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公开(公告)号：US20090246247A1
公开(公告)日：2009-10-01
申请号：US12411428
申请日：2009-03-26
Applicant: Dhanuraj Shetty , Sridevi Dhanaraj , Ziwei Wang , Jackie Jacobus Johannes Maria Donners
CPC classification number: A61K35/38 , A61F2/042 , A61K35/22 , A61L27/18 , A61L27/3604 , A61L27/3629 , A61L27/3679 , A61L27/56 , A61L2430/22 , C08L67/04
Abstract: The present invention relates to methods for tissue augmentation or regeneration. More specifically, the present invention provides for a composite enterocystoplasty procedure using a biocompatible scaffold and minced autologous tissue for implantation in a mammalian bladder.
Abstract translation: 本发明涉及组织增生或再生的方法。 更具体地，本发明提供了使用生物相容性支架和切割的自体组织用于植入哺乳动物膀胱中的复合肠内成形术程序。
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公开(公告)号：US20060154367A1
公开(公告)日：2006-07-13
申请号：US11322003
申请日：2005-12-29
Applicant: Anthony Kihm , Agnieszka Seyda , Sridevi Dhanaraj , Ziwei Wang , Alexander Harmon , Ian Harris , Darin Messina , Sanjay Mistry , Anna Gosiewska
Inventor： Anthony Kihm , Agnieszka Seyda , Sridevi Dhanaraj , Ziwei Wang , Alexander Harmon , Ian Harris , Darin Messina , Sanjay Mistry , Anna Gosiewska
CPC classification number: A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
Abstract: Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions.
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公开(公告)号：US20130006349A1
公开(公告)日：2013-01-03
申请号：US13173225
申请日：2011-06-30
Applicant: Iksoo Chun , Ziwei Wang , Kevin Cooper , Dennis Jamiolkowski , Modesto Erneta , Sasa Andjelic , Jianguo Jack Zhou
Inventor： Iksoo Chun , Ziwei Wang , Kevin Cooper , Dennis Jamiolkowski , Modesto Erneta , Sasa Andjelic , Jianguo Jack Zhou
CPC classification number: C12N5/0691 , A61F2/06 , B32B1/08 , B32B5/022 , B32B5/024 , B32B2262/02 , B32B2535/00 , C08G63/08 , C08G63/664 , C12N2533/40 , Y10T156/1033
Abstract: Compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease are disclosed.
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公开(公告)号：US20090148495A1
公开(公告)日：2009-06-11
申请号：US11954100
申请日：2007-12-11
Applicant: Joseph J. Hammer , Dhanuraj Shetty , Sridevi Dhanaraj , Ziwei Wang
Inventor： Joseph J. Hammer , Dhanuraj Shetty , Sridevi Dhanaraj , Ziwei Wang
CPC classification number: A61F2/30756 , A61F2/30907 , A61F2002/30062 , A61F2002/30766 , A61F2210/0004 , A61F2310/00329 , A61L27/18 , A61L27/38 , A61L27/56 , C08L67/04
Abstract: An implantable biodegradable porous fibrous matrix is disclosed, the fibrous matrix being constructed of fibers arranged in a nonwoven array. The density of the nonwoven array is adjusted in the manufacturing process to obtain an optimum density of the array for tissue ingrowth. When implanted, the optimum density fibrous matrix provides for a superior biological response of the host in terms of tissue growth, especially for tissues containing glycosaminoglycans (GAGs). The optimum density fibrous matrix is therefore provided with properties useful in repair and/or regeneration of mammalian tissue.
Abstract translation: 公开了可植入的可生物降解的多孔纤维基质，所述纤维基质由布置成无纺布阵列的纤维构成。 在制造过程中调节非织造布阵列的密度以获得用于组织向内生长的阵列的最佳密度。 当植入时，最佳密度纤维基质在组织生长方面提供了优异的宿主生物反应，特别是对于含有糖胺聚糖（GAG）的组织。 因此，最佳密度纤维基质具有可用于哺乳动物组织的修复和/或再生的性质。
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公开(公告)号：US20080081362A1
公开(公告)日：2008-04-03
申请号：US11856741
申请日：2007-09-18
Applicant: Daniel Keeley , Dhanuraj Shetty , Sridevi Dhanaraj , Ziwei Wang
Inventor： Daniel Keeley , Dhanuraj Shetty , Sridevi Dhanaraj , Ziwei Wang
IPC: C12M1/00
CPC classification number: C12M21/08 , A61L27/3604 , A61L27/38 , A61L27/3882 , A61L27/58 , A61L2430/22 , C12M25/14
Abstract: The present invention relates to devices and methods for tissue augmentation or regeneration and specifically, to a composite of bioabsorbable scaffold material and autologous tissue, suitable for implantation in tissue or organs.
Abstract translation: 本发明涉及用于组织增强或再生的装置和方法，具体涉及适于植入组织或器官的生物可吸收支架材料和自体组织的复合材料。
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Patent Agency Ranking
公开(公告)号：US20060286144A1
公开(公告)日：2006-12-21
申请号：US11156092
申请日：2005-06-17
Applicant: Chunlin Yang , Joseph Hammer , Ziwei Wang
Inventor： Chunlin Yang , Joseph Hammer , Ziwei Wang
IPC: A61K9/70
Abstract: A fiber reinforced basic collagen scaffold with neutralization capacity for delivery of protein based bioactives that have higher solubilities under acidic condition than at neutral pH.
