公开(公告)号：US07029693B2

公开(公告)日：2006-04-18

申请号：US09946889

申请日：2001-09-05

申请人： Mitsuhiko Hori ,  Kensuke Matsuoka ,  Kenjiro Minomi ,  Yoshihisa Nakano

发明人： Mitsuhiko Hori ,  Kensuke Matsuoka ,  Kenjiro Minomi ,  Yoshihisa Nakano

IPC分类号： A61K9/70 ,  A01N25/34

CPC分类号： A61K9/7061

摘要： A percutaneously absorptive preparation is provided, which preparation having a support and an adhesive layer having a release-controlling layer, which is formed at least on one side of the support, wherein the adhesive layer contains an adhesive and 0.5–60 wt % of a drug except 1,2-ethanediol derivatives.

公开(公告)号：US20060034900A1

公开(公告)日：2006-02-16

申请号：US11196935

申请日：2005-08-04

申请人： Yuji Saeki ,  Masato Nishimura ,  Kensuke Matsuoka ,  Takateru Muraoka ,  Yoshifumi Hosaka ,  Mitsuhiko Hori ,  Kazuhisa Ninomiya ,  Hitoshi Akemi ,  Hidetoshi Kuroda

发明人： Yuji Saeki ,  Masato Nishimura ,  Kensuke Matsuoka ,  Takateru Muraoka ,  Yoshifumi Hosaka ,  Mitsuhiko Hori ,  Kazuhisa Ninomiya ,  Hitoshi Akemi ,  Hidetoshi Kuroda

IPC分类号： A61K31/445 ,  A61F13/02

CPC分类号： A61K9/7053 ,  A61K31/4468

摘要： The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.

公开(公告)号：US4847260A

公开(公告)日：1989-07-11

申请号：US113352

申请日：1987-10-26

申请人： Yoko Abe ,  Susumu Satoh ,  Mitsuhiko Hori ,  Naoko Yamanaka

发明人： Yoko Abe ,  Susumu Satoh ,  Mitsuhiko Hori ,  Naoko Yamanaka

IPC分类号： A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/22 ,  C07D213/79 ,  C07D213/80

CPC分类号： C07D213/79 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/22 ,  A61K9/0014 ,  C07D213/80

摘要： A composition for percutaneous administration containing a nicotinic ester represented by formula (I) ##STR1## or an isonicotinic ester represented by formula (II) ##STR2## wherein R and R' each represents an alkyl group having 5 or more carbon atoms,with or without a specific polar compound. The composition improves percutaneous absorption of an active ingredient.

摘要翻译： 用于经皮给药的组合物，其含有由式（I）表示的烟酸酯或由式（II）表示的异烟酸酯其中R和R'各自表示具有5或 更多的碳原子，有或没有特定的极性化合物。 该组合物改善活性成分的经皮吸收。

公开(公告)号：US07964213B2

公开(公告)日：2011-06-21

申请号：US10411822

申请日：2003-04-11

申请人： Mitsuhiko Hori ,  Keiji Yamamoto ,  Kensuke Matsuoka ,  Yoshihisa Nakano

发明人： Mitsuhiko Hori ,  Keiji Yamamoto ,  Kensuke Matsuoka ,  Yoshihisa Nakano

IPC分类号： A61F13/00

CPC分类号： A61K9/7061 ,  Y10T442/2738 ,  Y10T442/674

摘要： The present invention relates to a patch containing a substrate, a non-crosslinked adhesive layer (A) containing a drug laminated on one surface of the substrate and a crosslinked adhesive layer (B) laminated on the adhesive layer (A). According to the present invention, the percutaneous absorbability of the drug can be improved, and a patch free of problems such as adhesive residue and adhesive bleed can be provided.

摘要翻译： 本发明涉及含有基材，含有层叠在基材的一个表面上的药物的非交联粘合剂层（A）和层压在粘合剂层（A）上的交联粘合剂层（B））的贴剂。 根据本发明，可以提高药物的经皮吸收性，并且可以提供没有诸如粘合剂残留和粘合剂渗色的问题的贴剂。

公开(公告)号：US20050214352A1

公开(公告)日：2005-09-29

申请号：US10511061

申请日：2003-04-11

申请人： Mitsuhiko Hori ,  Keiji Yamamoto ,  Kensuke Matsuoka ,  Yoshihisa Nakano ,  Kenjirou Mimomi ,  Masashi Yamada ,  Masaru Otsuka ,  Yasunori Suzuki ,  Akihiro Kawashima

发明人： Mitsuhiko Hori ,  Keiji Yamamoto ,  Kensuke Matsuoka ,  Yoshihisa Nakano ,  Kenjirou Mimomi ,  Masashi Yamada ,  Masaru Otsuka ,  Yasunori Suzuki ,  Akihiro Kawashima

IPC分类号： A61K9/70 ,  A61K31/137 ,  A61K47/10 ,  A61K47/14 ,  A61P9/02 ,  A61K31/138

CPC分类号： A61K9/7061 ,  A61K31/137

摘要： The present invention relates to a patch containing a substrate, a non-crosslinked adhesive layer (A) containing DMAE or a pharmacologically acceptable salt thereof laminated on one surface of the substrate and a crosslinked adhesive layer (B) laminated on the adhesive layer (A). According to the present invention, the percutaneous absorbability of DMAE or a pharmacologically acceptable salt thereof can be improved, and a patch free of problems such as adhesive residue and adhesive bleed can be provided.

