELLS HAVING REACTIVE SURFACES FOR NUCLEIC ACID SEQUENCE ANALYSIS
    18.
    发明申请
    FLOW CELLS HAVING REACTIVE SURFACES FOR NUCLEIC ACID SEQUENCE ANALYSIS 审中-公开

    公开(公告)号：US20190085390A1

    公开(公告)日：2019-03-21

    申请号：US16127617

    申请日：2018-09-11

    Applicant: Corning Incorporated

    Inventor： Ye Fang ,  Jeffrey Glenn Lynn ,  Wei Sun ,  Ying Wei

    IPC: C12Q1/6874

    Abstract: A flow cell article including: a chamber; and at least one surface of the chamber comprising: a solid substrate having a reactive surface comprising: a coupling agent covalently attached to the solid substrate; a polymer of the formula (I) as defined herein, covalently attached to the coupling agent; anda nucleic acid probe covalently attached to the polymer. Also disclosed is a method of making the article and a method of using the article.

Patent Agency Ranking