Abstract translation: 一种纤维增强的基础胶原支架，具有中和能力，用于递送蛋白质生物活性物质，在酸性条件下比在中性pH下具有更高的溶解度。
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7.发明申请Cartilage and bone repair and regeneration using postpartum-derived cells 审中-公开使用产后来源的细胞进行软骨和骨修复和再生公开(公告)号：US20050019865A1
公开(公告)日：2005-01-27
申请号：US10876998
申请日：2004-06-25
Applicant: Anthony Kihm , Agnieszka Seyda , Sridevi Dhanaraj , Ziwei Wang , Alexander Harmon , Ian Harris , Darin Messina , Sanjay Mistry , Anna Gosiewska , Chin-Feng Yi
Inventor： Anthony Kihm , Agnieszka Seyda , Sridevi Dhanaraj , Ziwei Wang , Alexander Harmon , Ian Harris , Darin Messina , Sanjay Mistry , Anna Gosiewska , Chin-Feng Yi
CPC classification number: A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
Abstract: Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions.
Abstract translation: 源自产后组织的细胞及其分离和诱导分化成软骨形成或成骨表型细胞的方法由本发明提供。 本发明进一步提供产后来源细胞的培养物和组合物及其相关的产品。 本发明的产后衍生细胞及其相关产品具有多种用途，包括但不限于研究，诊断和治疗应用，例如用于治疗骨和软骨病症。
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公开(公告)号：US20090263484A1
公开(公告)日：2009-10-22
申请号：US12107408
申请日：2008-04-22
Applicant: Joseph J. Hammer , Dhanuraj Shetty , Sridevi Dhanaraj , Ziwei Wang , Jeffrey C. Geesin , Daniel J. Keeley
Inventor： Joseph J. Hammer , Dhanuraj Shetty , Sridevi Dhanaraj , Ziwei Wang , Jeffrey C. Geesin , Daniel J. Keeley
CPC classification number: A61K35/34 , A61K35/22 , A61K38/00 , A61L27/3604 , A61L27/3834 , A61K2300/00
Abstract: Tissue engineering devices and methods are provided for the reconstruction, repair, augmentation, or replacement of a luminal organ or tissue structure involving the use of a biodegradable polymer matrix conforming to a portion of a laminarly arranged luminal organ, the processing of autologous, allogeneic or xenogeneic tissue comprising multiple cell populations to obtain a minced tissue composition, the seeding of the matrix with the composition, and the implanting of the seeded polymer matrix into a patient.
Abstract translation: 提供组织工程装置和方法用于重建，修复，增加或更换腔内器官或组织结构，其涉及使用符合层状布置的器官器官的一部分的生物可降解聚合物基质，自体，异基因或 包含多个细胞群体的异种组织以获得切碎的组织组合物，用组合物接种基质，以及将接种的聚合物基质植入患者体内。
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公开(公告)号：US20090075371A1
公开(公告)日：2009-03-19
申请号：US11856738
申请日：2007-09-18
Applicant: Daniel Keeley , Dhanuraj Shetty , Joseph J. Hammer , Ziwei Wang
Inventor： Daniel Keeley , Dhanuraj Shetty , Joseph J. Hammer , Ziwei Wang
CPC classification number: A61L27/54 , A61L27/18 , A61L27/24 , A61L27/3882 , A61L27/56 , A61L2300/402 , A61L2300/406 , A61L2300/408 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/43 , A61L2300/604
Abstract: The invention relates generally to devices for organ replacement and regenerative medicine providing a biocompatible and biodegradable scaffold capable of integral cell growth that forms a hollow chamber, as well as methods for producing such devices by lyophilizing biocompatible, biodegradable polymers to produce a seamless, three-dimensional shape.
Abstract translation: 本发明一般涉及用于器官置换和再生医学的装置，其提供能够形成中空室的整体细胞生长的生物相容性和可生物降解的支架，以及通过将生物相容性可生物降解的聚合物冻干以产生无缝， 尺寸形状。
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公开(公告)号：US11191789B2
公开(公告)日：2021-12-07
申请号：US10876998
申请日：2004-06-25
Applicant: Anthony J. Kihm , Agnieszka Seyda , Sridevi Dhanaraj , Ziwei Wang , Alexander M. Harmon , Ian Ross Harris , Darin J. Messina , Sanjay Mistry , Anna Gosiewska , Chin-Feng Yi
Inventor： Anthony J. Kihm , Agnieszka Seyda , Sridevi Dhanaraj , Ziwei Wang , Alexander M. Harmon , Ian Ross Harris , Darin J. Messina , Sanjay Mistry , Anna Gosiewska , Chin-Feng Yi
IPC: A61K48/00 , A61K35/51 , C12N5/074 , C12N5/073 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/27 , C12N5/0735 , A61K35/50 , A61K35/12
Abstract: Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions.
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