摘要翻译： 本发明涉及层叠在基材的一面上的含有基材，含有DMAE的非交联型粘合剂层（A）或其药理学上可接受的盐的贴剂和层叠在粘合剂层（A）上的交联粘合剂层 ）。 根据本发明，可以提高DMAE或其药理学上可接受的盐的经皮吸收性，并且可以提供没有粘合剂残留和粘合剂渗色等问题的贴剂。

公开(公告)号：US6146656A

公开(公告)日：2000-11-14

申请号：US232684

申请日：1999-01-19

申请人： Mitsuhiko Hori ,  Kenjiro Minomi ,  Yoshihisa Nakano

发明人： Mitsuhiko Hori ,  Kenjiro Minomi ,  Yoshihisa Nakano

IPC分类号： A61K9/70 ,  A61F13/02 ,  A61K31/445

CPC分类号： A61K9/7053 ,  A61K9/7061

摘要： The present invention provides a percutaneous absorption preparation which comprises a skin contact base containing therein at least one active ingredient selected from the group consisting of biperiden, trihexyphenidyl and pharmacologically acceptable salts thereof in an amount of from 0.5 to 60% by weight. The percutaneous absorption preparation makes it possible to permit the percutaneous absorption of biperiden, trihexyphenidyl or pharmacologically acceptable salt thereof as an active ingredient so that the medicament can be used effectively and at the same time, pharmacological effects can be sustained long and administration can be carried out conveniently. In addition, the active ingredient contained in it can be maintained stably.

摘要翻译： 本发明提供了一种经皮吸收制剂，其包含皮肤接触基质，其中含有至少一种活性成分，所述至少一种活性成分选自双倍哌啶，三己烯基及其药理学上可接受的盐，其量为0.5至60重量％。 经皮吸收制剂使得双倍哌啶，三己苯醌或其药理学上可接受的盐的经皮吸收作为活性成分成为可能，可以有效地使用药物，同时可以持续长时间的药理作用，可以进行给药 方便的 此外，其中包含的活性成分可以稳定地保持。

公开(公告)号：US6117447A

公开(公告)日：2000-09-12

申请号：US203749

申请日：1998-12-02

申请人： Yoshihisa Nakano ,  Mitsuhiko Hori ,  Keiji Yamamoto ,  Saburo Otsuka

发明人： Yoshihisa Nakano ,  Mitsuhiko Hori ,  Keiji Yamamoto ,  Saburo Otsuka

IPC分类号： A61K9/70 ,  A61K31/00 ,  A61K31/045 ,  A61K31/135 ,  A61P11/00 ,  A61P11/08

CPC分类号： A61K9/7053 ,  A61K31/135 ,  A61K9/7061 ,  Y10S514/946 ,  Y10S514/947

摘要： A percutaneous absorption type preparation comprising a support and a plaster layer laminated thereon, which composes tulobuterol in a proportion of not less than 5 wt % in a dissolution state and an adhesive. The preparation of the present invention retains the active ingredient, tulobuterol, at a high concentration in a complete dissolution state in the plaster layer. Therefore, it is free of time-course changes in drug releasing property and adhesive property caused by precipitation of drug crystals with the lapse of time. The inventive preparation is superior in percutaneous absorption of the drug, particularly percutaneous absorption rate at the initial stage of the administration; shows superior duration of efficacy by maintaining effective blood concentration for a long time; and is associated with less changes with the lapse of time in adhesive property such as adhesion to the skin.

摘要翻译： 一种经皮吸收型制剂，其包含层压在其上的支持体和石膏层，其在溶解状态下组成不小于5重量％的比例的丁非特罗和粘合剂。 本发明的制剂在石膏层中以完全溶解状态保持高浓度的活性成分，特鲁替罗。 因此，随着时间的流逝，药物释放性质和药物晶体析出引起的粘合性无时间变化。 本发明的制剂在药物的经皮吸收方面优异，特别是在给药的初始阶段的经皮吸收速率; 通过长期维持有效的血液浓度显示出优异的疗效持续时间; 并且随着粘合性（如粘附于皮肤）随着时间的推移而变化较小。

公开(公告)号：US5183665A

公开(公告)日：1993-02-02

申请号：US299506

申请日：1989-01-23

申请人： Mitsuhiko Hori

发明人： Mitsuhiko Hori

IPC分类号： A61K31/54 ,  A61K45/06

CPC分类号： A61K45/06 ,  A61K31/54 ,  Y10S514/946

摘要： The present invention relates to a composition for percutaneous administration which can enhance percutaneous absorption of a physiologically active ingredient and a method of enhancing percutaneous absorption of a physiologically active ingredient employing the same.

摘要翻译： 本发明涉及能够提高生理活性成分的经皮吸收的经皮给药用组合物和使用其的生理活性成分的经皮吸收增强方法。