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公开(公告)号：US07413734B2
公开(公告)日：2008-08-19
申请号：US10877541
申请日：2004-06-25
申请人： Sanjay Mistry , Darin J. Messina , Ian Ross Harris , Alexander M. Harmon , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
发明人： Sanjay Mistry , Darin J. Messina , Ian Ross Harris , Alexander M. Harmon , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of ocular tissue using the postpartum-derived cells are also disclosed.
摘要翻译： 公开了产自产后脐带和胎盘的细胞。 还公开了使用产后来源细胞再生或修复眼组织的药物组合物，装置和方法。
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12.发明授权Postpartum cells isolated from umbilical cord tissue, and methods of making and using the same 有权从脐带组织分离的产后细胞，以及制造和使用它们的方法公开(公告)号：US07510873B2
公开(公告)日：2009-03-31
申请号：US10877012
申请日：2004-06-25
申请人： Sanjay Mistry , Anthony J. Kihm , Ian Ross Harris , Alexander M. Harmon , Darin J. Messina , Chin-Feng Yi , Anna Gosiewska
发明人： Sanjay Mistry , Anthony J. Kihm , Ian Ross Harris , Alexander M. Harmon , Darin J. Messina , Chin-Feng Yi , Anna Gosiewska
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
摘要翻译： 公开了源自人脐带的细胞及其治疗用途的方法。 描述了相对于其细胞表面标志物的细胞的分离技术，培养方法和详细表征，基因表达及其营养因子的分泌。
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13.发明申请公开(公告)号：US20060234376A1
公开(公告)日：2006-10-19
申请号：US11317574
申请日：2005-12-23
申请人： Sanjay Mistry , Darin Messina , Ian Harris , Alexander Harmon , Anthony Kihm , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
发明人： Sanjay Mistry , Darin Messina , Ian Harris , Alexander Harmon , Anthony Kihm , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
IPC分类号： C12N5/08
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of ocular tissue using the postpartum-derived cells are also disclosed.
摘要翻译： 公开了产自产后脐带和胎盘的细胞。 还公开了使用产后来源细胞再生或修复眼组织的药物组合物，装置和方法。
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公开(公告)号：US20060153817A1
公开(公告)日：2006-07-13
申请号：US11321863
申请日：2005-12-29
申请人： Anthony Kihm , Agnieszka Seyda , Alexander Harmon , Ian Harris , Darin Messina , Sanjay Mistry , Anna Gosiewska , Chin-Feng Yi
发明人： Anthony Kihm , Agnieszka Seyda , Alexander Harmon , Ian Harris , Darin Messina , Sanjay Mistry , Anna Gosiewska , Chin-Feng Yi
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions.
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15.发明申请公开(公告)号：US20050032209A1
公开(公告)日：2005-02-10
申请号：US10877269
申请日：2004-06-25
申请人： Darin Messina , Sanjay Mistry , Alexander Harmon , Ian Harris , Anthony Kihm , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
发明人： Darin Messina , Sanjay Mistry , Alexander Harmon , Ian Harris , Anthony Kihm , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.
摘要翻译： 公开了产自产后脐带和胎盘的细胞。 还公开了使用产后来源细胞进行神经组织再生或修复的药物组合物，装置和方法。
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16.发明申请公开(公告)号：US20070014771A1
公开(公告)日：2007-01-18
申请号：US11481481
申请日：2006-07-06
申请人： Sanjay Mistry , Anthony Kihm , Ian Harris , Alexander Harmon , Darin Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
发明人： Sanjay Mistry , Anthony Kihm , Ian Harris , Alexander Harmon , Darin Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
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17.发明申请Postpartum cells derived from umbilical cord tissue, and methods of making and using the same 审中-公开来自脐带组织的产后细胞，以及制造和使用它们的方法公开(公告)号：US20070009494A1
公开(公告)日：2007-01-11
申请号：US11481480
申请日：2006-07-06
申请人： Sanjay Mistry , Anthony Kihm , Ian Harris , Alexander Harmon , Darin Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
发明人： Sanjay Mistry , Anthony Kihm , Ian Harris , Alexander Harmon , Darin Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
摘要翻译： 公开了源自人脐带的细胞及其治疗用途的方法。 描述了相对于其细胞表面标志物的细胞的分离技术，培养方法和详细表征，基因表达及其营养因子的分泌。
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18.发明申请Postpartum-derived cells for use in treatment of disease of the heart and circulatory system 审中-公开产后来源的细胞用于治疗心脏和循环系统疾病公开(公告)号：US20060188983A1
公开(公告)日：2006-08-24
申请号：US11322372
申请日：2005-12-30
申请人： Ian Harris , Alexander Harmon , Anthony Kihm , Darin Messina , Sanjay Mistry , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
发明人： Ian Harris , Alexander Harmon , Anthony Kihm , Darin Messina , Sanjay Mistry , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum tissue are disclosed along with methods for their therapeutic use in diseases of the heart or circulatory system are disclosed. Cells may be used therapeuticall in either differentiated or undifferentiated forms, in homogenous cultures, or as populations with other cells, and in conjunction with other bioactive factors.
摘要翻译： 公开了衍生自产后组织的细胞以及其在心脏或循环系统疾病中的治疗用途的方法。 细胞可以以分化或未分化的形式，在均匀培养物中，或与其他细胞群体一起使用，并与其它生物活性因子结合使用。
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公开(公告)号：US20050058629A1
公开(公告)日：2005-03-17
申请号：US10877009
申请日：2004-06-25
申请人： Alexander Harmon , Ian Harris , Anthony Kihm , Sanjay Mistry , Darin Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
发明人： Alexander Harmon , Ian Harris , Anthony Kihm , Sanjay Mistry , Darin Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum tissue having the potential to support cells of and/or differentiate to cells of a soft tissue lineage, and methods of preparation and use of those postpartum tissue-derived cells, are provided by the invention. The invention also provides methods for the use of such postpartum-derived cells and products related thereto in therapies for conditions of soft tissue.
摘要翻译： 本发明提供了具有支持细胞和/或分化为软组织谱系细胞的潜力的产后组织的细胞，以及这些产后组织来源的细胞的制备和使用方法。 本发明还提供了在用于软组织病症的疗法中使用这种产后衍生细胞和与之相关的产品的方法。
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20.发明申请Cartilage and bone repair and regeneration using postpartum-derived cells 审中-公开使用产后来源的细胞进行软骨和骨修复和再生公开(公告)号：US20050019865A1
公开(公告)日：2005-01-27
申请号：US10876998
申请日：2004-06-25
申请人： Anthony Kihm , Agnieszka Seyda , Sridevi Dhanaraj , Ziwei Wang , Alexander Harmon , Ian Harris , Darin Messina , Sanjay Mistry , Anna Gosiewska , Chin-Feng Yi
发明人： Anthony Kihm , Agnieszka Seyda , Sridevi Dhanaraj , Ziwei Wang , Alexander Harmon , Ian Harris , Darin Messina , Sanjay Mistry , Anna Gosiewska , Chin-Feng Yi
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions.
摘要翻译： 源自产后组织的细胞及其分离和诱导分化成软骨形成或成骨表型细胞的方法由本发明提供。 本发明进一步提供产后来源细胞的培养物和组合物及其相关的产品。 本发明的产后衍生细胞及其相关产品具有多种用途，包括但不限于研究，诊断和治疗应用，例如用于治疗骨和软骨病症。
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